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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding



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DNA topological change term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:32,983,492...33,020,492
Ensembl chr2B:127,922,483...127,959,372
JBrowse link
G HMGB2 high mobility group box 2 involved_in ISO (PMID:11275566) AgBase PMID:11275566 NCBI chr 4:165,559,848...165,562,625
Ensembl chr 4:177,797,457...177,800,952
JBrowse link
G TOP1 DNA topoisomerase I involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:16261531), (PMID:7842491) RGD
TreeGrafter
MGI
Ensembl
UniProt
InterPro
PMID:1332866 PMID:7842491 PMID:16261531 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1580856 NCBI chr20:37,368,606...37,464,649
Ensembl chr20:38,468,452...38,562,652
JBrowse link
G TOP1MT DNA topoisomerase I mitochondrial involved_in IEA UniProt
TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr 8:140,056,468...140,106,510 JBrowse link
G TOP2A DNA topoisomerase II alpha acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:1331984), (PMID:9224616) RGD
MGI
Ensembl
UniProt
InterPro
PMID:1331984 PMID:9224616 PMID:11334111 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 RGD:1580614 NCBI chr17:16,872,169...16,901,605
Ensembl chr17:17,097,778...17,126,207
JBrowse link
G TOP2B DNA topoisomerase II beta involved_in IEA UniProt
InterPro
Ensembl
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chr 3:25,499,239...25,566,029
Ensembl chr 3:25,828,879...25,896,912
JBrowse link
G TOP3A DNA topoisomerase III alpha involved_in IEA Ensembl
InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr17:32,814,448...32,858,076
Ensembl chr17:37,897,037...37,936,135
JBrowse link
G TOP3B DNA topoisomerase III beta involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chr22:4,076,295...4,102,086
Ensembl chr22:20,557,248...20,583,464
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19317
    cellular process 18871
      metabolic process 12822
        macromolecule metabolic process 10908
          nucleic acid metabolic process 6631
            DNA metabolic process 903
              DNA topological change 8
Path 2
Term Annotations click to browse term
  biological_process 19317
    cellular process 18871
      metabolic process 12822
        primary metabolic process 11236
          nucleobase-containing compound metabolic process 7154
            nucleic acid metabolic process 6631
              DNA metabolic process 903
                DNA topological change 8
paths to the root