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ONTOLOGY REPORT - ANNOTATIONS

Term:mismatch repair
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Accession:GO:0006298 term browser browse the term
Definition:A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
Synonyms:exact_synonym: MMR
 narrow_synonym: long patch mismatch repair system
 related_synonym: MutS/MutL/MutH pathway;   mismatch repair, MutL-like pathway
 alt_id: GO:0006300
 xref: Reactome:R-HSA-5358508 "Mismatch Repair";   Wikipedia:DNA_mismatch_repair


show annotations for term's descendants           Sort by:
mismatch repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exo1 exonuclease 1 involved_in ISO
IEA
IBA		 UniProtKB:P43246 (PMID:11809771), (PMID:14636568), (PMID:9788596)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:9788596 PMID:11809771 PMID:14636568 GO_REF:0000033 GO_REF:0000107 NCBI chr13:90,341,947...90,366,861
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Mlh1 mutL homolog 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000002
GO_REF:0000107
MGI:1857946|MGI:1858054|MGI:1930998 (PMID:10096563), (PMID:10359802), (PMID:10429667), (PMID:10657972), (PMID:10747038), (PMID:10851078), (PMID:11313994), (PMID:16204034), (PMID:16728433), (PMID:8674118), (PMID:9500552), (PMID:9560238)
GO_REF:0000033
UniProtKB:P43246|UniProtKB:P52701 (PMID:23603115)		 InterPro
Ensembl
RGD
GO_Central		 PMID:8674118 PMID:9500552 PMID:9560238 PMID:10096563 PMID:10359802 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Mlh3 mutL homolog 3 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
MGI:104288|MGI:2384218 (PMID:16204034)		 GO_Central
Ensembl
InterPro
RGD		 PMID:16204034 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:110,612,535...110,649,408
Ensembl chr 6:104,881,483...104,917,728 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000104
(PMID:17715146), (PMID:7923193), (PMID:9677427)
GO_REF:0000107
GO_REF:0000002
MGI:109519|MGI:1857940|MGI:1858055|MGI:2151801|MGI:2389314|MGI:2680817 (PMID:10581038), (PMID:10874005), (PMID:10992298), (PMID:11046134), (PMID:11890935), (PMID:12531017), (PMID:14744764), (PMID:16728433), (PMID:17331550), (PMID:23071719), (PMID:7628020), (PMID:8706033), (PMID:9157971), (PMID:9244348), (PMID:9288110), (PMID:9697842)
GO_REF:0000033
UniProtKB:P40692|UniProtKB:P52701 (PMID:11555625), (PMID:23603115)		 UniProt
RGD
Ensembl
InterPro
GO_Central		 PMID:7628020 PMID:7923193 PMID:8706033 PMID:9157971 PMID:9244348 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh3 mutS homolog 3 acts_upstream_of_or_within
involved_in		 ISO MGI:101816|MGI:1343961|MGI:1858056|MGI:88039 (PMID:10706084), (PMID:11691815), (PMID:16728433)
(PMID:17715146), (PMID:8782829), (PMID:9677427)		 RGD PMID:8782829 PMID:9677427 PMID:10706084 PMID:11691815 PMID:16728433 More... NCBI chr 2:25,179,400...25,320,857 JBrowse link
G Msh4 mutS homolog 4 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:245,445,118...245,504,493
Ensembl chr 2:242,792,661...242,843,487 		JBrowse link
G Msh5 mutS homolog 5 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:3,779,180...3,797,996
Ensembl chr20:3,776,942...3,793,336 		JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA
IMP		 UniProtKB:P40692|UniProtKB:P43246 (PMID:23603115)
(PMID:10871409), (PMID:17715146), (PMID:23622243), (PMID:8782829)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
MGI:109519|MGI:1858014|MGI:2151803|MGI:3653701|MGI:88039 (PMID:11691815), (PMID:12370835), (PMID:15324697), (PMID:16728433), (PMID:23071719), (PMID:9390556)		 RGD
Ensembl
InterPro
GO_Central		 PMID:8782829 PMID:9390556 PMID:10871409 PMID:11691815 PMID:12370835 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:2292505 NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Mutyh mutY DNA glycosylase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:135,510,666...135,522,777
Ensembl chr 5:130,274,122...130,286,146 		JBrowse link
G Pcna proliferating cell nuclear antigen involved_in ISO
IEA
IBA		 (PMID:11005803)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:11005803 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
MGI:1857948 (PMID:9500552)		 GO_Central
Ensembl
InterPro
RGD		 PMID:9500552 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:55,721,393...55,832,225
Ensembl chr 9:48,253,410...48,340,237 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 (PMID:10871409), (PMID:23709753), (PMID:9618520)
GO_REF:0000002
GO_REF:0000107
