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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA catabolic process
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Accession:GO:0006308 term browser browse the term
Definition:The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
Synonyms:exact_synonym: DNA breakdown;   DNA catabolism;   DNA degradation

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DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 involved_in ISO (PMID:1627644) UniProt PMID:1627644 NCBI chrNW_004624825:4,711,921...4,714,926
Ensembl chrNW_004624825:4,708,093...4,714,921 		JBrowse link
G Dffb DNA fragmentation factor subunit beta involved_in ISO (PMID:19944011) CAFA PMID:19944011 NCBI chrNW_004624818:6,700,120...6,712,449
Ensembl chrNW_004624818:6,700,050...6,712,450 		JBrowse link
G Dnase1 deoxyribonuclease 1 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624824:1,429,078...1,446,881
Ensembl chrNW_004624824:1,443,451...1,446,881 		JBrowse link
G Dnase1l1 deoxyribonuclease 1 like 1 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624946:858,638...869,859
Ensembl chrNW_004624946:864,657...870,396 		JBrowse link
G Dnase1l2 deoxyribonuclease 1 like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21307874) InterPro
TreeGrafter
MGI
Ensembl		 PMID:21307874 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624824:49,877...53,383
Ensembl chrNW_004624824:49,949...53,375 		JBrowse link
G Dnase1l3 deoxyribonuclease 1L3 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624821:845,631...871,156
Ensembl chrNW_004624821:849,434...871,609 		JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal acts_upstream_of_or_within ISO (PMID:15568025), (PMID:18991290) MGI PMID:15568025 PMID:18991290 NCBI chrNW_004624901:464,211...466,979
Ensembl chrNW_004624901:464,223...467,161 		JBrowse link
G Fbh1 F-box DNA helicase 1 acts_upstream_of_or_within ISO (PMID:23361013) MGI PMID:23361013 NCBI chrNW_004624775:788,388...844,968
Ensembl chrNW_004624775:788,463...837,524 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624768:15,949,591...15,958,816
Ensembl chrNW_004624768:15,949,470...15,960,653 		JBrowse link
G LOC101704237 histone-lysine N-methyltransferase SETMAR involved_in ISO (PMID:20521842), (PMID:21491884)
(PMID:24573677)		 UniProt PMID:20521842 PMID:21491884 PMID:24573677 NCBI chrNW_004624773:14,680,571...14,692,583 JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23361013) MGI
InterPro
UniProt		 PMID:23361013 GO_REF:0000002 GO_REF:0000104 NCBI chrNW_004624767:20,567,465...20,573,622
Ensembl chrNW_004624767:20,567,465...20,572,866 		JBrowse link
G Rexo4 REX4 homolog, 3'-5' exonuclease involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624760:1,851,008...1,861,370
Ensembl chrNW_004624760:1,851,877...1,859,387 		JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:18724932), (PMID:19923437), (PMID:23993650)
(PMID:20871604)
(PMID:25848017)		 MGI
TreeGrafter
Ensembl		 PMID:18724932 PMID:19923437 PMID:20871604 PMID:23993650 PMID:25848017 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624730:2,431,270...2,433,010
Ensembl chrNW_004624730:2,431,999...2,432,959 		JBrowse link
G Trex2 three prime repair exonuclease 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624946:187,147...188,805
Ensembl chrNW_004624946:187,056...210,497 		JBrowse link
apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cck cholecystokinin ISO pancreatic acinar cells RGD PMID:11964411 RGD:625521 NCBI chrNW_004624730:77,310,080...77,314,258
Ensembl chrNW_004624730:77,309,633...77,314,384 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624818:2,225,777...2,239,897 JBrowse link
G Dffb DNA fragmentation factor subunit beta acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15572351) MGI
TreeGrafter
InterPro
RGD		 PMID:11425895 PMID:15572351 GO_REF:0000002 GO_REF:0000118 RGD:628524 NCBI chrNW_004624818:6,700,120...6,712,449
Ensembl chrNW_004624818:6,700,050...6,712,450 		JBrowse link
G Dicer1 dicer 1, ribonuclease III involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624734:7,604,049...7,681,481
Ensembl chrNW_004624734:7,608,273...7,651,819 		JBrowse link
G Dnase1l3 deoxyribonuclease 1L3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12050166) MGI
TreeGrafter		 PMID:12050166 GO_REF:0000118 NCBI chrNW_004624821:845,631...871,156
Ensembl chrNW_004624821:849,434...871,609 		JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004624901:464,211...466,979
Ensembl chrNW_004624901:464,223...467,161 		JBrowse link
G Dnase2b deoxyribonuclease 2 beta involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004624742:13,052,355...13,066,284
Ensembl chrNW_004624742:13,052,261...13,066,563 		JBrowse link
G Endog endonuclease G acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14663139) MGI
TreeGrafter		 PMID:14663139 GO_REF:0000118 NCBI chrNW_004624760:6,193,168...6,196,209
Ensembl chrNW_004624760:6,193,173...6,196,374 		JBrowse link
G Exog exo/endonuclease G involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624731:2,515,294...2,550,531
