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ONTOLOGY REPORT - ANNOTATIONS


Term:mitochondrial DNA replication
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Accession:GO:0006264 term browser browse the term
Definition:The process in which new strands of DNA are synthesized in the mitochondrion.
Synonyms:exact_synonym: mtDNA replication;   replication of mitochondrial DNA
 related_synonym: mitochondrial DNA synthesis;   mtDNA synthesis
 only_in_taxon: NCBITaxon:2759 ! Eukaryota



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mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 acts_upstream_of_or_within ISO MGI:2182091|MGI:3040717 (MGI:3612004|PMID:16327803) RGD PMID:16327803 MGI:3612004 NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161
JBrowse link
G Mgme1 mitochondrial genome maintenance exonuclease 1 involved_in ISO
IBA
(PMID:23313956)
GO_REF:0000033
RGD
GO_Central
PMID:23313956 GO_REF:0000033 NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit acts_upstream_of_or_within
involved_in
ISO
IBA
IEA
MGI:3584444 (MGI:3583846|PMID:15888483)
GO_REF:0000033
(MGI:6212950|PMID:26095671)
GO_REF:0000107
(PMID:19837034), (PMID:26554610)
RGD
GO_Central
Ensembl
PMID:15888483 PMID:19837034 PMID:26095671 PMID:26554610 GO_REF:0000033 GO_REF:0000107 MGI:3583846 MGI:6212950 NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567
JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:19837034)
GO_REF:0000033
MGI:5470227 (MGI:5465384|PMID:23197651)
RGD
GO_Central
PMID:19837034 PMID:23197651 GO_REF:0000033 MGI:5465384 NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008
JBrowse link
G Primpol primase and DNA directed polymerase involved_in ISO
IBA
(PMID:24207056)
GO_REF:0000033
(MGI:5527006|PMID:24207056)
RGD
GO_Central
PMID:24207056 GO_REF:0000033 MGI:5527006 NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565
JBrowse link
G Rnaseh1 ribonuclease H1 acts_upstream_of_or_within ISO MGI:2655784 (MGI:2655010|PMID:12667461) RGD PMID:12667461 MGI:2655010 NCBI chr 6:45,282,849...45,292,258
Ensembl chr 6:45,282,854...45,292,236
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 involved_in ISO (PMID:17486094)
(MGI:3714223|PMID:17486094)
RGD PMID:17486094 MGI:3714223 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B acts_upstream_of_or_within
involved_in
ISO MGI:2672883 (MGI:3714223|PMID:17486094)
(PMID:17486094)
RGD PMID:17486094 MGI:3714223 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
JBrowse link
G Slc25a16 solute carrier family 25 member 16 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,691,474...25,717,558
Ensembl chr20:25,662,055...25,716,319
JBrowse link
G Ssbp1 single stranded DNA binding protein 1 involved_in IEA
IBA
GO_REF:0000118
GO_REF:0000033
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135
JBrowse link
G Tefm transcription elongation factor, mitochondrial NOT|involved_in ISO (PMID:21278163) RGD PMID:21278163 NCBI chr10:65,119,657...65,124,233
Ensembl chr10:65,119,659...65,124,486
JBrowse link
G Tk2 thymidine kinase 2 acts_upstream_of_or_within ISO MGI:3802583 (MGI:3801405|PMID:18434326) RGD PMID:18434326 MGI:3801405 NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924
JBrowse link
G Twnk twinkle mtDNA helicase involved_in ISO
IBA
(PMID:18971204)
GO_REF:0000033
(MGI:3826298|PMID:18971204)
RGD
GO_Central
PMID:18971204 GO_REF:0000033 MGI:3826298 NCBI chr 1:243,867,568...243,874,802
Ensembl chr 1:243,868,330...243,874,802
JBrowse link
negative regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg7 autophagy related 7 IMP RGD PMID:23800874 RGD:11557986 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Lig3 DNA ligase 3 involved_in ISO (PMID:21878356) RGD PMID:21878356 NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414
JBrowse link
positive regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endog endonuclease G involved_in ISO (PMID:29719607) RGD PMID:29719607 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Mtnap1 mitochondrial nucleoid associated protein 1 involved_in ISO (MGI:7564184|PMID:37676315) RGD PMID:37676315 MGI:7564184 NCBI chr10:98,728,661...98,738,693
Ensembl chr10:98,727,763...98,738,691
JBrowse link
G Ssbp1 single stranded DNA binding protein 1 involved_in ISO
ISS
IEA
(PMID:31550240)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:31550240 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135
JBrowse link
regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mettl4 methyltransferase 4, N6-adenosine involved_in ISO (PMID:32183942) RGD PMID:32183942 NCBI chr 9:111,440,976...111,523,871
Ensembl chr 9:111,441,027...111,464,749
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20295
    metabolic process 11722
      primary metabolic process 10273
        nucleobase-containing compound metabolic process 5702
          nucleic acid metabolic process 5109
            DNA metabolic process 984
              mitochondrial DNA metabolic process 28
                mitochondrial DNA replication 19
                  DNA synthesis involved in mitochondrial DNA replication 0
                  kinetoplast DNA replication 0
                  negative regulation of mitochondrial DNA replication 2
                  positive regulation of mitochondrial DNA replication 3
                  regulation of mitochondrial DNA replication + 6
Path 2
Term Annotations click to browse term
  biological_process 20295
    cellular process 18772
      cellular metabolic process 10283
        cellular aromatic compound metabolic process 5944
          nucleobase-containing compound metabolic process 5702
            nucleic acid metabolic process 5109
              DNA metabolic process 984
                DNA replication 272
                  DNA-templated DNA replication 156
                    mitochondrial DNA replication 19
                      DNA synthesis involved in mitochondrial DNA replication 0
                      kinetoplast DNA replication 0
                      negative regulation of mitochondrial DNA replication 2
                      positive regulation of mitochondrial DNA replication 3
                      regulation of mitochondrial DNA replication + 6
paths to the root