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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of protein kinase activity
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Accession:GO:0006469 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
Synonyms:exact_synonym: down regulation of protein kinase activity;   downregulation of protein kinase activity
 narrow_synonym: inhibition of protein kinase activity


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negative regulation of protein kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor IDA in PC12 cells, PKCzeta deactivated after long-term activation of Adora2a RGD PMID:12590138 RGD:1625697 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Akt1s1 AKT1 substrate 1 involved_in ISO (PMID:17386266) RGD PMID:17386266 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677 		JBrowse link
G Cav3 caveolin 3 acts_upstream_of_or_within ISO (PMID:14600260) RGD PMID:14600260 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:22496641) 		UniProt
RGD		 PMID:22496641 GO_REF:0000024 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Cep43 centrosomal protein 43 involved_in ISO (PMID:17888034) RGD PMID:17888034 NCBI chr 1:52,533,418...52,564,025
Ensembl chr 1:52,533,428...52,563,923 		JBrowse link
G Cep85 centrosomal protein 85 involved_in ISO (PMID:26220856) RGD PMID:26220856 NCBI chr 5:146,356,571...146,404,155
Ensembl chr 5:146,356,576...146,404,060 		JBrowse link
G Chp1 calcineurin-like EF-hand protein 1 involved_in IDA PMID:12966074 UniProt PMID:12966074 RGD:8553340 NCBI chr 3:126,989,800...127,025,071
Ensembl chr 3:106,536,004...106,571,251 		JBrowse link
G Daxx death-domain associated protein IMP RGD PMID:17289031 RGD:9587773 NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Dbndd2 dysbindin domain containing 2 involved_in ISO (PMID:16618118) RGD PMID:16618118 NCBI chr 3:153,216,300...153,220,651
Ensembl chr 3:153,191,090...153,220,651 		JBrowse link
G Deptor DEP domain containing MTOR-interacting protein involved_in ISO (PMID:19446321) RGD PMID:19446321 NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773 		JBrowse link
G Drd1 dopamine receptor D1 IMP RGD PMID:12688394 RGD:1581394 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd5 dopamine receptor D5 IMP RGD PMID:12688394 RGD:1581394 NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774 		JBrowse link
G Dusp19 dual specificity phosphatase 19 involved_in ISO (PMID:11959862) RGD PMID:11959862 NCBI chr 3:85,945,289...86,081,289
Ensembl chr 3:65,538,420...65,553,534 		JBrowse link
G Fabp4 fatty acid binding protein 4 acts_upstream_of_or_within ISO MGI:2148887 (PMID:15684432) RGD PMID:15684432 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha acts_upstream_of_or_within ISO (PMID:12124778) RGD PMID:12124778 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta acts_upstream_of_or_within ISO (PMID:12124778) RGD PMID:12124778 NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma acts_upstream_of_or_within ISO (PMID:12124778) RGD PMID:12124778 NCBI chr17:13,528,606...13,530,351
Ensembl chr17:13,376,839...13,378,610 		JBrowse link
G Gskip GSK3B interacting protein involved_in ISS
ISO 		GO_REF:0000024
(PMID:16981698) 		UniProt
RGD		 PMID:16981698 GO_REF:0000024 NCBI chr 6:124,586,087...124,609,106
Ensembl chr 6:124,586,070...124,609,100 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 IMP RGD PMID:21668448 RGD:10401931 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 involved_in ISO (PMID:15731106) RGD PMID:15731106 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Il6 interleukin 6 IDA Phospholamban phosphorylation RGD PMID:15845578 RGD:2306941 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ilk integrin-linked kinase IMP GSK-3 activity as a Tau protein kinase RGD PMID:12629168 RGD:2302091 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 involved_in ISO (PMID:20616313) RGD PMID:20616313 NCBI chr 6:46,549,994...46,564,735
Ensembl chr 6:40,821,339...40,836,037 		JBrowse link
G Mllt1 MLLT1, super elongation complex subunit acts_upstream_of_or_within ISO (PMID:11007757) RGD PMID:11007757 NCBI chr 9:1,731,077...1,775,985
Ensembl chr 9:1,731,080...1,775,970 		JBrowse link
