ONTOLOGY REPORT - ANNOTATIONS
Term: nucleotide-excision repair
Accession: GO:0006289
browse the term
Definition: A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
Comment: Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair.
Synonyms: exact_synonym: NER; pyrimidine-dimer repair, DNA damage excision
related_synonym: intrastrand cross-link repair
alt_id: GO:0045001
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Brca2
BRCA2, DNA repair associated
involved_in
ISO IEA
(PMID:16845393) GO_REF:0000107
RGD Ensembl
PMID:16845393
GO_REF:0000107
NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
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Brip1
BRCA1 interacting helicase 1
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324
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Cetn1
centrin 1
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr18:651,591...652,293
Ensembl chr18:651,591...652,293
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Cetn2
centrin 2
involved_in
IBA ISO
PMID:21873635 (PMID:15964821)
RGD
PMID:15964821 PMID:21873635
RGD:13792537
NCBI chr X:150,769,944...150,774,833
Ensembl chr X:150,769,953...150,774,919
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Cetn4
centrin 4
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 2:120,199,951...120,203,311
Ensembl chr 2:120,199,942...120,203,348
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Commd1
copper metabolism domain containing 1
involved_in
ISO
(PMID:23144634)
RGD
PMID:23144634
NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501
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Dclre1a
DNA cross-link repair 1A
acts_upstream_of_or_within
ISO
MGI:2180947 (MGI:1859725|PMID:10848582)
RGD
PMID:10848582
MGI:1859725
NCBI chr 1:255,569,911...255,589,815
Ensembl chr 1:255,569,919...255,589,678
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Ddb2
damage specific DNA binding protein 2
involved_in
ISO
(PMID:19109893)
RGD
PMID:19109893
NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
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Ercc1
ERCC excision repair 1, endonuclease non-catalytic subunit
acts_upstream_of_or_within involved_in
ISO
MGI:2183944 (MGI:63544|PMID:8275084) (PMID:3290851) (PMID:22547097) (PMID:7657672)
RGD
PMID:3290851 PMID:7657672 PMID:8275084 PMID:22547097
MGI:63544
NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
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Ercc2
ERCC excision repair 2, TFIIH core complex helicase subunit
acts_upstream_of_or_within involved_in
ISO
MGI:2183949 (MGI:1267106|PMID:9651581), (MGI:2179786|PMID:11950998) (PMID:8692841)
RGD
PMID:8692841 PMID:9651581 PMID:11950998
MGI:1267106 MGI:2179786
NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
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Ercc3
ERCC excision repair 3, TFIIH core complex helicase subunit
involved_in
ISO IEA
(PMID:17466626), (PMID:17509950), (PMID:8692841) GO_REF:0000002
RGD InterPro
PMID:8692841 PMID:17466626 PMID:17509950
GO_REF:0000002
NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329
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Ercc4
ERCC excision repair 4, endonuclease catalytic subunit
acts_upstream_of_or_within involved_in
ISO
(PMID:10644440) (PMID:10413517), (PMID:11790111), (PMID:14728600), (PMID:22547097), (PMID:32034146), (PMID:8797827)
RGD
PMID:8797827 PMID:10413517 PMID:10644440 PMID:11790111 PMID:14728600 PMID:22547097 PMID:32034146 More...
NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369
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Ercc5
ERCC excision repair 5, endonuclease
acts_upstream_of_or_within involved_in
ISO
MGI:2182793 (MGI:1333374|PMID:10022922) (PMID:11259578), (PMID:32522879), (PMID:32821917), (PMID:7657672), (PMID:8090225)
RGD
PMID:7657672 PMID:8090225 PMID:10022922 PMID:11259578 PMID:32522879 PMID:32821917 More...
