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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding


show annotations for term's descendants           Sort by:
DNA topological change term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit involved_in ISO (PMID:8663148) RGD PMID:8663148 NCBI chr18:24,157,831...24,188,543
Ensembl chr18:24,148,084...24,190,898 		JBrowse link
G Hmgb2 high mobility group box 2 involved_in ISO
ISS 		(PMID:11275566)
GO_REF:0000024 		RGD
AgBase		 PMID:11275566 GO_REF:0000024 NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860 		JBrowse link
G Hmgb2l1 high mobility group box 2-like 1 involved_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr11:60,721,545...60,722,608
Ensembl chr11:60,721,444...60,723,088 		JBrowse link
G Hmgb2l2 high mobility group box 2 like 2 involved_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr14:73,258,013...73,258,780
Ensembl chr14:73,183,379...73,258,876 		JBrowse link
G Top1 DNA topoisomerase I involved_in
acts_upstream_of_or_within 		IDA
ISO
IBA
IEA 		(PMID:14594810), (PMID:14654701), (PMID:8567649), (PMID:8631793), (PMID:8631794), (PMID:9611241)
GO_REF:0000033
(PMID:16261531), (PMID:7842491)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000104
GO_REF:0000117 		RGD
GO_Central
Ensembl
InterPro
UniProt		 PMID:7842491 PMID:8567649 PMID:8631793 PMID:8631794 PMID:9611241 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117, RGD:1580856 NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:169,713,130...169,796,327 		JBrowse link
G Top1mt DNA topoisomerase I mitochondrial involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000002
GO_REF:0000117
GO_REF:0000104 		GO_Central
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000117 NCBI chr 7:109,223,269...109,248,855
Ensembl chr 7:109,139,527...109,246,799 		JBrowse link
G Top2a DNA topoisomerase II alpha acts_upstream_of_or_within
involved_in 		IDA
ISO
IEA 		(PMID:1331984), (PMID:9224616)
(PMID:22323612)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000104 		RGD
InterPro
Ensembl
UniProt		 PMID:1331984 PMID:9224616 PMID:22323612 PMID:11334111 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107, RGD:1580614 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Top2b DNA topoisomerase II beta involved_in ISO
IEA 		(PMID:10684600)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000104 		RGD
Ensembl
InterPro
UniProt		 PMID:10684600 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chr15:11,482,089...11,542,464
Ensembl chr15:11,482,089...11,542,464 		JBrowse link
G Top3a DNA topoisomerase III alpha involved_in ISO
IBA
IEA 		(PMID:20445207)
GO_REF:0000033
GO_REF:0000002
GO_REF:0000107 		RGD
GO_Central
InterPro
Ensembl		 PMID:20445207 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr10:45,915,625...45,956,856
Ensembl chr10:45,915,625...45,956,856 		JBrowse link
G Top3b DNA topoisomerase III beta involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr11:97,601,223...97,629,678
Ensembl chr11:97,601,231...97,629,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      metabolic process 12252
        macromolecule metabolic process 10074
          nucleic acid metabolic process 5331
            DNA metabolic process 1000
              DNA topological change 10
Path 2
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      metabolic process 12252
        primary metabolic process 10845
          nucleobase-containing compound metabolic process 5964
            nucleic acid metabolic process 5331
              DNA metabolic process 1000
                DNA topological change 10
paths to the root