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ONTOLOGY REPORT - ANNOTATIONS

Term:tricarboxylic acid cycle
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Accession:GO:0006099 term browser browse the term
Definition:A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
Synonyms:exact_synonym: Krebs cycle;   TCA cycle;   citric acid cycle
 xref: MetaCyc:P105-PWY;   MetaCyc:P42-PWY;   MetaCyc:TCA;   Wikipedia:Tricarboxylic_acid_cycle


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tricarboxylic acid cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 4933405O20Rikl RIKEN cDNA 4933405O20 gene like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:100,300,241...100,301,711 JBrowse link
G Acly ATP citrate lyase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Aco1 aconitase 1 involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Aco2 aconitase 2 involved_in
acts_upstream_of_or_within		 IDA
IEA
ISO
IBA		 GO_REF:0000041
(PMID:9630632)
GO_REF:0000033
MGI:88529 (PMID:32212192)		 UniProt
RGD
GO_Central		 PMID:9630632 PMID:32212192 PMID:9712727 GO_REF:0000033 GO_REF:0000041, RGD:2306877 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain acts_upstream_of_or_within ISO MGI:2153356 (PMID:23437220) RGD PMID:23437220 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597 		JBrowse link
G Cs citrate synthase involved_in IDA
IEA
IBA		 GO_REF:0000041
GO_REF:0000033		 UniProt
GO_Central
RGD		 PMID:9712727 GO_REF:0000033 GO_REF:0000041, RGD:2306877 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Dhtkd1 dehydrogenase E1 and transketolase domain containing 1 involved_in IEA GO_REF:0000002
GO_REF:0000118		 InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr17:72,355,201...72,406,725
Ensembl chr17:72,355,201...72,406,723 		JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase involved_in IC
IEA
ISO
ISS
IBA		 GO_REF:0000041
(PMID:30929736)
GO_REF:0000024
GO_REF:0000118
GO_REF:0000033		 UniProt
RGD
TreeGrafter
GO_Central		 PMID:30929736 PMID:9405249 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000118, RGD:1359804 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
G ENSRNOG00000067101 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr10:36,665,594...36,666,343 JBrowse link
G ENSRNOG00000069895 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 2:184,126,435...184,129,119 JBrowse link
G Fh fumarate hydratase involved_in IEA
IBA
ISO		 GO_REF:0000041
GO_REF:0000033
MGI:3710112 (PMID:22405071)		 UniProt
GO_Central
RGD		 PMID:22405071 GO_REF:0000033 GO_REF:0000041 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha involved_in ISO
IEA
IBA		 (PMID:2252888)
(PMID:14555658)
GO_REF:0000117
GO_REF:0000114
GO_REF:0000033		 RGD
UniProt
ComplexPortal
GO_Central		 PMID:2252888 PMID:14555658 GO_REF:0000033 GO_REF:0000114 GO_REF:0000117 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084 		JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta involved_in ISO
IEA
IBA		 (PMID:14555658)
GO_REF:0000117
GO_REF:0000114
GO_REF:0000033		 RGD
UniProt
ComplexPortal
GO_Central		 PMID:14555658 GO_REF:0000033 GO_REF:0000114 GO_REF:0000117 NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982 		JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma involved_in TAS
ISO
IEA
IBA		 (PMID:14555658)
GO_REF:0000117
GO_REF:0000114
GO_REF:0000033		 RGD
UniProt
ComplexPortal
GO_Central		 PMID:14555658 PMID:8240232 GO_REF:0000033 GO_REF:0000114 GO_REF:0000117, RGD:633073 NCBI chr  X:151,515,244...151,524,175
Ensembl chr  X:151,515,247...151,524,171 		JBrowse link
G Ireb2 iron responsive element binding protein 2 involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Kgd4 alpha-ketoglutarate dehydrogenase subunit 4 involved_in ISO (MGI:6810699|PMID:25165143) RGD PMID:25165143 MGI:6810699 NCBI chr 2:31,870,549...31,878,335
Ensembl chr 2:31,870,551...31,880,730 		JBrowse link
G Mdh1 malate dehydrogenase 1 involved_in IEA
IBA		 GO_REF:0000043
