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ONTOLOGY REPORT - ANNOTATIONS

Term:GPI anchor biosynthetic process
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Accession:GO:0006506 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.
Synonyms:exact_synonym: GPI anchor anabolism;   GPI anchor biosynthesis;   GPI anchor formation;   GPI anchor synthesis;   glycosylphosphatidylinositol biosynthesis;   glycosylphosphatidylinositol biosynthetic process
 broad_synonym: GPI/GSI anchor biosynthesis;   GPI/GSI anchor biosynthetic process
 alt_id: GO:0015998


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GPI anchor biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cwh43 cell wall biogenesis 43 C-terminal homolog involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:73,563,394...73,610,778
Ensembl chr 5:73,563,418...73,610,778 		JBrowse link
G Dpm1 dolichyl-phosphate mannosyltransferase subunit 1, catalytic acts_upstream_of_or_within
involved_in		 ISO
IMP
IBA		 (PMID:9535917) MGI
GO_Central		 PMID:9535917 GO_REF:0000008 GO_REF:0000033 NCBI chr 2:168,050,968...168,072,299
Ensembl chr 2:168,050,968...168,072,511 		JBrowse link
G Dpm2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:9724629) MGI
GO_Central		 PMID:9724629 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:32,460,870...32,463,583
Ensembl chr 2:32,460,870...32,463,591 		JBrowse link
G Dpm3 dolichyl-phosphate mannosyltransferase polypeptide 3 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 3:89,166,567...89,174,386
Ensembl chr 3:89,166,665...89,174,386 		JBrowse link
G Gpaa1 GPI anchor attachment protein 1 acts_upstream_of_or_within ISS (PMID:10393431) MGI PMID:10393431 NCBI chr15:76,215,494...76,219,099
Ensembl chr15:76,215,431...76,219,107 		JBrowse link
G Mppe1 metallophosphoesterase 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr18:67,358,119...67,378,901
Ensembl chr18:67,358,114...67,378,901 		JBrowse link
G Pgap1 post-GPI attachment to proteins 1 involved_in ISO RGD
MGI		 PMID:14734546 GO_REF:0000096 MGI:4417868 RGD:1303970 NCBI chr 1:54,512,159...54,596,843
Ensembl chr 1:54,512,153...54,596,843 		JBrowse link
G Pgap2 post-GPI attachment to proteins 2 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr 7:101,859,153...101,887,771
Ensembl chr 7:101,859,415...101,887,774 		JBrowse link
G Pgap3 post-GPI attachment to proteins 3 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr11:98,279,498...98,292,022
Ensembl chr11:98,279,503...98,291,316 		JBrowse link
G Pgap4 post-GPI attachment to proteins GalNAc transferase 4 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 4:49,584,506...49,597,876
Ensembl chr 4:49,584,506...49,597,876 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:8611683) MGI
GO_Central		 PMID:8611683 GO_REF:0000033 NCBI chr  X:163,202,814...163,216,912
Ensembl chr  X:163,202,783...163,216,912 		JBrowse link
G Pigb phosphatidylinositol glycan anchor biosynthesis, class B involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 9:72,920,639...72,946,973
Ensembl chr 9:72,914,701...72,947,660 		JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:161,796,757...161,801,029
Ensembl chr 1:161,796,755...161,801,004 		JBrowse link
G Pigf phosphatidylinositol glycan anchor biosynthesis, class F involved_in IDA
IBA
ISO		 (MGI:1860649|PMID:10781593) UniProt
GO_Central
MGI		 PMID:10781593 GO_REF:0000033 GO_REF:0000119 MGI:1860649 MGI:4834177 NCBI chr17:87,304,686...87,332,972
Ensembl chr17:87,304,684...87,332,834 		JBrowse link
G Pigg phosphatidylinositol glycan anchor biosynthesis, class G acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:15632136) MGI
GO_Central		 PMID:15632136 GO_REF:0000033 NCBI chr 5:108,460,679...108,497,225
Ensembl chr 5:108,460,475...108,497,221 		JBrowse link
G Pigh phosphatidylinositol glycan anchor biosynthesis, class H involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr12:79,127,443...79,136,478
Ensembl chr12:79,127,438...79,136,425 		JBrowse link
G Pigk phosphatidylinositol glycan anchor biosynthesis, class K acts_upstream_of_or_within IEA UniProt GO_REF:0000043 MGI:1354194 NCBI chr 3:152,419,718...152,548,705
Ensembl chr 3:152,419,737...152,686,045 		JBrowse link
G Pigl phosphatidylinositol glycan anchor biosynthesis, class L involved_in ISO RGD
MGI		 PMID:9188481 GO_REF:0000096 MGI:4417868 RGD:729509 NCBI chr11:62,349,267...62,406,863
Ensembl chr11:62,349,286...62,405,243 		JBrowse link
G Pigm phosphatidylinositol glycan anchor biosynthesis, class M involved_in ISO
IBA		 RGD
GO_Central
MGI		 PMID:11226175 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:70624 NCBI chr 1:172,204,098...172,211,666
Ensembl chr 1:172,204,113...172,211,666 		JBrowse link
G Pign phosphatidylinositol glycan anchor biosynthesis, class N involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:105,446,147...105,591,466
Ensembl chr 1:105,446,147...105,591,402 		JBrowse link
G Pigo phosphatidylinositol glycan anchor biosynthesis, class O involved_in IDA
IBA		 (MGI:1860649|PMID:10781593) UniProt
GO_Central		 PMID:10781593 GO_REF:0000033 MGI:1860649 NCBI chr 4:43,016,964...43,026,369
Ensembl chr 4:43,017,635...43,025,819 		JBrowse link
G Pigp phosphatidylinositol glycan anchor biosynthesis, class P involved_in