G Nf1 neurofibromin 1 acts_upstream_of_or_within ISO MGI:1339753|MGI:1857478 (PMID:16835260), (PMID:17053831) RGD PMID:16835260 PMID:17053831 NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor acts_upstream_of_or_within ISO (PMID:14580336), (PMID:16405865) RGD PMID:14580336 PMID:16405865 NCBI chr14:83,850,894...83,934,263
Ensembl chr14:79,627,399...79,710,667 		JBrowse link
G Pcp4 Purkinje cell protein 4 IDA RGD PMID:10751438 RGD:1579763 NCBI chr11:35,759,711...35,861,725
Ensembl chr11:35,800,713...35,861,725 		JBrowse link
G Pkia cAMP-dependent protein kinase inhibitor alpha acts_upstream_of_or_within TAS
ISO 		(PMID:9218452) RGD PMID:9218452 PMID:1491692 RGD:729428 NCBI chr 2:94,398,869...94,473,638
Ensembl chr 2:94,398,869...94,414,282 		JBrowse link
G Pkig cAMP-dependent protein kinase inhibitor gamma acts_upstream_of_or_within ISO (PMID:9218452) RGD PMID:9218452 NCBI chr 3:152,330,477...152,398,085
Ensembl chr 3:152,366,041...152,398,082 		JBrowse link
G Pkn1 protein kinase N1 acts_upstream_of_or_within ISO MGI:5475202 (PMID:23223530) RGD PMID:23223530 NCBI chr19:24,442,130...24,470,107
Ensembl chr19:24,442,122...24,470,107 		JBrowse link
G Plec plectin involved_in ISO (PMID:12200133) RGD PMID:12200133 NCBI chr 7:109,768,447...109,829,798
Ensembl chr 7:107,887,764...107,945,467 		JBrowse link
G Ppia peptidylprolyl isomerase A involved_in ISS
ISO 		GO_REF:0000024
(PMID:26095851) 		UniProt
RGD		 PMID:26095851 GO_REF:0000024 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Ppial4d peptidylprolyl isomerase A (cyclophilin A)-like 4D involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr14:21,006,522...21,007,284
Ensembl chr14:21,006,538...21,007,310 		JBrowse link
G Ppm1e protein phosphatase, Mg2+/Mn2+ dependent, 1E involved_in ISO (PMID:11864573) RGD PMID:11864573 NCBI chr10:72,051,643...72,187,439
Ensembl chr10:72,055,208...72,187,282 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha acts_upstream_of_or_within ISO MGI:2182091|MGI:3512112 (PMID:18316483) RGD PMID:18316483 NCBI chr10:95,120,537...95,139,028
Ensembl chr10:94,620,039...94,639,041 		JBrowse link
G Prkca protein kinase C, alpha acts_upstream_of_or_within ISO MGI:2679305 (PMID:11923480) RGD PMID:11923480 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkrip1 PRKR interacting protein 1 acts_upstream_of_or_within ISO (PMID:12679338) RGD PMID:12679338 NCBI chr12:20,470,802...20,491,789
Ensembl chr12:20,470,820...20,489,115 		JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within ISO (PMID:12805290) RGD PMID:12805290 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in ISS
ISO 		GO_REF:0000024
(PMID:10970857)
(PMID:9197241) 		UniProt
RGD		 PMID:9197241 PMID:10970857 GO_REF:0000024 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in ISS
ISO 		GO_REF:0000024
UniProtKB:P21675 (PMID:9858607) 		UniProt
RGD		 PMID:9858607 GO_REF:0000024 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rgn regucalcin IMP RGD PMID:11455566 RGD:9590207 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Rtraf RNA transcription, translation and transport factor involved_in ISO (PMID:15147888) RGD PMID:15147888 NCBI chr15:4,447,243...4,457,973
Ensembl chr15:4,442,573...4,457,972 		JBrowse link
G Sh3bp5 SH3-domain binding protein 5 involved_in ISO (PMID:10339589) RGD PMID:10339589 NCBI chr16:6,589,877...6,676,524
Ensembl chr16:6,583,465...6,698,975 		JBrowse link
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within ISO MGI:3721903 (PMID:23528453) RGD PMID:23528453 NCBI chr 5:64,473,694...64,581,072
Ensembl chr 5:59,678,216...59,785,538 		JBrowse link
G Smyd3 SET and MYND domain containing 3 acts_upstream_of_or_within ISO (PMID:23752591) RGD PMID:23752591 NCBI chr13:90,709,263...91,266,209
Ensembl chr13:90,709,270...91,266,253 		JBrowse link
G Taf7 TATA-box binding protein associated factor 7 involved_in ISO (PMID:18391197) RGD PMID:18391197 NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134 		JBrowse link
G Thy1 Thy-1 cell surface antigen involved_in IDA PMID:15093746 UniProt PMID:15093746 RGD:8553684 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
G Trib3 tribbles pseudokinase 3 involved_in ISS
ISO 		GO_REF:0000024
(PMID:12791994) 		UniProt
RGD		 PMID:12791994 GO_REF:0000024 NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Trim27 tripartite motif-containing 27 involved_in ISO (PMID:22128329) RGD PMID:22128329 NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643 		JBrowse link
