Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:DNA catabolic process
go back to main search page
Accession:GO:0006308 term browser browse the term
Definition:The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
Synonyms:exact_synonym: DNA breakdown;   DNA catabolism;   DNA degradation


show annotations for term's descendants           Sort by:
 
DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffb DNA fragmentation factor subunit beta involved_in ISO (PMID:19944011) RGD PMID:19944011 NCBI chr 5:164,522,446...164,534,733 JBrowse link
G Dnase1 deoxyribonuclease 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:11,498,930...11,505,151 JBrowse link
G Dnase1l1 deoxyribonuclease 1-like 1 involved_in IEA
IBA
GO_REF:0000002
PMID:21873635
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr  X:152,056,942...152,065,518 JBrowse link
G Dnase1l2 deoxyribonuclease 1 like 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:5308556 (MGI:5308183|PMID:21307874)
RGD PMID:21307874, PMID:21873635 MGI:5308183, RGD:13792537 NCBI chr10:13,471,850...13,473,447 JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:16,922,335...16,948,322 JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO MGI:3052754|MGI:5751220 (MGI:3834787|PMID:18724932), (MGI:4414715|PMID:19923437), (MGI:4848004|PMID:20871604), (MGI:5562498|PMID:23993650), (MGI:5637600|PMID:25848017) RGD PMID:18724932 PMID:19923437 PMID:20871604 PMID:23993650 PMID:25848017 MGI:3834787 MGI:4414715 MGI:4848004 MGI:5562498 MGI:5637600 NCBI chr 8:109,706,613...109,707,913 JBrowse link
apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffa DNA fragmentation factor subunit alpha involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:159,540,718...159,553,639 JBrowse link
G Dffb DNA fragmentation factor subunit beta acts_upstream_of_or_within
involved_in
IDA
ISO
IEA
IBA
(PMID:15572351)
(PMID:22253444)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:15572351 PMID:22253444, PMID:11425895, PMID:21873635 GO_REF:0000107, RGD:628524, RGD:13792537 NCBI chr 5:164,522,446...164,534,733 JBrowse link
G Dicer1 dicer 1 ribonuclease III involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:123,627,529...123,692,278 JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 acts_upstream_of_or_within
involved_in
TAS
ISO
IBA
(MGI:2385551|PMID:12050166)
PMID:21873635
(PMID:23229555)
RGD PMID:12050166 PMID:23229555, PMID:9665719, PMID:21873635 MGI:2385551, RGD:728743, RGD:13792537 NCBI chr15:16,922,335...16,948,322 JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:23,244,661...23,247,329 JBrowse link
G Dnase2b deoxyribonuclease 2 beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:235,470,915...235,515,211 JBrowse link
G Endog endonuclease G involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3034030|MGI:3514265 (MGI:3029597|PMID:14663139)
RGD PMID:14663139, PMID:21873635 MGI:3029597, RGD:13792537 NCBI chr 3:13,449,113...13,451,715 JBrowse link
G Exog exo/endonuclease G involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:119,184,974...119,204,819 JBrowse link
G Foxl2 forkhead box L2 involved_in ISO (PMID:16153597) RGD PMID:16153597 NCBI chr 8:99,512,971...99,514,500 JBrowse link
DNA catabolic process, endonucleolytic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 involved_in ISO
IEA
(PMID:1627644)
GO_REF:0000107
RGD
Ensembl
PMID:1627644 GO_REF:0000107 NCBI chr15:24,144,595...24,146,785 JBrowse link
G Dnase1 deoxyribonuclease 1 involved_in ISS
ISO
IBA
PMID:29191910
(MGI:6094744|PMID:29191910)
PMID:21873635
RGD PMID:29191910, PMID:29191910, PMID:21873635 MGI:6094744, RGD:13464261, RGD:13792537 NCBI chr10:11,498,930...11,505,151 JBrowse link
G Dnase1l1 deoxyribonuclease 1-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:152,056,942...152,065,518 JBrowse link
G Dnase1l2 deoxyribonuclease 1 like 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:13,471,850...13,473,447 JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:6094744|PMID:29191910)
RGD PMID:29191910, PMID:21873635, PMID:29191910 MGI:6094744, RGD:13792537, RGD:13464261 NCBI chr15:16,922,335...16,948,322 JBrowse link
G Fbh1 F-box DNA helicase 1 acts_upstream_of_or_within ISO (PMID:23361013) RGD PMID:23361013 NCBI chr17:66,749,506...66,787,590 JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit acts_upstream_of_or_within ISO (PMID:23361013) RGD PMID:23361013 NCBI chr 1:202,790,295...202,796,008 JBrowse link
G Rexo4 REX4 homolog, 3'-5' exonuclease involved_in ISO
IBA
(PMID:21602889)
PMID:21873635
RGD PMID:21602889, PMID:21873635 RGD:13792537 NCBI chr 3:10,280,654...10,291,003 JBrowse link
