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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA replication initiation
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Accession:GO:0006270 term browser browse the term
Definition:The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
Synonyms:exact_synonym: DNA-dependent DNA replication initiation
 narrow_synonym: DNA endoreduplication initiation;   DNA re-replication initiation
 alt_id: GO:0042024


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DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNE1 cyclin E1 acts_upstream_of_or_within ISO (MGI:2673102|PMID:12941272) MGI PMID:12941272 MGI:2673102 NCBI chr 6:39,919,541...39,933,224
Ensembl chr 6:39,919,624...39,933,366 		JBrowse link
G CCNE2 cyclin E2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2673102|PMID:12941272) MGI
Ensembl		 PMID:12941272 GO_REF:0000107 MGI:2673102 NCBI chr 4:41,802,090...41,821,870
Ensembl chr 4:41,804,377...41,821,874 		JBrowse link
G CDC45 cell division cycle 45 involved_in IBA
IEA		 (PMID:21873635) GO_Central
InterPro		 PMID:21873635 GO_REF:0000002 NCBI chr14:51,133,111...51,158,604
Ensembl chr14:51,133,408...51,158,606 		JBrowse link
G CDC6 cell division cycle 6 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr12:22,101,281...22,118,441
Ensembl chr12:22,101,282...22,118,593 		JBrowse link
G MCM10 minichromosome maintenance 10 replication initiation factor involved_in IEA
IBA		 (PMID:21873635) InterPro
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000002 GO_REF:0000107 NCBI chr10:48,481,292...48,523,921
Ensembl chr10:48,480,705...48,538,952 		JBrowse link
G MCM2 minichromosome maintenance complex component 2 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr13:72,630,378...72,651,270
Ensembl chr13:72,630,380...72,657,786 		JBrowse link
G MCM3 minichromosome maintenance complex component 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr 7:46,084,648...46,104,425
Ensembl chr 7:46,084,662...46,104,375 		JBrowse link
G MCM4 minichromosome maintenance complex component 4 involved_in IEA InterPro GO_REF:0000002 NCBI chr 4:79,674,737...79,686,964
Ensembl chr 4:79,674,739...79,686,685 		JBrowse link
G MCM5 minichromosome maintenance complex component 5 involved_in IEA
IBA		 (PMID:21873635) UniProt
GO_Central
InterPro		 PMID:21873635 GO_REF:0000002 GO_REF:0000104
G MCM6 minichromosome maintenance complex component 6 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr15:15,923,638...15,978,587
Ensembl chr15:15,923,681...15,985,405 		JBrowse link
G MCM7 minichromosome maintenance complex component 7 involved_in IEA
IBA		 (PMID:21873635) InterPro
GO_Central		 PMID:21873635 GO_REF:0000002 NCBI chr 3:8,005,890...8,014,047
Ensembl chr 3:8,005,900...8,014,053 		JBrowse link
G NOC3L NOC3 like DNA replication regulator involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:105,766,299...105,806,368
Ensembl chr14:105,770,566...105,806,335 		JBrowse link
G ORC1 origin recognition complex subunit 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:159,819,302...159,852,306
Ensembl chr 6:159,819,339...159,852,305 		JBrowse link
G ORC4 origin recognition complex subunit 4 involved_in IEA
IBA		 (PMID:21873635) Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr15:4,096,539...4,176,332
Ensembl chr15:4,096,647...4,171,398 		JBrowse link
G ORC5 origin recognition complex subunit 5 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:104,078,792...104,166,530
Ensembl chr 9:104,083,830...104,166,541 		JBrowse link
G ORC6 origin recognition complex subunit 6 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:37,934,903...37,943,950
Ensembl chr 6:37,934,908...37,943,886 		JBrowse link
G POLA1 DNA polymerase alpha 1, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:20,756,674...21,064,265
Ensembl chr  X:20,756,725...21,062,175 		JBrowse link
G POLA2 DNA polymerase alpha 2, accessory subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:6,922,384...6,950,289
Ensembl chr 2:6,922,387...6,950,179 		JBrowse link
G PRIM1 DNA primase subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:22,064,248...22,089,441
Ensembl chr 5:22,062,989...22,089,436 		JBrowse link
