ONTOLOGY REPORT - ANNOTATIONS
Term: DNA topological change
Accession: GO:0006265
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Definition: The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment: Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms: narrow_synonym: DNA underwinding
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ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr15:25,189,644...25,224,381
Ensembl chr15:25,189,663...25,228,066
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HMGB2
high mobility group box 2
involved_in
IDA
(PMID:11275566)
AgBase
PMID:11275566
NCBI chr14:16,709,966...16,712,288
Ensembl chr14:16,710,047...16,717,101
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TOP1
DNA topoisomerase I
acts_upstream_of_or_within involved_in
ISO IBA IEA
(PMID:16261531), (PMID:7842491)
RGD MGI GO_Central UniProt InterPro
PMID:1332866 PMID:7842491 PMID:16261531
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 RGD:1580856
NCBI chr17:43,710,270...43,799,700
Ensembl chr17:43,710,290...43,799,700
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TOP1MT
DNA topoisomerase I mitochondrial
involved_in
IEA IBA
UniProt InterPro GO_Central
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104
NCBI chr 4:1,134,179...1,188,149
Ensembl chr 4:1,148,890...1,188,130
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TOP2A
DNA topoisomerase II alpha
acts_upstream_of_or_within involved_in
ISO IEA ISS
(PMID:1331984), (PMID:9224616)
RGD MGI InterPro UniProt Ensembl
PMID:1331984 PMID:9224616 PMID:11334111
GO_REF:0000002 GO_REF:0000024 GO_REF:0000104 GO_REF:0000107 RGD:1580614
NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450
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TOP2B
DNA topoisomerase II beta
involved_in
IEA
Ensembl InterPro UniProt
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107
NCBI chr13:12,507,738...12,575,042
Ensembl chr13:12,507,138...12,575,583
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TOP3A
DNA topoisomerase III alpha
involved_in
IEA IBA
InterPro GO_Central Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr12:60,443,592...60,468,968
Ensembl chr12:60,443,677...60,468,964
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TOP3B
DNA topoisomerase III beta
involved_in
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr14:50,020,412...50,037,854
Ensembl chr14:50,020,509...50,037,856
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