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ONTOLOGY REPORT - ANNOTATIONS

Term:glycerol-3-phosphate shuttle
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Accession:GO:0006127 term browser browse the term
Definition:The process of transferring reducing equivalents from NADH in the cytosol into the mitochondria via glycerol-3-phosphate. Cytosolic glycerol-3-phosphate dehydrogenase uses NADH to convert dihydroxyacetone phosphate (DHAP) to glycerol-3-phosphate (G3P) in the cytosol; G3P then diffuses into the mitochondria where mitochondrial glycerol-3-phosphate dehydrogenase uses FAD to convert G3P back to DHAP; the electrons on the reduced FADH2 are then available for use in the electron transport chain, and DHAP returns to the cytosol to complete the cycle.
Synonyms:exact_synonym: glycerol phosphate shuttle;   glycerophosphate shuttle
 xref: MetaCyc:PWY-6118

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glycerol-3-phosphate shuttle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpd1 glycerol-3-phosphate dehydrogenase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11147825) Ensembl
MGI		 PMID:11147825 GO_REF:0000107 NCBI chrNW_004936512:7,762,325...7,770,007
Ensembl chrNW_004936512:7,762,643...7,770,309 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 involved_in ISO (PMID:9974390) MGI PMID:9974390 NCBI chrNW_004936469:21,705,421...21,833,143
Ensembl chrNW_004936469:21,705,421...21,831,745 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17413
    cellular process 17016
      metabolic process 11317
        purine-containing compound metabolic process 506
          purine nucleotide metabolic process 379
            NAD metabolic process 63
              NADH metabolic process 41
                NADH oxidation 15
                  glycerol-3-phosphate shuttle 2
Path 2
Term Annotations click to browse term
  biological_process 17413
    cellular process 17016
      metabolic process 11317
        primary metabolic process 10066
          nucleobase-containing compound metabolic process 6200
            nucleobase-containing small molecule metabolic process 601
              nucleoside phosphate metabolic process 575
                nucleotide metabolic process 437
                  pyridine nucleotide metabolic process 178
                    nicotinamide nucleotide metabolic process 178
                      NAD metabolic process 63
                        NADH metabolic process 41
                          NADH oxidation 15
                            glycerol-3-phosphate shuttle 2
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