Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:DNA catabolic process
go back to main search page
Accession:GO:0006308 term browser browse the term
Definition:The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
Synonyms:exact_synonym: DNA breakdown;   DNA catabolism;   DNA degradation


show annotations for term's descendants           Sort by:
DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 involved_in ISO (PMID:1627644) UniProt PMID:1627644 NCBI chr15:17,786,808...17,789,422
Ensembl chr15:17,786,357...17,789,422 		JBrowse link
G DFFB DNA fragmentation factor subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:58,340,183...58,355,353
Ensembl chr 5:58,339,634...58,354,326 		JBrowse link
G DNASE1 deoxyribonuclease 1 involved_in IEA
ISS		 (PMID:29191910) InterPro
Ensembl
UniProt		 PMID:29191910 GO_REF:0000002 GO_REF:0000107 NCBI chr 6:37,596,735...37,599,953
Ensembl chr 6:37,595,911...37,599,827 		JBrowse link
G DNASE1L1 deoxyribonuclease 1 like 1 involved_in IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr  X:122,101,992...122,109,240
Ensembl chr  X:122,101,992...122,109,165 		JBrowse link
G DNASE1L2 deoxyribonuclease 1 like 2 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:21307874) InterPro
GO_Central
MGI
Ensembl		 PMID:21307874 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
G DNASE1L3 deoxyribonuclease 1L3 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr20:32,350,138...32,379,240
Ensembl chr20:32,358,110...32,379,245 		JBrowse link
G DNASE2 deoxyribonuclease 2, lysosomal involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:49,299,236...49,301,815
Ensembl chr20:49,299,406...49,301,814 		JBrowse link
G FBH1 F-box DNA helicase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23361013) Ensembl
MGI		 PMID:23361013 GO_REF:0000107 NCBI chr 2:30,047,994...30,095,761
Ensembl chr 2:30,048,567...30,095,696 		JBrowse link
G ISG20 interferon stimulated exonuclease gene 20 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:51,822,642...51,833,665
Ensembl chr 3:51,822,888...51,833,659 		JBrowse link
G MUS81 MUS81 structure-specific endonuclease subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23361013) InterPro
UniProt
MGI
Ensembl		 PMID:23361013 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chr18:51,396,980...51,404,563
Ensembl chr18:51,396,980...51,402,534 		JBrowse link
G REXO4 REX4 homolog, 3'-5' exonuclease involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:49,827,584...49,834,872
Ensembl chr 9:49,828,067...49,836,632 		JBrowse link
G SETMAR SET domain without mariner transposase fusion involved_in ISO (PMID:20521842), (PMID:21491884)
(PMID:24573677)		 UniProt PMID:20521842 PMID:21491884 PMID:24573677 NCBI chr20:13,214,241...13,224,020
Ensembl chr20:13,214,241...13,224,020 		JBrowse link
G TREX1 three prime repair exonuclease 1 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:18724932), (PMID:19923437), (PMID:23993650)
(PMID:25848017)
(PMID:20871604)		 Ensembl
GO_Central
MGI		 PMID:18724932 PMID:19923437 PMID:20871604 PMID:23993650 PMID:25848017 GO_REF:0000033 GO_REF:0000107 NCBI chr20:40,624,845...40,626,840
Ensembl chr20:40,624,891...40,626,906 		JBrowse link
apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCK cholecystokinin ISO pancreatic acinar cells RGD PMID:11964411 RGD:625521 NCBI chr23:11,414,254...11,419,990
Ensembl chr23:11,414,249...11,454,198 		JBrowse link
G DFFA DNA fragmentation factor subunit alpha involved_in IEA InterPro GO_REF:0000002 NCBI chr 2:85,364,819...85,372,473
Ensembl chr 2:85,364,851...85,373,772 		JBrowse link
G DFFB DNA fragmentation factor subunit beta involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA		 (PMID:15572351) RGD
GO_Central
Ensembl
InterPro
MGI		 PMID:11425895 PMID:15572351 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:628524 NCBI chr 5:58,340,183...58,355,353
Ensembl chr 5:58,339,634...58,354,326 		JBrowse link
G DICER1 dicer 1, ribonuclease III involved_in IBA GO_Central GO_REF:0000033 NCBI chr 8:63,970,245...64,029,438
Ensembl chr 8:63,972,027...64,019,879 		JBrowse link
G DNASE1L3 deoxyribonuclease 1L3 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:12050166) Ensembl
GO_Central
MGI		 PMID:12050166 GO_REF:0000033 GO_REF:0000107 NCBI chr20:32,350,138...32,379,240
Ensembl chr20:32,358,110...32,379,245 		JBrowse link
G DNASE2 deoxyribonuclease 2, lysosomal involved_in IEA
IBA		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr20:49,299,236...49,301,815
Ensembl chr20:49,299,406...49,301,814 		JBrowse link
G DNASE2B deoxyribonuclease 2 beta involved_in IEA
IBA		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr 6:63,465,477...63,481,893
Ensembl chr 6:63,466,106...63,481,723 		JBrowse link
G ENDOG endonuclease G involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:14663139) Ensembl
GO_Central
