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ONTOLOGY REPORT - ANNOTATIONS


Term:double-strand break repair
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Accession:GO:0006302 term browser browse the term
Definition:The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
Comment:Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable (PMID:22214610). To annotate gene products involved in mitochondrial double-strand break repair, please use GO:0097551 'mitochondrial double-strand break repair'.


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double-strand break repair term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abraxas1 BRCA1 A complex subunit JBrowse link 5 100,804,802 100,845,864 RGD:2290270
G Actr5 ARP5 actin-related protein 5 JBrowse link 2 158,624,881 158,639,211 RGD:2290270
G Actr8 ARP8 actin-related protein 8 JBrowse link 14 29,978,337 29,995,452 RGD:2290270
G Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 JBrowse link 7 105,558,465 105,581,924 RGD:2290270
G Aplf aprataxin and PNKP like factor JBrowse link 6 87,628,425 87,672,237 RGD:2290270
G Aptx aprataxin JBrowse link 4 40,682,078 40,721,667 RGD:2290270
G Babam1 BRISC and BRCA1 A complex member 1 JBrowse link 8 71,396,165 71,404,772 RGD:2290270
G Babam2 BRISC and BRCA1 A complex member 2 JBrowse link 5 31,697,978 32,084,950 RGD:2290270
G Brca1 breast cancer 1, early onset JBrowse link 11 101,488,761 101,551,955 RGD:2290270
G Brca2 breast cancer 2, early onset JBrowse link 5 150,522,297 150,570,147 RGD:2290270
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 JBrowse link X 75,416,628 75,455,702 RGD:2290270
G Cdca5 cell division cycle associated 5 JBrowse link 19 6,085,097 6,091,773 RGD:2290270
G Chek2 checkpoint kinase 2 JBrowse link 5 110,839,800 110,874,140 RGD:2290270
G Dclre1c DNA cross-link repair 1C JBrowse link 2 3,424,061 3,474,211 RGD:2290270
G Ddx1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 JBrowse link 12 13,219,307 13,249,174 RGD:2290270
G Dtx3l deltex 3-like, E3 ubiquitin ligase JBrowse link 16 35,926,515 35,939,027 RGD:2290270
G Eme1 essential meiotic structure-specific endonuclease 1 JBrowse link 11 94,644,972 94,653,836 RGD:2290270
G Eme2 essential meiotic structure-specific endonuclease subunit 2 JBrowse link 17 24,892,152 24,895,087 RGD:2290270
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 JBrowse link 7 19,344,067 19,356,524 RGD:2290270
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 JBrowse link 14 65,819,027 65,833,969 RGD:2290270
G Exd2 exonuclease 3'-5' domain containing 2 JBrowse link 12 80,463,095 80,498,135 RGD:2290270
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 1 14,168,953 14,311,035 RGD:2290270
G Eya3 EYA transcriptional coactivator and phosphatase 3 JBrowse link 4 132,639,025 132,724,765 RGD:2290270
G Ggn gametogenetin JBrowse link 7 29,168,391 29,173,938 RGD:2290270
G Gm28043 predicted gene, 28043 JBrowse link 17 29,614,789 29,705,979 RGD:2290270
G Gm5136 predicted gene 5136 JBrowse link 10 108,699,044 108,700,160 RGD:2290270
G Ino80 INO80 complex subunit JBrowse link 2 119,373,042 119,478,685 RGD:2290270
G Kat5 K(lysine) acetyltransferase 5 JBrowse link 19 5,603,014 5,611,556 RGD:2290270
G Lig3 ligase III, DNA, ATP-dependent JBrowse link 11 82,781,109 82,804,274 RGD:2290270
G Lig4 ligase IV, DNA, ATP-dependent JBrowse link 8 9,970,020 9,977,696 RGD:2290270
G Mad2l2 MAD2 mitotic arrest deficient-like 2 JBrowse link 4 148,130,158 148,145,704 RGD:2290270
G Marf1 meiosis regulator and mRNA stability 1 JBrowse link 16 14,109,166 14,159,278 RGD:2290270
G Meioc meiosis specific with coiled-coil domain JBrowse link 11 102,665,351 102,682,240 RGD:2290270
G Mre11a MRE11A homolog A, double strand break repair nuclease JBrowse link 9 14,784,654 14,837,125 RGD:2290270
G Msh2 mutS homolog 2 JBrowse link 17 87,672,532 87,723,713 RGD:2290270
G Mta1 metastasis associated 1 JBrowse link 12 113,098,248 113,137,206 RGD:2290270
G Nbn nibrin JBrowse link 4 15,957,587 15,992,589 RGD:2290270
G Nhej1 non-homologous end joining factor 1 JBrowse link 1 74,967,346 75,125,226 RGD:2290270
G Nipbl NIPBL cohesin loading factor JBrowse link 15 8,289,824 8,465,315 RGD:2290270
G Parp1 poly (ADP-ribose) polymerase family, member 1 JBrowse link 1 180,568,891 180,600,999 RGD:2290270
G Parp2 poly (ADP-ribose) polymerase family, member 2 JBrowse link 14 50,807,897 50,821,301 RGD:2290270
