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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding


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DNA topological change term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:2,926,410...2,963,802
Ensembl chr10:2,926,350...2,963,823
JBrowse link
G HMGB2 high mobility group box 2 involved_in ISO (PMID:11275566) AgBase PMID:11275566 NCBI chr 7:119,440,089...119,442,806
Ensembl chr 7:119,440,468...119,443,578
JBrowse link
G LOC103237562 DNA topoisomerase I mitochondrial involved_in IEA UniProt
TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr 8:137,523,739...137,574,672
Ensembl chr 8:137,523,955...137,552,407
JBrowse link
G TOP1 DNA topoisomerase I involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:16261531), (PMID:7842491) RGD
TreeGrafter
MGI
Ensembl
InterPro
UniProt
PMID:1332866 PMID:7842491 PMID:16261531 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1580856 NCBI chr 2:22,655,085...22,751,082
Ensembl chr 2:22,651,995...22,751,102
JBrowse link
G TOP2A DNA topoisomerase II alpha acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:1331984), (PMID:9224616) RGD
MGI
UniProt
Ensembl
InterPro
PMID:1331984 PMID:9224616 PMID:11334111 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 RGD:1580614 NCBI chr16:65,761,391...65,792,041
Ensembl chr16:65,761,416...65,792,701
JBrowse link
G TOP2B DNA topoisomerase II beta involved_in IEA Ensembl
InterPro
UniProt
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chr15:70,266,267...70,332,079
Ensembl chr15:70,266,601...70,332,824
JBrowse link
G TOP3A DNA topoisomerase III alpha involved_in IEA InterPro
TreeGrafter
Ensembl
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr16:17,315,466...17,358,863
Ensembl chr16:17,316,048...17,358,580
JBrowse link
G TOP3B DNA topoisomerase III beta involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chr19:4,137,823...4,163,860
Ensembl chr19:4,137,862...4,166,436
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19829
    cellular process 19347
      metabolic process 13137
        macromolecule metabolic process 11160
          nucleic acid metabolic process 6833
            DNA metabolic process 926
              DNA topological change 8
Path 2
Term Annotations click to browse term
  biological_process 19829
    cellular process 19347
      metabolic process 13137
        primary metabolic process 11566
          nucleobase-containing compound metabolic process 7370
            nucleic acid metabolic process 6833
              DNA metabolic process 926
                DNA topological change 8
paths to the root