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ONTOLOGY REPORT - ANNOTATIONS

Term:glycerol-3-phosphate shuttle
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Accession:GO:0006127 term browser browse the term
Definition:The process of transferring reducing equivalents from NADH in the cytosol into the mitochondria via glycerol-3-phosphate. Cytosolic glycerol-3-phosphate dehydrogenase uses NADH to convert dihydroxyacetone phosphate (DHAP) to glycerol-3-phosphate (G3P) in the cytosol; G3P then diffuses into the mitochondria where mitochondrial glycerol-3-phosphate dehydrogenase uses FAD to convert G3P back to DHAP; the electrons on the reduced FADH2 are then available for use in the electron transport chain, and DHAP returns to the cytosol to complete the cycle.
Synonyms:exact_synonym: glycerol phosphate shuttle;   glycerophosphate shuttle
 xref: MetaCyc:PWY-6118

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glycerol-3-phosphate shuttle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpd1 glycerol-3-phosphate dehydrogenase 1 acts_upstream_of_or_within
involved_in		 ISO (PMID:11147825)
(PMID:25603051)		 MGI PMID:11147825 PMID:25603051 NCBI chrNW_004955547:676,661...683,906
Ensembl chrNW_004955547:676,342...690,777 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 involved_in ISO (PMID:9974390) MGI PMID:9974390 NCBI chrNW_004955449:16,695,855...16,804,184
Ensembl chrNW_004955449:16,695,435...16,802,908 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12563
    cellular process 12002
      metabolic process 7932
        purine-containing compound metabolic process 416
          purine nucleotide metabolic process 315
            NAD metabolic process 52
              NADH metabolic process 36
                NADH oxidation 13
                  glycerol-3-phosphate shuttle 2
Path 2
Term Annotations click to browse term
  biological_process 12563
    cellular process 12002
      metabolic process 7932
        primary metabolic process 6950
          nucleobase-containing compound metabolic process 3907
            nucleobase-containing small molecule metabolic process 490
              nucleoside phosphate metabolic process 466
                nucleotide metabolic process 360
                  pyridine nucleotide metabolic process 160
                    nicotinamide nucleotide metabolic process 160
                      NAD metabolic process 52
                        NADH metabolic process 36
                          NADH oxidation 13
                            glycerol-3-phosphate shuttle 2
paths to the root