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ONTOLOGY REPORT - ANNOTATIONS


Term:mismatch repair
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Accession:GO:0006298 term browser browse the term
Definition:A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
Synonyms:exact_synonym: MMR
 narrow_synonym: long patch mismatch repair system
 related_synonym: MutS/MutL/MutH pathway;   mismatch repair, MutL-like pathway
 alt_id: GO:0006300
 xref: Wikipedia:DNA_mismatch_repair



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mismatch repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC095390.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Exo1 exonuclease 1 involved_in IBA
ISO
PMID:21873635
UniProtKB:P43246 (PMID:11809771), (PMID:14636568), (PMID:9788596)
RGD PMID:9788596 PMID:11809771 PMID:14636568 PMID:21873635 RGD:13792537 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
JBrowse link
G LOC100362927 replication protein A3-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:45,908,653...45,909,063
Ensembl chr12:45,908,683...45,909,048
JBrowse link
G Mlh1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
UniProtKB:P43246|UniProtKB:P52701 (PMID:23603115)
MGI:1857946|MGI:1858054|MGI:1930998 (MGI:1197799|PMID:9500552), (MGI:1203882|PMID:9560238), (MGI:1332740|PMID:10096563), (MGI:1339254|PMID:10359802), (MGI:1353727|PMID:10657972), (MGI:1354996|PMID:10747038), (MGI:1859717|PMID:10851078), (MGI:1933705|PMID:11313994), (MGI:3607956|PMID:16204034), (MGI:3691360|PMID:10429667), (MGI:3692242|PMID:16728433), (MGI:81371|PMID:8674118)
GO_REF:0000002
Ensembl
RGD
InterPro
PMID:8674118 PMID:9500552 PMID:9560238 PMID:10096563 PMID:10359802 More... GO_REF:0000002 GO_REF:0000107 MGI:1197799 MGI:1203882 MGI:1332740 MGI:1339254 MGI:1353727 MGI:1354996 MGI:1859717 MGI:1933705 MGI:3607956 MGI:3691360 MGI:3692242 MGI:81371, RGD:13792537 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Mlh3 mutL homolog 3 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:104288|MGI:2384218 (MGI:3607956|PMID:16204034)
RGD PMID:16204034 PMID:21873635 MGI:3607956, RGD:13792537 NCBI chr 6:104,881,483...104,917,686
Ensembl chr 6:104,881,483...104,917,728
JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IEA
IBA
ISO
GO_REF:0000104
PMID:21873635
(PMID:7923193), (PMID:9677427)
UniProtKB:P40692|UniProtKB:P52701 (PMID:11555625), (PMID:23603115)
MGI:109519|MGI:1857940|MGI:1858055|MGI:2151801|MGI:2389314|MGI:2680817 (MGI:1096207|PMID:9288110), (MGI:1275866|PMID:9697842), (MGI:1350445|PMID:10581038), (MGI:1861016|PMID:10874005), (MGI:1889760|PMID:10992298), (MGI:1926519|PMID:11046134), (MGI:2176101|PMID:11890935), (MGI:2388857|PMID:12531017), (MGI:3029112|PMID:14744764), (MGI:3692242|PMID:16728433), (MGI:3703647|PMID:17331550), (MGI:5464025|PMID:23071719), (MGI:74950|PMID:7628020), (MGI:82395|PMID:8706033), (MGI:87767|PMID:9157971), (MGI:894568|PMID:9244348)
UniProt
RGD
PMID:7628020 PMID:7923193 PMID:8706033 PMID:9157971 PMID:9244348 More... GO_REF:0000104 MGI:1096207 MGI:1275866 MGI:1350445 MGI:1861016 MGI:1889760 MGI:1926519 MGI:2176101 MGI:2388857 MGI:3029112 MGI:3692242 MGI:3703647 MGI:5464025 MGI:74950 MGI:82395 MGI:87767 MGI:894568, RGD:13792537 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Msh3 mutS homolog 3 acts_upstream_of_or_within
involved_in
ISO MGI:101816|MGI:1343961|MGI:1858056|MGI:88039 (MGI:1353715|PMID:10706084), (MGI:2154151|PMID:11691815), (MGI:3692242|PMID:16728433)
(PMID:8782829), (PMID:9677427)
RGD PMID:8782829 PMID:9677427 PMID:10706084 PMID:11691815 PMID:16728433 MGI:1353715 MGI:2154151 MGI:3692242 NCBI chr 2:23,444,326...23,585,777 JBrowse link
G Msh4 mutS homolog 4 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 2:242,785,392...242,844,609
Ensembl chr 2:242,792,661...242,843,487
JBrowse link
G Msh5 mutS homolog 5 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:3,773,867...3,793,337
Ensembl chr20:3,776,942...3,793,336
JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within
involved_in
ISO
IBA
IMP
MGI:109519|MGI:1858014|MGI:2151803|MGI:3653701|MGI:88039 (MGI:1100204|PMID:9390556), (MGI:2154151|PMID:11691815), (MGI:2388851|PMID:12370835), (MGI:3053495|PMID:15324697), (MGI:3692242|PMID:16728433), (MGI:5464025|PMID:23071719)
PMID:21873635
UniProtKB:P40692|UniProtKB:P43246 (PMID:23603115)
(PMID:10871409), (PMID:23622243), (PMID:8782829)
RGD PMID:8782829 PMID:9390556 PMID:10871409 PMID:11691815 PMID:12370835 More... MGI:1100204 MGI:2154151 MGI:2388851 MGI:3053495 MGI:3692242 MGI:5464025, RGD:13792537, RGD:2292505 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
JBrowse link
G Mutyh mutY DNA glycosylase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146
