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ONTOLOGY REPORT - ANNOTATIONS


Term:tricarboxylic acid cycle
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Accession:GO:0006099 term browser browse the term
Definition:A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
Synonyms:exact_synonym: Krebs cycle;   TCA cycle;   citric acid cycle
 xref: MIPS_funcat:02.10;   MetaCyc:P105-PWY;   MetaCyc:P42-PWY;   MetaCyc:TCA;   Wikipedia:Tricarboxylic_acid_cycle


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tricarboxylic acid cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aco1 aconitase 1 JBrowse link 5 56,425,076 56,481,218 RGD:13792537
G Aco2 aconitase 2 JBrowse link 7 123,102,493 123,145,608 RGD:2306877
RGD:13792537
RGD:1600115
RGD:1624291
G Cs citrate synthase JBrowse link 7 2,752,680 2,778,963 RGD:2306828
RGD:13792537
RGD:1600115
RGD:2306877
G Dhtkd1 dehydrogenase E1 and transketolase domain containing 1 JBrowse link 17 76,306,585 76,358,058 RGD:13792537
G Dlat dihydrolipoamide S-acetyltransferase JBrowse link 8 55,062,549 55,087,832 RGD:1600115
G Dlst dihydrolipoamide S-succinyltransferase JBrowse link 6 108,936,534 108,961,322 RGD:1359804
RGD:1600115
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:2306828
RGD:13792537
RGD:1600115
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 JBrowse link 9 71,882,108 71,911,645 RGD:1600115
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 JBrowse link 1 141,874,354 141,893,674 RGD:1600115
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha JBrowse link 8 59,164,601 59,183,899 RGD:2306828
RGD:13792537
RGD:1624291
RGD:1600115
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta JBrowse link 3 122,808,564 122,813,638 RGD:2306828
RGD:13792537
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma JBrowse link X 156,999,803 157,008,735 RGD:633073
RGD:13792537
RGD:1600115
RGD:2306828
G Ireb2 iron responsive element binding protein 2 JBrowse link 8 59,450,974 59,503,634 RGD:13792537
G LOC100125384 hypothetical protein LOC100125384 JBrowse link 1 105,935,449 105,936,919 RGD:13792537
G LOC103690168 probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial JBrowse link 1 106,404,925 106,410,154 RGD:13792537
G LOC103693780 2-oxoglutarate dehydrogenase, mitochondrial-like JBrowse link 14 86,599,906 86,614,963 RGD:13792537
G Mdh1 malate dehydrogenase 1 JBrowse link 14 106,378,349 106,393,642 RGD:13792537
G Mdh1b malate dehydrogenase 1B JBrowse link 9 70,403,612 70,450,204 RGD:13792537
G Mdh2 malate dehydrogenase 2 JBrowse link 12 23,941,451 23,954,406 RGD:2306828
RGD:13792537
G Ogdh oxoglutarate dehydrogenase JBrowse link 14 86,414,924 86,481,903 RGD:2306877
RGD:13792537
G Ogdhl oxoglutarate dehydrogenase-like JBrowse link 16 8,497,495 8,523,552 RGD:13792537
G Pdha1 pyruvate dehydrogenase E1 alpha 1 subunit JBrowse link X 37,329,779 37,343,410 RGD:1600115
G Pdha2 pyruvate dehydrogenase E1 alpha 2 subunit JBrowse link 2 246,736,449 246,737,997 RGD:1600115
G Pdhb pyruvate dehydrogenase E1 beta subunit JBrowse link 15 18,540,826 18,546,855 RGD:1600115
G Sdha succinate dehydrogenase complex flavoprotein subunit A JBrowse link 1 31,545,631 31,570,601 RGD:1600115
G Sdhaf2 succinate dehydrogenase complex assembly factor 2 JBrowse link 1 226,543,671 226,572,414 RGD:13792537
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:1600115
G Sdhc succinate dehydrogenase complex subunit C JBrowse link 13 89,498,047 89,518,979 RGD:1600115
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:1600115
RGD:13792537
RGD:1624291
G Sucla2 succinate-CoA ligase ADP-forming beta subunit JBrowse link 15 55,461,695 55,516,954 RGD:2306915
RGD:13792537
RGD:1600115
G Suclg1 succinate-CoA ligase, alpha subunit JBrowse link 4 101,181,315 101,210,692 RGD:2306915
RGD:13792537
RGD:1600115
G Suclg2 succinate-CoA ligase, GDP-forming, beta subunit JBrowse link 4 127,552,100 127,824,970 RGD:2306915
RGD:13792537
RGD:1600115

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Term Annotations click to browse term
  biological_process 18166
    metabolic process 10845
      primary metabolic process 9754
        tricarboxylic acid cycle 32
          reductive tricarboxylic acid cycle 0
Path 2
Term Annotations click to browse term
  biological_process 18166
    metabolic process 10845
      cellular metabolic process 9907
        generation of precursor metabolites and energy 436
          energy derivation by oxidation of organic compounds 256
            cellular respiration 167
              aerobic respiration 78
                tricarboxylic acid cycle 32
                  reductive tricarboxylic acid cycle 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.