G Tsc2 TSC complex subunit 2 acts_upstream_of_or_within ISO (PMID:15249583) RGD PMID:15249583 NCBI chr10:14,125,679...14,160,317
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing, B acts_upstream_of_or_within ISO (PMID:20585042), (PMID:27609517) RGD PMID:20585042 PMID:27609517 NCBI chr 8:50,282,510...50,430,034
Ensembl chr 8:41,388,341...41,532,201 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 involved_in ISO (PMID:22504299) RGD PMID:22504299 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269 		JBrowse link
G Wnk4 WNK lysine deficient protein kinase 4 involved_in ISO MGI:6414871 (PMID:30765526) RGD PMID:30765526 NCBI chr10:86,202,552...86,219,655
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
negative regulation of cAMP-dependent protein kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pkia cAMP-dependent protein kinase inhibitor alpha acts_upstream_of_or_within ISO (PMID:7905001) RGD PMID:7905001 NCBI chr 2:94,398,869...94,473,638
Ensembl chr 2:94,398,869...94,414,282 		JBrowse link
G Pkib cAMP-dependent protein kinase inhibitor beta acts_upstream_of_or_within ISO (PMID:7905001) RGD PMID:7905001 NCBI chr20:36,965,172...37,062,190
Ensembl chr20:36,905,340...37,062,187 		JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha involved_in ISO (PMID:22674394) RGD PMID:22674394 NCBI chr 8:118,271,608...118,337,332
Ensembl chr 8:109,395,833...109,455,628 		JBrowse link
negative regulation of cyclin-dependent protein kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A involved_in ISO (PMID:8876165) RGD PMID:8876165 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B involved_in ISO (PMID:8684460) RGD PMID:8684460 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C involved_in ISO (PMID:11746698) RGD PMID:11746698 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
negative regulation of cyclin-dependent protein serine/threonine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway involved_in ISS
ISO 		GO_REF:0000024
(PMID:8521819) 		UniProt
RGD		 PMID:8521819 GO_REF:0000024 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Casp3 caspase 3 acts_upstream_of_or_within ISO MGI:2178778 (PMID:12970760) RGD PMID:12970760 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:11882646) 		UniProt
RGD		 PMID:11882646 GO_REF:0000024 NCBI chr 3:142,838,081...142,872,669
Ensembl chr 3:142,708,028...142,872,677 		JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 IDA RGD PMID:10721722 RGD:632478 NCBI chr 5:88,807,402...88,976,005
Ensembl chr 5:83,792,284...83,960,782 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 IDA RGD PMID:10721722 RGD:632478 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A acts_upstream_of_or_within ISO (PMID:12130539) RGD PMID:12130539 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B acts_upstream_of_or_within
involved_in 		IMP
ISO 		(PMID:12130539)
(PMID:28666995) 		RGD PMID:12130539 PMID:28666995 PMID:22584582 RGD:10045364 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A acts_upstream_of_or_within ISO (PMID:7739547)
(PMID:12130539) 		RGD PMID:7739547 PMID:12130539 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C acts_upstream_of_or_within ISO (PMID:7739547) RGD PMID:7739547 NCBI chr 5:129,639,736...129,645,564
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Fbxo7 F-box protein 7 acts_upstream_of_or_within ISO (PMID:21652635) RGD PMID:21652635 NCBI chr 7:19,696,951...19,725,180
Ensembl chr 7:17,809,231...17,837,530 		JBrowse link
G Inca1 inhibitor of CDK, cyclin A1 interacting protein 1 acts_upstream_of_or_within ISO (PMID:21540187)
MGI:5292392 (PMID:21540187) 		RGD PMID:21540187 NCBI chr10:55,900,610...55,912,975
Ensembl chr10:55,401,982...55,414,114 		JBrowse link
G Kat2b lysine acetyltransferase 2B involved_in ISO (PMID:19773423) RGD PMID:19773423 NCBI chr 9:6,799,101...6,903,616
Ensembl chr 9:6,562,288...6,667,064 		JBrowse link
G Lats1 large tumor suppressor kinase 1 involved_in ISO (PMID:9988268) RGD PMID:9988268 NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640 		JBrowse link
G Lats2 large tumor suppressor kinase 2 involved_in ISO (PMID:12853976) RGD PMID:12853976 NCBI chr15:31,825,068...31,877,193
Ensembl chr15:31,825,092...31,877,220 		JBrowse link
