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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA methylation-dependent heterochromatin assembly
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Accession:GO:0006346 term browser browse the term
Definition:Repression of transcription by methylation of DNA, leading to the formation of heterochromatin.
Synonyms:exact_synonym: methylation-dependent heterochromatic silencing
 broad_synonym: methylation-dependent chromatin silencing



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DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 involved_in ISO
IEA
(MGI:3687778|PMID:10615135)
GO_REF:0000107
RGD
Ensembl
PMID:10615135 GO_REF:0000107 MGI:3687778 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha acts_upstream_of_or_within ISO MGI:1261819 (MGI:3611125|PMID:16322236), (MGI:3768461|PMID:17938196) RGD PMID:16322236 PMID:17938196 MGI:3611125 MGI:3768461 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta acts_upstream_of_or_within ISO MGI:1261827 (MGI:3768461|PMID:17938196) RGD PMID:17938196 MGI:3768461 NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Hdac1 histone deacetylase 1 involved_in ISO UniProtKB:Q9UBB5 (PMID:23770133) RGD PMID:23770133 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hells helicase, lymphoid specific involved_in IBA
ISO
PMID:21873635
(MGI:3573964|PMID:15647320)
RGD PMID:15647320 PMID:21873635 MGI:3573964, RGD:13792537 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
JBrowse link
G Kmt2b lysine methyltransferase 2B acts_upstream_of_or_within ISO MGI:3056522|MGI:3623309 (MGI:4849597|PMID:20808952) RGD PMID:20808952 MGI:4849597 NCBI chr 1:85,821,700...85,840,987
Ensembl chr 1:85,821,753...85,841,326
JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 involved_in ISO UniProtKB:Q13547 (PMID:23770133) RGD PMID:23770133 NCBI chr18:64,174,002...64,240,795
Ensembl chr18:64,174,002...64,240,794
JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 acts_upstream_of_or_within ISO (MGI:3611125|PMID:16322236) RGD PMID:16322236 MGI:3611125 NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165
JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 acts_upstream_of_or_within ISO (MGI:3611125|PMID:16322236) RGD PMID:16322236 MGI:3611125 NCBI chr 8:20,167,717...20,258,975
Ensembl chr 8:20,167,717...20,258,975
JBrowse link
negative regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase involved_in ISO (PMID:21496894) RGD PMID:21496894 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972
JBrowse link
G Apobec1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5285126|PMID:21496894)
UniProt
RGD
PMID:21496894 GO_REF:0000024 MGI:5285126 NCBI chr 4:155,800,030...155,828,515
Ensembl chr 4:155,800,887...155,827,390
JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 involved_in ISO (PMID:21496894) RGD PMID:21496894 NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052
JBrowse link
positive regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf7ip activating transcription factor 7 interacting protein involved_in ISO (PMID:27732843) RGD PMID:27732843 NCBI chr 4:169,385,872...169,471,652
Ensembl chr 4:169,385,872...169,471,650
JBrowse link
G Atf7ip2 activating transcription factor 7 interacting protein 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:5,403,099...5,445,989
Ensembl chr10:5,403,105...5,446,142
JBrowse link
G Dnmt1 DNA methyltransferase 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:24623306)
UniProt
Ensembl
RGD
PMID:24623306 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Morc2 MORC family CW-type zinc finger 2 involved_in ISO (PMID:28581500), (PMID:29211708)
(MGI:6271895|PMID:29728365)
RGD PMID:28581500 PMID:29211708 PMID:29728365 MGI:6271895 NCBI chr14:78,529,603...78,571,375
Ensembl chr14:78,527,009...78,571,343
JBrowse link
G Mphosph8 M-phase phosphoprotein 8 involved_in ISS
ISO
GO_REF:0000024
(PMID:28581500), (PMID:29211708)
UniProt
RGD
PMID:28581500 PMID:29211708 GO_REF:0000024 NCBI chr15:30,800,546...30,828,415 JBrowse link
