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ONTOLOGY REPORT - ANNOTATIONS

Term:base-excision repair, AP site formation
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Accession:GO:0006285 term browser browse the term
Definition:The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.


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base-excision repair, AP site formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc5 ERCC excision repair 5, endonuclease involved_in ISO (PMID:9927729) RGD PMID:9927729 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472 		JBrowse link
G Nthl1 nth-like DNA glycosylase 1 involved_in ISO
IBA		 (PMID:15358233), (PMID:9927729)
GO_REF:0000033		 RGD
GO_Central		 PMID:9927729 PMID:15358233 GO_REF:0000033 NCBI chr10:13,655,791...13,661,958
Ensembl chr10:13,655,785...13,661,957 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Tdg thymine-DNA glycosylase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:21,077,853...21,097,617
Ensembl chr 7:21,077,853...21,097,567 		JBrowse link
base-excision repair, AP site formation via deaminated base removal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ung uracil-DNA glycosylase involved_in ISO
IBA		 (PMID:18973764)
GO_REF:0000033		 RGD
GO_Central		 PMID:18973764 GO_REF:0000033 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12288
      macromolecule metabolic process 10146
        nucleic acid metabolic process 5148
          DNA metabolic process 960
            base-excision repair, AP site formation 5
              base-excision repair, AP site formation via deaminated base removal 1
              depurination 0
              depyrimidination 0
Path 2
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12288
      primary metabolic process 10923
        nucleobase-containing compound metabolic process 5736
          nucleic acid metabolic process 5148
            DNA metabolic process 960
              DNA repair 550
                base-excision repair 43
                  base-excision repair, AP site formation 5
                    base-excision repair, AP site formation via deaminated base removal 1
                    depurination 0
                    depyrimidination 0
paths to the root