G Men1 menin 1 involved_in ISO (PMID:15640349) RGD PMID:15640349 NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:203,639,000...203,644,871 		JBrowse link
G Tfap4 transcription factor AP-4 involved_in ISO (PMID:18818310) RGD PMID:18818310 NCBI chr10:11,001,338...11,019,386
Ensembl chr10:11,002,911...11,019,386 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (PMID:15962316) RGD PMID:15962316 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Wee2 WEE2 oocyte meiosis inhibiting kinase involved_in ISO (PMID:21454751) RGD PMID:21454751 NCBI chr 4:69,239,043...69,261,576
Ensembl chr 4:69,239,299...69,261,093 		JBrowse link
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp6 charged multivesicular body protein 6 involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in IDA
ISO
ISS 		PMID:17599051
(PMID:16648858)
(PMID:18046415)
GO_REF:0000024 		RGD
UniProt		 PMID:16648858 PMID:18046415 PMID:17599051 GO_REF:0000024, RGD:8553726 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A involved_in ISO (PMID:25744720) RGD PMID:25744720 NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260 		JBrowse link
G Psen1 presenilin 1 involved_in ISO (PMID:20208556) RGD PMID:20208556 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 involved_in ISO (PMID:20208556) RGD PMID:20208556 NCBI chr13:94,499,451...94,528,419
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Socs4 suppressor of cytokine signaling 4 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr15:23,003,130...23,017,615
Ensembl chr15:20,523,183...20,542,494 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr 6:13,235,157...13,266,161
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Vps25 vacuolar protein sorting 25 homolog involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:86,196,062...86,201,606
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO (PMID:19460345) RGD PMID:19460345 NCBI chr14:76,468,424...76,554,039
Ensembl chr14:76,468,424...76,554,039 		JBrowse link
G Zgpat zinc finger CCCH-type and G-patch domain containing involved_in ISS
ISO 		GO_REF:0000024
(PMID:19644445) 		UniProt
RGD		 PMID:19644445 GO_REF:0000024 NCBI chr 3:168,473,836...168,490,380
Ensembl chr 3:168,473,981...168,490,380 		JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated acts_upstream_of_or_within ISO (PMID:17681137) RGD PMID:17681137 NCBI chr13:94,940,311...94,967,920
Ensembl chr13:94,939,741...94,967,920 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:24512202) 		UniProt
RGD		 PMID:24512202 GO_REF:0000024 NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:55,842,426...55,853,967 		JBrowse link
G Dusp10 dual specificity phosphatase 10 acts_upstream_of_or_within ISO MGI:3052343 (PMID:15306813) RGD PMID:15306813 NCBI chr13:98,145,317...98,183,304
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dusp19 dual specificity phosphatase 19 involved_in ISO (PMID:11959862) RGD PMID:11959862 NCBI chr 3:85,945,289...86,081,289
Ensembl chr 3:65,538,420...65,553,534 		JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 involved_in ISO (PMID:11034606) RGD PMID:11034606 NCBI chr 3:90,796,980...90,866,701
Ensembl chr 3:90,800,296...90,867,759 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 involved_in IMP PMID:21076496 RGD
UniProt		 PMID:12064607 PMID:21076496 RGD:1299562, RGD:13673827 NCBI chr 3:98,810,540...98,829,302
Ensembl chr 3:78,355,048...78,372,884 		JBrowse link
G Nppa natriuretic peptide A involved_in ISO (PMID:22399583) RGD PMID:22399583 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Pdcd4 programmed cell death 4 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (PMID:23991106) RGD PMID:23991106 NCBI chr 2:194,055,165...194,103,209
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Serpinb3 serpin family B member 3 involved_in ISO (PMID:21383048) RGD PMID:21383048 NCBI chr13:23,274,120...23,280,660
Ensembl chr13:23,274,484...23,313,682 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 acts_upstream_of_or_within ISO MGI:108078|MGI:1860298 (PMID:19300477) RGD PMID:19300477 NCBI chr16:75,278,325...75,316,736
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of_or_within ISO MGI:1860298|MGI:892014 (PMID:19300477) RGD PMID:19300477 NCBI chr 2:171,387,536...171,395,081
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
