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ONTOLOGY REPORT - ANNOTATIONS

Term:double-strand break repair via nonhomologous end joining
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Accession:GO:0006303 term browser browse the term
Definition:The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
Synonyms:exact_synonym: NHEJ


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double-strand break repair via nonhomologous end joining term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLF aprataxin and PNKP like factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:68,509,314...68,629,192
Ensembl chr2A:69,632,459...69,744,611 		JBrowse link
G CYREN cell cycle regulator of NHEJ involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:127,130,587...127,148,824 JBrowse link
G DCLRE1A DNA cross-link repair 1A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:110,433,735...110,453,565
Ensembl chr10:113,866,759...113,886,141 		JBrowse link
G DCLRE1B DNA cross-link repair 1B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:88,643,664...88,651,962
Ensembl chr 1:123,692,915...123,701,403 		JBrowse link
G DCLRE1C DNA cross-link repair 1C involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:14,901,335...14,956,947
Ensembl chr10:15,236,558...15,269,043 		JBrowse link
G DNTT DNA nucleotidylexotransferase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:92,916,783...92,958,216
Ensembl chr10:96,423,819...96,457,742 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:42,356,039...42,427,754
Ensembl chr19:50,951,674...50,968,430 		JBrowse link
G ERCC4 ERCC excision repair 4, endonuclease catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:12,848,334...12,880,480
Ensembl chr16:14,272,417...14,304,496 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:9600082) GO_Central PMID:9600082 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527 		JBrowse link
G HMGB2 high mobility group box 2 involved_in ISO (PMID:9600082) GO_Central PMID:9600082 NCBI chr 4:165,559,848...165,562,625
Ensembl chr 4:177,797,457...177,800,952 		JBrowse link
G IFFO1 intermediate filament family orphan 1 involved_in ISO (PMID:31548606) UniProt PMID:31548606 NCBI chr12:6,670,415...6,686,972
Ensembl chr12:6,588,975...6,605,262 		JBrowse link
G KDM2A lysine demethylase 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:62,470,549...62,616,135
Ensembl chr11:65,793,464...65,930,498 		JBrowse link
G LIG1 DNA ligase 1 acts_upstream_of_or_within ISO (PMID:21655080) MGI PMID:21655080 NCBI chr19:45,056,737...45,110,867
Ensembl chr19:53,706,778...53,761,088 		JBrowse link
G LIG3 DNA ligase 3 acts_upstream_of_or_within ISO (PMID:21655080) MGI PMID:21655080 NCBI chr17:21,776,483...21,805,706
Ensembl chr17:22,074,046...22,095,220 		JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16777961)
(PMID:10823907)		 Ensembl
MGI
TreeGrafter		 PMID:10823907 PMID:16777961 GO_REF:0000107 GO_REF:0000118 NCBI chr13:89,336,434...89,347,418
Ensembl chr13:108,475,820...108,478,555 		JBrowse link
G LOC100970335 X-ray repair cross-complementing protein 6-like involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr  X:139,876,341...139,878,314 JBrowse link
G LOC100986203 histone-lysine N-methyltransferase SETMAR involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:4,256,539...4,271,593
Ensembl chr 3:4,357,890...4,371,791 		JBrowse link
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15084308) Ensembl
MGI		 PMID:15084308 GO_REF:0000107 NCBI chr 3:36,899,828...36,957,076
Ensembl chr 3:37,189,439...37,245,801 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:89,418,537...89,500,705
Ensembl chr11:92,918,549...92,985,966 		JBrowse link
G NHEJ1 non-homologous end joining factor 1 involved_in IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr2B:106,326,596...106,419,928
Ensembl chr2B:224,926,183...225,008,788 		JBrowse link
G NSMCE2 NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase NOT|involved_in ISO (PMID:16810316) UniProt PMID:16810316 NCBI chr 8:121,777,986...122,052,094
Ensembl chr 8:124,529,268...124,803,114 		JBrowse link
G PAXX PAXX non-homologous end joining factor involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:108,052,793...108,055,298
Ensembl chr 9:137,021,230...137,022,805 		JBrowse link
