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ONTOLOGY REPORT - ANNOTATIONS

Term:GPI anchor metabolic process
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Accession:GO:0006505 term browser browse the term
Definition:The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain.
Synonyms:exact_synonym: GPI anchor metabolism;   glycosylphosphatidylinositol metabolic process;   glycosylphosphatidylinositol metabolism
 broad_synonym: GPI/GSI anchor metabolic process;   GPI/GSI anchor metabolism
 alt_id: GO:0046472

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GPI anchor metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pgap1 post-GPI attachment to proteins inositol deacylase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936506:2,224,598...2,297,022
Ensembl chrNW_004936506:2,224,572...2,294,739 		JBrowse link
G Pgap3 post-GPI attachment to proteins phospholipase 3 involved_in IEA Ensembl
UniProt		 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936490:14,862,204...14,877,217
Ensembl chrNW_004936490:14,859,538...14,877,269 		JBrowse link
G Pigm phosphatidylinositol glycan anchor biosynthesis class M involved_in IEA UniProt GO_REF:0000104 NCBI chrNW_004936740:595,932...597,964
Ensembl chrNW_004936740:596,072...597,343 		JBrowse link
G Pigx phosphatidylinositol glycan anchor biosynthesis class X involved_in IEA UniProt GO_REF:0000104 NCBI chrNW_004936784:1,288,937...1,313,469
Ensembl chrNW_004936784:1,289,671...1,312,744 		JBrowse link
attachment of GPI anchor to protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpaa1 glycosylphosphatidylinositol anchor attachment 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936470:8,092,758...8,096,277
Ensembl chrNW_004936470:8,092,855...8,096,074 		JBrowse link
G Pigk phosphatidylinositol glycan anchor biosynthesis class K involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936571:4,002,243...4,132,837
Ensembl chrNW_004936571:3,998,773...4,132,876 		JBrowse link
G Pigs phosphatidylinositol glycan anchor biosynthesis class S involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936538:4,779,325...4,796,960
Ensembl chrNW_004936538:4,779,313...4,796,767 		JBrowse link
G Pigt phosphatidylinositol glycan anchor biosynthesis class T involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936514:7,471,134...7,481,183
Ensembl chrNW_004936514:7,470,922...7,481,199 		JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis class U involved_in IEA InterPro
Ensembl
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936561:6,013,145...6,104,548
Ensembl chrNW_004936561:6,013,145...6,107,667 		JBrowse link
GPI anchor biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cwh43 cell wall biogenesis 43 C-terminal homolog involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936482:14,902,011...14,952,123
Ensembl chrNW_004936482:14,902,011...14,952,123 		JBrowse link
G Dpm1 dolichyl-phosphate mannosyltransferase subunit 1, catalytic acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9535917), (PMID:9724629) MGI
TreeGrafter		 PMID:9535917 PMID:9724629 GO_REF:0000118 NCBI chrNW_004936514:3,832,284...3,850,064 JBrowse link
G Dpm2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory acts_upstream_of_or_within
involved_in		 ISO
IEA		 PMID:9724629 MGI
TreeGrafter
Ensembl		 PMID:9724629 GO_REF:0000107 GO_REF:0000118 RGD:69827 NCBI chrNW_004936487:15,565,151...15,567,856
Ensembl chrNW_004936487:15,565,176...15,567,881 		JBrowse link
G Dpm3 dolichyl-phosphate mannosyltransferase subunit 3, regulatory involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936580:4,664,653...4,665,199
Ensembl chrNW_004936580:4,664,653...4,665,188 		JBrowse link
G LOC101962300 phosphatidylinositol-glycan biosynthesis class F protein-like involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000041 NCBI chrNW_004936547:469,426...470,884 JBrowse link
G Mppe1 metallophosphoesterase 1 involved_in IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 NCBI chrNW_004936626:349,324...371,073
Ensembl chrNW_004936626:361,270...373,629 		JBrowse link
