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ONTOLOGY REPORT - ANNOTATIONS

Term:purine nucleobase metabolic process
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Accession:GO:0006144 term browser browse the term
Definition:The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
Synonyms:exact_synonym: purine base metabolic process;   purine base metabolism
 narrow_synonym: purine metabolic process;   purine metabolism

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purine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936529:5,661,772...5,723,108
Ensembl chrNW_004936529:5,661,702...5,725,363 		JBrowse link
G Adk adenosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936521:4,560,078...5,023,780
Ensembl chrNW_004936521:4,557,971...5,023,800 		JBrowse link
G Gmpr guanosine monophosphate reductase involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936552:2,458,728...2,496,145
Ensembl chrNW_004936552:2,458,698...2,497,191 		JBrowse link
G Gmpr2 guanosine monophosphate reductase 2 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936722:323,917...330,648 JBrowse link
G LOC101955123 GMP reductase 2-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936633:2,678,654...2,680,171 JBrowse link
G LOC101958661 5-hydroxyisourate hydrolase-like involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 NCBI chrNW_004937382:33,496...36,920 JBrowse link
G LOC101960605 5-hydroxyisourate hydrolase-like involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 NCBI chrNW_004936641:89,784...92,738 JBrowse link
G LOC101966455 uricase involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936608:1,213,940...1,232,214 JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936499:7,114,838...7,136,468
Ensembl chrNW_004936499:7,115,780...7,136,449 		JBrowse link
G Ttr transthyretin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936682:1,628,489...1,635,495
Ensembl chrNW_004936682:1,628,341...1,635,566 		JBrowse link
G Urad ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936472:23,151,674...23,161,292 JBrowse link
adenine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936500:8,750,928...8,782,303
Ensembl chrNW_004936500:8,753,463...8,786,236 		JBrowse link
adenine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aprt adenine phosphoribosyltransferase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8643571), (PMID:8894695)
(PMID:8894695)		 Ensembl
MGI		 PMID:8643571 PMID:8894695 GO_REF:0000107 NCBI chrNW_004936641:913,674...916,312
Ensembl chrNW_004936641:913,475...918,748 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8894695) Ensembl
MGI		 PMID:8894695 GO_REF:0000107 NCBI chrNW_004936691:650,753...694,362
Ensembl chrNW_004936691:652,769...694,463 		JBrowse link
adenine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aprt adenine phosphoribosyltransferase involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936641:913,674...916,312
Ensembl chrNW_004936641:913,475...918,748 		JBrowse link
GMP catabolic process to guanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nt5c2 5'-nucleotidase, cytosolic II involved_in ISO (PMID:5560407) MGI PMID:5560407 NCBI chrNW_004936600:2,828,277...2,892,795 JBrowse link
guanine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gda guanine deaminase involved_in IEA InterPro
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 NCBI chrNW_004936503:8,191,925...8,279,806
Ensembl chrNW_004936503:8,192,049...8,278,790 		JBrowse link
G LOC101966455 uricase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936608:1,213,940...1,232,214 JBrowse link
G Urad ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:23,151,674...23,161,292 JBrowse link
G Xdh xanthine dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936493:1,762,814...1,824,501
Ensembl chrNW_004936493:1,762,869...1,823,238 		JBrowse link
guanine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gda guanine deaminase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936503:8,191,925...8,279,806
Ensembl chrNW_004936503:8,192,049...8,278,790 		JBrowse link
G Kdm1a lysine demethylase 1A ISO RGD PMID:20418916 RGD:9588315 NCBI chrNW_004936474:8,262,913...8,319,089
Ensembl chrNW_004936474:8,262,885...8,319,092 		JBrowse link
guanine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hprt1 hypoxanthine phosphoribosyltransferase 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936691:650,753...694,362
Ensembl chrNW_004936691:652,769...694,463 		JBrowse link
G Prtfdc1 phosphoribosyl transferase domain containing 1 NOT|involved_in ISO
IEA		 (PMID:21054786) UniProt
TreeGrafter		 PMID:21054786 GO_REF:0000118 NCBI chrNW_004936484:568,056...650,820
Ensembl chrNW_004936484:566,543...650,896 		JBrowse link
hypoxanthine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within ISO (PMID:10720488) MGI PMID:10720488 NCBI chrNW_004936530:2,217,713...2,224,070 JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936499:7,114,838...7,136,468
