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ONTOLOGY REPORT - ANNOTATIONS

Term:glycoprotein catabolic process
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Accession:GO:0006516 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
Synonyms:exact_synonym: glycoprotein breakdown;   glycoprotein catabolism;   glycoprotein degradation


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glycoprotein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 acts_upstream_of_or_within ISO (MGI:3654428|PMID:16431915) MGI PMID:16431915 MGI:3654428 NCBI chr 1:184,690,237...184,754,858
Ensembl chr 1:184,690,237...184,754,907 		JBrowse link
G FBXO17 F-box protein 17 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:38,941,401...38,975,742
Ensembl chr19:38,941,401...38,975,742 		JBrowse link
G FBXO2 F-box protein 2 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA
ISS		 (MGI:3573989|PMID:15723043)
(PMID:21873635)		 MGI
Ensembl
GO_Central
UniProt		 PMID:15723043 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:3573989 NCBI chr 1:11,648,387...11,654,429
Ensembl chr 1:11,637,018...11,655,785 		JBrowse link
G FBXO27 F-box protein 27 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:39,005,842...39,032,549
Ensembl chr19:38,990,714...39,032,785 		JBrowse link
G FBXO44 F-box protein 44 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:11,654,407...11,663,327
Ensembl chr 1:11,654,375...11,663,327 		JBrowse link
G FBXO6 F-box protein 6 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (MGI:3573989|PMID:15723043)
(PMID:21873635)		 MGI
Ensembl
GO_Central		 PMID:15723043 PMID:21873635 GO_REF:0000107 MGI:3573989 NCBI chr 1:11,664,200...11,674,354
Ensembl chr 1:11,664,200...11,674,354 		JBrowse link
G MANBA mannosidase beta acts_upstream_of_or_within
involved_in		 ISO
IBA
ISS		 (MGI:57603|PMID:3447593)
(PMID:21873635)		 MGI
GO_Central
UniProt		 PMID:3447593 PMID:21873635 GO_REF:0000024 MGI:57603 NCBI chr 4:102,630,770...102,760,968
Ensembl chr 4:102,630,770...102,760,994 		JBrowse link
G NCCRP1 NCCRP1, F-box associated domain containing involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:39,196,964...39,201,884
Ensembl chr19:39,196,964...39,201,884 		JBrowse link
G NEU2 neuraminidase 2 involved_in IDA (PMID:14613940) UniProt PMID:14613940 NCBI chr 2:233,032,672...233,035,057
Ensembl chr 2:233,032,672...233,035,057 		JBrowse link
G NEU4 neuraminidase 4 involved_in IEA
IDA		 (PMID:15213228), (PMID:15847605) Ensembl
UniProt		 PMID:15213228 PMID:15847605 GO_REF:0000107 NCBI chr 2:241,809,193...241,817,413
Ensembl chr 2:241,809,065...241,817,413 		JBrowse link
G NGLY1 N-glycanase 1 involved_in IEA
IBA
IDA		 (PMID:21873635)
(PMID:15358861)		 Ensembl
GO_Central
InterPro
UniProt		 PMID:15358861 PMID:21873635 GO_REF:0000002 GO_REF:0000107 NCBI chr 3:25,718,944...25,790,039
Ensembl chr 3:25,718,944...25,790,039 		JBrowse link
G OGA O-GlcNAcase involved_in TAS (PMID:9811929) PINC PMID:9811929 NCBI chr10:101,784,450...101,818,444
Ensembl chr10:101,784,443...101,818,465 		JBrowse link
G PPP6R3 protein phosphatase 6 regulatory subunit 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr11:68,460,752...68,615,334
Ensembl chr11:68,460,731...68,615,334 		JBrowse link
G STT3B STT3 oligosaccharyltransferase complex catalytic subunit B involved_in IMP (PMID:22607976) UniProt PMID:22607976 NCBI chr 3:31,532,925...31,637,616
Ensembl chr 3:31,532,638...31,637,616 		JBrowse link
elastin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CELA1 chymotrypsin like elastase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5641427|PMID:24793170) MGI
Ensembl		 PMID:24793170 GO_REF:0000107 MGI:5641427 NCBI chr12:51,328,442...51,346,679
Ensembl chr12:51,328,442...51,346,679 		JBrowse link
G CTSL cathepsin L involved_in ISS UniProt GO_REF:0000024 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469 		JBrowse link
G MMP12 matrix metallopeptidase 12 involved_in IDA (PMID:29101312) ARUK-UCL PMID:29101312 NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982 		JBrowse link
heparan sulfate proteoglycan catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLB1 galactosidase beta 1 involved_in TAS Reactome Reactome:R-HSA-2024096 NCBI chr 3:32,961,108...33,097,146
Ensembl chr 3:32,996,609...33,097,202 		JBrowse link
G GPC1 glypican 1 involved_in IDA (PMID:12732622) UniProt PMID:12732622 NCBI chr 2:240,435,663...240,468,076
Ensembl chr 2:240,435,663...240,468,076 		JBrowse link
G GUSB glucuronidase beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215 		JBrowse link
G HGSNAT heparan-alpha-glucosaminide N-acetyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:43,140,464...43,202,855
Ensembl chr 8:43,140,464...43,202,855 		JBrowse link
G HPSE heparanase involved_in IDA