G Sfrp5 secreted frizzled-related protein 5 acts_upstream_of_or_within ISO MGI:108078|MGI:892014 (PMID:19300477) RGD PMID:19300477 NCBI chr 1:241,006,762...241,011,224
Ensembl chr 1:241,006,762...241,011,224 		JBrowse link
negative regulation of MAP kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
ISO 		GO_REF:0000024
(PMID:19460854) 		UniProt
RGD		 PMID:19460854 GO_REF:0000024 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Agt angiotensinogen involved_in ISO (PMID:28283184) RGD PMID:28283184 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:9685360) RGD PMID:9685360 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Cav1 caveolin 1 acts_upstream_of_or_within ISO MGI:2180364 (PMID:12388746) RGD PMID:12388746 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cd300a Cd300a molecule involved_in ISO (PMID:16254138) RGD PMID:16254138 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISS
ISO 		GO_REF:0000024
(PMID:21283629) 		UniProt
RGD		 PMID:21283629 GO_REF:0000024 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590 		JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:7593328) 		UniProt
RGD		 PMID:7593328 GO_REF:0000024 NCBI chr10:17,184,853...17,187,646 JBrowse link
G Dusp7 dual specificity phosphatase 7 involved_in ISO (PMID:9788880) RGD PMID:9788880 NCBI chr 8:115,888,091...115,895,126
Ensembl chr 8:107,008,528...107,016,404 		JBrowse link
G Fem1a fem-1 homolog A acts_upstream_of_or_within ISO (PMID:18270204) RGD PMID:18270204 NCBI chr 9:1,091,695...1,093,901
Ensembl chr 9:1,090,527...1,100,628 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IMP RGD PMID:17182785 RGD:2301767 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase acts_upstream_of_or_within ISO MGI:97306 (PMID:12409258), (PMID:16271875) RGD PMID:12409258 PMID:16271875 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:16865359) RGD PMID:16865359 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 IMP RGD PMID:12933696 RGD:1626126 NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 involved_in ISO (PMID:17379480) RGD PMID:17379480 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Kng2 kininogen 2 IDA in ConA- or PHA-stimulated Jurkat cells RGD PMID:16140359 RGD:1600541 NCBI chr11:91,418,470...91,440,841
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISS
ISO 		GO_REF:0000024
(PMID:9252121) 		UniProt
RGD		 PMID:9252121 GO_REF:0000024 NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Nf1 neurofibromin 1 acts_upstream_of_or_within ISO MGI:1857478|MGI:2176055|MGI:2176057|MGI:96159|MGI:96677|MGI:96974 (PMID:10620616), (PMID:11297510), (PMID:12409258), (PMID:16271875) RGD PMID:10620616 PMID:11297510 PMID:12409258 PMID:16271875 NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Nup62 nucleoporin 62 involved_in ISO (PMID:11489947) RGD PMID:11489947 NCBI chr 1:104,435,532...104,451,392
Ensembl chr 1:95,295,526...95,315,174 		JBrowse link
G Paqr3 progestin and adipoQ receptor family member 3 acts_upstream_of_or_within ISO (PMID:17724343)
MGI:3757569 (PMID:17724343) 		RGD PMID:17724343 NCBI chr14:12,766,539...12,796,461
Ensembl chr14:12,462,563...12,479,994 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO (PMID:22045810) RGD PMID:22045810 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 IDA RGD PMID:9857190 RGD:10044039 NCBI chr 1:106,756,896...106,817,369
Ensembl chr 1:97,620,642...97,679,882 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 acts_upstream_of_or_within ISO MGI:1856074 (PMID:9064344), (PMID:9254656) RGD PMID:9064344 PMID:9254656 NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (PMID:19494114)
(PMID:12833140) 		RGD PMID:12833140 PMID:19494114 NCBI chr 3:96,861,785...97,017,702
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Rgs14 regulator of G-protein signaling 14 involved_in ISS
ISO 		GO_REF:0000024
(PMID:20837545) 		UniProt
RGD		 PMID:20837545 GO_REF:0000024 NCBI chr17:9,254,112...9,268,233
Ensembl chr17:9,249,019...9,263,104 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 involved_in ISO (PMID:19127022) RGD PMID:19127022 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 acts_upstream_of_or_within ISO (PMID:16339969) RGD PMID:16339969 NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 acts_upstream_of_or_within ISO (PMID:16339969) RGD PMID:16339969 NCBI chr15:89,106,809...89,111,926
