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ONTOLOGY REPORT - ANNOTATIONS


Term:glutamate decarboxylation to succinate
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Accession:GO:0006540 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes.
Comment:Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively).
Synonyms:exact_synonym: 4-aminobutyrate shunt;   GABA shunt;   degradation of glutamate to succinate through GABA;   gamma-aminobutyrate shunt;   glutamate degradation via 4-aminobutyrate;   glutamate degradation via GABA
 xref: MetaCyc:GLUDEG-I-PWY;   MetaCyc:PWY-4321;   MetaCyc:PWY3O-210


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glutamate decarboxylation to succinate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gad2 glutamate decarboxylase 2 IDA RGD PMID:8999827 RGD:1625237 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
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  biological_process 20020
    metabolic process 12263
      primary metabolic process 10900
        cellular amino acid metabolic process 268
          cellular amino acid catabolic process 94
            glutamate catabolic process 5
              glutamate decarboxylation to succinate 1
                glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity 0
                glutamate catabolic process to succinate via succinate semialdehyde 0
Path 2
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      cellular metabolic process 11073
        organic acid metabolic process 1008
          oxoacid metabolic process 970
            carboxylic acid metabolic process 951
              cellular amino acid metabolic process 268
                alpha-amino acid metabolic process 190
                  glutamine family amino acid metabolic process 75
                    glutamate metabolic process 35
                      glutamate catabolic process 5
                        glutamate decarboxylation to succinate 1
                          glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity 0
                          glutamate catabolic process to succinate via succinate semialdehyde 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.