Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of protein kinase activity
go back to main search page
Accession:GO:0006469 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
Synonyms:exact_synonym: down regulation of protein kinase activity;   downregulation of protein kinase activity
 narrow_synonym: inhibition of protein kinase activity



show annotations for term's descendants           Sort by:
negative regulation of protein kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO in PC12 cells, PKCzeta deactivated after long-term activation of Adora2a RGD PMID:12590138 RGD:1625697 NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598
JBrowse link
G DAXX death domain associated protein ISO RGD PMID:17289031 RGD:9587773 NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340
JBrowse link
G DRD1 dopamine receptor D1 ISO RGD PMID:12688394 RGD:1581394 NCBI chr 4:37,550,454...37,554,641
Ensembl chr 4:37,549,708...37,553,287
JBrowse link
G DRD5 dopamine receptor D5 ISO RGD PMID:12688394 RGD:1581394 NCBI chr 3:69,621,187...69,623,522
Ensembl chr 3:69,621,734...69,623,893
JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO RGD PMID:21668448 RGD:10401931 NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182
JBrowse link
G IL6 interleukin 6 ISO Phospholamban phosphorylation RGD PMID:15845578 RGD:2306941 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519
JBrowse link
G ILK integrin linked kinase ISO GSK-3 activity as a Tau protein kinase RGD PMID:12629168 RGD:2302091 NCBI chr21:29,911,326...29,917,972
Ensembl chr21:29,911,364...29,917,974
JBrowse link
G PCP4 Purkinje cell protein 4 ISO RGD PMID:10751438 RGD:1579763 NCBI chr31:34,529,688...34,584,497
Ensembl chr31:34,529,683...34,584,501
JBrowse link
G RGN regucalcin ISO RGD PMID:11455566 RGD:9590207 NCBI chr  X:40,697,292...40,715,491
Ensembl chr  X:40,698,768...40,715,490
JBrowse link
negative regulation of cyclin-dependent protein serine/threonine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 ISO RGD PMID:10721722 RGD:632478 NCBI chr11:73,548,003...73,693,044
Ensembl chr11:73,548,038...73,690,199
JBrowse link
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 ISO RGD PMID:10721722 RGD:632478 NCBI chr 9:24,276,660...24,286,273
Ensembl chr 9:24,276,768...24,286,272
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO RGD PMID:22584582 RGD:10045364 NCBI chr27:33,609,154...33,613,558
Ensembl chr27:33,611,760...33,612,906
JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:12064607 RGD:1299562 NCBI chr18:43,517,186...43,522,603
Ensembl chr18:43,517,677...43,526,379
JBrowse link
negative regulation of MAP kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSK3B glycogen synthase kinase 3 beta ISO RGD PMID:17182785 RGD:2301767 NCBI chr33:23,458,369...23,659,878
Ensembl chr33:23,463,767...23,659,666
JBrowse link
G INPPL1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chr21:25,900,308...25,914,527
Ensembl chr21:25,900,900...25,915,577
JBrowse link
G PTPN5 protein tyrosine phosphatase non-receptor type 5 ISO RGD PMID:9857190 RGD:10044039 NCBI chr21:41,097,563...41,154,247
Ensembl chr21:41,097,569...41,136,706
JBrowse link
G TSC2 TSC complex subunit 2 ISO RGD PMID:14612383 RGD:1580517 NCBI chr 6:38,865,509...38,898,977
Ensembl chr 6:38,865,507...38,898,960
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17874
    metabolic process 10929
      primary metabolic process 9495
        protein metabolic process 4323
          protein modification process 1987
            protein phosphorylation 804
              negative regulation of protein phosphorylation 198
                negative regulation of protein kinase activity 17
                  negative regulation of cyclin-dependent protein kinase activity + 3
                  negative regulation of protein histidine kinase activity 0
                  negative regulation of protein kinase activity by regulation of protein phosphorylation 0
                  negative regulation of protein serine/threonine kinase activity + 8
                  negative regulation of protein tyrosine kinase activity + 0
                  negative regulation of tau-protein kinase activity 0
                  peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity 0
Path 2
Term Annotations click to browse term
  biological_process 17874
    biological regulation 12345
      regulation of biological process 11994
        regulation of metabolic process 6339
          regulation of cellular metabolic process 5887
            regulation of phosphorus metabolic process 946
              regulation of phosphate metabolic process 943
                regulation of phosphorylation 783
                  regulation of protein phosphorylation 726
                    negative regulation of protein phosphorylation 198
                      negative regulation of protein kinase activity 17
                        negative regulation of cyclin-dependent protein kinase activity + 3
                        negative regulation of protein histidine kinase activity 0
                        negative regulation of protein kinase activity by regulation of protein phosphorylation 0
                        negative regulation of protein serine/threonine kinase activity + 8
                        negative regulation of protein tyrosine kinase activity + 0
                        negative regulation of tau-protein kinase activity 0
                        peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity 0
paths to the root