G Parp3 poly (ADP-ribose) polymerase family, member 3 JBrowse link 9 106,470,322 106,476,949 RGD:2290270
G Parp9 poly (ADP-ribose) polymerase family, member 9 JBrowse link 16 35,938,470 35,972,621 RGD:2290270
G Polq polymerase (DNA directed), theta JBrowse link 16 37,011,741 37,095,419 RGD:2290270
G Prkdc protein kinase, DNA activated, catalytic polypeptide JBrowse link 16 15,637,444 15,842,239 RGD:2290270
G Rad21 RAD21 cohesin complex component JBrowse link 15 51,962,604 51,993,538 RGD:2290270
G Rad21l RAD21-like (S. pombe) JBrowse link 2 151,644,366 151,670,622 RGD:2290270
G Rad50 RAD50 double strand break repair protein JBrowse link 11 53,649,519 53,707,319 RGD:2290270
G Rad54l RAD54 like (S. cerevisiae) JBrowse link 4 116,094,261 116,123,700 RGD:2290270
G Rec8 REC8 meiotic recombination protein JBrowse link 14 55,618,002 55,625,395 RGD:2290270
G Rnf168 ring finger protein 168 JBrowse link 16 32,277,461 32,301,442 RGD:2290270
G Rnf8 ring finger protein 8 JBrowse link 17 29,614,789 29,641,664 RGD:2290270
G Setx senataxin JBrowse link 2 29,123,588 29,182,471 RGD:2290270
G Smchd1 SMC hinge domain containing 1 JBrowse link 17 71,344,489 71,475,366 RGD:2290270
G Tdp1 tyrosyl-DNA phosphodiesterase 1 JBrowse link 12 99,884,463 99,955,223 RGD:2290270
G Tdp2 tyrosyl-DNA phosphodiesterase 2 JBrowse link 13 24,831,659 24,842,153 RGD:2290270
G Tnks1bp1 tankyrase 1 binding protein 1 JBrowse link 2 85,048,013 85,073,048 RGD:2290270
G Trip13 thyroid hormone receptor interactor 13 JBrowse link 13 73,912,450 73,937,795 RGD:2290270
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:2290270
G Uimc1 ubiquitin interaction motif containing 1 JBrowse link 13 55,027,880 55,100,363 RGD:2290270
G Vcp valosin containing protein JBrowse link 4 42,979,964 43,000,507 RGD:2290270
G Wrn Werner syndrome RecQ like helicase JBrowse link 8 33,234,372 33,385,543 RGD:2290270
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 JBrowse link 13 89,848,914 90,089,608 RGD:2290270
G Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 JBrowse link 1 72,307,417 72,394,953 RGD:2290270
G Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 JBrowse link 15 81,987,833 82,040,085 RGD:2290270
DNA double-strand break processing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Blm Bloom syndrome, RecQ like helicase JBrowse link 7 80,454,993 80,535,148 RGD:2290270
G Dna2 DNA replication helicase/nuclease 2 JBrowse link 10 62,946,983 62,974,188 RGD:2290270
G Exd2 exonuclease 3'-5' domain containing 2 JBrowse link 12 80,463,095 80,498,135 RGD:2290270
G Smarcad1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 JBrowse link 6 65,042,591 65,116,061 RGD:2290270
G Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 10 95,515,162 95,545,658 RGD:2290270
G Ube2v2 ubiquitin-conjugating enzyme E2 variant 2 JBrowse link 16 15,550,986 15,594,518 RGD:2290270
DNA double-strand break processing involved in repair via single-strand annealing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 6 119,901,722 119,922,827 RGD:2290270
G Rbbp8 retinoblastoma binding protein 8, endonuclease JBrowse link 18 11,633,276 11,743,207 RGD:2290270
G Rnf138 ring finger protein 138 JBrowse link 18 21,001,245 21,028,224 RGD:2290270
G Rnf138rt1 ring finger protein 138, retrogene 1 JBrowse link X 163,760,139 163,761,332 RGD:2290270
G Slx4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) JBrowse link 16 3,979,105 4,003,829 RGD:2290270
DNA recombinase assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dmc1 DNA meiotic recombinase 1 JBrowse link 15 79,561,497 79,605,159 RGD:2290270
G Rad51 RAD51 recombinase JBrowse link 2 119,112,814 119,136,073 RGD:2290270
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 6 119,901,722 119,922,827 RGD:2290270
G Swi5 SWI5 recombination repair homolog (yeast) JBrowse link 2 32,278,805 32,288,136 RGD:2290270
double-strand break repair involved in meiotic recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brip1 BRCA1 interacting protein C-terminal helicase 1 JBrowse link 11 86,058,136 86,201,215 RGD:2290270
G Fancd2 Fanconi anemia, complementation group D2 JBrowse link 6 113,531,640 113,597,020 RGD:2290270
G Mcmdc2 minichromosome maintenance domain containing 2 JBrowse link 1 9,906,157 9,943,606 RGD:2290270
G Morc2b microrchidia 2B JBrowse link 17 33,135,588 33,150,499 RGD:2290270
G Prdm9 PR domain containing 9 JBrowse link 17 15,543,072 15,564,374 RGD:2290270
G Spo11 SPO11 meiotic protein covalently bound to DSB JBrowse link 2 172,977,379 172,993,576 RGD:2290270
