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ONTOLOGY REPORT - ANNOTATIONS


Term:lagging strand elongation
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Accession:GO:0006273 term browser browse the term
Definition:The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork.


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lagging strand elongation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pola1 DNA polymerase alpha 1, catalytic subunit involved_in ISO (PMID:2175912), (PMID:7910375) UniProt PMID:2175912 PMID:7910375 NCBI chrNW_004936836:1,151...287,438 JBrowse link
DNA replication, Okazaki fragment processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 involved_in IEA Ensembl
InterPro
UniProt
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936521:9,843,867...9,884,248 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14954
    cellular process 14088
      cellular metabolic process 8560
        cellular macromolecule metabolic process 5073
          DNA metabolic process 879
            DNA strand elongation 24
              DNA strand elongation involved in DNA replication 2
                lagging strand elongation 2
                  DNA replication, Okazaki fragment processing + 1
                  lagging strand initiation 0
                  mitotic DNA replication lagging strand elongation 0
Path 2
Term Annotations click to browse term
  biological_process 14954
    metabolic process 9452
      cellular metabolic process 8560
        heterocycle metabolic process 4545
          nucleobase-containing compound metabolic process 4415
            nucleic acid metabolic process 4031
              DNA metabolic process 879
                DNA replication 245
                  DNA-templated DNA replication 133
                    DNA strand elongation involved in DNA replication 2
                      lagging strand elongation 2
                        DNA replication, Okazaki fragment processing + 1
                        lagging strand initiation 0
                        mitotic DNA replication lagging strand elongation 0
paths to the root