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ONTOLOGY REPORT - ANNOTATIONS


Term:leucine metabolic process
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Accession:GO:0006551 term browser browse the term
Definition:The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid.
Synonyms:exact_synonym: leucine metabolism


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leucine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcat2 branched chain amino acid transaminase 2 ISO MGI:MGI:3028726|MGI:MGI:3772355 (MGI:MGI:3027291|PMID:14755340), (MGI:MGI:3770498|PMID:17767905) RGD PMID:14755340, PMID:17767905 MGI:MGI:3027291, MGI:MGI:3770498 NCBI chr 1:101,553,900...101,572,103
Ensembl chr 1:101,554,642...101,572,080
JBrowse link
G Dao D-amino-acid oxidase ISO MGI:MGI:3528694 (MGI:MGI:3525958|PMID:15026304) RGD PMID:15026304 MGI:MGI:3525958 NCBI chr12:48,353,691...48,373,647
Ensembl chr12:48,354,196...48,365,784
JBrowse link
G Ivd isovaleryl-CoA dehydrogenase TAS RGD PMID:2777793 RGD:631718 NCBI chr 3:110,669,355...110,689,789
Ensembl chr 3:110,669,312...110,690,173
JBrowse link
leucine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcat1 branched chain amino acid transaminase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:179,259,305...179,340,021
Ensembl chr 4:179,259,308...179,339,795
JBrowse link
G Bcat2 branched chain amino acid transaminase 2 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:11733007, PMID:21873635 RGD:1582175, RGD:13792537 NCBI chr 1:101,553,900...101,572,103
Ensembl chr 1:101,554,642...101,572,080
JBrowse link
leucine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Auh AU RNA binding methylglutaconyl-CoA hydratase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr17:12,310,178...12,405,224
Ensembl chr17:12,310,214...12,405,205
JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase IMP RGD PMID:27472223 RGD:39131293 NCBI chr 1:199,351,628...199,356,299
Ensembl chr 1:199,351,628...199,356,881
JBrowse link
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:154,294,841...154,308,582
Ensembl chr 5:154,294,806...154,308,640
JBrowse link
G Hmgcll1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:83,069,837...83,204,778
Ensembl chr 8:83,070,545...83,205,441
JBrowse link
G Ivd isovaleryl-CoA dehydrogenase IEA
ISO
IDA
GO_REF:0000041
(PMID:7640268)
PMID:6401713
UniProt
RGD
PMID:7640268, PMID:6401713 GO_REF:0000041, RGD:8554099 NCBI chr 3:110,669,355...110,689,789
Ensembl chr 3:110,669,312...110,690,173
JBrowse link
G Mccc1 methylcrotonoyl-CoA carboxylase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:122,550,777...122,690,540
Ensembl chr 2:122,550,775...122,690,617
JBrowse link
G Mccc2 methylcrotonoyl-CoA carboxylase 2 IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 2:30,175,017...30,246,028
Ensembl chr 2:30,175,018...30,246,010
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      primary metabolic process 10920
        cellular amino acid metabolic process 276
          alpha-amino acid metabolic process 201
            leucine metabolic process 10
              D-leucine metabolic process + 0
              leucine biosynthetic process + 2
              leucine catabolic process + 7
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      small molecule metabolic process 1874
        organic acid metabolic process 1095
          oxoacid metabolic process 1066
            carboxylic acid metabolic process 1009
              cellular amino acid metabolic process 276
                alpha-amino acid metabolic process 201
                  leucine metabolic process 10
                    D-leucine metabolic process + 0
                    leucine biosynthetic process + 2
                    leucine catabolic process + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.