MGI:1353455|MGI:1857946|MGI:1857947 (PMID:10359802), (PMID:10429667), (PMID:11313994), (PMID:16204034), (PMID:16728433), (PMID:23071719), (PMID:9500552)
GO_REF:0000033		 RGD
InterPro
Ensembl
GO_Central		 PMID:9500552 PMID:9618520 PMID:10359802 PMID:10429667 PMID:10871409 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr12:15,790,478...15,814,790
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Rnaseh2a ribonuclease H2, subunit A acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:23603115)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:23603115 GO_REF:0000033 GO_REF:0000107 NCBI chr19:40,091,206...40,100,904
Ensembl chr19:23,186,383...23,196,041 		JBrowse link
G Rpa1 replication protein A1 involved_in ISO
IEA		 (PMID:9430682)
GO_REF:0000107		 RGD
Ensembl		 PMID:9430682 GO_REF:0000107 NCBI chr10:60,647,185...60,698,279
Ensembl chr10:60,148,793...60,199,949 		JBrowse link
G Rpa2 replication protein A2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:9430682)		 UniProt
RGD		 PMID:9430682 GO_REF:0000024 NCBI chr 5:150,260,668...150,271,329
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Rpa3 replication protein A3 involved_in ISO
IBA		 (PMID:9430682)
GO_REF:0000033		 RGD
GO_Central		 PMID:9430682 GO_REF:0000033 NCBI chr 4:37,270,966...37,273,997
Ensembl chr 4:36,304,651...36,307,709 		JBrowse link
G Rpa3l1 replication protein A3 like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:45,908,653...45,909,063
Ensembl chr12:45,908,683...45,909,048 		JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase involved_in ISO
IEA		 (PMID:23622243)
GO_REF:0000107		 RGD
Ensembl		 PMID:23622243 GO_REF:0000107 NCBI chr 8:119,390,207...119,475,863
Ensembl chr 8:110,511,772...110,597,489 		JBrowse link
G Thsd8 thrombospondin type 1 domain containing 8 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr19:23,186,394...23,188,323
Ensembl chr19:23,186,364...23,196,042 		JBrowse link
G Wrn WRN RecQ like helicase involved_in ISO (PMID:17715146) RGD PMID:17715146 NCBI chr16:65,466,552...65,602,951
Ensembl chr16:58,763,504...58,895,450 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:125,550,833...125,578,084
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcm9 minichromosome maintenance 9 homologous recombination repair factor involved_in ISO
IEA		 (PMID:26300262)
GO_REF:0000107		 RGD
Ensembl		 PMID:26300262 GO_REF:0000107 NCBI chr20:32,818,219...32,929,577
Ensembl chr20:32,844,951...32,929,600 		JBrowse link
positive regulation of mismatch repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac10 histone deacetylase 10 involved_in ISS
ISO		 GO_REF:0000024
(PMID:26221039)		 UniProt
RGD		 PMID:26221039 GO_REF:0000024 NCBI chr 7:122,078,768...122,084,457
Ensembl chr 7:120,199,129...120,204,228 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:15014079) RGD PMID:15014079 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Prkcg protein kinase C, gamma involved_in ISO
IEA		 (PMID:15808853)
GO_REF:0000107		 RGD
Ensembl		 PMID:15808853 GO_REF:0000107 NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
regulation of mismatch repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axin2 axin 2 involved_in ISO
IEA		 (PMID:11017067)
GO_REF:0000107		 RGD
Ensembl		 PMID:11017067 GO_REF:0000107 NCBI chr10:94,393,379...94,426,579
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    response to stimulus 11067
      response to stress 4344
        cellular response to stress 2072
          DNA damage response 879
            DNA repair 557
              mismatch repair 26
                meiotic mismatch repair + 0
                mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication + 1
                negative regulation of mismatch repair 0
                positive regulation of mismatch repair 3
                regulation of mismatch repair + 4
Path 2
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        primary metabolic process 10745
          nucleobase-containing compound metabolic process 5888
            nucleic acid metabolic process 5280
              DNA metabolic process 976
                DNA repair 557
                  mismatch repair 26
                    meiotic mismatch repair + 0
                    mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication + 1
                    negative regulation of mismatch repair 0
                    positive regulation of mismatch repair 3
                    regulation of mismatch repair + 4
paths to the root