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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding



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DNA topological change term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:25,189,644...25,224,381
Ensembl chr15:25,189,663...25,228,066
JBrowse link
G HMGB2 high mobility group box 2 involved_in IDA (PMID:11275566) AgBase PMID:11275566 NCBI chr14:16,709,966...16,712,288
Ensembl chr14:16,710,047...16,717,101
JBrowse link
G TOP1 DNA topoisomerase I acts_upstream_of_or_within
involved_in
ISO
IBA
IEA
(PMID:16261531), (PMID:7842491) RGD
MGI
GO_Central
UniProt
InterPro
PMID:1332866 PMID:7842491 PMID:16261531 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 RGD:1580856 NCBI chr17:43,710,270...43,799,700
Ensembl chr17:43,710,290...43,799,700
JBrowse link
G TOP1MT DNA topoisomerase I mitochondrial involved_in IEA
IBA
UniProt
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr 4:1,134,179...1,188,149
Ensembl chr 4:1,148,890...1,188,130
JBrowse link
G TOP2A DNA topoisomerase II alpha acts_upstream_of_or_within
involved_in
ISO
IEA
ISS
(PMID:1331984), (PMID:9224616) RGD
MGI
InterPro
UniProt
Ensembl
PMID:1331984 PMID:9224616 PMID:11334111 GO_REF:0000002 GO_REF:0000024 GO_REF:0000104 GO_REF:0000107 RGD:1580614 NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450
JBrowse link
G TOP2B DNA topoisomerase II beta involved_in IEA Ensembl
InterPro
UniProt
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chr13:12,507,738...12,575,042
Ensembl chr13:12,507,138...12,575,583
JBrowse link
G TOP3A DNA topoisomerase III alpha involved_in IEA
IBA
InterPro
GO_Central
Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr12:60,443,592...60,468,968
Ensembl chr12:60,443,677...60,468,964
JBrowse link
G TOP3B DNA topoisomerase III beta involved_in IEA
IBA
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr14:50,020,412...50,037,854
Ensembl chr14:50,020,509...50,037,856
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18954
    cellular process 18495
      metabolic process 11730
        macromolecule metabolic process 9815
          nucleic acid metabolic process 5821
            DNA metabolic process 907
              DNA topological change 8
Path 2
Term Annotations click to browse term
  biological_process 18954
    cellular process 18495
      metabolic process 11730
        primary metabolic process 10388
          nucleobase-containing compound metabolic process 6336
            nucleic acid metabolic process 5821
              DNA metabolic process 907
                DNA topological change 8
paths to the root