MGI:1333374
NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
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Fan1
FANCD2 and FANCI associated nuclease 1
involved_in
ISO
(PMID:20603015), (PMID:20603016), (PMID:25430771)
RGD
PMID:20603015 PMID:20603016 PMID:25430771
NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977
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Fancc
FA complementation group C
involved_in acts_upstream_of_or_within
IBA ISO IEA
PMID:21873635 MGI:1858041 (MGI:1355066|PMID:8704201) GO_REF:0000107
RGD Ensembl
PMID:8704201 PMID:21873635
GO_REF:0000107 MGI:1355066 , RGD:13792537
NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376
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Gtf2h1
general transcription factor IIH subunit 1
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 1:97,321,417...97,349,455
Ensembl chr 1:97,321,394...97,349,455
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Gtf2h2
general transcription factor IIH subunit 2
involved_in
IBA IEA
PMID:21873635 GO_REF:0000104
UniProt
PMID:21873635
GO_REF:0000104, RGD:13792537
NCBI chr 2:31,623,752...31,652,697
Ensembl chr 2:31,624,678...31,652,592
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Gtf2h3
general transcription factor IIH subunit 3
involved_in
IBA IEA
PMID:21873635 GO_REF:0000104
UniProt
PMID:21873635
GO_REF:0000104, RGD:13792537
NCBI chr12:32,009,010...32,025,484
Ensembl chr12:32,009,014...32,025,497
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Gtf2h5
general transcription factor IIH subunit 5
acts_upstream_of_or_within
ISO
MGI:5514340 (MGI:5506835|PMID:23637614) (PMID:23637614)
RGD
PMID:23637614
MGI:5506835
NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939
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Hus1
HUS1 checkpoint clamp component
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442
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Kat5
lysine acetyltransferase 5
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:32034146)
UniProt Ensembl RGD
PMID:32034146
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458
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Mnat1
MNAT1 component of CDK activating kinase
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 6:91,814,703...91,971,945
Ensembl chr 6:91,814,749...91,970,744
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Nthl1
nth-like DNA glycosylase 1
involved_in
ISO
(PMID:8990169) (MGI:1289919|PMID:9743625)
RGD
PMID:8990169 PMID:9743625
MGI:1289919
NCBI chr10:13,655,791...13,661,958
Ensembl chr10:13,655,785...13,661,957
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Ogg1
8-oxoguanine DNA glycosylase
acts_upstream_of_or_within
ISO
(PMID:19506022)
RGD
PMID:19506022
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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Pola1
DNA polymerase alpha 1, catalytic subunit
NOT|involved_in
ISO
(PMID:1508673)
RGD
PMID:1508673
NCBI chr X:58,034,617...58,348,612
Ensembl chr X:58,034,619...58,348,536
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Poll
DNA polymerase lambda
involved_in
ISO
(PMID:10982892)
RGD
PMID:10982892
NCBI chr 1:244,400,202...244,408,762
Ensembl chr 1:244,400,204...244,408,662
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Rad23a
RAD23 homolog A, nucleotide excision repair protein
involved_in
ISO
(PMID:9372924)
RGD
PMID:9372924
NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695
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Rad23b
RAD23 homolog B, nucleotide excision repair protein
involved_in
ISO IEA
(PMID:19941824), (PMID:8168482), (PMID:9734359) GO_REF:0000104
RGD UniProt
PMID:8168482 PMID:9734359 PMID:19941824
GO_REF:0000104
NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319
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Rad51d
RAD51 paralog D
acts_upstream_of_or_within NOT|acts_upstream_of_or_within
ISO
(MGI:4430476|PMID:19327148)
RGD
PMID:19327148
MGI:4430476
NCBI chr10:67,805,720...67,824,452
Ensembl chr10:67,740,712...67,824,434
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Rpa1
replication protein A1
involved_in
ISO IBA
(PMID:9430682) PMID:21873635
RGD
PMID:9430682 PMID:21873635
RGD:13792537
NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949
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Rpa2
replication protein A2
involved_in
ISO IBA ISS
(PMID:9430682) PMID:21873635 GO_REF:0000024
RGD UniProt
PMID:9430682 PMID:21873635
GO_REF:0000024, RGD:13792537
NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
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Rpa3
replication protein A3
involved_in
ISO IBA
(PMID:9430682) PMID:21873635
RGD
PMID:9430682 PMID:21873635
RGD:13792537
NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709
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Rpa3l1
replication protein A3 like 1
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr12:45,908,653...45,909,063
Ensembl chr12:45,908,683...45,909,048
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Slx4
SLX4 structure-specific endonuclease subunit
involved_in
ISO
(PMID:19596236)
RGD
PMID:19596236
NCBI chr10:11,526,623...11,549,313
Ensembl chr10:11,528,424...11,549,295
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Tp53
tumor protein p53
involved_in
ISO IEA ISS
(PMID:7663514) GO_REF:0000107 GO_REF:0000024
RGD Ensembl UniProt
PMID:7663514
GO_REF:0000024 GO_REF:0000107
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Xpa
XPA, DNA damage recognition and repair factor
acts_upstream_of_or_within involved_in
ISO
MGI:1857939 (MGI:2179786|PMID:11950998), (MGI:2448221|PMID:12509265) (PMID:21148310)
RGD
PMID:11950998 PMID:12509265 PMID:21148310
MGI:2179786 MGI:2448221
NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726
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Xpc
XPC complex subunit, DNA damage recognition and repair factor
involved_in acts_upstream_of_or_within
IBA ISO
PMID:21873635 MGI:1859840|MGI:1931883 (MGI:2667287|PMID:12815074), (MGI:3697767|PMID:17049932), (MGI:4365898|PMID:19615386), (MGI:86029|PMID:9067411) (PMID:11259578), (PMID:19941824), (PMID:8168482), (PMID:9734359) (MGI:5427285|PMID:22431748)
RGD
PMID:8168482 PMID:9067411 PMID:9734359 PMID:11259578 PMID:12815074 PMID:17049932 PMID:19615386 PMID:19941824 PMID:22431748 PMID:21873635 More...
