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ONTOLOGY REPORT - ANNOTATIONS


Term:lagging strand elongation
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Accession:GO:0006273 term browser browse the term
Definition:The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork.



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lagging strand elongation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lig1 ligase I, DNA, ATP-dependent involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 7:13,277,175...13,311,426
Ensembl chr 7:13,277,283...13,311,433
JBrowse link
G Lig3 ligase III, DNA, ATP-dependent involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr11:82,781,109...82,804,274
Ensembl chr11:82,781,108...82,804,274
JBrowse link
G Pola1 polymerase (DNA directed), alpha 1 involved_in ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr  X:93,304,766...93,632,387
Ensembl chr  X:93,304,767...93,632,155
JBrowse link
DNA replication, Okazaki fragment processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr10:62,946,983...62,974,188
Ensembl chr10:62,947,026...62,974,185
JBrowse link
Okazaki fragment processing involved in mitotic DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lig1 ligase I, DNA, ATP-dependent involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 7:13,277,175...13,311,426
Ensembl chr 7:13,277,283...13,311,433
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28615
    cellular process 17655
      cellular metabolic process 10169
        cellular macromolecule metabolic process 5723
          DNA metabolic process 911
            DNA strand elongation 36
              DNA strand elongation involved in DNA replication 13
                lagging strand elongation 4
                  DNA replication, Okazaki fragment processing + 2
                  lagging strand initiation 0
                  mitotic DNA replication lagging strand elongation 0
Path 2
Term Annotations click to browse term
  biological_process 28615
    metabolic process 11339
      organic substance metabolic process 10921
        macromolecule metabolic process 9377
          macromolecule biosynthetic process 4668
            cellular macromolecule biosynthetic process 1512
              DNA replication 282
                DNA-dependent DNA replication 153
                  DNA strand elongation involved in DNA replication 13
                    lagging strand elongation 4
                      DNA replication, Okazaki fragment processing + 2
                      lagging strand initiation 0
                      mitotic DNA replication lagging strand elongation 0
paths to the root