double-strand break repair via alternative nonhomologous end joining term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmces 5-hydroxymethylcytosine (hmC) binding, ES cell specific JBrowse link 6 87,913,907 87,936,619 RGD:2290270
G Lig3 ligase III, DNA, ATP-dependent JBrowse link 11 82,781,109 82,804,274 RGD:2290270
G Polq polymerase (DNA directed), theta JBrowse link 16 37,011,741 37,095,419 RGD:2290270
double-strand break repair via break-induced replication term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc45 cell division cycle 45 JBrowse link 16 18,780,447 18,811,972 RGD:2290270
G Cdc7 cell division cycle 7 (S. cerevisiae) JBrowse link 5 106,964,315 106,984,440 RGD:2290270
G Gins2 GINS complex subunit 2 (Psf2 homolog) JBrowse link 8 120,581,266 120,589,075 RGD:2290270
G Gins4 GINS complex subunit 4 (Sld5 homolog) JBrowse link 8 23,226,610 23,237,668 RGD:2290270
G Mcm2 minichromosome maintenance complex component 2 JBrowse link 6 88,883,474 88,898,780 RGD:2290270
G Mcm3 minichromosome maintenance complex component 3 JBrowse link 1 20,802,966 20,820,312 RGD:2290270
G Mcm4 minichromosome maintenance complex component 4 JBrowse link 16 15,623,897 15,637,400 RGD:2290270
G Mcm5 minichromosome maintenance complex component 5 JBrowse link 8 75,109,468 75,128,439 RGD:2290270
G Mcm6 minichromosome maintenance complex component 6 JBrowse link 1 128,331,575 128,359,705 RGD:2290270
G Mcm7 minichromosome maintenance complex component 7 JBrowse link 5 138,164,583 138,172,111 RGD:2290270
G Mus81 MUS81 structure-specific endonuclease subunit JBrowse link 19 5,482,561 5,488,389 RGD:2290270
double-strand break repair via classical nonhomologous end joining term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 JBrowse link 14 32,513,291 32,580,990 RGD:2290270
G Ercc8 excision repaiross-complementing rodent repair deficiency, complementation group 8 JBrowse link 13 108,158,711 108,201,204 RGD:2290270
G Lig4 ligase IV, DNA, ATP-dependent JBrowse link 8 9,970,020 9,977,696 RGD:2290270
G Uvrag UV radiation resistance associated gene JBrowse link 7 98,886,742 99,141,167 RGD:2290270
G Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 JBrowse link 15 81,987,833 82,040,085 RGD:2290270
G Zbtb7a zinc finger and BTB domain containing 7a JBrowse link 10 81,135,225 81,152,222 RGD:2290270
double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap5s1 adaptor-related protein 5 complex, sigma 1 subunit JBrowse link 2 131,210,360 131,213,514 RGD:2290270
G Ap5z1 adaptor-related protein complex 5, zeta 1 subunit JBrowse link 5 142,463,207 142,478,716 RGD:2290270
G Atm ataxia telangiectasia mutated JBrowse link 9 53,437,122 53,536,828 RGD:2290270
G Aunip aurora kinase A and ninein interacting protein JBrowse link 4 134,510,999 134,523,922 RGD:2290270
G Blm Bloom syndrome, RecQ like helicase JBrowse link 7 80,454,993 80,535,148 RGD:2290270
G Brca1 breast cancer 1, early onset JBrowse link 11 101,488,761 101,551,955 RGD:2290270
G Brca2 breast cancer 2, early onset JBrowse link 5 150,522,297 150,570,147 RGD:2290270
G Ercc4 excision repair cross-complementing rodent repair deficiency, complementation group 4 JBrowse link 16 13,109,366 13,152,009 RGD:2290270
G Exd2 exonuclease 3'-5' domain containing 2 JBrowse link 12 80,463,095 80,498,135 RGD:2290270
G Fan1 FANCD2/FANCI-associated nuclease 1 JBrowse link 7 64,345,385 64,374,128 RGD:2290270
G Fbh1 F-box DNA helicase 1 JBrowse link 2 11,742,573 11,777,585 RGD:2290270
G Gen1 GEN1, Holliday junction 5' flap endonuclease JBrowse link 12 11,238,928 11,266,029 RGD:2290270
G H2ax H2A.X variant histone JBrowse link 9 44,334,715 44,336,077 RGD:2290270
G Helq helicase, POLQ-like JBrowse link 5 100,762,144 100,798,661 RGD:2290270
G Hus1 HUS1 checkpoint clamp component JBrowse link 11 8,993,137 9,011,236 RGD:2290270
G Hus1b HUS1 checkpoint clamp component B JBrowse link 13 30,946,576 30,947,761 RGD:2290270
G Ino80 INO80 complex subunit JBrowse link 2 119,373,042 119,478,685 RGD:2290270
G Kash5 KASH domain containing 5 JBrowse link 7 45,183,619 45,204,919 RGD:2290270
G Kdm4d lysine (K)-specific demethylase 4D JBrowse link 9 14,462,548 14,500,522 RGD:2290270
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor JBrowse link 2 132,816,137 132,844,197 RGD:2290270
G Mcm9 minichromosome maintenance 9 homologous recombination repair factor JBrowse link 10 53,536,315 53,630,006 RGD:2290270