G PNKP polynucleotide kinase 3'-phosphatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:46,874,216...46,880,954
Ensembl chr19:55,790,048...55,796,762 		JBrowse link
G POLA1 DNA polymerase alpha 1, catalytic subunit involved_in ISO (PMID:11470886) UniProt PMID:11470886 NCBI chr  X:17,290,805...17,592,163
Ensembl chr  X:24,657,878...24,960,231 		JBrowse link
G POLB DNA polymerase beta involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:41,582,370...41,615,950
Ensembl chr 8:39,026,991...39,060,464 		JBrowse link
G POLL DNA polymerase lambda involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:98,181,049...98,190,463
Ensembl chr10:101,653,978...101,663,360 		JBrowse link
G POLM DNA polymerase mu involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:44,785,797...44,796,624
Ensembl chr 7:44,852,594...44,862,816 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23836881) Ensembl
MGI
InterPro		 PMID:23836881 GO_REF:0000002 GO_REF:0000107 NCBI chr 8:44,201,391...44,386,803
Ensembl chr 8:41,593,029...41,778,299 		JBrowse link
G PRPF19 pre-mRNA processing factor 19 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:56,153,965...56,169,821
Ensembl chr11:59,595,120...59,607,828 		JBrowse link
G PSMD14 proteasome 26S subunit, non-ATPase 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:48,602,395...48,705,229
Ensembl chr2B:165,972,229...166,074,879 		JBrowse link
G RNF168 ring finger protein 168 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:193,814,785...193,848,620
Ensembl chr 3:203,756,589...203,790,687 		JBrowse link
G RNF8 ring finger protein 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:36,918,705...36,955,380
Ensembl chr 6:38,108,414...38,145,949 		JBrowse link
G SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:103,672,934...103,743,802
Ensembl chr2B:222,276,353...222,347,258 		JBrowse link
G SMC5 structural maintenance of chromosomes 5 NOT|involved_in ISO (PMID:16810316) UniProt PMID:16810316 NCBI chr 9:54,446,863...54,543,249 JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:22,364,696...22,472,499
Ensembl chr15:40,519,012...40,626,741 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr19:40,485,052...40,522,188
Ensembl chr19:49,094,014...49,125,520 		JBrowse link
G XRCC4 X-ray repair cross complementing 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17713479) Ensembl
MGI
TreeGrafter
UniProt		 PMID:17713479 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr 5:31,927,463...32,202,394
Ensembl chr 5:32,246,320...32,521,490 		JBrowse link
G XRCC5 X-ray repair cross complementing 5 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr2B:103,371,459...103,468,419
Ensembl chr2B:221,972,742...222,071,235 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11751629) Ensembl
MGI
TreeGrafter
InterPro		 PMID:11751629 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr22:22,516,281...22,557,379
Ensembl chr22:40,603,038...40,643,314 		JBrowse link
double-strand break repair via alternative nonhomologous end joining term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HELQ helicase, POLQ like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:40,740,392...40,788,907
Ensembl chr 4:46,586,882...46,635,108 		JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific involved_in ISO (MGI:6393148|PMID:31806351) UniProt PMID:31806351 MGI:6393148 NCBI chr 3:126,339,758...126,367,166
Ensembl chr 3:133,694,676...133,721,519 		JBrowse link
G LIG3 DNA ligase 3 involved_in ISO (PMID:24837021)
(MGI:5014103|PMID:21655080)		 BHF-UCL PMID:21655080 PMID:24837021 MGI:5014103 NCBI chr17:21,776,483...21,805,706
Ensembl chr17:22,074,046...22,095,220 		JBrowse link
G NBN nibrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:86,622,797...86,674,202
Ensembl chr 8:88,575,198...88,626,307 		JBrowse link
G PLK1 polo like kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:14,420,972...14,432,821
Ensembl chr16:23,928,773...23,940,779 		JBrowse link
G POLN DNA polymerase nu involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:2,214,154...2,385,094
Ensembl chr 4:2,122,309...2,292,431 		JBrowse link
G POLQ DNA polymerase theta involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:118,535,968...118,648,275
Ensembl chr 3:125,446,829...125,559,283 		JBrowse link
G RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,999,089...3,011,911
Ensembl chr12:2,930,957...2,943,419 		JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:130,667,998...130,729,569
Ensembl chr 3:138,143,893...138,203,363 		JBrowse link
double-strand break repair via classical nonhomologous end joining term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC6 ERCC excision repair 6, chromatin remodeling factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:44,703,720...44,784,948 JBrowse link
G ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:53,053,712...53,131,563
Ensembl chr 5:54,693,987...54,765,496 		JBrowse link
G LIG4 DNA ligase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:89,336,434...89,347,418
Ensembl chr13:108,475,820...108,478,555 		JBrowse link
G RNF168 ring finger protein 168 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:193,814,785...193,848,620
Ensembl chr 3:203,756,589...203,790,687 		JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:130,667,998...130,729,569
Ensembl chr 3:138,143,893...138,203,363 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:22,364,696...22,472,499
Ensembl chr15:40,519,012...40,626,741 		JBrowse link
G UVRAG UV radiation resistance associated involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:70,870,341...71,197,559
Ensembl chr11:74,172,919...74,496,046 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:22,516,281...22,557,379
Ensembl chr22:40,603,038...40,643,314 		JBrowse link
G ZBTB7A zinc finger and BTB domain containing 7A involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:3,066,554...3,090,285 JBrowse link
negative regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AUNIP aurora kinase A and ninein interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:25,090,690...25,118,062
Ensembl chr 1:26,157,953...26,185,578 		JBrowse link
G CYREN cell cycle regulator of NHEJ involved_in IEA InterPro GO_REF:0000002 NCBI chr 7:127,130,587...127,148,824 JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:44,703,720...44,784,948 JBrowse link
G HMGA2 high mobility group AT-hook 2 involved_in ISO (PMID:19549901) UniProt PMID:19549901 NCBI chr12:22,954,946...23,096,623 JBrowse link
G HSF1 heat shock transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:141,055,310...141,078,360
Ensembl chr 8:144,062,137...144,067,866 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:89,418,537...89,500,705
Ensembl chr11:92,918,549...92,985,966 		JBrowse link
G NUDT16L1 nudix hydrolase 16 like 1 involved_in ISO (PMID:28241136) UniProt PMID:28241136 NCBI chr16:3,615,841...3,620,526
Ensembl chr16:4,785,358...4,786,775 		JBrowse link
positive regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FH fumarate hydratase involved_in ISO (PMID:26237645) UniProt PMID:26237645 NCBI chr 1:217,059,847...217,081,795
Ensembl chr 1:222,041,142...222,064,212 		JBrowse link
G KDM4D lysine demethylase 4D acts_upstream_of_or_within ISO (PMID:24550317) MGI PMID:24550317 NCBI chr11:89,987,537...90,013,421 JBrowse link
G KMT5B lysine methyltransferase 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:63,239,796...63,297,113
Ensembl chr11:66,549,230...66,581,475 		JBrowse link
G KMT5C lysine methyltransferase 5C involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:52,381,963...52,390,507
Ensembl chr19:61,073,396...61,078,717 		JBrowse link
G LOC100986203 histone-lysine N-methyltransferase SETMAR involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:4,256,539...4,271,593
Ensembl chr 3:4,357,890...4,371,791 		JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:10,436,532...10,454,023
Ensembl chr 1:11,654,963...11,661,526 		JBrowse link
G PARP3 poly(ADP-ribose) polymerase family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:51,883,695...51,890,266
Ensembl chr 3:53,112,494...53,119,053 		JBrowse link
G PNKP polynucleotide kinase 3'-phosphatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:46,874,216...46,880,954
Ensembl chr19:55,790,048...55,796,762 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:44,201,391...44,386,803
Ensembl chr 8:41,593,029...41,778,299 		JBrowse link
G RIF1 replication timing regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:38,721,658...38,818,488