Ensembl chr15:82,692,143...82,698,009 		JBrowse link
G Spry4 sprouty RTK signaling antagonist 4 acts_upstream_of_or_within ISO (PMID:16339969) RGD PMID:16339969 NCBI chr18:30,687,633...30,702,546
Ensembl chr18:30,436,443...30,453,004 		JBrowse link
G Stk38 serine/threonine kinase 38 involved_in ISO (PMID:17906693) RGD PMID:17906693 NCBI chr20:7,034,245...7,067,803
Ensembl chr20:7,034,242...7,068,198 		JBrowse link
G Tsc2 TSC complex subunit 2 IMP RGD PMID:14612383 RGD:1580517 NCBI chr10:14,125,679...14,160,317
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
negative regulation of non-membrane spanning protein tyrosine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnf4a hepatocyte nuclear factor 4, alpha IDA RGD PMID:16584384 RGD:1625011 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
negative regulation of protein kinase activity by regulation of protein phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific involved_in ISS
ISO 		GO_REF:0000024
(PMID:18362360)
(PMID:18362360), (PMID:19651874) 		UniProt
RGD		 PMID:18362360 PMID:19651874 GO_REF:0000024 NCBI chr 2:175,138,391...175,178,280
Ensembl chr 2:175,138,403...175,178,282 		JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:21289159) 		UniProt
RGD		 PMID:21289159 GO_REF:0000024 NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISS
ISO 		GO_REF:0000024
(PMID:21283629) 		UniProt
RGD		 PMID:21283629 GO_REF:0000024 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590 		JBrowse link
G Coro1c coronin 1C involved_in ISO (PMID:19913511) RGD PMID:19913511 NCBI chr12:42,713,024...42,785,179
Ensembl chr12:42,712,991...42,785,179 		JBrowse link
G Dusp10 dual specificity phosphatase 10 acts_upstream_of_or_within ISO (PMID:23977283) RGD PMID:23977283 NCBI chr13:98,145,317...98,183,304
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 acts_upstream_of_or_within ISO MGI:109583 (PMID:20418913) RGD PMID:20418913 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Npm1 nucleophosmin 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:12882984) 		UniProt
RGD		 PMID:12882984 GO_REF:0000024 NCBI chr10:18,245,739...18,255,913
Ensembl chr10:17,739,941...17,751,645
Ensembl chr  X:17,739,941...17,751,645 		JBrowse link
G Pten phosphatase and tensin homolog acts_upstream_of_or_within ISO MGI:1921405 (PMID:20418913) RGD PMID:20418913 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
negative regulation of protein serine/threonine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISS
ISO 		GO_REF:0000024
(PMID:19223857) 		UniProt
RGD		 PMID:19223857 GO_REF:0000024 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISO (PMID:19903888) RGD PMID:19903888 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Dtnbp1 dystrobrevin binding protein 1 acts_upstream_of_or_within ISO MGI:1856628 (PMID:25297099) RGD PMID:25297099 NCBI chr17:19,891,313...19,982,770
Ensembl chr17:19,685,215...19,776,661 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha involved_in ISO (PMID:23329839) RGD PMID:23329839 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Macroh2a1 macroH2A.1 histone involved_in ISO (PMID:22194607) RGD PMID:22194607 NCBI chr17:8,484,340...8,547,268
Ensembl chr17:8,479,372...8,542,072 		JBrowse link
G Prkch protein kinase C, eta involved_in ISO (PMID:34593629) RGD PMID:34593629 NCBI chr 6:98,027,830...98,226,486
Ensembl chr 6:92,292,000...92,490,654 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:12486103) RGD PMID:12486103 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 acts_upstream_of_or_within ISO (PMID:29274751) RGD PMID:29274751 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Slc8a3 solute carrier family 8 member A3 acts_upstream_of_or_within ISO (PMID:29274751) RGD PMID:29274751 NCBI chr 6:100,874,359...101,007,989
Ensembl chr 6:100,874,369...101,007,508 		JBrowse link
negative regulation of protein tyrosine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggnbp2 gametogenetin binding protein 2 acts_upstream_of_or_within ISO MGI:4072637 (PMID:26764350) RGD PMID:26764350 NCBI chr10:69,711,527...69,743,134
Ensembl chr10:69,711,532...69,743,365 		JBrowse link
G Mvp major vault protein involved_in ISO (PMID:16441665) RGD PMID:16441665 NCBI chr 1:191,025,259...191,052,866
Ensembl chr 1:181,594,734...181,622,380 		JBrowse link
