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ONTOLOGY REPORT - ANNOTATIONS

Term:glycerol-3-phosphate shuttle
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Accession:GO:0006127 term browser browse the term
Definition:The process of transferring reducing equivalents from NADH in the cytosol into the mitochondria via glycerol-3-phosphate. Cytosolic glycerol-3-phosphate dehydrogenase uses NADH to convert dihydroxyacetone phosphate (DHAP) to glycerol-3-phosphate (G3P) in the cytosol; G3P then diffuses into the mitochondria where mitochondrial glycerol-3-phosphate dehydrogenase uses FAD to convert G3P back to DHAP; the electrons on the reduced FADH2 are then available for use in the electron transport chain, and DHAP returns to the cytosol to complete the cycle.
Synonyms:exact_synonym: glycerol phosphate shuttle;   glycerophosphate shuttle
 xref: MetaCyc:PWY-6118


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glycerol-3-phosphate shuttle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPD1 glycerol-3-phosphate dehydrogenase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11147825) Ensembl
MGI		 PMID:11147825 GO_REF:0000107 NCBI chr27:4,614,878...4,622,013
Ensembl chr27:4,614,864...4,621,922 		JBrowse link
G GPD2 glycerol-3-phosphate dehydrogenase 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr36:2,678,749...2,780,173
Ensembl chr36:2,681,188...2,777,535 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22103
    cellular process 21633
      metabolic process 15381
        purine-containing compound metabolic process 604
          purine nucleotide metabolic process 472
            NAD metabolic process 64
              NADH metabolic process 43
                NADH oxidation 16
                  glycerol-3-phosphate shuttle 2
Path 2
Term Annotations click to browse term
  biological_process 22103
    cellular process 21633
      metabolic process 15381
        primary metabolic process 13982
          nucleobase-containing compound metabolic process 9611
            nucleobase-containing small molecule metabolic process 704
              nucleoside phosphate metabolic process 672
                nucleotide metabolic process 532
                  pyridine nucleotide metabolic process 210
                    nicotinamide nucleotide metabolic process 210
                      NAD metabolic process 64
                        NADH metabolic process 43
                          NADH oxidation 16
                            glycerol-3-phosphate shuttle 2
paths to the root