G Pgap1 post-GPI attachment to proteins inositol deacylase 1 ISO RGD PMID:14734546 RGD:1303970 NCBI chrNW_004936506:2,224,598...2,297,022
Ensembl chrNW_004936506:2,224,572...2,294,739 		JBrowse link
G Pgap2 post-GPI attachment to proteins 2 involved_in IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936498:1,088,345...1,112,108
Ensembl chrNW_004936498:1,088,230...1,104,275 		JBrowse link
G Pgap3 post-GPI attachment to proteins phospholipase 3 involved_in IEA Ensembl
TreeGrafter
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936490:14,862,204...14,877,217
Ensembl chrNW_004936490:14,859,538...14,877,269 		JBrowse link
G Pgap4 post-GPI attachment to proteins GalNAc transferase 4 involved_in IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936524:9,627,945...9,640,026
Ensembl chrNW_004936524:9,627,945...9,640,031 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis class A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8611683) InterPro
MGI
TreeGrafter
Ensembl
UniProt		 PMID:8611683 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936470:4,730,955...4,746,958
Ensembl chrNW_004936470:4,730,961...4,746,985 		JBrowse link
G Pigb phosphatidylinositol glycan anchor biosynthesis class B involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936471:16,828,910...16,857,140
Ensembl chrNW_004936471:16,829,159...16,861,536 		JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis class C involved_in IEA InterPro
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 NCBI chrNW_004936481:14,962,572...14,964,929
Ensembl chrNW_004936481:14,962,613...14,964,861 		JBrowse link
G Pigf phosphatidylinositol glycan anchor biosynthesis class F involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000041 NCBI chrNW_004936508:5,659,059...5,695,441 JBrowse link
G Pigg phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group) acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15632136) MGI
TreeGrafter
UniProt
Ensembl
InterPro		 PMID:15632136 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936477:22,524,227...22,563,536
Ensembl chrNW_004936477:22,523,729...22,563,708 		JBrowse link
G Pigh phosphatidylinositol glycan anchor biosynthesis class H involved_in IEA Ensembl
TreeGrafter
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936495:10,971,448...10,979,622
Ensembl chrNW_004936495:10,969,364...10,979,620 		JBrowse link
G Pigk phosphatidylinositol glycan anchor biosynthesis class K involved_in IEA UniProt GO_REF:0000041 GO_REF:0000043 NCBI chrNW_004936571:4,002,243...4,132,837
Ensembl chrNW_004936571:3,998,773...4,132,876 		JBrowse link
G Pigl phosphatidylinositol glycan anchor biosynthesis class L involved_in ISO
IEA		 RGD
TreeGrafter
UniProt		 PMID:9188481 GO_REF:0000041 GO_REF:0000118 RGD:729509 NCBI chrNW_004936821:290,240...381,126
Ensembl chrNW_004936821:288,026...381,172 		JBrowse link
G Pigm phosphatidylinositol glycan anchor biosynthesis class M involved_in ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro		 PMID:11226175 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000118 RGD:70624 NCBI chrNW_004936740:595,932...597,964
Ensembl chrNW_004936740:596,072...597,343 		JBrowse link
G Pign phosphatidylinositol glycan anchor biosynthesis class N involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000118 NCBI chrNW_004936497:3,121,184...3,230,912
Ensembl chrNW_004936497:3,124,557...3,234,061 		JBrowse link
G Pigo phosphatidylinositol glycan anchor biosynthesis class O involved_in IEA UniProt
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000118 NCBI chrNW_004936524:3,116,627...3,126,681
Ensembl chrNW_004936524:3,118,010...3,125,587 		JBrowse link
G Pigp phosphatidylinositol glycan anchor biosynthesis class P involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10944123) UniProt
MGI
TreeGrafter
Ensembl
InterPro		 PMID:10944123 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936500:5,724,178...5,732,081
Ensembl chrNW_004936500:5,724,202...5,731,885 		JBrowse link
G Pigq phosphatidylinositol glycan anchor biosynthesis class Q involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10373468)
(PMID:9729469)		 InterPro