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000043 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Mdh1b malate dehydrogenase 1B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:65,120,370...65,168,008
Ensembl chr 9:65,119,029...65,167,933 		JBrowse link
G Mdh2 malate dehydrogenase 2 involved_in IEA
IBA
ISO		 GO_REF:0000043
GO_REF:0000033
(PMID:35063410)		 UniProt
GO_Central
RGD		 PMID:35063410 GO_REF:0000033 GO_REF:0000043 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271 		JBrowse link
G Ndp norrin cystine knot growth factor NDP acts_upstream_of_or_within ISO MGI:4414794 (PMID:30988181) RGD PMID:30988181 NCBI chr  X:5,796,487...5,820,934
Ensembl chr  X:5,796,487...5,820,934 		JBrowse link
G Ogdh oxoglutarate dehydrogenase involved_in IDA
IEA
IBA		 GO_REF:0000002
GO_REF:0000033
GO_REF:0000118		 InterPro
GO_Central
TreeGrafter
RGD		 PMID:9712727 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118, RGD:2306877 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479 		JBrowse link
G Ogdhl oxoglutarate dehydrogenase L involved_in IDA
IEA
IBA		 PMID:18783430
GO_REF:0000002
GO_REF:0000033
GO_REF:0000118		 InterPro
GO_Central
TreeGrafter		 PMID:18783430 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118, RGD:42721998 NCBI chr16:7,578,343...7,604,385
Ensembl chr16:7,578,367...7,604,386 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:229,872,300...229,873,848 JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500 		JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A involved_in IEA
NAS		 GO_REF:0000041
PMID:30030361		 UniProt PMID:30030361 GO_REF:0000041, RGD:151356635 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535 		JBrowse link
G Sdhaf2 succinate dehydrogenase complex assembly factor 2 involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:207,139,070...207,167,830
Ensembl chr 1:207,139,112...207,168,616 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B involved_in IEA
NAS		 GO_REF:0000041
PMID:30030361		 UniProt PMID:30030361 GO_REF:0000041, RGD:151356635 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
G Sdhc succinate dehydrogenase complex subunit C involved_in NAS
IEA		 PMID:30030361
GO_REF:0000043
GO_REF:0000002		 UniProt
InterPro		 PMID:30030361 GO_REF:0000002 GO_REF:0000043, RGD:151356635 NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253 		JBrowse link
G Sdhd succinate dehydrogenase complex subunit D involved_in ISO
IEA
NAS
IBA		 (PMID:9533030)
GO_REF:0000041
GO_REF:0000043
PMID:30030361
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:9533030 PMID:30030361 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043, RGD:151356635 NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238 		JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta involved_in IDA
IEA
IBA		 GO_REF:0000041
GO_REF:0000033		 UniProt
GO_Central
RGD		 PMID:17403370 GO_REF:0000033 GO_REF:0000041, RGD:2306915 NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138 		JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha involved_in IDA
IEA
IBA		 GO_REF:0000041
GO_REF:0000033		 UniProt
GO_Central
RGD		 PMID:17403370 GO_REF:0000033 GO_REF:0000041, RGD:2306915 NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600 		JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta involved_in IDA
IEA
IBA		 GO_REF:0000041
GO_REF:0000033		 UniProt
GO_Central
RGD		 PMID:17403370 GO_REF:0000033 GO_REF:0000041, RGD:2306915 NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      primary metabolic process 10352
        tricarboxylic acid cycle 36
          reductive tricarboxylic acid cycle 0
Path 2
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      cellular metabolic process 9901
        generation of precursor metabolites and energy 562
          energy derivation by oxidation of organic compounds 381
            cellular respiration 273
              aerobic respiration 220
                tricarboxylic acid cycle 36
                  reductive tricarboxylic acid cycle 0
paths to the root