MGI:2667287 MGI:3697767 MGI:4365898 MGI:5427285 MGI:86029 , RGD:13792537
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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Ercc4
ERCC excision repair 4, endonuclease catalytic subunit
involved_in
ISO IBA
(PMID:32034146) PMID:21873635
RGD
PMID:32034146 PMID:21873635
RGD:13792537
NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369
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Ercc4l1
excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr10:954,927...983,651
Ensembl chr10:954,977...983,174
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Xpa
XPA, DNA damage recognition and repair factor
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726
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Xpa
XPA, DNA damage recognition and repair factor
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726
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Ercc3
ERCC excision repair 3, TFIIH core complex helicase subunit
involved_in
ISO
(PMID:17466626)
RGD
PMID:17466626
NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329
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Lig4
DNA ligase 4
involved_in
IBA ISO
PMID:21873635 (PMID:12517771), (PMID:17290226)
RGD
PMID:12517771 PMID:17290226 PMID:21873635
RGD:13792537
NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040
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Polb
DNA polymerase beta
NOT|involved_in
ISO
(PMID:20227374)
RGD
PMID:20227374
NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812
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Pold1
DNA polymerase delta 1, catalytic subunit
involved_in
ISO IEA IBA
(PMID:20227374) GO_REF:0000107 PMID:21873635
RGD Ensembl
PMID:20227374 PMID:21873635
GO_REF:0000107, RGD:13792537
NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465
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Pold3
DNA polymerase delta 3, accessory subunit
involved_in
ISO IBA
(PMID:20227374) PMID:21873635
RGD
PMID:20227374 PMID:21873635
RGD:13792537
NCBI chr 1:154,417,893...154,456,687
Ensembl chr 1:154,418,084...154,456,665
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Pole
DNA polymerase epsilon, catalytic subunit
involved_in
ISO IBA
(PMID:20227374) PMID:21873635
RGD
PMID:20227374 PMID:21873635
RGD:13792537
NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939
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Polk
DNA polymerase kappa
involved_in
ISO
(PMID:20227374)
RGD
PMID:20227374
NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313
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Gtf2h5
general transcription factor IIH subunit 5
involved_in acts_upstream_of_or_within
IBA ISO
PMID:21873635 MGI:5514340 (MGI:5506835|PMID:23637614)
RGD
PMID:23637614 PMID:21873635
MGI:5506835 , RGD:13792537
NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939
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LOC120103497
general transcription factor IIH subunit 5-like
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 6:27,109,209...27,114,478
Ensembl chr 6:27,111,331...27,111,546
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Ercc1
ERCC excision repair 1, endonuclease non-catalytic subunit
acts_upstream_of_or_within
ISO
(MGI:1342943|PMID:10454634)
RGD
PMID:10454634
MGI:1342943
NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
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Hmgn1
high mobility group nucleosome binding domain 1
acts_upstream_of_or_within
ISO
MGI:3590648 (MGI:3590574|PMID:12660172)
RGD
PMID:12660172
MGI:3590574
NCBI chr11:35,422,328...35,428,247
Ensembl chr11:35,422,328...35,428,254
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Sirt1
sirtuin 1
involved_in
ISO IEA
(PMID:21149730) GO_REF:0000107 (MGI:5298332|PMID:21149730)
RGD Ensembl
PMID:21149730
GO_REF:0000107 MGI:5298332
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Xpc
XPC complex subunit, DNA damage recognition and repair factor
acts_upstream_of_or_within
ISO
MGI:1931883 (MGI:3697767|PMID:17049932)
RGD
PMID:17049932
MGI:3697767
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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Cul4a
cullin 4A
acts_upstream_of_or_within
ISO
MGI:3851025 (MGI:3850765|PMID:19481525)
RGD
PMID:19481525
MGI:3850765
NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330
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Hmgb1
high mobility group box 1
involved_in
ISO
(MGI:3807115|PMID:18650382)
RGD
PMID:18650382
MGI:3807115
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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Kat7
lysine acetyltransferase 7
involved_in
ISO ISS
(PMID:28719581) GO_REF:0000024
RGD UniProt
PMID:28719581
GO_REF:0000024
NCBI chr10:80,221,519...80,255,590
Ensembl chr10:80,221,524...80,255,567
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Rad52
RAD52 homolog, DNA repair protein
acts_upstream_of_or_within
ISO
(PMID:19506022)
RGD
PMID:19506022
NCBI chr 4:153,106,062...153,128,598
Ensembl chr 4:153,106,062...153,128,207
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Ercc8
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
involved_in
ISO
(PMID:16916636), (PMID:17297471)
RGD
PMID:16916636 PMID:17297471
NCBI chr 2:39,647,393...39,686,229
Ensembl chr 2:39,647,452...39,684,859
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Ercc2
ERCC excision repair 2, TFIIH core complex helicase subunit
involved_in
ISO
(PMID:8663148)
RGD
PMID:8663148
NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
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Ercc3
ERCC excision repair 3, TFIIH core complex helicase subunit
involved_in
ISO
(PMID:8663148)
RGD
PMID:8663148
NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329
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Ercc5
ERCC excision repair 5, endonuclease
involved_in
ISO
(PMID:16246722)
RGD
PMID:16246722
NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
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Ercc6
ERCC excision repair 6, chromatin remodeling factor
acts_upstream_of_or_within involved_in
ISO IBA IMP
MGI:1932102 (MGI:2448221|PMID:12509265), (MGI:87553|PMID:9150142) (PMID:10564257), (PMID:26620705) PMID:21873635
RGD
PMID:9150142 PMID:10564257 PMID:12509265 PMID:26620705 PMID:21873635 PMID:31644904 More...
