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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA replication initiation
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Accession:GO:0006270 term browser browse the term
Definition:The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
Synonyms:exact_synonym: DNA-dependent DNA replication initiation
 narrow_synonym: DNA endoreduplication initiation;   DNA re-replication initiation
 alt_id: GO:0042024


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DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccne1 cyclin E1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2675473 (MGI:2673102|PMID:12941272)
Ensembl
RGD
PMID:12941272 GO_REF:0000107 MGI:2673102 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 acts_upstream_of_or_within ISO MGI:2675474 (MGI:2673102|PMID:12941272) RGD PMID:12941272 MGI:2673102 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cdc45 cell division cycle 45 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdc6 cell division cycle 6 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Gmnc geminin coiled-coil domain containing involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:77,237,033...77,247,723
Ensembl chr11:77,239,098...77,246,315
JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:77,224,218...77,245,486
Ensembl chr17:77,224,112...77,246,478
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 involved_in ISO (PMID:16899510) RGD PMID:16899510 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Noc3l NOC3-like DNA replication regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:257,469,538...257,498,844
Ensembl chr 1:257,469,538...257,498,844
JBrowse link
G Orc1 origin recognition complex, subunit 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:128,186,651...128,212,901
Ensembl chr 5:128,190,708...128,210,445
JBrowse link
G Orc3 origin recognition complex, subunit 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:50,019,159...50,075,533
Ensembl chr 5:50,020,815...50,075,454
JBrowse link
G Orc4 origin recognition complex, subunit 4 involved_in ISO
IBA
ISS
(PMID:9353276)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:9353276, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 3:33,034,913...33,075,833
Ensembl chr 3:33,037,034...33,075,685
JBrowse link
G Orc5 origin recognition complex, subunit 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:9,160,050...9,223,998
Ensembl chr 4:9,160,067...9,223,997
JBrowse link
G Orc6 origin recognition complex, subunit 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:27,457,541...27,464,804
Ensembl chr19:27,457,474...27,464,805
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit involved_in ISS
ISO
GO_REF:0000024
(PMID:2175912)
UniProt
RGD
PMID:2175912 GO_REF:0000024 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:221,297,417...221,321,601
Ensembl chr 1:221,273,538...221,321,570
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:111,790,655...111,835,224
Ensembl chr 8:111,790,678...111,827,151
JBrowse link
mitotic DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gins3 GINS complex subunit 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:9,835,113...9,843,649
Ensembl chr19:9,835,057...9,843,673
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
positive regulation of DNA-dependent DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk2 cyclin dependent kinase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1920234 (MGI:4439421|PMID:20215406)
Ensembl
RGD
PMID:20215406 GO_REF:0000107 MGI:4439421 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Ciz1 CDKN1A interacting zinc finger protein 1 acts_upstream_of_or_within ISO MGI:104772 (MGI:3513706|PMID:15585571), (MGI:4439421|PMID:20215406) RGD PMID:15585571 PMID:20215406 MGI:3513706 MGI:4439421 NCBI chr 3:11,392,046...11,409,218
Ensembl chr 3:11,392,791...11,410,180
JBrowse link
regulation of DNA-dependent DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO
IBA
(PMID:11125146)
(MGI:2388867|PMID:12192004)
PMID:21873635
RGD PMID:11125146 PMID:12192004, PMID:21873635 MGI:2388867, RGD:13792537 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Kat7 lysine acetyltransferase 7 involved_in ISO
ISS
IEA
(PMID:26620551)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:26620551 GO_REF:0000024 GO_REF:0000107 NCBI chr10:83,095,067...83,128,342
Ensembl chr10:83,095,068...83,128,297
JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator involved_in ISO
IBA
(PMID:20116089)
PMID:21873635
RGD PMID:20116089, PMID:21873635 RGD:13792537 NCBI chr 1:141,391,738...141,433,615
Ensembl chr 1:141,391,262...141,433,109
JBrowse link
G Wdr18 WD repeat domain 18 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:12,561,318...12,569,120
Ensembl chr 7:12,561,324...12,569,143
JBrowse link
G Wrnip1 WRN helicase interacting protein 1 involved_in ISO
IEA
ISS
(PMID:15670210)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15670210 GO_REF:0000024 GO_REF:0000107 NCBI chr17:32,933,395...32,953,641
Ensembl chr17:32,933,396...32,953,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      cellular metabolic process 10755
        cellular macromolecule metabolic process 8243
          DNA metabolic process 882
            DNA replication initiation 29
              cell cycle DNA replication initiation + 5
              negative regulation of DNA-dependent DNA replication initiation + 0
              positive regulation of DNA-dependent DNA replication initiation + 2
              regulation of DNA-dependent DNA replication initiation + 7
Path 2
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      organic substance metabolic process 11337
        organic substance biosynthetic process 6028
          macromolecule biosynthetic process 5089
            cellular macromolecule biosynthetic process 5048
              DNA replication 254
                DNA-dependent DNA replication 152
                  DNA replication initiation 29
                    cell cycle DNA replication initiation + 5
                    negative regulation of DNA-dependent DNA replication initiation + 0
                    positive regulation of DNA-dependent DNA replication initiation + 2
                    regulation of DNA-dependent DNA replication initiation + 7
paths to the root