G Meiob meiosis specific with OB domains JBrowse link 17 24,804,301 24,839,788 RGD:2290270
G Mms22l MMS22-like, DNA repair protein JBrowse link 4 24,496,451 24,602,950 RGD:2290270
G Morf4l1 mortality factor 4 like 1 JBrowse link 9 90,091,669 90,114,820 RGD:2290270
G Mre11a MRE11A homolog A, double strand break repair nuclease JBrowse link 9 14,784,654 14,837,125 RGD:2290270
G Nabp1 nucleic acid binding protein 1 JBrowse link 1 51,464,968 51,478,475 RGD:2290270
G Nabp2 nucleic acid binding protein 2 JBrowse link 10 128,401,394 128,411,548 RGD:2290270
G Nbn nibrin JBrowse link 4 15,957,587 15,992,589 RGD:2290270
G Nsmce1 NSE1 homolog, SMC5-SMC6 complex component JBrowse link 7 125,467,644 125,493,056 RGD:2290270
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase JBrowse link 15 59,374,198 59,601,684 RGD:2290270
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 JBrowse link 1 131,910,458 131,936,321 RGD:2290270
G Palb2 partner and localizer of BRCA2 JBrowse link 7 122,107,262 122,132,980 RGD:2290270
G Poll polymerase (DNA directed), lambda JBrowse link 19 45,552,275 45,560,564 RGD:2290270
G Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 JBrowse link 2 61,711,694 61,800,376 RGD:2290270
G Rad21l RAD21-like (S. pombe) JBrowse link 2 151,644,366 151,670,622 RGD:2290270
G Rad51 RAD51 recombinase JBrowse link 2 119,112,814 119,136,073 RGD:2290270
G Rad51ap1 RAD51 associated protein 1 JBrowse link 6 126,923,415 126,939,621 RGD:2290270
G Rad51b RAD51 paralog B JBrowse link 12 79,297,282 79,848,260 RGD:2290270
G Rad51c RAD51 paralog C JBrowse link 11 87,376,645 87,404,954 RGD:2290270
G Rad51d RAD51 paralog D JBrowse link 11 82,871,960 82,890,624 RGD:2290270
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 6 119,901,722 119,922,827 RGD:2290270
G Rad54b RAD54 homolog B (S. cerevisiae) JBrowse link 4 11,558,920 11,615,808 RGD:2290270
G Rad54l RAD54 like (S. cerevisiae) JBrowse link 4 116,094,261 116,123,700 RGD:2290270
G Rbbp8 retinoblastoma binding protein 8, endonuclease JBrowse link 18 11,633,276 11,743,207 RGD:2290270
G Rec8 REC8 meiotic recombination protein JBrowse link 14 55,618,002 55,625,395 RGD:2290270
G Recql RecQ protein-like JBrowse link 6 142,350,342 142,387,100 RGD:2290270
G Recql4 RecQ protein-like 4 JBrowse link 15 76,703,553 76,710,616 RGD:2290270
G Recql5 RecQ protein-like 5 JBrowse link 11 115,892,595 115,933,514 RGD:2290270
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit JBrowse link 10 39,731,561 39,875,211 RGD:2290270
G Rfwd3 ring finger and WD repeat domain 3 JBrowse link 8 111,270,944 111,300,222 RGD:2290270
G Rmi1 RecQ mediated genome instability 1 JBrowse link 13 58,402,248 58,411,149 RGD:2290270
G Rnf138 ring finger protein 138 JBrowse link 18 21,001,245 21,028,224 RGD:2290270
G Rnf138rt1 ring finger protein 138, retrogene 1 JBrowse link X 163,760,139 163,761,332 RGD:2290270
G Rpa1 replication protein A1 JBrowse link 11 75,300,259 75,348,454 RGD:2290270
G Rpa2 replication protein A2 JBrowse link 4 132,768,360 132,778,746 RGD:2290270
G Rpa3 replication protein A3 JBrowse link 6 8,255,936 8,259,141 RGD:2290270
G Samhd1 SAM domain and HD domain, 1 JBrowse link 2 157,097,534 157,135,096 RGD:2290270
G Sem1 SEM1, 26S proteasome complex subunit JBrowse link 6 6,558,275 6,578,658 RGD:2290270
G Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) JBrowse link 4 127,020,716 127,051,101 RGD:2290270
G Sfr1 SWI5 dependent recombination repair 1 JBrowse link 19 47,731,714 47,735,588 RGD:2290270
G Slx1b SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) JBrowse link 7 126,688,927 126,695,783 RGD:2290270
G Slx4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) JBrowse link 16 3,979,105 4,003,829 RGD:2290270
G Smc5 structural maintenance of chromosomes 5 JBrowse link 19 23,206,441 23,273,922 RGD:2290270
G Spidr scaffolding protein involved in DNA repair JBrowse link 16 15,889,224 16,146,851 RGD:2290270
G Stn1 STN1, CST complex subunit JBrowse link 19 47,501,031 47,545,845 RGD:2290270
G Swi5 SWI5 recombination repair homolog (yeast) JBrowse link 2 32,278,805 32,288,136 RGD:2290270
G Swsap1 SWIM type zinc finger 7 associated protein 1 JBrowse link 9 21,955,753 21,958,270 RGD:2290270
G Tonsl tonsoku-like, DNA repair protein JBrowse link 15 76,626,237 76,639,929 RGD:2290270
G Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 10 95,515,162 95,545,658 RGD:2290270
G Wdr48 WD repeat domain 48 JBrowse link 9 119,894,895 119,926,586 RGD:2290270
