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ONTOLOGY REPORT - ANNOTATIONS

Term:2-oxoglutarate metabolic process
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Accession:GO:0006103 term browser browse the term
Definition:The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
Synonyms:exact_synonym: 2-ketoglutarate metabolic process;   2-ketoglutarate metabolism;   2-oxoglutarate metabolism;   alpha-ketoglutarate metabolic process;   alpha-ketoglutarate metabolism;   alpha-oxoglutarate metabolic process;   alpha-oxoglutarate metabolism
 xref: Reactome:R-HSA-2978092 "Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate";   Reactome:R-HSA-880009 "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"


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2-oxoglutarate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase involved_in ISO
ISS 		(PMID:18620547)
GO_REF:0000024 		RGD
UniProt		 PMID:18620547 GO_REF:0000024 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332 		JBrowse link
G AC132020.1 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 Ensembl chr 9:76,367,193...76,367,615 JBrowse link
G Col6a1 collagen type VI alpha 1 chain acts_upstream_of_or_within ISO
IEA 		MGI:2153356 (PMID:23437220)
GO_REF:0000107 		RGD
Ensembl		 PMID:23437220 GO_REF:0000107 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597 		JBrowse link
G Dld dihydrolipoamide dehydrogenase involved_in IDA
IBA 		GO_REF:0000033 GO_Central
RGD		 PMID:3571202 GO_REF:0000033, RGD:2306876 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase involved_in IDA
ISO 		(PMID:10806400) RGD PMID:10806400 PMID:3571202 RGD:2306876 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
G ENSRNOG00000069392 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 6:132,462,789...132,465,038 JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr19:9,180,428...9,206,113
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 involved_in ISO (PMID:11863375) RGD PMID:11863375 NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 involved_in ISO
ISS
IDA
IEA 		(PMID:19935646)
GO_REF:0000024
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:19935646 PMID:16489927 GO_REF:0000024 GO_REF:0000107, RGD:13504861 NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Kgd4 alpha-ketoglutarate dehydrogenase subunit 4 involved_in ISO
IBA
IEA 		(PMID:25165143), (PMID:36854377)
GO_REF:0000033
GO_REF:0000002 		RGD
GO_Central
InterPro		 PMID:25165143 PMID:36854377 GO_REF:0000002 GO_REF:0000033 NCBI chr 2:31,870,549...31,878,335
Ensembl chr 2:31,870,551...31,880,730 		JBrowse link
G Kyat3 kynurenine aminotransferase 3 involved_in ISO (PMID:19029248) RGD PMID:19029248 NCBI chr 2:231,701,881...231,747,462
Ensembl chr 2:231,701,963...231,747,227 		JBrowse link
G Ogdh oxoglutarate dehydrogenase involved_in IDA
ISO
IEA 		(PMID:24495017), (PMID:29211711)
GO_REF:0000107 		RGD
Ensembl		 PMID:24495017 PMID:29211711 PMID:3571202 PMID:9712727 GO_REF:0000107, RGD:2306876, RGD:2306877 NCBI chr14:85,363,949...85,431,405
Ensembl chr14:81,150,091...81,217,479 		JBrowse link
G Ogdhl oxoglutarate dehydrogenase L involved_in IDA PMID:18783430 UniProt PMID:18783430 RGD:42721998 NCBI chr16:7,578,343...7,604,385
Ensembl chr16:7,578,367...7,604,386 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase involved_in ISO
IEA 		(PMID:16186124)
GO_REF:0000107 		RGD
Ensembl		 PMID:16186124 GO_REF:0000107 NCBI chr17:78,238,747...78,255,645
Ensembl chr17:73,329,082...73,346,409 		JBrowse link
G Tat tyrosine aminotransferase involved_in ISO
IEA 		(PMID:7999802)
(PMID:21153519)
GO_REF:0000107 		RGD
Ensembl		 PMID:7999802 PMID:21153519 GO_REF:0000107 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        small molecule metabolic process 1944
          organic acid metabolic process 1062
            oxoacid metabolic process 1040
              carboxylic acid metabolic process 1025
                dicarboxylic acid metabolic process 113
                  2-oxoglutarate metabolic process 17
                    2-oxoglutarate decarboxylation to succinyl-CoA 0
                    L-arabinose catabolic process to 2-oxoglutarate 0
                    L-histidine catabolic process to 2-oxoglutarate 0
                    acetyl-CoA assimilation pathway 0
                    mixed acid fermentation 0
                    proline catabolic process to 2-oxoglutarate 0
paths to the root