G Setmar SET domain and mariner transposase fusion gene involved_in ISO (PMID:20521842), (PMID:21491884), (PMID:24573677) RGD PMID:20521842 PMID:21491884 PMID:24573677 NCBI chr 4:141,046,058...141,058,183 JBrowse link
DNA catabolic process, exonucleolytic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Isg20 interferon stimulated exonuclease gene 20 involved_in IBA
ISO
PMID:21873635
(PMID:11401564)
RGD PMID:11401564, PMID:21873635 RGD:13792537 NCBI chr 1:132,829,303...132,837,027 JBrowse link
G Rexo4 REX4 homolog, 3'-5' exonuclease involved_in ISO
IBA
(PMID:21602889)
PMID:21873635
RGD PMID:21602889, PMID:21873635 RGD:13792537 NCBI chr 3:10,280,654...10,291,003 JBrowse link
G Trex1 three prime repair exonuclease 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:109,706,613...109,707,913 JBrowse link
G Trex2 three prime repair exonuclease 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:151,151,862...151,153,470 JBrowse link
G Xrn2 5'-3' exoribonuclease 2 involved_in ISO (PMID:15565158) RGD PMID:15565158 NCBI chr 3:134,436,916...134,509,308 JBrowse link
negative regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffa DNA fragmentation factor subunit alpha acts_upstream_of_or_within ISO MGI:2179456 (MGI:2182584|PMID:10601318), (MGI:3029597|PMID:14663139)
(PMID:15572351)
RGD PMID:10601318 PMID:14663139 PMID:15572351 MGI:2182584 MGI:3029597 NCBI chr 5:159,540,718...159,553,639 JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 IMP RGD PMID:27184051 RGD:13781945 NCBI chr 5:159,910,242...159,928,201 JBrowse link
G Pam16 presequence translocase associated motor 16 IDA RGD PMID:24069394 RGD:13462066 NCBI chr10:10,942,534...10,950,654 JBrowse link
negative regulation of DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin IDA RGD PMID:2001740 RGD:9590215 NCBI chr  X:1,619,030...1,634,456 JBrowse link
positive regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator involved_in ISO
IEA
(PMID:11350920)
GO_REF:0000107
RGD
Ensembl
PMID:11350920 GO_REF:0000107 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Endog endonuclease G IMP RGD PMID:16407272 RGD:9685355 NCBI chr 3:13,449,113...13,451,715 JBrowse link
G Hsf1 heat shock transcription factor 1 IMP RGD PMID:21192280 RGD:10403035 NCBI chr 7:108,196,040...108,223,011 JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 IMP RGD PMID:15125883 RGD:10402776 NCBI chr14:82,056,347...82,064,083 JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:28433754) RGD PMID:28433754 NCBI chr 4:5,214,602...5,219,178 JBrowse link
positive regulation of DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP RGD PMID:27895165 RGD:12879393 NCBI chr 8:53,828,741...53,932,773 JBrowse link
regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 acts_upstream_of_or_within ISO MGI:1306796 (MGI:3577148|PMID:15703386) RGD PMID:15703386 MGI:3577148 NCBI chr  X:127,650,223...127,689,356 JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 acts_upstream_of_or_within ISO MGI:1349414 (MGI:3577148|PMID:15703386) RGD PMID:15703386 MGI:3577148 NCBI chr 7:25,494,143...25,579,540 JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:12082630) RGD PMID:12082630 NCBI chr 5:103,984,949...103,992,143 JBrowse link
G Cidea cell death-inducing DFFA-like effector a involved_in ISO (MGI:1203887|PMID:9564035) RGD PMID:9564035 MGI:1203887 NCBI chr18:60,894,917...60,920,485 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      cellular metabolic process 10753
        cellular macromolecule metabolic process 8240
          DNA metabolic process 883
            DNA catabolic process 33
              DNA catabolic process, endonucleolytic + 27
              DNA catabolic process, exonucleolytic 5
              mitochondrial DNA catabolic process 0
              negative regulation of DNA catabolic process + 4
              positive regulation of DNA catabolic process + 6
              regulation of DNA catabolic process + 14
Path 2
Term Annotations click to browse term
  biological_process 19492
    cellular process 18342
      cellular metabolic process 10753
        cellular aromatic compound metabolic process 5636
          nucleobase-containing compound metabolic process 5419
            nucleic acid metabolic process 4929
              DNA metabolic process 883
                DNA catabolic process 33
                  DNA catabolic process, endonucleolytic + 27
                  DNA catabolic process, exonucleolytic 5
                  mitochondrial DNA catabolic process 0
                  negative regulation of DNA catabolic process + 4
                  positive regulation of DNA catabolic process + 6
                  regulation of DNA catabolic process + 14
paths to the root