MGI:2448221 MGI:87553 , RGD:13792537 , RGD:126925983
NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
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Ercc8
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
involved_in acts_upstream_of_or_within
IBA ISO
PMID:21873635 (PMID:12732143)
RGD
PMID:12732143 PMID:21873635
RGD:13792537
NCBI chr 2:39,647,393...39,686,229
Ensembl chr 2:39,647,452...39,684,859
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Hmgn1
high mobility group nucleosome binding domain 1
acts_upstream_of_or_within
ISO
MGI:3590648 (MGI:3590574|PMID:12660172)
RGD
PMID:12660172
MGI:3590574
NCBI chr11:35,422,328...35,428,247
Ensembl chr11:35,422,328...35,428,254
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Polr2i
RNA polymerase II subunit I
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 1:85,483,515...85,484,952
Ensembl chr 1:85,483,515...85,484,952
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Usp7
ubiquitin specific peptidase 7
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:22466612)
UniProt Ensembl RGD
PMID:22466612
GO_REF:0000024 GO_REF:0000107
NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355
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Uvssa
UV-stimulated scaffold protein A
involved_in
ISO IEA ISS IBA
(PMID:22466610), (PMID:22466611), (PMID:22466612) GO_REF:0000107 GO_REF:0000024 PMID:21873635
RGD Ensembl UniProt
PMID:22466610 PMID:22466611 PMID:22466612 PMID:21873635
GO_REF:0000024 GO_REF:0000107, RGD:13792537
NCBI chr14:77,309,188...77,351,922
Ensembl chr14:77,314,056...77,351,903
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Xab2
XPA binding protein 2
involved_in
ISO IEA ISS
(PMID:10944529) GO_REF:0000107
RGD Ensembl
PMID:10944529 PMID:10944529
GO_REF:0000107, RGD:8554289
NCBI chr12:1,667,672...1,679,702
Ensembl chr12:1,667,672...1,679,692
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
biological_process
19553
cellular process
18233
cellular response to stimulus
8778
cellular response to stress
2097
DNA damage response
830
DNA repair
525
nucleotide-excision repair
57
global genome nucleotide-excision repair
0
nucleotide-excision repair involved in interstrand cross-link repair
3
nucleotide-excision repair, DNA damage recognition +
1
nucleotide-excision repair, DNA damage removal
0
nucleotide-excision repair, DNA duplex unwinding
1
nucleotide-excision repair, DNA gap filling
6
nucleotide-excision repair, preincision complex assembly
2
nucleotide-excision repair, preincision complex stabilization
0
pyrimidine dimer repair by nucleotide-excision repair
4
regulation of nucleotide-excision repair +
5
transcription-coupled nucleotide-excision repair +
10
Path 2
biological_process
19553
metabolic process
11538
cellular metabolic process
10124
cellular aromatic compound metabolic process
5773
nucleobase-containing compound metabolic process
5539
nucleic acid metabolic process
4966
DNA metabolic process
993
DNA repair
525
nucleotide-excision repair
57
global genome nucleotide-excision repair
0
nucleotide-excision repair involved in interstrand cross-link repair
3
nucleotide-excision repair, DNA damage recognition +
1
nucleotide-excision repair, DNA damage removal
0
nucleotide-excision repair, DNA duplex unwinding
1
nucleotide-excision repair, DNA gap filling
6
nucleotide-excision repair, preincision complex assembly
2
nucleotide-excision repair, preincision complex stabilization
0
pyrimidine dimer repair by nucleotide-excision repair
4
regulation of nucleotide-excision repair +
5
transcription-coupled nucleotide-excision repair +
10