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ONTOLOGY REPORT - ANNOTATIONS


Term:GPI anchor biosynthetic process
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Accession:GO:0006506 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.
Synonyms:exact_synonym: GPI anchor anabolism;   GPI anchor biosynthesis;   GPI anchor formation;   GPI anchor synthesis;   glycosylphosphatidylinositol biosynthesis;   glycosylphosphatidylinositol biosynthetic process
 broad_synonym: GPI/GSI anchor biosynthesis;   GPI/GSI anchor biosynthetic process
 alt_id: GO:0015998



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GPI anchor biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cwh43 cell wall biogenesis 43 C-terminal homolog involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:34,754,279...34,800,530
Ensembl chr14:34,754,289...34,800,814
JBrowse link
G Dpm1 dolichyl-phosphate mannosyltransferase subunit 1, catalytic involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:9535917), (PMID:9724629)
(PMID:10835346), (PMID:9535917)
(MGI:1329093|PMID:9535917)
RGD PMID:9535917 PMID:9724629 PMID:10835346 PMID:21873635 MGI:1329093, RGD:13792537 NCBI chr 3:156,919,979...156,939,522
Ensembl chr 3:156,919,979...156,939,536
JBrowse link
G Dpm2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory acts_upstream_of_or_within
involved_in
TAS
IDA
IBA
IEA
ISO
PMID:9724629
PMID:21873635
GO_REF:0000107
(PMID:10835346), (PMID:16162815)
Ensembl
RGD
PMID:10835346 PMID:16162815 PMID:9724629 PMID:9724629 PMID:21873635 GO_REF:0000107, RGD:69827, RGD:69827, RGD:13792537 NCBI chr 3:15,855,952...15,858,867 JBrowse link
G Dpm3 dolichyl-phosphate mannosyltransferase subunit 3, regulatory involved_in IBA
ISO
PMID:21873635
(PMID:10835346)
RGD PMID:10835346 PMID:21873635 RGD:13792537 NCBI chr 2:174,676,532...174,677,047
Ensembl chr 2:174,676,363...174,677,668
Ensembl chr15:174,676,363...174,677,668
JBrowse link
G Gpaa1 glycosylphosphatidylinositol anchor attachment 1 TAS RGD PMID:10702226 RGD:1331364 NCBI chr 7:108,051,896...108,055,479
Ensembl chr 7:108,051,861...108,055,484
JBrowse link
G Mppe1 metallophosphoesterase 1 involved_in ISO
ISS
(PMID:29374258)
GO_REF:0000024
RGD
UniProt
PMID:29374258 GO_REF:0000024 NCBI chr18:60,763,418...60,781,553
Ensembl chr18:60,763,419...60,781,553
JBrowse link
G Pgap1 post-GPI attachment to proteins inositol deacylase 1 IMP RGD PMID:14734546 RGD:1303970 NCBI chr 9:55,975,574...56,044,325
Ensembl chr 9:55,975,667...56,044,464
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 involved_in IEA
IMP
ISO
IBA
GO_REF:0000107
PMID:16407401
(PMID:29374258)
PMID:21873635
Ensembl
RGD
PMID:29374258 PMID:16407401 PMID:21873635 GO_REF:0000107, RGD:8553507, RGD:13792537 NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114
JBrowse link
G Pgap3 post-GPI attachment to proteins phospholipase 3 involved_in ISO
IBA
(PMID:29374258)
PMID:21873635
RGD PMID:29374258 PMID:21873635 RGD:13792537 NCBI chr10:83,387,113...83,399,357
Ensembl chr10:83,387,113...83,398,628
JBrowse link
G Pgap4 post-GPI attachment to proteins GalNAc transferase 4 involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:29374258)
PMID:21873635
UniProt
RGD
PMID:29374258 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:63,931,916...63,947,004
Ensembl chr 5:63,930,682...63,951,716
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000041
MGI:3652879 (MGI:80283|PMID:8611683)
PMID:21873635
UniProt
RGD
PMID:8611683 PMID:21873635 GO_REF:0000041 MGI:80283, RGD:13792537 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804
JBrowse link
G Pigb phosphatidylinositol glycan anchor biosynthesis, class B involved_in IBA
ISO
PMID:21873635
(PMID:8861954)
RGD PMID:8861954 PMID:21873635 RGD:13792537 NCBI chr 8:73,751,756...73,775,679