G Ptk6 protein tyrosine kinase 6 involved_in ISO (PMID:15539407) RGD PMID:15539407 NCBI chr 3:168,307,073...168,315,664
Ensembl chr 3:168,307,073...168,315,664 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO (PMID:21216966) RGD PMID:21216966 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:17525734) 		UniProt
RGD		 PMID:17525734 GO_REF:0000024 NCBI chr10:82,502,911...82,569,882
Ensembl chr10:82,504,393...82,571,040 		JBrowse link
negative regulation of Rho-dependent protein serine/threonine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chordc1 cysteine and histidine rich domain containing 1 involved_in ISO (PMID:20230755) RGD PMID:20230755 NCBI chr 8:23,650,721...23,674,786
Ensembl chr 8:15,374,471...15,399,162 		JBrowse link
G Heg1 heart development protein with EGF-like domains 1 involved_in ISO (PMID:26780829) RGD PMID:26780829 NCBI chr11:80,512,096...80,600,150
Ensembl chr11:66,957,190...67,095,051 		JBrowse link
G Rasip1 Ras interacting protein 1 involved_in ISO (PMID:26780829) RGD PMID:26780829 NCBI chr 1:96,097,135...96,109,564
Ensembl chr 1:96,091,074...96,109,562 		JBrowse link
negative regulation of tau-protein kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blvra biliverdin reductase A acts_upstream_of_or_within ISO (PMID:27738106) RGD PMID:27738106 NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033 		JBrowse link
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp4 acid phosphatase 4 involved_in ISO (PMID:15219672) RGD PMID:15219672 NCBI chr 1:94,736,376...94,751,871
Ensembl chr 1:94,735,514...94,744,623 		JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in ISO (PMID:28759036) RGD PMID:28759036 NCBI chr10:87,420,213...87,434,202
Ensembl chr10:86,920,014...86,933,962 		JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B involved_in ISO (PMID:26063811) RGD PMID:26063811 NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748 		JBrowse link
G Ptprh protein tyrosine phosphatase, receptor type, H involved_in ISO (PMID:26063811) RGD PMID:26063811 NCBI chr 1:78,272,414...78,318,977
Ensembl chr 1:69,242,321...69,285,077 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (PMID:26063811) RGD PMID:26063811 NCBI chr 3:96,861,785...97,017,702
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Ptpro protein tyrosine phosphatase, receptor type, O involved_in ISO (PMID:26063811) RGD PMID:26063811 NCBI chr 4:171,895,104...172,105,911
Ensembl chr 4:170,164,431...170,374,771 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of molecular function 1381
        regulation of catalytic activity 874
          regulation of transferase activity 506
            negative regulation of transferase activity 180
              negative regulation of kinase activity 164
                negative regulation of protein kinase activity 150
                  negative regulation of cyclin-dependent protein kinase activity + 19
                  negative regulation of protein kinase activity by regulation of protein phosphorylation 8
                  negative regulation of protein serine/threonine kinase activity + 75
                  negative regulation of protein tyrosine kinase activity + 17
                  peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity 6
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        regulation of cellular process 13032
          regulation of metabolic process 6776
            regulation of macromolecule metabolic process 6244
              regulation of protein metabolic process 1968
                regulation of protein modification process 1038
                  regulation of protein phosphorylation 776
                    negative regulation of protein phosphorylation 244
                      negative regulation of protein kinase activity 150
                        negative regulation of cyclin-dependent protein kinase activity + 19
                        negative regulation of protein kinase activity by regulation of protein phosphorylation 8
                        negative regulation of protein serine/threonine kinase activity + 75
                        negative regulation of protein tyrosine kinase activity + 17
                        peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity 6
paths to the root