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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of protein kinase activity
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Accession:GO:0006469 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
Synonyms:exact_synonym: down regulation of protein kinase activity;   downregulation of protein kinase activity
 narrow_synonym: inhibition of protein kinase activity


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negative regulation of protein kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO in PC12 cells, PKCzeta deactivated after long-term activation of Adora2a RGD PMID:12590138 RGD:1625697 NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618 		JBrowse link
G Daxx Fas death domain-associated protein ISO RGD PMID:17289031 RGD:9587773 NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564 		JBrowse link
G Drd1 dopamine receptor D1 ISO RGD PMID:12688394 RGD:1581394 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Drd5 dopamine receptor D5 ISO RGD PMID:12688394 RGD:1581394 NCBI chr 5:38,476,742...38,479,868
Ensembl chr 5:38,476,710...38,479,861 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 ISO RGD PMID:21668448 RGD:10401931 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Il6 interleukin 6 ISO Phospholamban phosphorylation RGD PMID:15845578 RGD:2306941 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ilk integrin linked kinase ISO GSK-3 activity as a Tau protein kinase RGD PMID:12629168 RGD:2302091 NCBI chr 7:105,385,797...105,392,132
Ensembl chr 7:105,385,799...105,392,132 		JBrowse link
G Pcp4 Purkinje cell protein 4 ISO RGD PMID:10751438 RGD:1579763 NCBI chr16:96,268,806...96,326,993
Ensembl chr16:96,268,806...96,326,993 		JBrowse link
G Rgn regucalcin ISO RGD PMID:11455566 RGD:9590207 NCBI chr  X:20,413,980...20,428,328
Ensembl chr  X:20,416,026...20,428,328 		JBrowse link
negative regulation of cyclin-dependent protein serine/threonine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 ISO RGD PMID:10721722 RGD:632478 NCBI chr 4:70,135,092...70,328,672
Ensembl chr 4:70,135,093...70,328,680 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 ISO RGD PMID:10721722 RGD:632478 NCBI chr11:96,798,251...96,807,359
Ensembl chr11:96,798,252...96,807,322 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B ISO RGD PMID:22584582 RGD:10045364 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:12064607 RGD:1299562 NCBI chr 2:92,214,021...92,231,608
Ensembl chr 2:92,214,021...92,231,608 		JBrowse link
negative regulation of MAP kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsk3b glycogen synthase kinase 3 beta ISO RGD PMID:17182785 RGD:2301767 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chr 7:101,471,839...101,487,419
Ensembl chr 7:101,471,839...101,487,436 		JBrowse link
G Kng2 kininogen 2 ISO in ConA- or PHA-stimulated Jurkat cells RGD PMID:16140359 RGD:1600541 NCBI chr16:22,804,602...22,847,851
Ensembl chr16:22,804,604...22,848,232 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 ISO RGD PMID:9857190 RGD:10044039 NCBI chr 7:46,727,543...46,783,774
Ensembl chr 7:46,727,543...46,783,432 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:14612383 RGD:1580517 NCBI chr17:24,814,788...24,851,607
Ensembl chr17:24,814,790...24,851,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    metabolic process 10995
      primary metabolic process 9507
        protein metabolic process 4150
          protein modification process 1916
            protein phosphorylation 824
              negative regulation of protein phosphorylation 207
                negative regulation of protein kinase activity 18
                  negative regulation of cyclin-dependent protein kinase activity + 3
                  negative regulation of protein histidine kinase activity 0
                  negative regulation of protein kinase activity by regulation of protein phosphorylation 0
                  negative regulation of protein serine/threonine kinase activity + 9
                  negative regulation of protein tyrosine kinase activity + 0
                  negative regulation of tau-protein kinase activity 0
                  peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity 0
Path 2
Term Annotations click to browse term
  biological_process 28573
    biological regulation 13112
      regulation of biological process 12722
        regulation of metabolic process 6601
          regulation of cellular metabolic process 6139
            regulation of phosphorus metabolic process 971
              regulation of phosphate metabolic process 968
                regulation of phosphorylation 806
                  regulation of protein phosphorylation 745
                    negative regulation of protein phosphorylation 207
                      negative regulation of protein kinase activity 18
                        negative regulation of cyclin-dependent protein kinase activity + 3
                        negative regulation of protein histidine kinase activity 0
                        negative regulation of protein kinase activity by regulation of protein phosphorylation 0
                        negative regulation of protein serine/threonine kinase activity + 9
                        negative regulation of protein tyrosine kinase activity + 0
                        negative regulation of tau-protein kinase activity 0
                        peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity 0
paths to the root