ONTOLOGY REPORT - ANNOTATIONS
Term: DNA topological change
Accession: GO:0006265
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Definition: The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment: Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms: narrow_synonym: DNA underwinding
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ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr10:2,926,410...2,963,802
Ensembl chr10:2,926,350...2,963,823
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HMGB2
high mobility group box 2
involved_in
ISO
(PMID:11275566)
AgBase
PMID:11275566
NCBI chr 7:119,440,089...119,442,806
Ensembl chr 7:119,440,468...119,443,578
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LOC103237562
DNA topoisomerase I mitochondrial
involved_in
IEA
UniProt TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118
NCBI chr 8:137,523,739...137,574,672
Ensembl chr 8:137,523,955...137,552,407
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TOP1
DNA topoisomerase I
involved_in acts_upstream_of_or_within
ISO IEA
(PMID:16261531), (PMID:7842491)
RGD TreeGrafter MGI Ensembl InterPro UniProt
PMID:1332866 PMID:7842491 PMID:16261531
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1580856
NCBI chr 2:22,655,085...22,751,082
Ensembl chr 2:22,651,995...22,751,102
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TOP2A
DNA topoisomerase II alpha
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:1331984), (PMID:9224616)
RGD MGI UniProt Ensembl InterPro
PMID:1331984 PMID:9224616 PMID:11334111
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 RGD:1580614
NCBI chr16:65,761,391...65,792,041
Ensembl chr16:65,761,416...65,792,701
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TOP2B
DNA topoisomerase II beta
involved_in
IEA
Ensembl InterPro UniProt
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107
NCBI chr15:70,266,267...70,332,079
Ensembl chr15:70,266,601...70,332,824
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TOP3A
DNA topoisomerase III alpha
involved_in
IEA
InterPro TreeGrafter Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr16:17,315,466...17,358,863
Ensembl chr16:17,316,048...17,358,580
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TOP3B
DNA topoisomerase III beta
involved_in
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr19:4,137,823...4,163,860
Ensembl chr19:4,137,862...4,166,436
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