G PRIM2 DNA primase subunit 2 involved_in IEA
IBA		 (PMID:21873635) Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 7:28,274,626...28,566,633
Ensembl chr 7:28,274,627...28,631,514 		JBrowse link
mitotic DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GINS3 GINS complex subunit 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:20,162,264...20,170,385
Ensembl chr 6:20,162,636...20,170,258 		JBrowse link
G MCM3 minichromosome maintenance complex component 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:46,084,648...46,104,425
Ensembl chr 7:46,084,662...46,104,375 		JBrowse link
G MCM4 minichromosome maintenance complex component 4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:79,674,737...79,686,964
Ensembl chr 4:79,674,739...79,686,685 		JBrowse link
G POLA1 DNA polymerase alpha 1, catalytic subunit involved_in IEA InterPro GO_REF:0000002 NCBI chr  X:20,756,674...21,064,265
Ensembl chr  X:20,756,725...21,062,175 		JBrowse link
positive regulation of DNA-templated DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK2 cyclin dependent kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4439421|PMID:20215406) MGI
Ensembl		 PMID:20215406 GO_REF:0000107 MGI:4439421 NCBI chr 5:21,365,723...21,372,170
Ensembl chr 5:21,365,764...21,372,168 		JBrowse link
G CIZ1 CDKN1A interacting zinc finger protein 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4439421|PMID:20215406)
(MGI:3513706|PMID:15585571)		 MGI
Ensembl		 PMID:15585571 PMID:20215406 GO_REF:0000107 MGI:3513706 MGI:4439421 NCBI chr 1:268,618,972...268,642,064
Ensembl chr 1:268,617,087...268,641,893 		JBrowse link
G RAB5B RAB5B, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:21,373,333...21,392,729
Ensembl chr 5:21,387,250...21,389,745 		JBrowse link
regulation of DNA-templated DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 involved_in IEA
IBA		 (PMID:21873635) InterPro
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000002 GO_REF:0000107 NCBI chr 6:893,377...897,706
Ensembl chr 6:893,381...897,934 		JBrowse link
G GMNN geminin DNA replication inhibitor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:19,585,968...19,595,346
Ensembl chr 7:19,586,002...19,595,344 		JBrowse link
G KAT7 lysine acetyltransferase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:25,970,966...26,005,006
Ensembl chr12:25,970,962...26,008,302 		JBrowse link
G MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:34,377,130...34,386,095
Ensembl chr16:34,376,959...34,384,453 		JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:55,142,957...55,200,259
Ensembl chr 7:55,143,240...55,200,640 		JBrowse link
G WRNIP1 WRN helicase interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:1,656,952...1,667,885
Ensembl chr 7:1,656,984...1,667,879 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17223
    metabolic process 10710
      organic substance metabolic process 10276
        macromolecule metabolic process 8345
          nucleic acid metabolic process 2117
            DNA metabolic process 938
              DNA replication initiation 30
                cell cycle DNA replication initiation + 4
                negative regulation of DNA-templated DNA replication initiation + 0
                positive regulation of DNA-templated DNA replication initiation + 3
                regulation of DNA-templated DNA replication initiation + 9
Path 2
Term Annotations click to browse term
  biological_process 17223
    metabolic process 10710
      cellular metabolic process 6581
        heterocycle metabolic process 2744
          nucleobase-containing compound metabolic process 2588
            nucleic acid metabolic process 2117
              DNA metabolic process 938
                DNA replication 258
                  DNA-templated DNA replication 144
                    DNA replication initiation 30
                      cell cycle DNA replication initiation + 4
                      negative regulation of DNA-templated DNA replication initiation + 0
                      positive regulation of DNA-templated DNA replication initiation + 3
                      regulation of DNA-templated DNA replication initiation + 9
paths to the root