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ONTOLOGY REPORT - ANNOTATIONS

Term:GPI anchor biosynthetic process
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Accession:GO:0006506 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.
Synonyms:exact_synonym: GPI anchor anabolism;   GPI anchor biosynthesis;   GPI anchor formation;   GPI anchor synthesis;   glycosylphosphatidylinositol biosynthesis;   glycosylphosphatidylinositol biosynthetic process
 broad_synonym: GPI/GSI anchor biosynthesis;   GPI/GSI anchor biosynthetic process
 alt_id: GO:0015998


show annotations for term's descendants           Sort by:
GPI anchor biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07038703.1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr  X:54,564,018...54,565,271 JBrowse link
G Cwh43 cell wall biogenesis 43 C-terminal homolog involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:34,754,279...34,800,530
Ensembl chr14:34,754,289...34,800,814 		JBrowse link
G Dpm1 dolichyl-phosphate mannosyltransferase subunit 1, catalytic involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:10835346), (PMID:9535917)
(PMID:9535917)
GO_REF:0000033
(PMID:9535917), (PMID:9724629)		 RGD
GO_Central		 PMID:9535917 PMID:9724629 PMID:10835346 GO_REF:0000033 NCBI chr 3:156,919,979...156,939,522
Ensembl chr 3:156,919,979...156,939,536 		JBrowse link
G Dpm2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory acts_upstream_of_or_within
involved_in		 TAS
IDA
ISO
IEA
IBA		 PMID:9724629
(PMID:10835346), (PMID:16162815)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:10835346 PMID:16162815 PMID:9724629 PMID:9724629 GO_REF:0000033 GO_REF:0000107, RGD:69827, RGD:69827 NCBI chr 3:15,855,952...15,858,867
Ensembl chr 3:15,856,182...15,869,165
Ensembl chr 3:15,856,182...15,869,165 		JBrowse link
G Dpm3 dolichyl-phosphate mannosyltransferase subunit 3, regulatory involved_in ISO
IBA		 (PMID:10835346)
GO_REF:0000033		 RGD
GO_Central		 PMID:10835346 GO_REF:0000033 NCBI chr 2:174,676,532...174,677,047
Ensembl chr 2:174,676,363...174,677,668
Ensembl chr15:174,676,363...174,677,668 		JBrowse link
G Gpaa1 glycosylphosphatidylinositol anchor attachment 1 TAS RGD PMID:10702226 RGD:1331364 NCBI chr 7:108,051,896...108,055,479
Ensembl chr 7:108,051,861...108,055,484 		JBrowse link
G Mppe1 metallophosphoesterase 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000043
(PMID:29374258)		 UniProt
RGD		 PMID:29374258 GO_REF:0000024 GO_REF:0000043 NCBI chr18:60,763,418...60,781,553
Ensembl chr18:60,763,419...60,781,553 		JBrowse link
G Pgap1 post-GPI attachment to proteins inositol deacylase 1 IMP RGD PMID:14734546 RGD:1303970 NCBI chr 9:55,975,574...56,044,325
Ensembl chr 9:55,975,667...56,044,464 		JBrowse link
G Pgap2 post-GPI attachment to proteins 2 involved_in IMP
ISO
IEA
IBA		 PMID:16407401
(PMID:29374258)
GO_REF:0000043
GO_REF:0000033
GO_REF:0000118		 RGD
UniProt
GO_Central
TreeGrafter		 PMID:29374258 PMID:16407401 GO_REF:0000033 GO_REF:0000043 GO_REF:0000118, RGD:8553507 NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114 		JBrowse link
G Pgap3 post-GPI attachment to proteins phospholipase 3 involved_in ISO
IBA		 (PMID:29374258)
GO_REF:0000033		 RGD
GO_Central		 PMID:29374258 GO_REF:0000033 NCBI chr10:83,387,113...83,399,357
Ensembl chr10:83,387,113...83,398,628 		JBrowse link
G Pgap4 post-GPI attachment to proteins GalNAc transferase 4 involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:29374258)		 UniProt
GO_Central
RGD		 PMID:29374258 GO_REF:0000024 GO_REF:0000033 NCBI chr 5:63,931,916...63,947,004
Ensembl chr 5:63,930,682...63,951,716 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000041
MGI:3652879 (PMID:8611683)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:8611683 GO_REF:0000033 GO_REF:0000041 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804 		JBrowse link
