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ONTOLOGY REPORT - ANNOTATIONS


Term:tricarboxylic acid cycle
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Accession:GO:0006099 term browser browse the term
Definition:A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
Synonyms:exact_synonym: Krebs cycle;   TCA cycle;   citric acid cycle
 xref: MetaCyc:P105-PWY;   MetaCyc:P42-PWY;   MetaCyc:TCA;   Wikipedia:Tricarboxylic_acid_cycle


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tricarboxylic acid cycle term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC141220.4 IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr17:76,306,649...76,374,507 JBrowse link
G Aco1 aconitase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Aco2 aconitase 2 IDA
IBA
IEA
ISO
PMID:21873635
GO_REF:0000041
(PMID:9630632)
UniProt
RGD
PMID:9630632, PMID:9712727, PMID:21873635 GO_REF:0000041, RGD:2306877, RGD:13792537 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Cs citrate synthase IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:938457, PMID:21873635, PMID:9712727 GO_REF:0000041, RGD:2306828, RGD:13792537, RGD:2306877 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Dhtkd1 dehydrogenase E1 and transketolase domain containing 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:76,306,585...76,358,058
Ensembl chr17:76,306,585...76,358,058
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 8:55,062,549...55,087,832
Ensembl chr 8:55,062,551...55,087,832
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase IC
IEA
ISS
ISO
GO_REF:0000041
GO_REF:0000024
(PMID:30929736)
UniProt
RGD
PMID:30929736, PMID:9405249 GO_REF:0000024, GO_REF:0000041, RGD:1359804 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803
JBrowse link
G Fh fumarate hydratase IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:938457, PMID:21873635 GO_REF:0000041, RGD:2306828, RGD:13792537 NCBI chr13:93,651,486...93,677,371
Ensembl chr13:93,651,484...93,677,377
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha IDA
IBA
ISO
IEA
PMID:21873635
(PMID:2252888)
GO_REF:0000104
RGD
UniProt
PMID:2252888, PMID:938457, PMID:21873635 GO_REF:0000104, RGD:2306828, RGD:13792537 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:938457, PMID:21873635 RGD:2306828, RGD:13792537 NCBI chr 3:122,808,564...122,813,638
Ensembl chr 3:122,808,564...122,813,583
JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma TAS
IBA
IEA
IDA
PMID:21873635
GO_REF:0000104
UniProt PMID:8240232, PMID:21873635, PMID:938457 GO_REF:0000104, RGD:633073, RGD:13792537, RGD:2306828 NCBI chr  X:156,999,803...157,008,735
Ensembl chr  X:156,999,826...157,008,733
JBrowse link
G Ireb2 iron responsive element binding protein 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G LOC100125384 hypothetical protein LOC100125384 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:105,935,449...105,936,919
Ensembl chr 1:106,405,002...106,406,469
JBrowse link
G LOC103690168 probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:106,404,925...106,410,154
Ensembl chr 1:106,405,002...106,406,469
JBrowse link
G LOC103693780 2-oxoglutarate dehydrogenase, mitochondrial-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:86,599,906...86,614,963
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Mdh1 malate dehydrogenase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:106,378,349...106,393,642
Ensembl chr14:106,378,942...106,393,670
JBrowse link
G Mdh1b malate dehydrogenase 1B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:70,403,612...70,450,204
Ensembl chr 9:70,404,093...70,450,170
JBrowse link
G Mdh2 malate dehydrogenase 2 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:938457, PMID:21873635 RGD:2306828, RGD:13792537 NCBI chr12:23,941,451...23,954,406
Ensembl chr12:23,941,448...23,954,431
JBrowse link
G Ogdh oxoglutarate dehydrogenase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:9712727, PMID:21873635 RGD:2306877, RGD:13792537 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Ogdhl oxoglutarate dehydrogenase L IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:8,497,495...8,523,552
Ensembl chr16:8,497,569...8,523,557
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr  X:37,329,779...37,343,410
Ensembl chr  X:37,329,779...37,343,410
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:246,736,449...246,737,997
Ensembl chr 2:246,736,459...246,737,997
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:18,540,826...18,546,855
Ensembl chr15:18,539,210...18,546,854
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:31,545,631...31,570,601
Ensembl chr 1:31,545,631...31,570,601
JBrowse link
G Sdhaf2 succinate dehydrogenase complex assembly factor 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:226,543,671...226,572,414
Ensembl chr 1:226,547,531...226,572,349
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:159,484,378...159,505,063
Ensembl chr 5:159,484,370...159,505,064
JBrowse link
G Sdhc succinate dehydrogenase complex subunit C IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:89,498,047...89,518,979
Ensembl chr13:89,498,048...89,518,939
JBrowse link
G Sdhd succinate dehydrogenase complex subunit D IEA
IBA
ISO
GO_REF:0000041
PMID:21873635
(PMID:9533030)
UniProt
RGD
PMID:9533030, PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 8:55,028,125...55,037,604
Ensembl chr 8:55,028,125...55,037,604
JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:17403370, PMID:21873635 GO_REF:0000041, RGD:2306915, RGD:13792537 NCBI chr15:55,461,695...55,516,954
Ensembl chr15:55,461,695...55,516,952
JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:17403370, PMID:21873635 GO_REF:0000041, RGD:2306915, RGD:13792537 NCBI chr 4:101,181,315...101,210,692
Ensembl chr 4:101,180,404...101,210,746
JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:17403370, PMID:21873635 GO_REF:0000041, RGD:2306915, RGD:13792537 NCBI chr 4:127,552,100...127,824,970
Ensembl chr 4:127,552,101...127,824,970
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      primary metabolic process 10920
        tricarboxylic acid cycle 33
          reductive tricarboxylic acid cycle 0
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      cellular metabolic process 11085
        generation of precursor metabolites and energy 508
          energy derivation by oxidation of organic compounds 266
            cellular respiration 177
              aerobic respiration 85
                tricarboxylic acid cycle 33
                  reductive tricarboxylic acid cycle 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.