MGI
TreeGrafter
Ensembl		 PMID:9729469 PMID:10373468 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936501:415,232...429,902
Ensembl chrNW_004936501:414,905...429,600 		JBrowse link
G Pigs phosphatidylinositol glycan anchor biosynthesis class S involved_in IEA UniProt GO_REF:0000041 GO_REF:0000043 NCBI chrNW_004936538:4,779,325...4,796,960
Ensembl chrNW_004936538:4,779,313...4,796,767 		JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis class U involved_in IEA UniProt
Ensembl		 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 NCBI chrNW_004936561:6,013,145...6,104,548
Ensembl chrNW_004936561:6,013,145...6,107,667 		JBrowse link
G Pigv phosphatidylinositol glycan anchor biosynthesis class V involved_in IEA InterPro
TreeGrafter
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936474:11,204,595...11,215,677
Ensembl chrNW_004936474:11,205,368...11,216,528 		JBrowse link
G Pigw phosphatidylinositol glycan anchor biosynthesis class W involved_in IEA UniProt
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000118 NCBI chrNW_004936490:1,675,592...1,678,494
Ensembl chrNW_004936490:1,675,765...1,677,279 		JBrowse link
G Pigx phosphatidylinositol glycan anchor biosynthesis class X involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 NCBI chrNW_004936784:1,288,937...1,313,469
Ensembl chrNW_004936784:1,289,671...1,312,744 		JBrowse link
G Pigy phosphatidylinositol glycan anchor biosynthesis class Y acts_upstream_of_or_within ISO (PMID:16162815) MGI PMID:16162815 NCBI chrNW_004936685:984,606...985,106 JBrowse link
G Pigz phosphatidylinositol glycan anchor biosynthesis class Z involved_in IEA UniProt
TreeGrafter		 GO_REF:0000043 GO_REF:0000118 NCBI chrNW_004936833:902,002...918,321 JBrowse link
G Slc30a5 solute carrier family 30 member 5 acts_upstream_of_positive_effect
involved_in		 ISO
IEA		 (PMID:35525268) UniProt
Ensembl		 PMID:35525268 GO_REF:0000107 NCBI chrNW_004936480:418,621...454,303
Ensembl chrNW_004936480:417,205...454,277 		JBrowse link
GPI anchor release term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpep1 dipeptidase 1 involved_in ISO (PMID:17615681) UniProt PMID:17615681 NCBI chrNW_004936641:379,112...384,711
Ensembl chrNW_004936641:379,083...391,918 		JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9716655) Ensembl
MGI
TreeGrafter		 PMID:9716655 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936671:780,173...827,628
Ensembl chrNW_004936671:782,135...827,771 		JBrowse link
G Notum notum, palmitoleoyl-protein carboxylesterase NOT|involved_in ISO (MGI:5640887|PMID:25771893) UniProt PMID:25771893 MGI:5640887 NCBI chrNW_004936594:5,458,825...5,465,135
Ensembl chrNW_004936594:5,457,687...5,465,162 		JBrowse link
preassembly of GPI anchor in ER membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pigl phosphatidylinositol glycan anchor biosynthesis class L involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936821:290,240...381,126
Ensembl chrNW_004936821:288,026...381,172 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15871
    metabolic process 9527
      organic substance metabolic process 9091
        carbohydrate derivative metabolic process 983
          liposaccharide metabolic process 100
            glycolipid metabolic process 99
              GPI anchor metabolic process 36
                GPI anchor biosynthetic process + 33
                GPI anchor release 3
                mannosyl diphosphorylinositol ceramide metabolic process 0
Path 2
Term Annotations click to browse term
  biological_process 15871
    metabolic process 9527
      cellular metabolic process 8291
        phosphorus metabolic process 1722
          organophosphate metabolic process 921
            phospholipid metabolic process 359
              glycerophospholipid metabolic process 277
                phosphatidylinositol metabolic process 152
                  GPI anchor metabolic process 36
                    GPI anchor biosynthetic process + 33
                    GPI anchor release 3
                    mannosyl diphosphorylinositol ceramide metabolic process 0
paths to the root