MGI		 PMID:14663139 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:54,809,470...54,812,795
Ensembl chr 9:54,809,530...54,813,042 		JBrowse link
G EXOG exo/endonuclease G involved_in IBA GO_Central GO_REF:0000033 NCBI chr23:8,231,469...8,260,572
Ensembl chr23:8,231,484...8,258,710 		JBrowse link
G FOXL2 forkhead box L2 involved_in ISO (PMID:16153597) UniProt PMID:16153597 NCBI chr23:35,145,856...35,147,185 JBrowse link
G LOC100686111 nuclease EXOG, mitochondrial-like involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:104,857,047...104,858,004 JBrowse link
G VPS54 VPS54 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:63,598,373...63,676,753
Ensembl chr10:63,599,229...63,676,747 		JBrowse link
mitochondrial DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENDOG endonuclease G involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:54,809,470...54,812,795
Ensembl chr 9:54,809,530...54,813,042 		JBrowse link
negative regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DFFA DNA fragmentation factor subunit alpha acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15572351)
(PMID:10601318), (PMID:14663139)		 MGI
Ensembl		 PMID:10601318 PMID:14663139 PMID:15572351 GO_REF:0000107 NCBI chr 2:85,364,819...85,372,473
Ensembl chr 2:85,364,851...85,373,772 		JBrowse link
G DFFB DNA fragmentation factor subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:58,340,183...58,355,353
Ensembl chr 5:58,339,634...58,354,326 		JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:27184051 RGD:13781945 NCBI chr 5:63,122,379...63,152,078
Ensembl chr 5:63,122,498...63,151,661 		JBrowse link
G PAM16 presequence translocase associated motor 16 ISO RGD PMID:24069394 RGD:13462066 NCBI chr 6:37,040,484...37,047,708 JBrowse link
negative regulation of DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGN regucalcin ISO RGD PMID:2001740 RGD:9590215 NCBI chr  X:40,697,292...40,715,491
Ensembl chr  X:40,698,768...40,715,490 		JBrowse link
positive regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464 		JBrowse link
G ENDOG endonuclease G ISO RGD PMID:16407272 RGD:9685355 NCBI chr 9:54,809,470...54,812,795
Ensembl chr 9:54,809,530...54,813,042 		JBrowse link
G GATA5 GATA binding protein 5 ISO RGD PMID:25726415 RGD:155260369 NCBI chr24:46,417,404...46,427,617
Ensembl chr24:46,417,391...46,429,858 		JBrowse link
G HSF1 heat shock transcription factor 1 ISO RGD PMID:21192280 RGD:10403035 NCBI chr13:37,724,741...37,745,259
Ensembl chr13:37,724,759...37,745,252 		JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 ISO RGD PMID:15125883 RGD:10402776 NCBI chr16:1,021,855...1,027,604
Ensembl chr16:1,021,972...1,026,392 		JBrowse link
G IL6 interleukin 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
positive regulation of DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase ISO RGD PMID:27895165 RGD:12879393 NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207 		JBrowse link
regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15703386) Ensembl
MGI		 PMID:15703386 GO_REF:0000107 NCBI chr  X:101,275,027...101,307,551
Ensembl chr  X:101,275,017...101,307,367 		JBrowse link
G APAF1 apoptotic peptidase activating factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15703386) Ensembl
MGI		 PMID:15703386 GO_REF:0000107 NCBI chr15:38,026,893...38,160,842
Ensembl chr15:38,028,132...38,114,987 		JBrowse link
G CIDEA cell death inducing DFFA like effector a involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:77,685,383...77,703,320
Ensembl chr 7:77,684,863...77,702,934 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22103
    cellular process 21633
      metabolic process 15381
        macromolecule metabolic process 13372
          macromolecule catabolic process 1573
            nucleic acid catabolic process 426
              DNA catabolic process 34
                apoptotic DNA fragmentation + 22
                mitochondrial DNA catabolic process 1
                negative regulation of DNA catabolic process + 5
                positive regulation of DNA catabolic process + 7
                regulation of DNA catabolic process + 15
Path 2
Term Annotations click to browse term
  biological_process 22103
    cellular process 21633
      metabolic process 15381
        primary metabolic process 13982
          nucleobase-containing compound metabolic process 9611
            nucleic acid metabolic process 9019
              nucleic acid catabolic process 426
                DNA catabolic process 34
                  apoptotic DNA fragmentation + 22
                  mitochondrial DNA catabolic process 1
                  negative regulation of DNA catabolic process + 5
                  positive regulation of DNA catabolic process + 7
                  regulation of DNA catabolic process + 15
paths to the root