G Wrn Werner syndrome RecQ like helicase JBrowse link 8 33,234,372 33,385,543 RGD:2290270
G Xrcc2 X-ray repair complementing defective repair in Chinese hamster cells 2 JBrowse link 5 25,689,814 25,705,797 RGD:2290270
G Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 JBrowse link 12 111,803,192 111,813,893 RGD:2290270
G Yy1 YY1 transcription factor JBrowse link 12 108,792,945 108,820,148 RGD:2290270
G Zfyve26 zinc finger, FYVE domain containing 26 JBrowse link 12 79,232,346 79,296,323 RGD:2290270
G Zswim7 zinc finger SWIM-type containing 7 JBrowse link 11 62,267,224 62,281,395 RGD:2290270
double-strand break repair via nonhomologous end joining term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyren cell cycle regulator of NHEJ JBrowse link 6 34,871,771 34,878,065 RGD:2290270
G Dclre1a DNA cross-link repair 1A JBrowse link 19 56,529,161 56,548,284 RGD:2290270
G Dclre1b DNA cross-link repair 1B JBrowse link 3 103,800,605 103,809,387 RGD:2290270
G Dclre1c DNA cross-link repair 1C JBrowse link 2 3,424,061 3,474,211 RGD:2290270
G Dntt deoxynucleotidyltransferase, terminal JBrowse link 19 41,029,275 41,059,525 RGD:2290270
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 JBrowse link 7 19,344,067 19,356,524 RGD:2290270
G Ercc4 excision repair cross-complementing rodent repair deficiency, complementation group 4 JBrowse link 16 13,109,366 13,152,009 RGD:2290270
G Kdm2a lysine (K)-specific demethylase 2A JBrowse link 19 4,316,144 4,398,721 RGD:2290270
G Lig1 ligase I, DNA, ATP-dependent JBrowse link 7 13,277,313 13,311,427 RGD:2290270
G Lig3 ligase III, DNA, ATP-dependent JBrowse link 11 82,781,109 82,804,274 RGD:2290270
G Lig4 ligase IV, DNA, ATP-dependent JBrowse link 8 9,970,020 9,977,696 RGD:2290270
G Mlh1 mutL homolog 1 JBrowse link 9 111,228,228 111,271,786 RGD:2290270
G Mre11a MRE11A homolog A, double strand break repair nuclease JBrowse link 9 14,784,654 14,837,125 RGD:2290270
G Nhej1 non-homologous end joining factor 1 JBrowse link 1 74,967,346 75,125,226 RGD:2290270
G Paxx non-homologous end joining factor JBrowse link 2 25,455,120 25,462,654 RGD:2290270
G Pola1 polymerase (DNA directed), alpha 1 JBrowse link X 93,304,766 93,632,387 RGD:2290270
G Polb polymerase (DNA directed), beta JBrowse link 8 22,628,119 22,653,464 RGD:2290270
G Poll polymerase (DNA directed), lambda JBrowse link 19 45,552,275 45,560,564 RGD:2290270
G Polm polymerase (DNA directed), mu JBrowse link 11 5,827,860 5,838,832 RGD:2290270
G Prkdc protein kinase, DNA activated, catalytic polypeptide JBrowse link 16 15,637,444 15,842,239 RGD:2290270
G Prpf19 pre-mRNA processing factor 19 JBrowse link 19 10,895,231 10,909,559 RGD:2290270
G Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 JBrowse link 2 61,711,694 61,800,376 RGD:2290270
G Rnf8 ring finger protein 8 JBrowse link 17 29,614,789 29,641,664 RGD:2290270
G Smarcal1 SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 JBrowse link 1 72,536,695 72,636,790 RGD:2290270
G Trp53bp1 transformation related protein 53 binding protein 1 JBrowse link 2 121,194,835 121,296,354 RGD:2290270
G Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 JBrowse link 7 24,546,699 24,573,438 RGD:2290270
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 JBrowse link 13 89,848,914 90,089,608 RGD:2290270
G Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 JBrowse link 1 72,307,417 72,394,953 RGD:2290270
G Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 JBrowse link 15 81,987,833 82,040,085 RGD:2290270
double-strand break repair via single-strand annealing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 6 119,901,722 119,922,827 RGD:2290270
double-strand break repair via synthesis-dependent strand annealing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fancm Fanconi anemia, complementation group M JBrowse link 12 65,074,110 65,131,842 RGD:2290270
G Rad54l RAD54 like (S. cerevisiae) JBrowse link 4 116,094,261 116,123,700 RGD:2290270
G Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 JBrowse link 12 111,803,192 111,813,893 RGD:2290270
late meiotic recombination nodule assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mcmdc2 minichromosome maintenance domain containing 2 JBrowse link 1 9,906,157 9,943,606 RGD:2290270
meiotic DNA double-strand break processing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slx4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) JBrowse link 16 3,979,105 4,003,829 RGD:2290270