Ensembl chr 8:73,751,798...73,775,679
JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C involved_in ISO
IEA
ISS
(PMID:16162815), (PMID:27694521)
GO_REF:0000041
GO_REF:0000024
RGD
UniProt
PMID:16162815 PMID:27694521 GO_REF:0000024 GO_REF:0000041 NCBI chr13:74,343,619...74,346,148
Ensembl chr13:74,296,854...74,346,211
JBrowse link
G Pigf phosphatidylinositol glycan anchor biosynthesis, class F involved_in IBA
ISO
IEA
PMID:21873635
(MGI:1860649|PMID:10781593)
GO_REF:0000041
RGD
UniProt
PMID:10781593 PMID:21873635 GO_REF:0000041 MGI:1860649, RGD:13792537 NCBI chr 6:7,589,528...7,617,721
Ensembl chr 6:7,589,570...7,639,675
JBrowse link
G Pigg phosphatidylinositol glycan anchor biosynthesis, class G involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
PMID:21873635
(PMID:15632136)
GO_REF:0000041
RGD
UniProt
PMID:15632136 PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr14:1,404,911...1,433,199
Ensembl chr14:1,406,798...1,433,187
JBrowse link
G Pigh phosphatidylinositol glycan anchor biosynthesis, class H involved_in ISO
IEA
IBA
(PMID:16162815)
GO_REF:0000041
PMID:21873635
RGD
UniProt
PMID:16162815 PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 6:97,874,903...97,897,188
Ensembl chr 6:97,882,903...97,897,142
JBrowse link
G Pigl phosphatidylinositol glycan anchor biosynthesis, class L involved_in IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:9188481 PMID:21873635 GO_REF:0000041, RGD:729509, RGD:13792537 NCBI chr10:47,142,160...47,199,892
Ensembl chr10:47,141,780...47,200,145
JBrowse link
G Pigm phosphatidylinositol glycan anchor biosynthesis, class M involved_in IDA
IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:11226175 PMID:21873635 GO_REF:0000041, RGD:70624, RGD:13792537 NCBI chr13:84,838,329...84,842,026
Ensembl chr13:84,838,175...84,843,381
JBrowse link
G Pign phosphatidylinositol glycan anchor biosynthesis, class N involved_in IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr13:21,659,092...21,812,932
Ensembl chr13:21,662,455...21,806,790
JBrowse link
G Pigo phosphatidylinositol glycan anchor biosynthesis, class O involved_in IEA
ISO
IBA
GO_REF:0000041
(MGI:1860649|PMID:10781593)
PMID:21873635
UniProt
RGD
PMID:10781593 PMID:21873635 GO_REF:0000041 MGI:1860649, RGD:13792537 NCBI chr 5:57,244,721...57,256,252
Ensembl chr 5:57,245,166...57,254,146
JBrowse link
G Pigp phosphatidylinositol glycan anchor biosynthesis, class P involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:16162815), (PMID:28334793)
(MGI:3804747|PMID:10944123)
GO_REF:0000041
RGD
UniProt
PMID:10944123 PMID:16162815 PMID:28334793 GO_REF:0000041 MGI:3804747 NCBI chr11:33,682,943...33,689,071
Ensembl chr11:33,682,948...33,689,321
JBrowse link
G Pigq phosphatidylinositol glycan anchor biosynthesis, class Q involved_in
acts_upstream_of_or_within
ISO (PMID:16162815)
PomBase:SPBC30D10.11|SGD:S000003448 (MGI:1307040|PMID:9729469), (MGI:1339481|PMID:10373468)
RGD PMID:9729469 PMID:10373468 PMID:16162815 MGI:1307040 MGI:1339481 NCBI chr10:14,942,571...14,958,584
Ensembl chr10:14,942,577...14,958,584
JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U involved_in ISO (PMID:15034568) RGD PMID:15034568 NCBI chr 3:143,784,831...143,881,268
Ensembl chr 3:143,784,832...143,880,807
JBrowse link
G Pigv phosphatidylinositol glycan anchor biosynthesis, class V involved_in ISO
IBA
IEA
UniProtKB:P38211 (PMID:15623507), (PMID:15720390)
PMID:21873635
GO_REF:0000041
RGD
UniProt
PMID:15623507 PMID:15720390 PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 5:145,889,642...145,901,533
Ensembl chr 5:145,889,646...145,901,533
JBrowse link
G Pigw phosphatidylinositol glycan anchor biosynthesis, class W involved_in IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr10:69,746,996...69,782,656
