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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA replication initiation
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Accession:GO:0006270 term browser browse the term
Definition:The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
Synonyms:exact_synonym: DNA-dependent DNA replication initiation
 narrow_synonym: DNA endoreduplication initiation;   DNA re-replication initiation
 alt_id: GO:0042024


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DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC129365.1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 2:141,551,434...141,554,016 JBrowse link
G Ccne1 cyclin E1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2675473 (MGI:2673102|PMID:12941272)		 Ensembl
RGD		 PMID:12941272 GO_REF:0000107 MGI:2673102 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccne2 cyclin E2 acts_upstream_of_or_within ISO MGI:2675474 (MGI:2673102|PMID:12941272) RGD PMID:12941272 MGI:2673102 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cdc45 cell division cycle 45 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619 		JBrowse link
G Cdc6 cell division cycle 6 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor involved_in ISO
IBA		 (PMID:32865517)
PMID:21873635		 RGD PMID:32865517 PMID:21873635 RGD:13792537 NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 involved_in ISO (PMID:16899510) RGD PMID:16899510 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063 		JBrowse link
G Noc3l NOC3-like DNA replication regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:236,556,037...236,585,372
Ensembl chr 1:236,556,789...236,585,318 		JBrowse link
G Orc1 origin recognition complex, subunit 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375 		JBrowse link
G Orc3 origin recognition complex, subunit 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:49,123,758...49,181,552
Ensembl chr 5:49,126,955...49,181,633 		JBrowse link
G Orc4 origin recognition complex, subunit 4 involved_in ISO
IBA
ISS		 (PMID:9353276)
PMID:21873635
GO_REF:0000024		 RGD
UniProt		 PMID:9353276 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 3:33,290,844...33,334,022
Ensembl chr 3:33,294,355...33,333,824 		JBrowse link
G Orc5 origin recognition complex, subunit 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:12,548,007...12,612,611
Ensembl chr 4:12,548,007...12,612,568 		JBrowse link
G Orc6 origin recognition complex, subunit 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:21,757,867...21,765,638
Ensembl chr19:21,757,866...21,765,662 		JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit involved_in ISS
ISO		 GO_REF:0000024
GO_REF:0000114
(MGI:3687659|PMID:10523676)
(PMID:2175912), (PMID:26975377)		 UniProt
ComplexPortal
RGD		 PMID:2175912 PMID:10523676 PMID:26975377 GO_REF:0000024 GO_REF:0000114 MGI:3687659 NCBI chr  X:58,034,617...58,348,612
Ensembl chr  X:58,034,619...58,348,536 		JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit involved_in ISO
IBA
IEA		 (PMID:26975377)
GO_REF:0000114
PMID:21873635
GO_REF:0000107
(MGI:3687659|PMID:10523676)		 RGD
ComplexPortal
Ensembl		 PMID:10523676 PMID:26975377 PMID:21873635 GO_REF:0000107 GO_REF:0000114 MGI:3687659, RGD:13792537 NCBI chr 1:203,227,183...203,251,350
Ensembl chr 1:203,203,388...203,251,348 		JBrowse link
G Prim1 DNA primase subunit 1 involved_in ISO (PMID:26975377)
(MGI:3687659|PMID:10523676)		 RGD PMID:10523676 PMID:26975377 MGI:3687659 NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526 		JBrowse link
G Prim2 DNA primase subunit 2 involved_in ISO (PMID:26975377)
GO_REF:0000114
(MGI:3687659|PMID:10523676)		 RGD
ComplexPortal		 PMID:10523676 PMID:26975377 GO_REF:0000114 MGI:3687659 NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:35,692,376...35,903,030 		JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674 		JBrowse link
mitotic DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gins3 GINS complex subunit 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Mcm4 minichromosome maintenance complex component 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144 		JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit involved_in IBA
IEA		 PMID:21873635
GO_REF:0000002		 InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr  X:58,034,617...58,348,612
Ensembl chr  X:58,034,619...58,348,536 		JBrowse link
positive regulation of DNA-templated DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk2 cyclin dependent kinase 2 acts_upstream_of_or_within ISO MGI:1920234 (MGI:4439421|PMID:20215406) RGD PMID:20215406 MGI:4439421 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Ciz1 CDKN1A interacting zinc finger protein 1 acts_upstream_of_or_within ISO MGI:104772 (MGI:3513706|PMID:15585571), (MGI:4439421|PMID:20215406) RGD PMID:15585571 PMID:20215406 MGI:3513706 MGI:4439421 NCBI chr 3:15,658,479...15,675,716
Ensembl chr 3:15,658,539...15,673,762 		JBrowse link
regulation of DNA-templated DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO
IBA		 (PMID:11125146)
PMID:21873635
(MGI:2388867|PMID:12192004)		 RGD PMID:11125146 PMID:12192004 PMID:21873635 MGI:2388867, RGD:13792537 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659 		JBrowse link
G Gmnn geminin, DNA replication inhibitor involved_in ISO (PMID:24064211) RGD PMID:24064211 NCBI chr17:40,301,771...40,310,054
Ensembl chr17:40,301,808...40,310,054 		JBrowse link
G Kat7 lysine acetyltransferase 7 involved_in ISO
ISS		 (PMID:26620551)
GO_REF:0000024		 RGD
UniProt		 PMID:26620551 GO_REF:0000024 NCBI chr10:80,221,519...80,255,590
Ensembl chr10:80,221,524...80,255,567 		JBrowse link
G Mcidas multiciliate differentiation and DNA synthesis associated cell cycle protein involved_in ISO
IEA		 (PMID:24064211)
GO_REF:0000107		 RGD
Ensembl		 PMID:24064211 GO_REF:0000107 NCBI chr 2:44,636,581...44,643,730
Ensembl chr 2:44,636,856...44,642,601 		JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator involved_in ISO
IBA		 (PMID:20116089)
PMID:21873635		 RGD PMID:20116089 PMID:21873635 RGD:13792537 NCBI chr 1:133,597,618...133,639,513
Ensembl chr 1:133,597,716...133,639,523 		JBrowse link
G Wrnip1 WRN helicase interacting protein 1 involved_in ISO
IEA
ISS		 (PMID:15670210)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:15670210 GO_REF:0000024 GO_REF:0000107 NCBI chr17:31,621,410...31,641,659
Ensembl chr17:31,621,411...31,641,659 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19748
    metabolic process 12047
      organic substance metabolic process 11599
        macromolecule metabolic process 9961
          nucleic acid metabolic process 5130
            DNA metabolic process 1020
              DNA replication initiation 32
                cell cycle DNA replication initiation + 5
                negative regulation of DNA-templated DNA replication initiation + 0
                positive regulation of DNA-templated DNA replication initiation + 2
                regulation of DNA-templated DNA replication initiation + 8
Path 2
Term Annotations click to browse term
  biological_process 19748
    metabolic process 12047
      cellular metabolic process 9535
        heterocycle metabolic process 5771
          nucleobase-containing compound metabolic process 5616
            nucleic acid metabolic process 5130
              DNA metabolic process 1020
                DNA replication 278
                  DNA-templated DNA replication 158
                    DNA replication initiation 32
                      cell cycle DNA replication initiation + 5
                      negative regulation of DNA-templated DNA replication initiation + 0
                      positive regulation of DNA-templated DNA replication initiation + 2
                      regulation of DNA-templated DNA replication initiation + 8
paths to the root