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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding


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DNA topological change term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit involved_in ISO (PMID:8663148) RGD PMID:8663148 NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329 		JBrowse link
G Hmgb2 high mobility group box 2 involved_in ISO
ISS		 (PMID:11275566)
GO_REF:0000024		 RGD
AgBase		 PMID:11275566 GO_REF:0000024 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140 		JBrowse link
G Hmgb2l1 high mobility group box 2-like 1 involved_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr11:47,252,583...47,253,646
Ensembl chr11:47,252,569...47,253,669 		JBrowse link
G RGD1559962 similar to High mobility group protein 2 (HMG-2) involved_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 1:19,409,285...19,410,183
Ensembl chr 1:19,409,539...19,410,168 		JBrowse link
G Top1 DNA topoisomerase I acts_upstream_of_or_within
involved_in		 IDA
ISO
IEA
IBA		 (MGI:3612364|PMID:16261531), (MGI:70738|PMID:7842491)
GO_REF:0000104
PMID:21873635
(PMID:14594810), (PMID:14654701), (PMID:8567649), (PMID:8631793), (PMID:8631794), (PMID:9611241)		 RGD
UniProt		 PMID:7842491 PMID:8567649 PMID:8631793 PMID:8631794 PMID:9611241 More... GO_REF:0000104 MGI:3612364 MGI:70738, RGD:1580856, RGD:13792537 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623 		JBrowse link
G Top1mt DNA topoisomerase I mitochondrial involved_in IEA
IBA		 GO_REF:0000104
PMID:21873635		 UniProt PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr 7:107,338,092...107,368,125
Ensembl chr 7:107,342,527...107,366,049 		JBrowse link
G Top2a DNA topoisomerase II alpha acts_upstream_of_or_within
involved_in		 IDA
ISO
IEA		 (MGI:51613|PMID:1331984), (MGI:895157|PMID:9224616)
(PMID:12711669), (PMID:22323612)
GO_REF:0000104		 RGD
UniProt		 PMID:1331984 PMID:9224616 PMID:12711669 PMID:22323612 PMID:11334111 GO_REF:0000104 MGI:51613 MGI:895157, RGD:1580614 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Top2b DNA topoisomerase II beta involved_in ISO (PMID:10684600) RGD PMID:10684600 NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085 		JBrowse link
G Top3a DNA topoisomerase III alpha involved_in ISO
IBA		 (PMID:20445207)
PMID:21873635		 RGD PMID:20445207 PMID:21873635 RGD:13792537 NCBI chr10:45,419,219...45,457,356
Ensembl chr10:45,419,217...45,457,559 		JBrowse link
G Top3b DNA topoisomerase III beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:84,097,018...84,125,474
Ensembl chr11:84,097,026...84,125,392 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    metabolic process 11458
      cellular metabolic process 9697
        cellular macromolecule metabolic process 3403
          DNA metabolic process 992
            DNA topological change 10
Path 2
Term Annotations click to browse term
  biological_process 18734
    metabolic process 11458
      cellular metabolic process 9697
        cellular nitrogen compound metabolic process 6417
          nucleobase-containing compound metabolic process 5335
            nucleic acid metabolic process 4844
              DNA metabolic process 992
                DNA topological change 10
paths to the root