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ONTOLOGY REPORT - ANNOTATIONS

Term:glycerol-3-phosphate shuttle
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Accession:GO:0006127 term browser browse the term
Definition:The process of transferring reducing equivalents from NADH in the cytosol into the mitochondria via glycerol-3-phosphate. Cytosolic glycerol-3-phosphate dehydrogenase uses NADH to convert dihydroxyacetone phosphate (DHAP) to glycerol-3-phosphate (G3P) in the cytosol; G3P then diffuses into the mitochondria where mitochondrial glycerol-3-phosphate dehydrogenase uses FAD to convert G3P back to DHAP; the electrons on the reduced FADH2 are then available for use in the electron transport chain, and DHAP returns to the cytosol to complete the cycle.
Synonyms:exact_synonym: glycerol phosphate shuttle;   glycerophosphate shuttle
 xref: MetaCyc:PWY-6118

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glycerol-3-phosphate shuttle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpd1 glycerol-3-phosphate dehydrogenase 1 acts_upstream_of_or_within
involved_in		 ISO (PMID:11147825)
(PMID:25603051)		 MGI PMID:11147825 PMID:25603051 NCBI chrNW_004624816:2,203,731...2,211,006
Ensembl chrNW_004624816:2,203,731...2,210,509 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 involved_in ISO (PMID:9974390) MGI PMID:9974390 NCBI chrNW_004624732:9,298,156...9,447,883 JBrowse link
Term paths to the root
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Term Annotations click to browse term
  biological_process 17640
    cellular process 17222
      metabolic process 11022
        purine-containing compound metabolic process 505
          purine nucleotide metabolic process 377
            NAD metabolic process 61
              NADH metabolic process 42
                NADH oxidation 16
                  glycerol-3-phosphate shuttle 2
Path 2
Term Annotations click to browse term
  biological_process 17640
    cellular process 17222
      metabolic process 11022
        primary metabolic process 9867
          nucleobase-containing compound metabolic process 5892
            nucleobase-containing small molecule metabolic process 603
              nucleoside phosphate metabolic process 574
                nucleotide metabolic process 438
                  pyridine nucleotide metabolic process 174
                    nicotinamide nucleotide metabolic process 174
                      NAD metabolic process 61
                        NADH metabolic process 42
                          NADH oxidation 16
                            glycerol-3-phosphate shuttle 2
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