Ensembl chr2B:155,985,960...156,052,926 		JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:5,753,262...5,858,728
Ensembl chr20:5,537,488...5,642,107 		JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in ISO (PMID:29656893), (PMID:29789392) UniProt PMID:29656893 PMID:29789392 NCBI chr10:83,639,020...83,643,420 JBrowse link
G SHLD3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chr 5:48,376,338...48,382,052 JBrowse link
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:11,479,742...11,627,035
Ensembl chr18:13,785,912...13,933,887 		JBrowse link
G TOP2B DNA topoisomerase II beta ISO RGD PMID:22019940 RGD:13432143 NCBI chr 3:25,499,239...25,566,029
Ensembl chr 3:25,828,879...25,896,912 		JBrowse link
G WRAP53 WD repeat containing antisense to TP53 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,715,897...7,735,873
Ensembl chr17:7,707,221...7,723,394 		JBrowse link
regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTR2 actin related protein 2 NOT|involved_in ISO (PMID:29925947) UniProt PMID:29925947 NCBI chr2A:65,289,675...65,333,219 JBrowse link
G DEK DEK proto-oncogene involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21653549) Ensembl
MGI		 PMID:21653549 GO_REF:0000107 NCBI chr 6:18,071,928...18,112,245
Ensembl chr 6:18,427,844...18,465,606 		JBrowse link
G MRNIP MRN complex interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:174,989,967...175,020,550
Ensembl chr 5:182,299,016...182,340,632 		JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23241889) Ensembl
MGI		 PMID:23241889 GO_REF:0000107 NCBI chr 4:2,009,276...2,119,182
Ensembl chr 4:1,945,307...2,027,425 		JBrowse link
G POT1 protection of telomeres 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:116,807,913...116,926,998
Ensembl chr 7:129,487,571...129,605,558 		JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr20:5,753,262...5,858,728
Ensembl chr20:5,537,488...5,642,107 		JBrowse link
G USP51 ubiquitin specific peptidase 51 involved_in ISO (PMID:27083998) UniProt PMID:27083998 NCBI chr  X:47,747,547...47,753,119 JBrowse link
G WAS WASP actin nucleation promoting factor NOT|involved_in ISO (PMID:29925947) UniProt PMID:29925947 NCBI chr  X:40,982,132...40,989,767
Ensembl chr  X:48,842,765...48,850,380 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    response to stimulus 8500
      response to stress 3906
        cellular response to stress 1899
          DNA damage response 824
            DNA repair 513
              double-strand break repair 295
                double-strand break repair via nonhomologous end joining 75
                  double-strand break repair via alternative nonhomologous end joining 9
                  double-strand break repair via classical nonhomologous end joining 9
                  gap filling involved in double-strand break repair via nonhomologous end joining 0
                  negative regulation of double-strand break repair via nonhomologous end joining 7
                  positive regulation of double-strand break repair via nonhomologous end joining 16
                  regulation of double-strand break repair via nonhomologous end joining + 30
Path 2
Term Annotations click to browse term
  biological_process 16440
    metabolic process 10303
      organic substance metabolic process 9869
        organic cyclic compound metabolic process 5562
          nucleobase-containing compound metabolic process 5109
            nucleic acid metabolic process 4613
              DNA metabolic process 917
                DNA repair 513
                  double-strand break repair 295
                    double-strand break repair via nonhomologous end joining 75
                      double-strand break repair via alternative nonhomologous end joining 9
                      double-strand break repair via classical nonhomologous end joining 9
                      gap filling involved in double-strand break repair via nonhomologous end joining 0
                      negative regulation of double-strand break repair via nonhomologous end joining 7
                      positive regulation of double-strand break repair via nonhomologous end joining 16
                      regulation of double-strand break repair via nonhomologous end joining + 30
paths to the root