G Spo11 SPO11 meiotic protein covalently bound to DSB JBrowse link 2 172,977,379 172,993,576 RGD:2290270
meiotic DNA double-strand break processing involved in reciprocal meiotic recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G 4930447C04Rik RIKEN cDNA 4930447C04 gene JBrowse link 12 72,880,193 72,917,957 RGD:2290270
G Brip1 BRCA1 interacting protein C-terminal helicase 1 JBrowse link 11 86,058,136 86,201,215 RGD:2290270
meiotic recombination nodule assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mcmdc2 minichromosome maintenance domain containing 2 JBrowse link 1 9,906,157 9,943,606 RGD:2290270
mitochondrial double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mre11a MRE11A homolog A, double strand break repair nuclease JBrowse link 9 14,784,654 14,837,125 RGD:2290270
negative regulation of double-strand break repair term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rnf169 ring finger protein 169 JBrowse link 7 99,920,254 99,981,330 RGD:2290270
G Trip12 thyroid hormone receptor interactor 12 JBrowse link 1 84,721,189 84,850,004 RGD:2290270
G Twist1 twist basic helix-loop-helix transcription factor 1 JBrowse link 12 33,957,671 33,959,831 RGD:2290270
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 JBrowse link 15 37,967,328 38,078,862 RGD:2290270
negative regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cgas cyclic GMP-AMP synthase JBrowse link 9 78,430,518 78,443,237 RGD:2290270
G Fancb Fanconi anemia, complementation group B JBrowse link X 164,980,480 164,997,272 RGD:2290270
G Fbh1 F-box DNA helicase 1 JBrowse link 2 11,742,573 11,777,585 RGD:2290270
G Helb helicase (DNA) B JBrowse link 10 120,083,608 120,113,010 RGD:2290270
G Klhl15 kelch-like 15 JBrowse link X 94,232,278 94,277,724 RGD:2290270
G Mad2l2 MAD2 mitotic arrest deficient-like 2 JBrowse link 4 148,130,158 148,145,704 RGD:2290270
G Parpbp PARP1 binding protein JBrowse link 10 88,091,398 88,146,969 RGD:2290270
G Polq polymerase (DNA directed), theta JBrowse link 16 37,011,741 37,095,419 RGD:2290270
G Radx RPA1 related single stranded DNA binding protein, X-linked JBrowse link X 139,480,367 139,554,584 RGD:2290270
G Recql5 RecQ protein-like 5 JBrowse link 11 115,892,595 115,933,514 RGD:2290270
G Rif1 replication timing regulatory factor 1 JBrowse link 2 52,072,815 52,126,769 RGD:2290270
G Rmi2 RecQ mediated genome instability 2 JBrowse link 16 10,835,059 10,843,235 RGD:2290270
G Shld1 shieldin complex subunit 1 JBrowse link 2 132,686,931 132,751,055 RGD:2290270
G Shld2 shieldin complex subunit 2 JBrowse link 14 34,236,948 34,310,651 RGD:2290270
G Smchd1 SMC hinge domain containing 1 JBrowse link 17 71,344,489 71,475,366 RGD:2290270
G Trp53bp1 transformation related protein 53 binding protein 1 JBrowse link 2 121,194,835 121,296,354 RGD:2290270
G Ubqln4 ubiquilin 4 JBrowse link 3 88,553,677 88,569,725 RGD:2290270
negative regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aunip aurora kinase A and ninein interacting protein JBrowse link 4 134,510,999 134,523,922 RGD:2290270
G Cyren cell cycle regulator of NHEJ JBrowse link 6 34,871,771 34,878,065 RGD:2290270
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 JBrowse link 14 32,513,291 32,580,990 RGD:2290270
G Hsf1 heat shock factor 1 JBrowse link 15 76,477,362 76,501,155 RGD:2290270
G Nudt16l1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 JBrowse link 16 4,939,111 4,941,028 RGD:2290270
negative regulation of double-strand break repair via single-strand annealing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ogg1 8-oxoguanine DNA-glycosylase 1 JBrowse link 6 113,326,972 113,334,877 RGD:2290270
positive regulation of double-strand break repair term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddx11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 JBrowse link 17 66,123,513 66,152,174 RGD:2290270
G Fmn2 formin 2 JBrowse link 1 174,501,752 174,822,729 RGD:2290270
G Foxm1 forkhead box M1 JBrowse link 6 128,362,994 128,375,886 RGD:2290270
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link 7 136,894,463 137,128,193 RGD:2290270
G Nudt16 nudix (nucleoside diphosphate linked moiety X)-type motif 16 JBrowse link 9 105,129,332 105,133,133 RGD:2290270
G Slf1 SMC5-SMC6 complex localization factor 1 JBrowse link 13 77,043,088 77,135,513 RGD:2290270
G Slf2 SMC5-SMC6 complex localization factor 2 JBrowse link 19 44,918,506 44,983,786 RGD:2290270
G Spidr scaffolding protein involved in DNA repair JBrowse link 16 15,889,224 16,146,851 RGD:2290270