Ensembl chrNW_004624731:2,514,513...2,550,617 		JBrowse link
G Foxl2 forkhead box L2 involved_in ISO (PMID:16153597) UniProt PMID:16153597 NCBI chrNW_004624730:15,489,261...15,492,645
Ensembl chrNW_004624730:15,490,664...15,491,800 		JBrowse link
G Vps54 VPS54 subunit of GARP complex involved_in ISO (PMID:11403940) MGI PMID:11403940 NCBI chrNW_004624762:9,457,283...9,570,311
Ensembl chrNW_004624762:9,457,705...9,563,779 		JBrowse link
mitochondrial DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endog endonuclease G involved_in ISO (PMID:29719607) UniProt PMID:29719607 NCBI chrNW_004624760:6,193,168...6,196,209
Ensembl chrNW_004624760:6,193,173...6,196,374 		JBrowse link
negative regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffa DNA fragmentation factor subunit alpha acts_upstream_of_or_within
involved_in		 ISO (PMID:15572351)
(PMID:10601318), (PMID:14663139)
(PMID:11371636)		 MGI
ComplexPortal		 PMID:10601318 PMID:11371636 PMID:14663139 PMID:15572351 NCBI chrNW_004624818:2,225,777...2,239,897 JBrowse link
G Dffb DNA fragmentation factor subunit beta involved_in ISO (PMID:11371636) ComplexPortal PMID:11371636 NCBI chrNW_004624818:6,700,120...6,712,449
Ensembl chrNW_004624818:6,700,050...6,712,450 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:27184051 RGD:13781945 NCBI chrNW_004624818:2,575,476...2,591,423
Ensembl chrNW_004624818:2,573,498...2,580,095 		JBrowse link
G Pam16 presequence translocase associated motor 16 ISO RGD PMID:24069394 RGD:13462066 NCBI chrNW_004624746:18,235,774...18,237,603 JBrowse link
negative regulation of DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin ISO RGD PMID:2001740 RGD:9590215 NCBI chrNW_004624887:3,881,624...3,900,144
Ensembl chrNW_004624887:3,883,213...3,899,277 		JBrowse link
positive regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator involved_in ISO (PMID:11350920) BHF-UCL PMID:11350920 NCBI chrNW_004624832:5,050,222...5,068,565
Ensembl chrNW_004624832:5,050,222...5,055,506 		JBrowse link
G Endog endonuclease G ISO RGD PMID:16407272 RGD:9685355 NCBI chrNW_004624760:6,193,168...6,196,209
Ensembl chrNW_004624760:6,193,173...6,196,374 		JBrowse link
G Gata5 GATA binding protein 5 ISO RGD PMID:25726415 RGD:155260369 NCBI chrNW_004624741:28,310,679...28,322,209
Ensembl chrNW_004624741:28,310,201...28,321,095 		JBrowse link
G Hsf1 heat shock transcription factor 1 ISO RGD PMID:21192280 RGD:10403035 NCBI chrNW_004624735:12,536,818...12,562,643
Ensembl chrNW_004624735:12,537,128...12,562,644 		JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 ISO RGD PMID:15125883 RGD:10402776 NCBI chrNW_004624740:6,878,818...6,886,512
Ensembl chrNW_004624740:6,877,348...6,886,512 		JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:28433754) ARUK-UCL PMID:28433754 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
positive regulation of DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase ISO RGD PMID:27895165 RGD:12879393 NCBI chrNW_004624784:2,933,172...3,080,131
Ensembl chrNW_004624784:2,937,499...3,078,216 		JBrowse link
regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor mitochondria associated 1 acts_upstream_of_or_within ISO (PMID:15703386) MGI PMID:15703386 NCBI chrNW_004624797:9,346,620...9,384,531
Ensembl chrNW_004624797:9,345,726...9,384,645 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 acts_upstream_of_or_within ISO (PMID:15703386) MGI PMID:15703386 NCBI chrNW_004624750:8,835,521...8,940,957
Ensembl chrNW_004624750:8,837,037...8,938,009 		JBrowse link
G Cidea cell death inducing DFFA like effector a involved_in ISO (PMID:9564035) BHF-UCL PMID:9564035 NCBI chrNW_004624770:19,559,735...19,573,394
Ensembl chrNW_004624770:19,559,692...19,573,788 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17640
    cellular process 17222
      metabolic process 11022
        macromolecule metabolic process 9138
          macromolecule catabolic process 1346
            nucleic acid catabolic process 322
              DNA catabolic process 34
                apoptotic DNA fragmentation + 21
                mitochondrial DNA catabolic process 1
                negative regulation of DNA catabolic process + 5
                positive regulation of DNA catabolic process + 7
                regulation of DNA catabolic process + 15
Path 2
Term Annotations click to browse term
  biological_process 17640
    cellular process 17222
      metabolic process 11022
        primary metabolic process 9867
          nucleobase-containing compound metabolic process 5892
            nucleic acid metabolic process 5391
              nucleic acid catabolic process 322
                DNA catabolic process 34
                  apoptotic DNA fragmentation + 21
                  mitochondrial DNA catabolic process 1
                  negative regulation of DNA catabolic process + 5
                  positive regulation of DNA catabolic process + 7
                  regulation of DNA catabolic process + 15
paths to the root