JBrowse link
G Pcna proliferating cell nuclear antigen involved_in ISO
IBA
(PMID:11005803)
PMID:21873635
RGD PMID:11005803 PMID:21873635 RGD:13792537 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component acts_upstream_of_or_within
involved_in
ISO
IBA
MGI:1857948 (MGI:1197799|PMID:9500552)
PMID:21873635
RGD PMID:9500552 PMID:21873635 MGI:1197799, RGD:13792537 NCBI chr 9:48,229,403...48,340,237
Ensembl chr 9:48,253,410...48,340,237
JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:10871409), (PMID:23709753), (PMID:9618520)
MGI:1353455|MGI:1857946|MGI:1857947 (MGI:1197799|PMID:9500552), (MGI:1339254|PMID:10359802), (MGI:1933705|PMID:11313994), (MGI:3607956|PMID:16204034), (MGI:3691360|PMID:10429667), (MGI:3692242|PMID:16728433), (MGI:5464025|PMID:23071719)
PMID:21873635
RGD PMID:9500552 PMID:9618520 PMID:10359802 PMID:10429667 PMID:10871409 More... MGI:1197799 MGI:1339254 MGI:1933705 MGI:3607956 MGI:3691360 MGI:3692242 MGI:5464025, RGD:13792537 NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066
JBrowse link
G Rnaseh2a ribonuclease H2, subunit A involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:23603115)
(MGI:5499950|PMID:23603115)
RGD PMID:23603115 PMID:21873635 MGI:5499950, RGD:13792537 NCBI chr19:23,186,325...23,196,045
Ensembl chr19:23,186,383...23,196,041
JBrowse link
G Rpa1 replication protein A1 involved_in ISO (PMID:9430682) RGD PMID:9430682 NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949
JBrowse link
G Rpa2 replication protein A2 involved_in ISS
ISO
GO_REF:0000024
(PMID:9430682)
UniProt
RGD
PMID:9430682 GO_REF:0000024 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
JBrowse link
G Rpa3 replication protein A3 involved_in IBA
ISO
PMID:21873635
(PMID:9430682)
RGD PMID:9430682 PMID:21873635 RGD:13792537 NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709
JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase involved_in ISO (PMID:23622243) RGD PMID:23622243 NCBI chr 8:110,511,808...110,597,489
Ensembl chr 8:110,511,772...110,597,489
JBrowse link
G Tdg thymine-DNA glycosylase involved_in ISO (PMID:22573813) RGD PMID:22573813 NCBI chr 7:21,077,853...21,097,617
Ensembl chr 7:21,077,853...21,097,567
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
JBrowse link
meiotic mismatch repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcm9 minichromosome maintenance 9 homologous recombination repair factor involved_in ISO (PMID:26300262)
(MGI:5705200|PMID:26300262)
RGD PMID:26300262 MGI:5705200 NCBI chr20:32,818,219...32,929,577
Ensembl chr20:32,844,951...32,929,600
JBrowse link
positive regulation of mismatch repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac10 histone deacetylase 10 involved_in ISS
ISO
GO_REF:0000024
(PMID:26221039)
UniProt
RGD
PMID:26221039 GO_REF:0000024 NCBI chr 7:120,199,126...120,205,850
Ensembl chr 7:120,199,129...120,204,228
JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:15014079) RGD PMID:15014079 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Prkcg protein kinase C, gamma involved_in ISO (PMID:15808853) RGD PMID:15808853 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
regulation of mismatch repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axin2 axin 2 involved_in ISO
IEA
(PMID:11017067)
GO_REF:0000107
RGD
Ensembl
PMID:11017067 GO_REF:0000107 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18877
    metabolic process 11591
      cellular metabolic process 9831
        cellular macromolecule metabolic process 3481
          DNA metabolic process 999
            DNA repair 512
              mismatch repair 27
                meiotic mismatch repair + 1
                mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication + 1
                negative regulation of mismatch repair 0
                positive regulation of mismatch repair 3
                regulation of mismatch repair + 4
Path 2
Term Annotations click to browse term
  biological_process 18877
    metabolic process 11591
      cellular metabolic process 9831
        cellular aromatic compound metabolic process 5651
          nucleobase-containing compound metabolic process 5422
            nucleic acid metabolic process 4890
              DNA metabolic process 999
                DNA repair 512
                  mismatch repair 27
                    meiotic mismatch repair + 1
                    mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication + 1
                    negative regulation of mismatch repair 0
                    positive regulation of mismatch repair 3
                    regulation of mismatch repair + 4
paths to the root