G Spire1 spire type actin nucleation factor 1 JBrowse link 18 67,488,209 67,612,810 RGD:2290270
G Spire2 spire type actin nucleation factor 2 JBrowse link 8 123,332,713 123,369,518 RGD:2290270
G Timeless timeless circadian clock 1 JBrowse link 10 128,232,063 128,252,941 RGD:2290270
G Wrap53 WD repeat containing, antisense to Trp53 JBrowse link 11 69,561,754 69,580,250 RGD:2290270
positive regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actr2 ARP2 actin-related protein 2 JBrowse link 11 20,062,304 20,112,951 RGD:2290270
G Arid2 AT rich interactive domain 2 (ARID, RFX-like) JBrowse link 15 96,287,522 96,405,463 RGD:2290270
G Blm Bloom syndrome, RecQ like helicase JBrowse link 7 80,454,993 80,535,148 RGD:2290270
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 JBrowse link 14 32,513,291 32,580,990 RGD:2290270
G Fancb Fanconi anemia, complementation group B JBrowse link X 164,980,480 164,997,272 RGD:2290270
G Mms19 MMS19 cytosolic iron-sulfur assembly component JBrowse link 19 41,943,707 41,981,207 RGD:2290270
G Mrnip MRN complex interacting protein JBrowse link 11 50,174,851 50,200,116 RGD:2290270
G Parp1 poly (ADP-ribose) polymerase family, member 1 JBrowse link 1 180,568,891 180,600,999 RGD:2290270
G Timeless timeless circadian clock 1 JBrowse link 10 128,232,063 128,252,941 RGD:2290270
G Was Wiskott-Aldrich syndrome JBrowse link X 8,081,466 8,090,491 RGD:2290270
G Wrap53 WD repeat containing, antisense to Trp53 JBrowse link 11 69,561,754 69,580,250 RGD:2290270
positive regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dtx3l deltex 3-like, E3 ubiquitin ligase JBrowse link 16 35,926,515 35,939,027 RGD:2290270
G Fh1 fumarate hydratase 1 JBrowse link 1 175,601,378 175,625,635 RGD:2290270
G Kdm4d lysine (K)-specific demethylase 4D JBrowse link 9 14,462,548 14,500,522 RGD:2290270
G Kmt5b lysine methyltransferase 5B JBrowse link 19 3,767,362 3,818,303 RGD:2290270
G Kmt5c lysine methyltransferase 5C JBrowse link 7 4,740,092 4,747,514 RGD:2290270
G Mad2l2 MAD2 mitotic arrest deficient-like 2 JBrowse link 4 148,130,158 148,145,704 RGD:2290270
G Parp3 poly (ADP-ribose) polymerase family, member 3 JBrowse link 9 106,470,322 106,476,949 RGD:2290270
G Parp9 poly (ADP-ribose) polymerase family, member 9 JBrowse link 16 35,938,470 35,972,621 RGD:2290270
G Pnkp polynucleotide kinase 3'- phosphatase JBrowse link 7 44,856,479 44,865,337 RGD:2290270
G Prkdc protein kinase, DNA activated, catalytic polypeptide JBrowse link 16 15,637,444 15,842,239 RGD:2290270
G Rif1 replication timing regulatory factor 1 JBrowse link 2 52,072,815 52,126,769 RGD:2290270
G Shld1 shieldin complex subunit 1 JBrowse link 2 132,686,931 132,751,055 RGD:2290270
G Shld2 shieldin complex subunit 2 JBrowse link 14 34,236,948 34,310,651 RGD:2290270
G Smchd1 SMC hinge domain containing 1 JBrowse link 17 71,344,489 71,475,366 RGD:2290270
G Top2b topoisomerase (DNA) II beta JBrowse link 14 16,365,206 16,430,787 RGD:2290270
G Wrap53 WD repeat containing, antisense to Trp53 JBrowse link 11 69,561,754 69,580,250 RGD:2290270
regulation of DNA double-strand break processing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Helb helicase (DNA) B JBrowse link 10 120,083,608 120,113,010 RGD:2290270
G Wdr70 WD repeat domain 70 JBrowse link 15 7,873,055 8,099,209 RGD:2290270
regulation of double-strand break repair term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dek DEK proto-oncogene (DNA binding) JBrowse link 13 47,084,767 47,107,530 RGD:2290270
G Pml promyelocytic leukemia JBrowse link 9 58,217,179 58,249,796 RGD:2290270
G Trip12 thyroid hormone receptor interactor 12 JBrowse link 1 84,721,189 84,850,004 RGD:2290270
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 JBrowse link 15 37,967,328 38,078,862 RGD:2290270
regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chek1 checkpoint kinase 1 JBrowse link 9 36,708,482 36,726,658 RGD:2290270
G Fign fidgetin JBrowse link 2 63,971,508 64,098,038 RGD:2290270
G Fignl1 fidgetin-like 1 JBrowse link 11 11,800,288 11,808,995 RGD:2290270
G Fignl2 fidgetin-like 2 JBrowse link 15 101,050,192 101,078,584 RGD:2290270
G Kdm1a lysine (K)-specific demethylase 1A JBrowse link 4 136,550,533 136,602,787 RGD:2290270
G Ppp4c protein phosphatase 4, catalytic subunit JBrowse link 7 126,785,866 126,792,557 RGD:2290270
G Ppp4r2 protein phosphatase 4, regulatory subunit 2 JBrowse link 6 100,833,620 100,869,934 RGD:2290270
