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ONTOLOGY REPORT - ANNOTATIONS


Term:lagging strand elongation
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Accession:GO:0006273 term browser browse the term
Definition:The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork.



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lagging strand elongation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lig1 DNA ligase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413
JBrowse link
G Lig3 DNA ligase 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:67,717,796...67,741,141
Ensembl chr10:67,717,812...67,798,414
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:2175912), (PMID:7910375)
UniProt
RGD
PMID:2175912 PMID:7910375 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr  X:58,034,617...58,348,612
Ensembl chr  X:58,034,619...58,348,536
JBrowse link
DNA replication, Okazaki fragment processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 involved_in ISO
ISS
IEA
(PMID:22570407)
GO_REF:0000024
GO_REF:0000104
RGD
UniProt
PMID:22570407 GO_REF:0000024 GO_REF:0000104 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319
JBrowse link
G Slc25a16 solute carrier family 25 member 16 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr20:25,661,158...25,717,558
Ensembl chr20:25,662,055...25,716,319
JBrowse link
Okazaki fragment processing involved in mitotic DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lig1 DNA ligase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19512
    cellular process 18319
      cellular metabolic process 10675
        cellular macromolecule metabolic process 6169
          DNA metabolic process 998
            DNA strand elongation 39
              DNA strand elongation involved in DNA replication 17
                lagging strand elongation 5
                  DNA replication, Okazaki fragment processing + 3
                  lagging strand initiation 0
                  mitotic DNA replication lagging strand elongation 0
Path 2
Term Annotations click to browse term
  biological_process 19512
    metabolic process 11791
      cellular metabolic process 10675
        heterocycle metabolic process 5599
          nucleobase-containing compound metabolic process 5452
            nucleic acid metabolic process 4971
              DNA metabolic process 998
                DNA replication 277
                  DNA-templated DNA replication 158
                    DNA strand elongation involved in DNA replication 17
                      lagging strand elongation 5
                        DNA replication, Okazaki fragment processing + 3
                        lagging strand initiation 0
                        mitotic DNA replication lagging strand elongation 0
paths to the root