G Pigb phosphatidylinositol glycan anchor biosynthesis, class B involved_in ISO
IBA		 (PMID:8861954)
GO_REF:0000033		 RGD
GO_Central		 PMID:8861954 GO_REF:0000033 NCBI chr 8:73,751,756...73,775,679
Ensembl chr 8:73,751,798...73,775,679 		JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000041
(PMID:16162815), (PMID:27694521)		 UniProt
RGD		 PMID:16162815 PMID:27694521 GO_REF:0000024 GO_REF:0000041 NCBI chr13:74,343,619...74,346,148
Ensembl chr13:74,296,854...74,346,211 		JBrowse link
G Pigf phosphatidylinositol glycan anchor biosynthesis, class F involved_in ISO
IBA
IEA		 (PMID:33386993)
GO_REF:0000033
GO_REF:0000041
(MGI:1860649|PMID:10781593)		 RGD
GO_Central
UniProt		 PMID:10781593 PMID:33386993 GO_REF:0000033 GO_REF:0000041 MGI:1860649 NCBI chr 6:7,589,584...7,617,719
Ensembl chr 6:7,589,570...7,639,675 		JBrowse link
G Pigg phosphatidylinositol glycan anchor biosynthesis, class G acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15632136)
GO_REF:0000041		 RGD
UniProt		 PMID:15632136 GO_REF:0000041 NCBI chr14:1,404,911...1,433,199
Ensembl chr14:1,406,798...1,433,187 		JBrowse link
G Pigh phosphatidylinositol glycan anchor biosynthesis, class H involved_in ISO
IBA
IEA		 (PMID:16162815)
GO_REF:0000033
GO_REF:0000041		 RGD
GO_Central
UniProt		 PMID:16162815 GO_REF:0000033 GO_REF:0000041 NCBI chr 6:97,874,903...97,897,188
Ensembl chr 6:97,882,903...97,897,142 		JBrowse link
G Pigl phosphatidylinositol glycan anchor biosynthesis, class L IDA RGD PMID:9188481 RGD:729509 NCBI chr10:47,142,160...47,199,892
Ensembl chr10:47,141,780...47,200,145 		JBrowse link
G Pigm phosphatidylinositol glycan anchor biosynthesis, class M involved_in IDA
IEA
IBA		 GO_REF:0000041
GO_REF:0000033		 UniProt
GO_Central
RGD		 PMID:11226175 GO_REF:0000033 GO_REF:0000041, RGD:70624 NCBI chr13:84,838,329...84,842,026
Ensembl chr13:84,838,175...84,843,381 		JBrowse link
G Pign phosphatidylinositol glycan anchor biosynthesis, class N involved_in IEA
IBA		 GO_REF:0000041
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000041 NCBI chr13:21,659,092...21,812,932
Ensembl chr13:21,662,455...21,806,790 		JBrowse link
G Pigo phosphatidylinositol glycan anchor biosynthesis, class O involved_in ISO
IBA
IEA		 (MGI:1860649|PMID:10781593)
GO_REF:0000033
GO_REF:0000041		 RGD
GO_Central
UniProt		 PMID:10781593 GO_REF:0000033 GO_REF:0000041 MGI:1860649 NCBI chr 5:57,244,721...57,256,252
Ensembl chr 5:57,245,166...57,254,146 		JBrowse link
G Pigp phosphatidylinositol glycan anchor biosynthesis, class P involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:16162815), (PMID:28334793)
(PMID:10944123)
GO_REF:0000033		 RGD
GO_Central		 PMID:10944123 PMID:16162815 PMID:28334793 GO_REF:0000033 NCBI chr11:33,682,943...33,689,111
Ensembl chr11:33,682,948...33,689,321 		JBrowse link
G Pigq phosphatidylinositol glycan anchor biosynthesis, class Q involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:16162815)
PomBase:SPBC30D10.11|SGD:S000003448 (PMID:10373468), (PMID:9729469)
GO_REF:0000033		 RGD
GO_Central		 PMID:9729469 PMID:10373468 PMID:16162815 GO_REF:0000033 NCBI chr10:14,942,571...14,958,584
Ensembl chr10:14,942,577...14,958,584 		JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U involved_in ISO (PMID:15034568) RGD PMID:15034568 NCBI chr 3:143,784,831...143,881,268
Ensembl chr 3:143,784,832...143,880,807 		JBrowse link
G Pigv phosphatidylinositol glycan anchor biosynthesis, class V involved_in ISO
IBA
IEA		 UniProtKB:P38211 (PMID:15623507), (PMID:15720390)
GO_REF:0000033
GO_REF:0000041		 RGD
GO_Central
UniProt		 PMID:15623507 PMID:15720390 GO_REF:0000033 GO_REF:0000041 NCBI chr 5:145,889,642...145,901,533
Ensembl chr 5:145,889,646...145,901,533 		JBrowse link
G Pigw phosphatidylinositol glycan anchor biosynthesis, class W involved_in IEA
