Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:DNA replication initiation
go back to main search page
Accession:GO:0006270 term browser browse the term
Definition:The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
Synonyms:exact_synonym: DNA-dependent DNA replication initiation
 narrow_synonym: DNA endoreduplication initiation;   DNA re-replication initiation
 alt_id: GO:0042024


show annotations for term's descendants           Sort by:
DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNE1 cyclin E1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2673102|PMID:12941272) MGI
Ensembl		 PMID:12941272 GO_REF:0000107 MGI:2673102 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CCNE2 cyclin E2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2673102|PMID:12941272) MGI
Ensembl		 PMID:12941272 GO_REF:0000107 MGI:2673102 NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678 		JBrowse link
G CDC34 cell division cycle 34, ubiqiutin conjugating enzyme involved_in NAS (PMID:8248134) UniProt PMID:8248134 NCBI chr19:531,760...542,087
Ensembl chr19:531,760...542,092 		JBrowse link
G CDC45 cell division cycle 45 involved_in TAS
IEA
IBA		 (PMID:9660782)
(PMID:21873635)		 PINC
InterPro
GO_Central		 PMID:9660782 PMID:21873635 GO_REF:0000002 NCBI chr22:19,479,466...19,520,612
Ensembl chr22:19,479,457...19,520,612 		JBrowse link
G CDC6 cell division cycle 6 involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr17:40,287,879...40,304,657
Ensembl chr17:40,287,879...40,304,657 		JBrowse link
G LRWD1 leucine rich repeats and WD repeat domain containing 1 involved_in TAS (PMID:20932478) UniProt PMID:20932478 NCBI chr 7:102,464,984...102,473,168
Ensembl chr 7:102,464,956...102,473,168 		JBrowse link
G MCM10 minichromosome maintenance 10 replication initiation factor involved_in IEA
IBA
IMP		 (PMID:21873635)
(PMID:32865517)		 InterPro
GO_Central
UniProt		 PMID:21873635 PMID:32865517 GO_REF:0000002 NCBI chr10:13,161,558...13,211,110
Ensembl chr10:13,161,558...13,211,110 		JBrowse link
G MCM2 minichromosome maintenance complex component 2 involved_in IEA
IMP		 (PMID:16899510) InterPro
UniProt		 PMID:16899510 GO_REF:0000002 NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,410...127,622,436 		JBrowse link
G MCM3 minichromosome maintenance complex component 3 involved_in TAS
IEA		 (PMID:1549468) PINC
InterPro		 PMID:1549468 GO_REF:0000002 NCBI chr 6:52,264,015...52,284,742
Ensembl chr 6:52,264,014...52,284,881 		JBrowse link
G MCM4 minichromosome maintenance complex component 4 involved_in IEA InterPro GO_REF:0000002 NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160 		JBrowse link
G MCM5 minichromosome maintenance complex component 5 involved_in IEA
IBA		 (PMID:21873635) InterPro
GO_Central
UniProt		 PMID:21873635 GO_REF:0000002 GO_REF:0000104 NCBI chr22:35,400,140...35,455,031
Ensembl chr22:35,400,134...35,425,431 		JBrowse link
G MCM6 minichromosome maintenance complex component 6 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443 		JBrowse link
G MCM7 minichromosome maintenance complex component 7 involved_in IEA
IBA		 (PMID:21873635) InterPro
GO_Central		 PMID:21873635 GO_REF:0000002 NCBI chr 7:100,092,728...100,101,397
Ensembl chr 7:100,092,728...100,101,940 		JBrowse link
G NOC3L NOC3 like DNA replication regulator involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:94,314,907...94,362,939
Ensembl chr10:94,333,226...94,362,959 		JBrowse link
G ORC1 origin recognition complex subunit 1 involved_in TAS
IBA		 (PMID:7502077)
(PMID:21873635)		 PINC
GO_Central		 PMID:7502077 PMID:21873635 NCBI chr 1:52,372,829...52,409,503
Ensembl chr 1:52,372,829...52,404,423 		JBrowse link
G ORC2 origin recognition complex subunit 2 involved_in TAS (PMID:8808289) PINC PMID:8808289 NCBI chr 2:200,908,977...200,963,660
Ensembl chr 2:200,908,977...200,963,680 		JBrowse link
G ORC3 origin recognition complex subunit 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:87,590,135...87,677,823