Ensembl chrNW_004936499:7,115,780...7,136,449 		JBrowse link
hypoxanthine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101966455 uricase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936608:1,213,940...1,232,214 JBrowse link
G Urad ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:23,151,674...23,161,292 JBrowse link
G Xdh xanthine dehydrogenase involved_in ISO
IEA		 RGD
Ensembl		 PMID:232638 GO_REF:0000107 RGD:13210503 NCBI chrNW_004936493:1,762,814...1,824,501
Ensembl chrNW_004936493:1,762,869...1,823,238 		JBrowse link
hypoxanthine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hprt1 hypoxanthine phosphoribosyltransferase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10037486)
(PMID:3029599)		 RGD
MGI
TreeGrafter
Ensembl		 PMID:3029599 PMID:6206848 PMID:10037486 GO_REF:0000107 GO_REF:0000118 RGD:1580844 NCBI chrNW_004936691:650,753...694,362
Ensembl chrNW_004936691:652,769...694,463 		JBrowse link
G Prtfdc1 phosphoribosyl transferase domain containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936484:568,056...650,820
Ensembl chrNW_004936484:566,543...650,896 		JBrowse link
hypoxanthine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936530:2,217,713...2,224,070 JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936691:650,753...694,362
Ensembl chrNW_004936691:652,769...694,463 		JBrowse link
G LOC101972479 adenosine deaminase-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936530:2,034,514...2,041,099 JBrowse link
purine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chrNW_004936500:8,750,928...8,782,303
Ensembl chrNW_004936500:8,753,463...8,786,236 		JBrowse link
G LOC101961407 phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936482:18,649,093...18,664,629
Ensembl chrNW_004936482:18,626,015...18,667,164 		JBrowse link
G Ppat phosphoribosyl pyrophosphate amidotransferase involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936482:18,606,124...18,648,989
Ensembl chrNW_004936482:18,606,124...18,648,681 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936741:1,849,239...1,877,724
Ensembl chrNW_004936741:1,849,609...1,877,727 		JBrowse link
purine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpyd dihydropyrimidine dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936537:1,660,461...2,439,305
Ensembl chrNW_004936537:1,660,477...2,439,273 		JBrowse link
G LOC101966455 uricase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936608:1,213,940...1,232,214 JBrowse link
xanthine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within ISO (PMID:10720488) MGI PMID:10720488 NCBI chrNW_004936530:2,217,713...2,224,070 JBrowse link
xanthine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101966455 uricase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936608:1,213,940...1,232,214 JBrowse link
G Urad ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:23,151,674...23,161,292 JBrowse link
G Xdh xanthine dehydrogenase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936493:1,762,814...1,824,501
Ensembl chrNW_004936493:1,762,869...1,823,238 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    metabolic process 9630
      small molecule metabolic process 1637
        nucleobase-containing small molecule metabolic process 583
          nucleobase metabolic process 41
            purine nucleobase metabolic process 25
              adenine metabolic process + 3
              guanine metabolic process + 8
              hypoxanthine metabolic process + 8
              negative regulation of purine nucleobase metabolic process 0
              positive regulation of purine nucleobase metabolic process 0
              purine nucleobase biosynthetic process + 10
              purine nucleobase catabolic process + 5
              regulation of purine nucleobase metabolic process + 0
              xanthine metabolic process + 4
Path 2
Term Annotations click to browse term
  biological_process 15969
    metabolic process 9630
      organic substance metabolic process 9204
        organic cyclic compound metabolic process 5206
          nucleobase-containing compound metabolic process 4756
            nucleobase-containing small molecule metabolic process 583
              nucleobase metabolic process 41
                purine nucleobase metabolic process 25
                  adenine metabolic process + 3
                  guanine metabolic process + 8
                  hypoxanthine metabolic process + 8
                  negative regulation of purine nucleobase metabolic process 0
                  positive regulation of purine nucleobase metabolic process 0
                  purine nucleobase biosynthetic process + 10
                  purine nucleobase catabolic process + 5
                  regulation of purine nucleobase metabolic process + 0
                  xanthine metabolic process + 4
paths to the root