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ONTOLOGY REPORT - ANNOTATIONS

Term:lagging strand elongation
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Accession:GO:0006273 term browser browse the term
Definition:The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork.


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lagging strand elongation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LIG3 DNA ligase 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:21,776,483...21,805,706
Ensembl chr17:22,074,046...22,095,220 		JBrowse link
G POLA1 DNA polymerase alpha 1, catalytic subunit involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:17,290,805...17,592,163
Ensembl chr  X:24,657,878...24,960,231 		JBrowse link
DNA replication, Okazaki fragment processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC25A16 solute carrier family 25 member 16 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:64,898,024...64,956,541
Ensembl chr10:67,506,006...67,549,308
Ensembl chr10:67,506,006...67,549,308 		JBrowse link
Okazaki fragment processing involved in mitotic DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LIG1 DNA ligase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:45,056,737...45,110,867
Ensembl chr19:53,706,778...53,761,088 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16313
    metabolic process 10179
      primary metabolic process 8792
        nucleobase-containing compound metabolic process 4994
          nucleic acid metabolic process 4498
            DNA metabolic process 917
              DNA strand elongation 35
                DNA strand elongation involved in DNA replication 13
                  lagging strand elongation 4
                    DNA replication, Okazaki fragment processing + 2
                    lagging strand initiation 0
                    mitotic DNA replication lagging strand elongation 0
Path 2
Term Annotations click to browse term
  biological_process 16313
    metabolic process 10179
      organic substance metabolic process 9739
        organic cyclic compound metabolic process 5446
          nucleobase-containing compound metabolic process 4994
            nucleic acid metabolic process 4498
              DNA metabolic process 917
                DNA replication 264
                  DNA-templated DNA replication 154
                    DNA strand elongation involved in DNA replication 13
                      lagging strand elongation 4
                        DNA replication, Okazaki fragment processing + 2
                        lagging strand initiation 0
                        mitotic DNA replication lagging strand elongation 0
paths to the root