Ensembl chr 6:87,590,067...87,667,453 		JBrowse link
G ORC4 origin recognition complex subunit 4 involved_in IMP
IBA		 (PMID:9353276)
(PMID:21873635)		 UniProt
GO_Central		 PMID:9353276 PMID:21873635 NCBI chr 2:147,930,396...148,021,551
Ensembl chr 2:147,930,396...148,021,604 		JBrowse link
G ORC5 origin recognition complex subunit 5 involved_in IBA
TAS		 (PMID:21873635)
(PMID:9765232)		 GO_Central
PINC		 PMID:9765232 PMID:21873635 NCBI chr 7:104,126,341...104,208,013
Ensembl chr 7:104,126,341...104,208,047 		JBrowse link
G ORC6 origin recognition complex subunit 6 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:46,689,659...46,698,394
Ensembl chr16:46,689,643...46,698,394 		JBrowse link
G POLA1 DNA polymerase alpha 1, catalytic subunit involved_in IDA
IEA		 (PMID:2175912), (PMID:26975377) ComplexPortal
Ensembl		 PMID:2175912 PMID:26975377 GO_REF:0000107 NCBI chr  X:24,693,918...24,996,986
Ensembl chr  X:24,693,873...24,996,986 		JBrowse link
G POLA2 DNA polymerase alpha 2, accessory subunit involved_in IDA
IBA
IEA		 (PMID:26975377)
(PMID:21873635)		 ComplexPortal
GO_Central
Ensembl		 PMID:21873635 PMID:26975377 GO_REF:0000107 NCBI chr11:65,261,962...65,305,985
Ensembl chr11:65,261,913...65,305,959 		JBrowse link
G PRIM1 DNA primase subunit 1 involved_in IDA (PMID:26975377) ComplexPortal PMID:26975377 NCBI chr12:56,731,580...56,752,323
Ensembl chr12:56,730,438...56,752,374 		JBrowse link
G PRIM2 DNA primase subunit 2 involved_in IEA
IBA
IDA		 (PMID:21873635)
(PMID:26975377)		 Ensembl
GO_Central
ComplexPortal		 PMID:21873635 PMID:26975377 GO_REF:0000107 NCBI chr 6:57,221,540...57,646,850
Ensembl chr 6:57,314,805...57,646,850 		JBrowse link
G PURA purine rich element binding protein A involved_in TAS (PMID:1545807) PINC PMID:1545807 NCBI chr 5:140,114,109...140,125,619
Ensembl chr 5:140,107,777...140,125,619 		JBrowse link
G RNY3 RNA, Ro60-associated Y3 acts_upstream_of_or_within ISO (MGI:4361062|PMID:19657016) MGI PMID:19657016 MGI:4361062 NCBI chr 7:148,983,755...148,983,856
Ensembl chr 7:148,983,755...148,983,856 		JBrowse link
G RPA4 replication protein A4 involved_in TAS (PMID:7760808) PINC PMID:7760808 NCBI chr  X:96,883,908...96,885,467
Ensembl chr  X:96,883,908...96,885,467 		JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:133,600,238...133,661,941
Ensembl chr 3:133,598,175...133,662,380 		JBrowse link
mitotic DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GINS3 GINS complex subunit 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:58,392,471...58,406,147
Ensembl chr16:58,295,080...58,406,147 		JBrowse link
G MCM2 minichromosome maintenance complex component 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,410...127,622,436 		JBrowse link
G MCM3 minichromosome maintenance complex component 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:52,264,015...52,284,742
Ensembl chr 6:52,264,014...52,284,881 		JBrowse link
G MCM4 minichromosome maintenance complex component 4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160 		JBrowse link
G POLA1 DNA polymerase alpha 1, catalytic subunit involved_in IBA
IEA		 (PMID:21873635) GO_Central
InterPro		 PMID:21873635 GO_REF:0000002 NCBI chr  X:24,693,918...24,996,986
Ensembl chr  X:24,693,873...24,996,986 		JBrowse link
positive regulation of DNA-templated DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK2 cyclin dependent kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4439421|PMID:20215406) MGI
Ensembl		 PMID:20215406 GO_REF:0000107 MGI:4439421 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CIZ1 CDKN1A interacting zinc finger protein 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4439421|PMID:20215406)
(MGI:3513706|PMID:15585571)		 MGI
Ensembl		 PMID:15585571 PMID:20215406 GO_REF:0000107 MGI:3513706 MGI:4439421 NCBI chr 9:128,166,065...128,204,222
Ensembl chr 9:128,161,251...128,204,383 		JBrowse link
regulation of DNA-templated DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 involved_in IDA
