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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA catabolic process
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Accession:GO:0006308 term browser browse the term
Definition:The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
Synonyms:exact_synonym: DNA breakdown;   DNA catabolism;   DNA degradation


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DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:78,451,845...78,454,938
Ensembl chr 7:78,451,851...78,454,938 		JBrowse link
G DFFB DNA fragmentation factor subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:65,310,868...65,323,816
Ensembl chr 6:65,310,864...65,323,806 		JBrowse link
G DNASE1 deoxyribonuclease 1 involved_in IEA
IBA
ISS		 (PMID:29191910) InterPro
GO_Central
Ensembl
UniProt		 PMID:29191910 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:38,590,045...38,646,852
Ensembl chr 3:38,586,602...38,646,833 		JBrowse link
G DNASE1L1 deoxyribonuclease 1 like 1 involved_in IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr  X:124,931,410...124,937,569
Ensembl chr  X:124,931,410...124,939,965 		JBrowse link
G DNASE1L2 deoxyribonuclease 1 like 2 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:21307874) InterPro
GO_Central
MGI
Ensembl		 PMID:21307874 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:39,757,725...39,761,497
Ensembl chr 3:39,757,296...39,761,080 		JBrowse link
G DNASE1L3 deoxyribonuclease 1L3 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr13:39,958,384...39,976,114
Ensembl chr13:39,958,387...39,975,946 		JBrowse link
G DNASE2 deoxyribonuclease 2, lysosomal involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15568025), (PMID:18991290) Ensembl
MGI		 PMID:15568025 PMID:18991290 GO_REF:0000107 NCBI chr 2:66,150,071...66,152,857
Ensembl chr 2:66,149,862...66,152,855 		JBrowse link
G FBH1 F-box DNA helicase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23361013) MGI
Ensembl		 PMID:23361013 GO_REF:0000107 NCBI chr10:65,060,714...65,108,975
Ensembl chr10:65,060,312...65,108,379 		JBrowse link
G ISG20 interferon stimulated exonuclease gene 20 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:191,155,853...191,195,601
Ensembl chr 1:191,183,599...191,195,475 		JBrowse link
G LOC100514009 histone-lysine N-methyltransferase SETMAR involved_in ISO (PMID:20521842), (PMID:21491884)
(PMID:24573677)		 UniProt PMID:20521842 PMID:21491884 PMID:24573677 NCBI chr13:60,914,412...60,933,064 JBrowse link
G MUS81 MUS81 structure-specific endonuclease subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23361013) InterPro
UniProt
Ensembl
MGI		 PMID:23361013 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chr 2:6,462,825...6,470,780
Ensembl chr 2:6,463,413...6,469,112 		JBrowse link
G REXO4 REX4 homolog, 3'-5' exonuclease involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:273,011,736...273,021,956
Ensembl chr 1:273,011,734...273,021,938 		JBrowse link
G TREX1 three prime repair exonuclease 1 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:18724932), (PMID:19923437), (PMID:23993650)
(PMID:20871604)
(PMID:25848017)		 Ensembl
GO_Central
MGI		 PMID:18724932 PMID:19923437 PMID:20871604 PMID:23993650 PMID:25848017 GO_REF:0000033 GO_REF:0000107 NCBI chr13:31,177,604...31,180,764
Ensembl chr13:31,179,291...31,180,747 		JBrowse link
apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCK cholecystokinin ISO pancreatic acinar cells RGD PMID:11964411 RGD:625521 NCBI chr13:25,940,674...25,945,879
Ensembl chr13:25,937,645...25,945,793 		JBrowse link
G DFFA DNA fragmentation factor subunit alpha involved_in IEA InterPro GO_REF:0000002 NCBI chr 6:70,725,403...70,736,264
Ensembl chr 6:70,724,590...70,736,236 		JBrowse link
G DFFB DNA fragmentation factor subunit beta involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA		 (PMID:15572351) RGD
GO_Central
Ensembl
InterPro
MGI		 PMID:11425895 PMID:15572351 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:628524 NCBI chr 6:65,310,868...65,323,816
Ensembl chr 6:65,310,864...65,323,806 		JBrowse link
G DICER1 dicer 1, ribonuclease III involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:116,361,630...116,436,471
Ensembl chr 7:116,365,802...116,411,224 		JBrowse link
G DNASE1L3 deoxyribonuclease 1L3 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:12050166) Ensembl
GO_Central
MGI		 PMID:12050166 GO_REF:0000033 GO_REF:0000107 NCBI chr13:39,958,384...39,976,114
Ensembl chr13:39,958,387...39,975,946 		JBrowse link
G DNASE2 deoxyribonuclease 2, lysosomal involved_in IBA
IEA		 GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000104 NCBI chr 2:66,150,071...66,152,857
Ensembl chr 2:66,149,862...66,152,855 		JBrowse link
G DNASE2B deoxyribonuclease 2 beta involved_in IEA
IBA		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr 6:129,329,737...129,343,003
