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ONTOLOGY REPORT - ANNOTATIONS


Term:membrane protein ectodomain proteolysis
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Accession:GO:0006509 term browser browse the term
Definition:The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
Synonyms:exact_synonym: ectodomain cleavage
 broad_synonym: ectoderm shedding
 related_synonym: membrane protein solubilization;   receptor shedding


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membrane protein ectodomain proteolysis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam10 ADAM metallopeptidase domain 10 JBrowse link 8 77,107,355 77,237,483 RGD:1600115
RGD:1624291
RGD:13792537
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:1559178
RGD:13792537
RGD:1624291
RGD:1600115
RGD:2317978
G Adam19 ADAM metallopeptidase domain 19 JBrowse link 10 31,146,107 31,240,582 RGD:1624291
G Adam9 ADAM metallopeptidase domain 9 JBrowse link 16 71,810,377 71,887,926 RGD:1624291
G Aph1a aph-1 homolog A, gamma secretase subunit JBrowse link 2 198,006,247 198,009,837 RGD:1624291
G Bace1 beta-secretase 1 JBrowse link 8 50,140,092 50,162,388 RGD:1624291
RGD:13792537
G Bace2 beta-secretase 2 JBrowse link 11 37,798,397 37,880,624 RGD:1600115
RGD:13792537
RGD:1624291
G Dag1 dystroglycan 1 JBrowse link 8 116,980,501 116,993,182 RGD:1624291
G Erap1 endoplasmic reticulum aminopeptidase 1 JBrowse link 2 1,410,877 1,449,734 RGD:1600115
RGD:1624291
G Hm13 histocompatibility minor 13 JBrowse link 3 148,150,695 148,189,623 RGD:1624291
G Myh9 myosin, heavy chain 9 JBrowse link 7 118,740,005 118,792,507 RGD:1624291
G Myh9l1 myosin heavy chain 9-like 1 JBrowse link 7 118,991,251 119,071,722 RGD:1600115
G Ncstn nicastrin JBrowse link 13 90,451,046 90,467,256 RGD:1624291
RGD:1600115
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Prkcq protein kinase C, theta JBrowse link 17 70,971,915 71,105,286 RGD:1624291
RGD:1600115
G Prtn3 proteinase 3 JBrowse link 7 12,643,712 12,646,951 RGD:1624291
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1626321
RGD:13792537
RGD:1600115
RGD:1624291
G Psen2 presenilin 2 JBrowse link 13 98,513,600 98,539,347 RGD:1624291
RGD:13792537
G Psenen presenilin enhancer gamma secretase subunit JBrowse link 1 89,016,093 89,017,449 RGD:1624291
G Rbmx RNA binding motif protein, X-linked JBrowse link X 159,881,835 159,891,405 RGD:1624291
G Rbmxl1 RBMX like 1 JBrowse link 19 33,081,473 33,084,988 RGD:1600115
G Sppl2a signal peptide peptidase-like 2A JBrowse link 3 119,361,651 119,405,453 RGD:1624291
G Sppl2b signal peptide peptidase-like 2B JBrowse link 7 11,712,187 11,724,915 RGD:1600115
RGD:1624291
G Sppl2c signal peptide peptidase like 2C JBrowse link 10 92,245,434 92,248,758 RGD:1624291
G Sppl3 signal peptide peptidase like 3 JBrowse link 12 47,276,485 47,360,552 RGD:1624291
constitutive protein ectodomain proteolysis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam10 ADAM metallopeptidase domain 10 JBrowse link 8 77,107,355 77,237,483 RGD:1624291
negative regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1624291
RGD:1600115
G Lrig2 leucine-rich repeats and immunoglobulin-like domains 2 JBrowse link 2 206,928,708 206,997,915 RGD:1624291
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 JBrowse link 5 74,248,996 74,368,167 RGD:1624291
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:1624291
RGD:13792537
G Timp2 TIMP metallopeptidase inhibitor 2 JBrowse link 10 107,338,465 107,386,072 RGD:13792537
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:1624291
RGD:13792537
RGD:1600115
G Timp4 TIMP metallopeptidase inhibitor 4 JBrowse link 4 147,156,948 147,163,467 RGD:13792537
PMA-inducible membrane protein ectodomain proteolysis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam10 ADAM metallopeptidase domain 10 JBrowse link 8 77,107,355 77,237,483 RGD:1624291
RGD:13792537
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:1624291
RGD:13792537
RGD:1600115
G Adam9 ADAM metallopeptidase domain 9 JBrowse link 16 71,810,377 71,887,926 RGD:1624291
positive regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam8 ADAM metallopeptidase domain 8 JBrowse link 1 212,317,510 212,332,895 RGD:1624291
G Adam9 ADAM metallopeptidase domain 9 JBrowse link 16 71,810,377 71,887,926 RGD:1624291
G Adra2a adrenoceptor alpha 2A JBrowse link 1 274,766,283 274,769,083 RGD:1624291
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1600115
RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 JBrowse link 17 42,085,027 42,131,344 RGD:1600115
RGD:1624291
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1624291
RGD:1600115
G Nrdc nardilysin convertase JBrowse link 5 128,629,949 128,694,209 RGD:1624291
RGD:1600115
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 JBrowse link 3 80,072,425 80,081,058 RGD:1624291
G Rgma repulsive guidance molecule BMP co-receptor a JBrowse link 1 134,699,053 134,742,512 RGD:1624291
G Sh3d19 SH3 domain containing 19 JBrowse link 2 185,268,028 185,431,834 RGD:1624291
G Snx33 sorting nexin 33 JBrowse link 8 61,584,656 61,596,055 RGD:1624291
G Snx9 sorting nexin 9 JBrowse link 1 46,780,142 46,826,250 RGD:1624291
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      primary metabolic process 10750
        protein metabolic process 6186
          proteolysis 1882
            membrane protein proteolysis 57
              membrane protein ectodomain proteolysis 47
                PMA-inducible membrane protein ectodomain proteolysis 3
                constitutive protein ectodomain proteolysis 1
                negative regulation of membrane protein ectodomain proteolysis 7
                positive regulation of membrane protein ectodomain proteolysis 16
                regulation of membrane protein ectodomain proteolysis + 23
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      organic substance metabolic process 11495
        macromolecule metabolic process 9944
          protein metabolic process 6186
            proteolysis 1882
              membrane protein proteolysis 57
                membrane protein ectodomain proteolysis 47
                  PMA-inducible membrane protein ectodomain proteolysis 3
                  constitutive protein ectodomain proteolysis 1
                  negative regulation of membrane protein ectodomain proteolysis 7
                  positive regulation of membrane protein ectodomain proteolysis 16
                  regulation of membrane protein ectodomain proteolysis + 23
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.