Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:DNA topological change
go back to main search page
Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding

show annotations for term's descendants           Sort by:
 
DNA topological change term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit involved_in ISO (PMID:8663148) RGD PMID:8663148 NCBI chr18:25,037,668...25,068,380
Ensembl chr18:25,037,625...25,068,389 		JBrowse link
G Hmgb2 high mobility group box 2 involved_in ISO
ISS		 (PMID:11275566)
GO_REF:0000024		 RGD
AgBase		 PMID:11275566 GO_REF:0000024 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191 		JBrowse link
G Hmgb2l1 high mobility group box 2-like 1 involved_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr11:49,708,038...49,709,128
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191 		JBrowse link
G RGD1559962 similar to High mobility group protein 2 (HMG-2) involved_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 1:20,416,735...20,417,959
Ensembl chr 1:20,417,008...20,417,637 		JBrowse link
G Top1 DNA topoisomerase I acts_upstream_of_or_within
involved_in		 IDA
ISO
IEA
IBA		 (MGI:3612364|PMID:16261531), (MGI:70738|PMID:7842491)
GO_REF:0000104
PMID:21873635
(PMID:14594810), (PMID:14654701), (PMID:8567649), (PMID:8631793), (PMID:8631794), (PMID:9611241)		 RGD
UniProt		 PMID:7842491 PMID:8567649 PMID:8631793 PMID:8631794 PMID:9611241 PMID:14594810 PMID:14654701 PMID:16261531, PMID:1332866, PMID:21873635 GO_REF:0000104 MGI:3612364 MGI:70738, RGD:1580856, RGD:13792537 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686 		JBrowse link
G Top1mt DNA topoisomerase I mitochondrial involved_in IEA
IBA		 GO_REF:0000104
PMID:21873635		 UniProt PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr 7:116,688,801...116,714,421
Ensembl chr 7:116,688,701...116,712,387 		JBrowse link
G Top2a DNA topoisomerase II alpha acts_upstream_of_or_within
involved_in		 IDA
ISO
IEA		 (MGI:51613|PMID:1331984), (MGI:895157|PMID:9224616)
(PMID:12711669), (PMID:22323612)
GO_REF:0000104		 RGD
UniProt		 PMID:1331984 PMID:9224616 PMID:12711669 PMID:22323612, PMID:11334111 GO_REF:0000104 MGI:51613 MGI:895157, RGD:1580614 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154 		JBrowse link
G Top2b DNA topoisomerase II beta involved_in ISO (PMID:10684600) RGD PMID:10684600 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233 		JBrowse link
G Top3a DNA topoisomerase III alpha involved_in ISO
IBA		 (PMID:20445207)
PMID:21873635		 RGD PMID:20445207, PMID:21873635 RGD:13792537 NCBI chr10:46,980,646...47,018,728
Ensembl chr10:46,981,958...47,018,537 		JBrowse link
G Top3b DNA topoisomerase III beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:88,346,305...88,374,896
Ensembl chr11:88,346,313...88,374,679 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      cellular metabolic process 10755
        cellular macromolecule metabolic process 8243
          DNA metabolic process 882
            DNA topological change 10
Path 2
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      cellular metabolic process 10755
        cellular nitrogen compound metabolic process 6601
          nucleobase-containing compound metabolic process 5420
            nucleic acid metabolic process 4930
              DNA metabolic process 882
                DNA topological change 10
paths to the root