IBA
IEA		 (PMID:11125146)
(PMID:21873635)		 UniProt
GO_Central
InterPro
Ensembl		 PMID:11125146 PMID:21873635 GO_REF:0000002 GO_REF:0000107 NCBI chr16:88,803,789...88,809,258
Ensembl chr16:88,803,789...88,809,258 		JBrowse link
G GMNN geminin DNA replication inhibitor involved_in IDA (PMID:24064211) ComplexPortal PMID:24064211 NCBI chr 6:24,774,937...24,786,099
Ensembl chr 6:24,774,931...24,786,099 		JBrowse link
G KAT7 lysine acetyltransferase 7 involved_in IDA (PMID:26620551) UniProt PMID:26620551 NCBI chr17:49,788,681...49,835,026
Ensembl chr17:49,788,624...49,835,026 		JBrowse link
G MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein involved_in IDA (PMID:24064211) ComplexPortal PMID:24064211 NCBI chr 5:55,219,564...55,227,315
Ensembl chr 5:55,219,564...55,227,315 		JBrowse link
G MCM2 minichromosome maintenance complex component 2 involved_in NAS (PMID:30069701) ComplexPortal PMID:30069701 NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,410...127,622,436 		JBrowse link
G MCM3 minichromosome maintenance complex component 3 involved_in NAS (PMID:30069701) ComplexPortal PMID:30069701 NCBI chr 6:52,264,015...52,284,742
Ensembl chr 6:52,264,014...52,284,881 		JBrowse link
G MCM4 minichromosome maintenance complex component 4 involved_in NAS (PMID:30069701) ComplexPortal PMID:30069701 NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160 		JBrowse link
G MCM5 minichromosome maintenance complex component 5 involved_in NAS (PMID:30069701) ComplexPortal PMID:30069701 NCBI chr22:35,400,140...35,455,031
Ensembl chr22:35,400,134...35,425,431 		JBrowse link
G MCM6 minichromosome maintenance complex component 6 involved_in NAS (PMID:30069701) ComplexPortal PMID:30069701 NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443 		JBrowse link
G MCM7 minichromosome maintenance complex component 7 involved_in NAS (PMID:30069701) ComplexPortal PMID:30069701 NCBI chr 7:100,092,728...100,101,397
Ensembl chr 7:100,092,728...100,101,940 		JBrowse link
G NBN nibrin involved_in TAS (PMID:9590181) UniProt PMID:9590181 NCBI chr 8:89,933,331...89,984,667
Ensembl chr 8:89,924,515...90,003,228 		JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator involved_in IBA
IMP		 (PMID:21873635)
(PMID:20116089)		 GO_Central
UniProt		 PMID:20116089 PMID:21873635 NCBI chr15:89,575,469...89,628,023
Ensembl chr15:89,575,469...89,631,056 		JBrowse link
G WRNIP1 WRN helicase interacting protein 1 involved_in IDA (PMID:15670210) UniProt PMID:15670210 NCBI chr 6:2,765,393...2,786,952
Ensembl chr 6:2,765,393...2,786,952 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19600
    metabolic process 12946
      organic substance metabolic process 12475
        macromolecule metabolic process 10287
          nucleic acid metabolic process 3021
            DNA metabolic process 1125
              DNA replication initiation 38
                cell cycle DNA replication initiation + 5
                negative regulation of DNA-templated DNA replication initiation + 0
                positive regulation of DNA-templated DNA replication initiation + 2
                regulation of DNA-templated DNA replication initiation + 15
Path 2
Term Annotations click to browse term
  biological_process 19600
    metabolic process 12946
      cellular metabolic process 7995
        heterocycle metabolic process 3814
          nucleobase-containing compound metabolic process 3613
            nucleic acid metabolic process 3021
              DNA metabolic process 1125
                DNA replication 306
                  DNA-templated DNA replication 172
                    DNA replication initiation 38
                      cell cycle DNA replication initiation + 5
                      negative regulation of DNA-templated DNA replication initiation + 0
                      positive regulation of DNA-templated DNA replication initiation + 2
                      regulation of DNA-templated DNA replication initiation + 15
paths to the root