G Rad51 RAD51 recombinase JBrowse link 2 119,112,814 119,136,073 RGD:2290270
G Rad51ap1 RAD51 associated protein 1 JBrowse link 6 126,923,415 126,939,621 RGD:2290270
G Rpa2 replication protein A2 JBrowse link 4 132,768,360 132,778,746 RGD:2290270
G Rtel1 regulator of telomere elongation helicase 1 JBrowse link 2 181,319,711 181,356,616 RGD:2290270
G Setd2 SET domain containing 2 JBrowse link 9 110,532,500 110,618,633 RGD:2290270
G Shld3 shieldin complex subunit 3 JBrowse link 13 104,173,721 104,178,459 RGD:2290270
G Sirt6 sirtuin 6 JBrowse link 10 81,621,786 81,627,792 RGD:2290270
G Spidr scaffolding protein involved in DNA repair JBrowse link 16 15,889,224 16,146,851 RGD:2290270
G Terf2ip telomeric repeat binding factor 2, interacting protein JBrowse link 8 112,011,359 112,020,528 RGD:2290270
G Tex15 testis expressed gene 15 JBrowse link 8 33,516,689 33,592,503 RGD:2290270
G Usp51 ubiquitin specific protease 51 JBrowse link X 153,006,469 153,011,364 RGD:2290270
G Zfp365 zinc finger protein 365 JBrowse link 10 67,886,105 67,912,662 RGD:2290270
regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dek DEK proto-oncogene (DNA binding) JBrowse link 13 47,084,767 47,107,530 RGD:2290270
G Mrnip MRN complex interacting protein JBrowse link 11 50,174,851 50,200,116 RGD:2290270
G Nsd2 nuclear receptor binding SET domain protein 2 JBrowse link 5 33,820,676 33,897,966 RGD:2290270
G Pot1a protection of telomeres 1A JBrowse link 6 25,743,940 25,809,277 RGD:2290270
G Shld1 shieldin complex subunit 1 JBrowse link 2 132,686,931 132,751,055 RGD:2290270
G Sirt7 sirtuin 7 JBrowse link 11 120,618,371 120,625,014 RGD:2290270
G Usp51 ubiquitin specific protease 51 JBrowse link X 153,006,469 153,011,364 RGD:2290270
replication-born double-strand break repair via sister chromatid exchange term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Blm Bloom syndrome, RecQ like helicase JBrowse link 7 80,454,993 80,535,148 RGD:2290270
G Fancb Fanconi anemia, complementation group B JBrowse link X 164,980,480 164,997,272 RGD:2290270
G Nipbl NIPBL cohesin loading factor JBrowse link 15 8,289,824 8,465,315 RGD:2290270
G Rad51 RAD51 recombinase JBrowse link 2 119,112,814 119,136,073 RGD:2290270
G Recql5 RecQ protein-like 5 JBrowse link 11 115,892,595 115,933,514 RGD:2290270
G Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 JBrowse link 7 24,546,699 24,573,438 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23111
    metabolic process 10612
      cellular metabolic process 9570
        cellular macromolecule metabolic process 7272
          DNA metabolic process 842
            DNA repair 484
              double-strand break repair 234
                DNA double-strand break processing + 16
                double-strand break repair involved in meiotic recombination 6
                double-strand break repair via homologous recombination + 131
                double-strand break repair via nonhomologous end joining + 59
                double-strand break repair via single-strand annealing + 6
                mitochondrial double-strand break repair + 1
                negative regulation of double-strand break repair + 27
                positive regulation of double-strand break repair + 36
                regulation of double-strand break repair + 80
Path 2
Term Annotations click to browse term
  biological_process 23111
    metabolic process 10612
      cellular metabolic process 9570
        cellular aromatic compound metabolic process 5071
          nucleobase-containing compound metabolic process 4853
            nucleic acid metabolic process 4422
              DNA metabolic process 842
                DNA repair 484
                  double-strand break repair 234
                    DNA double-strand break processing + 16
                    double-strand break repair involved in meiotic recombination 6
                    double-strand break repair via homologous recombination + 131
                    double-strand break repair via nonhomologous end joining + 59
                    double-strand break repair via single-strand annealing + 6
                    mitochondrial double-strand break repair + 1
                    negative regulation of double-strand break repair + 27
                    positive regulation of double-strand break repair + 36
                    regulation of double-strand break repair + 80
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.