IEA		 (PMID:12213822) UniProt
Ensembl		 PMID:12213822 GO_REF:0000107 NCBI chr 4:83,292,461...83,335,153
Ensembl chr 4:83,292,461...83,335,153 		JBrowse link
G IDS iduronate 2-sulfatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:149,476,988...149,505,306
Ensembl chr  X:149,476,988...149,521,096 		JBrowse link
G IDUA alpha-L-iduronidase involved_in TAS Reactome Reactome:R-HSA-2024096 NCBI chr 4:986,997...1,008,351
Ensembl chr 4:986,997...1,004,564 		JBrowse link
G NAGLU N-acetyl-alpha-glucosaminidase involved_in IEA
TAS		 Ensembl
Reactome		 GO_REF:0000107 Reactome:R-HSA-2024096 NCBI chr17:42,536,241...42,544,449
Ensembl chr17:42,536,241...42,544,449 		JBrowse link
G SGSH N-sulfoglucosamine sulfohydrolase involved_in IMP
IBA
TAS
IEA		 (PMID:15146460)
(PMID:21873635)		 UniProt
GO_Central
Reactome
Ensembl		 PMID:15146460 PMID:21873635 GO_REF:0000107 Reactome:R-HSA-2024096 NCBI chr17:80,200,673...80,220,333
Ensembl chr17:80,206,716...80,220,923 		JBrowse link
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 involved_in IEA
TAS
IMP		 (PMID:25092655) InterPro
Reactome
ParkinsonsUK-UCL		 PMID:25092655 GO_REF:0000002 Reactome:R-HSA-6782685 NCBI chr 3:5,187,707...5,219,958
Ensembl chr 3:5,187,646...5,219,958 		JBrowse link
G EDEM2 ER degradation enhancing alpha-mannosidase like protein 2 involved_in IEA
IMP		 (PMID:25092655) InterPro
ParkinsonsUK-UCL		 PMID:25092655 GO_REF:0000002 NCBI chr20:35,115,364...35,147,336
Ensembl chr20:35,115,364...35,147,336 		JBrowse link
G EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 involved_in TAS
IMP
IEA		 (PMID:25092655) Reactome
ParkinsonsUK-UCL
InterPro		 PMID:25092655 GO_REF:0000002 Reactome:R-HSA-6782685 NCBI chr 1:184,690,237...184,754,858
Ensembl chr 1:184,690,237...184,754,907 		JBrowse link
G MAN1A1 mannosidase alpha class 1A member 1 involved_in IDA (PMID:27108681) UniProt PMID:27108681 NCBI chr 6:119,177,205...119,350,605
Ensembl chr 6:119,177,205...119,349,761 		JBrowse link
G MAN1B1 mannosidase alpha class 1B member 1 involved_in IMP
TAS		 (PMID:18003979), (PMID:21062743)
(PMID:22160784)		 ParkinsonsUK-UCL PMID:18003979 PMID:21062743 PMID:22160784 NCBI chr 9:137,086,985...137,109,183
Ensembl chr 9:137,086,857...137,109,189 		JBrowse link
G MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough involved_in IMP
IEA		 (PMID:25092655) ParkinsonsUK-UCL
InterPro		 PMID:25092655 GO_REF:0000002 NCBI chr20:35,115,364...35,278,122 JBrowse link
negative regulation of elastin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CST3 cystatin C involved_in IMP (PMID:10545518) BHF-UCL PMID:10545518 NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473 		JBrowse link
positive regulation of elastin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR181B1 microRNA 181b-1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:198,858,873...198,858,982
Ensembl chr 1:198,858,873...198,858,982 		JBrowse link
G MIR181B2 microRNA 181b-2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 9:124,693,710...124,693,798
Ensembl chr 9:124,693,710...124,693,798 		JBrowse link
proteoglycan catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif 12 involved_in IDA (PMID:17895370) BHF-UCL PMID:17895370 NCBI chr 5:33,523,535...33,891,990
Ensembl chr 5:33,523,535...33,892,019 		JBrowse link
G BTK Bruton tyrosine kinase involved_in ISO
IEA		 RGD
Ensembl		 PMID:32083858 GO_REF:0000107 RGD:151665122 NCBI chr  X:101,349,450...101,390,796
Ensembl chr  X:101,349,338...101,390,796 		JBrowse link
ubiquitin-dependent glycoprotein ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 involved_in IMP (PMID:21062743), (PMID:25092655) ParkinsonsUK-UCL PMID:21062743 PMID:25092655 NCBI chr 3:5,187,707...5,219,958
Ensembl chr 3:5,187,646...5,219,958 		JBrowse link
G EDEM2 ER degradation enhancing alpha-mannosidase like protein 2 involved_in IMP (PMID:15537790) ParkinsonsUK-UCL PMID:15537790 NCBI chr20:35,115,364...35,147,336
Ensembl chr20:35,115,364...35,147,336 		JBrowse link
G MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough involved_in IMP (PMID:15537790) ParkinsonsUK-UCL PMID:15537790 NCBI chr20:35,115,364...35,278,122 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19532
    metabolic process 12880
      organic substance metabolic process 12429
        macromolecule metabolic process 10250
          macromolecule catabolic process 1257
            glycoprotein catabolic process 36
              O-sialoglycoprotein catabolic process 0
              elastin catabolic process + 6
              mannoprotein catabolic process 0
              protein deglycosylation involved in glycoprotein catabolic process + 6
              proteoglycan catabolic process + 11
              ubiquitin-dependent glycoprotein ERAD pathway + 6
paths to the root