G Pphln1 periphilin 1 involved_in ISO (PMID:28581500) RGD PMID:28581500 NCBI chr 7:124,538,594...124,629,985
Ensembl chr 7:124,538,627...124,629,985
JBrowse link
G Resf1 retroelement silencing factor 1 involved_in ISO
IBA
(MGI:6271895|PMID:29728365)
PMID:21873635
RGD PMID:29728365 PMID:21873635 MGI:6271895, RGD:13792537 NCBI chr 4:182,325,913...182,362,054
Ensembl chr 4:182,335,454...182,362,054
JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 involved_in IBA
ISO
PMID:21873635
(MGI:5440670|PMID:20164836), (MGI:6271895|PMID:29728365)
(PMID:24623306), (PMID:27732843)
RGD PMID:20164836 PMID:24623306 PMID:27732843 PMID:29728365 PMID:21873635 MGI:5440670 MGI:6271895, RGD:13792537 NCBI chr 2:182,898,738...182,930,283
Ensembl chr 2:182,898,738...182,930,506
JBrowse link
G Setdb2 SET domain bifurcated histone lysine methyltransferase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:33,553,657...33,606,586
Ensembl chr15:33,453,952...33,606,470
JBrowse link
G Tasor transcription activation suppressor involved_in ISO
IBA
(PMID:28581500), (PMID:29211708)
PMID:21873635
RGD PMID:28581500 PMID:29211708 PMID:21873635 RGD:13792537 NCBI chr16:2,606,807...2,669,902
Ensembl chr16:2,603,936...2,667,292
JBrowse link
G Trim28 tripartite motif-containing 28 involved_in ISS
ISO
GO_REF:0000024
(MGI:5440670|PMID:20164836)
(PMID:24623306)
UniProt
RGD
PMID:20164836 PMID:24623306 GO_REF:0000024 MGI:5440670 NCBI chr 1:73,652,441...73,659,388
Ensembl chr 1:73,652,709...73,659,380
JBrowse link
regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1a lysine demethylase 1A involved_in ISO
IEA
(PMID:33980486)
GO_REF:0000107
RGD
Ensembl
PMID:33980486 GO_REF:0000107 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319
JBrowse link
G L3mbtl3 L3MBTL histone methyl-lysine binding protein 3 involved_in ISO (PMID:33980486) RGD PMID:33980486 NCBI chr 1:18,988,763...19,089,247
Ensembl chr 1:18,990,618...19,089,263
JBrowse link
G Pou5f1 POU class 5 homeobox 1 involved_in ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Samd1 sterile alpha motif domain containing 1 involved_in ISO (PMID:33980486) RGD PMID:33980486 NCBI chr19:24,151,136...24,154,475 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    negative regulation of biological process 5677
      negative regulation of metabolic process 3218
        negative regulation of macromolecule metabolic process 2990
          negative regulation of gene expression 1145
            negative regulation of gene expression, epigenetic 118
              heterochromatin assembly 112
                facultative heterochromatin assembly 0
                  DNA methylation-dependent heterochromatin assembly 26
                    gene silencing by RNA-directed DNA methylation 0
                    negative regulation of DNA methylation-dependent heterochromatin assembly 3
                    positive regulation of DNA methylation-dependent heterochromatin assembly 11
                    regulation of DNA methylation-dependent heterochromatin assembly + 18
Path 2
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      cellular component organization or biogenesis 6620
        cellular component organization 6378
          organelle organization 3888
            chromosome organization 964
              chromatin organization 530
                chromatin assembly or disassembly 244
                  chromatin assembly 226
                    heterochromatin assembly 112
                      facultative heterochromatin assembly 0
                        DNA methylation-dependent heterochromatin assembly 26
                          gene silencing by RNA-directed DNA methylation 0
                          negative regulation of DNA methylation-dependent heterochromatin assembly 3
                          positive regulation of DNA methylation-dependent heterochromatin assembly 11
                          regulation of DNA methylation-dependent heterochromatin assembly + 18
paths to the root