ONTOLOGY REPORT - ANNOTATIONS
Term: DNA topological change
Accession: GO:0006265
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Definition: The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment: Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms: narrow_synonym: DNA underwinding
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ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr2B:32,983,492...33,020,492
Ensembl chr2B:127,922,483...127,959,372
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HMGB2
high mobility group box 2
involved_in
ISO
(PMID:11275566)
AgBase
PMID:11275566
NCBI chr 4:165,559,848...165,562,625
Ensembl chr 4:177,797,457...177,800,952
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TOP1
DNA topoisomerase I
involved_in acts_upstream_of_or_within
ISO IEA
(PMID:16261531), (PMID:7842491)
RGD TreeGrafter MGI Ensembl UniProt InterPro
PMID:1332866 PMID:7842491 PMID:16261531
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1580856
NCBI chr20:37,368,606...37,464,649
Ensembl chr20:38,468,452...38,562,652
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TOP1MT
DNA topoisomerase I mitochondrial
involved_in
IEA
UniProt TreeGrafter InterPro
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118
NCBI chr 8:140,056,468...140,106,510
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TOP2A
DNA topoisomerase II alpha
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:1331984), (PMID:9224616)
RGD MGI Ensembl UniProt InterPro
PMID:1331984 PMID:9224616 PMID:11334111
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 RGD:1580614
NCBI chr17:16,872,169...16,901,605
Ensembl chr17:17,097,778...17,126,207
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TOP2B
DNA topoisomerase II beta
involved_in
IEA
UniProt InterPro Ensembl
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107
NCBI chr 3:25,499,239...25,566,029
Ensembl chr 3:25,828,879...25,896,912
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TOP3A
DNA topoisomerase III alpha
involved_in
IEA
Ensembl InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr17:32,814,448...32,858,076
Ensembl chr17:37,897,037...37,936,135
G
TOP3B
DNA topoisomerase III beta
involved_in
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr22:4,076,295...4,102,086
Ensembl chr22:20,557,248...20,583,464
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