acts_upstream_of_or_within		 ISO
IMP
IBA		 (PMID:10944123) MGI
GO_Central		 PMID:10944123 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr16:94,159,622...94,171,874
Ensembl chr16:94,159,622...94,172,701 		JBrowse link
G Pigq phosphatidylinositol glycan anchor biosynthesis, class Q involved_in
acts_upstream_of_or_within		 ISO
IBA
IGI
IMP		 (PMID:9729469)
(PMID:10373468)		 MGI
GO_Central		 PMID:9729469 PMID:10373468 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr17:26,145,398...26,161,855
Ensembl chr17:26,145,395...26,163,910 		JBrowse link
G Pigs phosphatidylinositol glycan anchor biosynthesis, class S acts_upstream_of_or_within IEA UniProt GO_REF:0000043 MGI:1354194 NCBI chr11:78,219,272...78,233,602
Ensembl chr11:78,219,241...78,233,608 		JBrowse link
G Pigt phosphatidylinositol glycan anchor biosynthesis, class T acts_upstream_of_or_within IEA UniProt GO_REF:0000043 MGI:1354194 NCBI chr 2:164,339,461...164,350,221
Ensembl chr 2:164,339,440...164,350,221 		JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:155,120,163...155,199,344
Ensembl chr 2:155,120,163...155,199,350 		JBrowse link
G Pigv phosphatidylinositol glycan anchor biosynthesis, class V involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 4:133,387,071...133,401,498
Ensembl chr 4:133,387,698...133,399,958 		JBrowse link
G Pigw phosphatidylinositol glycan anchor biosynthesis, class W involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:84,767,139...84,771,111
Ensembl chr11:84,767,141...84,771,111 		JBrowse link
G Pigx phosphatidylinositol glycan anchor biosynthesis, class X involved_in
acts_upstream_of_or_within		 IEA UniProt GO_REF:0000002 GO_REF:0000043 MGI:1354194 MGI:2152098 NCBI chr16:31,903,234...31,918,545
Ensembl chr16:31,903,234...31,918,558 		JBrowse link
G Pigyl phosphatidylinositol glycan anchor biosynthesis, class Y-like acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:16162815) MGI
GO_Central		 PMID:16162815 GO_REF:0000033 NCBI chr 9:22,068,142...22,069,651
Ensembl chr 9:22,068,142...22,069,654 		JBrowse link
G Pigz phosphatidylinositol glycan anchor biosynthesis, class Z involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr16:31,745,797...31,764,866
Ensembl chr16:31,752,669...31,764,864 		JBrowse link
G Pyurf Pigy upstream reading frame acts_upstream_of_or_within ISA (PMID:16162815) MGI PMID:16162815 NCBI chr 6:57,661,724...57,669,063
Ensembl chr 6:57,663,561...57,669,063 		JBrowse link
G Slc30a5 solute carrier family 30 (zinc transporter), member 5 acts_upstream_of_positive_effect ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:100,939,153...100,969,988
Ensembl chr13:100,939,156...100,969,935 		JBrowse link
attachment of GPI anchor to protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpaa1 GPI anchor attachment protein 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:76,215,494...76,219,099
Ensembl chr15:76,215,431...76,219,107 		JBrowse link
G Pigk phosphatidylinositol glycan anchor biosynthesis, class K involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:152,419,718...152,548,705
Ensembl chr 3:152,419,737...152,686,045 		JBrowse link
G Pigs phosphatidylinositol glycan anchor biosynthesis, class S involved_in IMP
IBA		 (MGI:3688056|PMID:11483512) UniProt
GO_Central		 PMID:11483512 GO_REF:0000033 MGI:3688056 NCBI chr11:78,219,272...78,233,602
Ensembl chr11:78,219,241...78,233,608 		JBrowse link
G Pigt phosphatidylinositol glycan anchor biosynthesis, class T involved_in IMP
IBA		 (MGI:3688056|PMID:11483512) UniProt
GO_Central		 PMID:11483512 GO_REF:0000033 MGI:3688056 NCBI chr 2:164,339,461...164,350,221
Ensembl chr 2:164,339,440...164,350,221 		JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:155,120,163...155,199,344
Ensembl chr 2:155,120,163...155,199,350 		JBrowse link
preassembly of GPI anchor in ER membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pigl phosphatidylinositol glycan anchor biosynthesis, class L involved_in ISO MGI GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr11:62,349,267...62,406,863
Ensembl chr11:62,349,286...62,405,243 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    metabolic process 11001
      primary metabolic process 9512
        protein metabolic process 4154
          protein modification process 1919
            protein lipidation 44
              GPI anchor biosynthetic process 33
                GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine 0
                attachment of GPI anchor to protein 5
                preassembly of GPI anchor in ER membrane 1
Path 2
Term Annotations click to browse term
  biological_process 28573
    metabolic process 11001
      cellular metabolic process 9207
        phosphorus metabolic process 1887
          phosphate-containing compound metabolic process 1862
            phospholipid metabolic process 375
              glycerophospholipid metabolic process 283
                phosphatidylinositol metabolic process 155
                  GPI anchor metabolic process 36
                    GPI anchor biosynthetic process 33
                      GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine 0
                      attachment of GPI anchor to protein 5
                      preassembly of GPI anchor in ER membrane 1
paths to the root