IBA		 GO_REF:0000041
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000041 NCBI chr10:69,746,996...69,782,656
Ensembl chr10:69,748,789...69,790,475 		JBrowse link
G Pigx phosphatidylinositol glycan anchor biosynthesis, class X involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr11:68,687,126...68,703,067
Ensembl chr11:68,687,093...68,703,472 		JBrowse link
G Pigy phosphatidylinositol glycan anchor biosynthesis, class Y acts_upstream_of_or_within ISO (PMID:16162815) RGD PMID:16162815 NCBI chr 8:20,689,621...20,691,863
Ensembl chr 8:20,689,502...20,692,585 		JBrowse link
G Pigz phosphatidylinositol glycan anchor biosynthesis, class Z involved_in ISO UniProtKB:Q04174 (PMID:15208306) RGD PMID:15208306 NCBI chr11:68,831,847...68,851,798 JBrowse link
G Slc30a5 solute carrier family 30 member 5 acts_upstream_of_positive_effect ISO (PMID:35525268) RGD PMID:35525268 NCBI chr 2:31,945,745...31,975,969
Ensembl chr 2:31,945,729...31,975,934 		JBrowse link
attachment of GPI anchor to protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpaa1 glycosylphosphatidylinositol anchor attachment 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,051,896...108,055,479
Ensembl chr 7:108,051,861...108,055,484 		JBrowse link
G Pigk phosphatidylinositol glycan anchor biosynthesis, class K involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:241,630,021...241,715,493
Ensembl chr 2:241,630,053...241,716,134 		JBrowse link
G Pigs phosphatidylinositol glycan anchor biosynthesis, class S involved_in ISO
IBA		 (MGI:3688056|PMID:11483512)
GO_REF:0000033		 RGD
GO_Central		 PMID:11483512 GO_REF:0000033 MGI:3688056 NCBI chr10:63,222,611...63,237,190
Ensembl chr10:63,222,572...63,237,187 		JBrowse link
G Pigt phosphatidylinositol glycan anchor biosynthesis, class T involved_in ISO
IBA		 (MGI:3688056|PMID:11483512)
GO_REF:0000033		 RGD
GO_Central		 PMID:11483512 GO_REF:0000033 MGI:3688056 NCBI chr 3:153,227,749...153,236,922
Ensembl chr 3:153,227,420...153,236,887 		JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U involved_in IEA
ISO
IBA		 GO_REF:0000002
(PMID:12802054)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000118		 InterPro
RGD
Ensembl
GO_Central
TreeGrafter		 PMID:12802054 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:143,784,831...143,881,268
Ensembl chr 3:143,784,832...143,880,807 		JBrowse link
preassembly of GPI anchor in ER membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pigl phosphatidylinositol glycan anchor biosynthesis, class L involved_in IDA
ISO		 PMID:10085243
(PMID:10085243)		 RGD PMID:10085243 PMID:10085243 RGD:401901217 NCBI chr10:47,142,160...47,199,892
Ensembl chr10:47,141,780...47,200,145 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      primary metabolic process 10352
        protein metabolic process 4746
          protein modification process 2027
            protein lipidation 45
              GPI anchor biosynthetic process 33
                GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine 0
                attachment of GPI anchor to protein 5
                preassembly of GPI anchor in ER membrane 1
Path 2
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      cellular metabolic process 9901
        phosphorus metabolic process 1927
          phosphate-containing compound metabolic process 1899
            phospholipid metabolic process 386
              glycerophospholipid metabolic process 290
                phosphatidylinositol metabolic process 158
                  GPI anchor metabolic process 36
                    GPI anchor biosynthetic process 33
                      GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine 0
                      attachment of GPI anchor to protein 5
                      preassembly of GPI anchor in ER membrane 1
paths to the root