Ensembl chr10:69,748,789...69,790,475
JBrowse link
G Pigx phosphatidylinositol glycan anchor biosynthesis, class X involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr11:68,687,126...68,703,067
Ensembl chr11:68,687,093...68,703,472
JBrowse link
G Pigy phosphatidylinositol glycan anchor biosynthesis, class Y involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:16162815)
RGD PMID:16162815 PMID:21873635 RGD:13792537 NCBI chr 8:20,689,621...20,691,863
Ensembl chr 8:20,689,502...20,692,585
JBrowse link
G Pigz phosphatidylinositol glycan anchor biosynthesis, class Z involved_in IBA
ISO
PMID:21873635
UniProtKB:Q04174 (PMID:15208306)
RGD PMID:15208306 PMID:21873635 RGD:13792537 NCBI chr11:68,831,790...68,835,647 JBrowse link
G Pyurf PIGY upstream open reading frame involved_in ISO
IBA
ISS
(PMID:16162815)
PMID:21873635
GO_REF:0000024
RGD
HGNC-UCL
PMID:16162815 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 4:87,501,859...87,505,494
Ensembl chr 4:87,501,859...87,505,494
JBrowse link
attachment of GPI anchor to protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpaa1 glycosylphosphatidylinositol anchor attachment 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:108,051,896...108,055,479
Ensembl chr 7:108,051,861...108,055,484
JBrowse link
G Pigk phosphatidylinositol glycan anchor biosynthesis, class K involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:241,630,021...241,715,493
Ensembl chr 2:241,630,053...241,716,134
JBrowse link
G Pigs phosphatidylinositol glycan anchor biosynthesis, class S involved_in ISO
IBA
(MGI:3688056|PMID:11483512)
PMID:21873635
RGD PMID:11483512 PMID:21873635 MGI:3688056, RGD:13792537 NCBI chr10:63,222,611...63,237,190
Ensembl chr10:63,222,572...63,237,187
JBrowse link
G Pigt phosphatidylinositol glycan anchor biosynthesis, class T involved_in IBA
ISO
PMID:21873635
(MGI:3688056|PMID:11483512)
RGD PMID:11483512 PMID:21873635 MGI:3688056, RGD:13792537 NCBI chr 3:153,227,749...153,236,922
Ensembl chr 3:153,227,420...153,236,887
JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U involved_in IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(PMID:12802054)
GO_REF:0000002
Ensembl
RGD
InterPro
PMID:12802054 PMID:21873635 GO_REF:0000002 GO_REF:0000107, RGD:13792537 NCBI chr 3:143,784,831...143,881,268
Ensembl chr 3:143,784,832...143,880,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19494
    metabolic process 11798
      biosynthetic process 6072
        organic substance biosynthetic process 5970
          carbohydrate derivative biosynthetic process 576
            glycolipid biosynthetic process 63
              GPI anchor biosynthetic process 32
                GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine 0
                GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine 0
                attachment of GPI anchor to protein 5
                preassembly of GPI anchor in ER membrane 0
Path 2
Term Annotations click to browse term
  biological_process 19494
    metabolic process 11798
      cellular metabolic process 10718
        phosphorus metabolic process 2828
          phosphate-containing compound metabolic process 2806
            phospholipid metabolic process 377
              glycerophospholipid metabolic process 288
                phosphatidylinositol metabolic process 154
                  GPI anchor metabolic process 35
                    GPI anchor biosynthetic process 32
                      GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine 0
                      GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine 0
                      attachment of GPI anchor to protein 5
                      preassembly of GPI anchor in ER membrane 0
paths to the root