Ensembl chr 6:129,329,867...129,340,980 		JBrowse link
G ENDOG endonuclease G involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:14663139) Ensembl
MGI
GO_Central		 PMID:14663139 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:269,153,955...269,157,789
Ensembl chr 1:269,154,090...269,157,788 		JBrowse link
G EXOG exo/endonuclease G involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:23,278,458...23,330,540
Ensembl chr13:23,278,932...23,307,566 		JBrowse link
G FOXL2 forkhead box L2 involved_in ISS UniProt GO_REF:0000024 NCBI chr13:79,708,693...79,709,825
Ensembl chr13:79,708,693...79,709,825 		JBrowse link
G VPS54 VPS54 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:77,856,093...77,978,194
Ensembl chr 3:77,856,138...77,975,429 		JBrowse link
mitochondrial DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENDOG endonuclease G involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:269,153,955...269,157,789
Ensembl chr 1:269,154,090...269,157,788 		JBrowse link
negative regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DFFA DNA fragmentation factor subunit alpha acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15572351)
(PMID:10601318), (PMID:14663139)		 MGI
Ensembl		 PMID:10601318 PMID:14663139 PMID:15572351 GO_REF:0000107 NCBI chr 6:70,725,403...70,736,264
Ensembl chr 6:70,724,590...70,736,236 		JBrowse link
G DFFB DNA fragmentation factor subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:65,310,868...65,323,816
Ensembl chr 6:65,310,864...65,323,806 		JBrowse link
G LOC100513346 mitochondrial import inner membrane translocase subunit TIM16 ISO RGD PMID:24069394 RGD:13462066 NCBI chr 3:37,928,098...38,005,619
Ensembl chr 3:37,928,096...37,985,151 		JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:27184051 RGD:13781945 NCBI chr 6:70,271,296...70,307,403
Ensembl chr 6:70,272,014...70,310,707 		JBrowse link
negative regulation of DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGN regucalcin ISO RGD PMID:2001740 RGD:9590215 NCBI chr  X:41,725,660...41,749,736
Ensembl chr  X:41,726,526...41,749,381 		JBrowse link
positive regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147 		JBrowse link
G ENDOG endonuclease G ISO RGD PMID:16407272 RGD:9685355 NCBI chr 1:269,153,955...269,157,789
Ensembl chr 1:269,154,090...269,157,788 		JBrowse link
G GATA5 GATA binding protein 5 ISO RGD PMID:25726415 RGD:155260369 NCBI chr17:61,824,891...61,834,742
Ensembl chr17:61,824,899...61,834,267 		JBrowse link
G HSF1 heat shock transcription factor 1 ISO RGD PMID:21192280 RGD:10403035 NCBI chr 4:463,531...486,483
Ensembl chr 4:463,393...486,473 		JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 ISO RGD PMID:15125883 RGD:10402776 NCBI chr18:50,002,921...50,009,425
Ensembl chr18:50,003,022...50,010,690 		JBrowse link
G IL6 interleukin 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
positive regulation of DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase ISO RGD PMID:27895165 RGD:12879393 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552 		JBrowse link
regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15703386) Ensembl
MGI		 PMID:15703386 GO_REF:0000107 NCBI chr  X:106,676,596...106,708,290
Ensembl chr  X:106,670,520...106,708,317 		JBrowse link
G APAF1 apoptotic peptidase activating factor 1 acts_upstream_of_or_within ISO (PMID:15703386) MGI PMID:15703386 NCBI chr 5:85,166,616...85,258,751
Ensembl chr 5:85,166,628...85,258,364 		JBrowse link
G CIDEA cell death inducing DFFA like effector a involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:97,253,074...97,268,355
Ensembl chr 6:97,253,074...97,267,405 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18933
    cellular process 18475
      metabolic process 11716
        macromolecule metabolic process 9806
          macromolecule catabolic process 1518
            nucleic acid catabolic process 391
              DNA catabolic process 33
                apoptotic DNA fragmentation + 21
                mitochondrial DNA catabolic process 1
                negative regulation of DNA catabolic process + 5
                positive regulation of DNA catabolic process + 7
                regulation of DNA catabolic process + 15
Path 2
Term Annotations click to browse term
  biological_process 18933
    cellular process 18475
      metabolic process 11716
        primary metabolic process 10385
          nucleobase-containing compound metabolic process 6331
            nucleic acid metabolic process 5817
              nucleic acid catabolic process 391
                DNA catabolic process 33
                  apoptotic DNA fragmentation + 21
                  mitochondrial DNA catabolic process 1
                  negative regulation of DNA catabolic process + 5
                  positive regulation of DNA catabolic process + 7
                  regulation of DNA catabolic process + 15
paths to the root