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ONTOLOGY REPORT - ANNOTATIONS


Term:pentose-phosphate shunt
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Accession:GO:0006098 term browser browse the term
Definition:The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate).
Synonyms:exact_synonym: hexose monophosphate pathway;   pentose phosphate pathway
 xref: KEGG_PATHWAY:00030;   MetaCyc:PENTOSE-P-PWY;   Reactome:R-HSA-71336 "Pentose phosphate pathway (hexose monophosphate shunt), Homo sapiens";   Wikipedia:Pentose_phosphate_pathway


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pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pd glucose-6-phosphate dehydrogenase involved_in IDA
ISO
(PMID:2297768) RGD PMID:2297768, PMID:2843500 RGD:1599574 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) acts_upstream_of_or_within ISO (MGI:2668276|PMID:12831846) RGD PMID:12831846 MGI:2668276 NCBI chr 5:166,994,683...167,030,441
Ensembl chr 5:166,998,881...167,030,441
JBrowse link
G Kif1b kinesin family member 1B involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:165,994,803...166,133,497
Ensembl chr 5:165,938,576...166,133,491
JBrowse link
G Pgd phosphogluconate dehydrogenase involved_in IDA
ISS
GO_REF:0000024 UniProt PMID:2843500 GO_REF:0000024, RGD:1599574 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Pgls 6-phosphogluconolactonase involved_in ISO
IEA
(PMID:10518023)
GO_REF:0000041
RGD
UniProt
PMID:10518023 GO_REF:0000041 NCBI chr16:20,020,444...20,025,930
Ensembl chr16:20,020,444...20,025,930
JBrowse link
G Rpe ribulose-5-phosphate-3-epimerase involved_in IDA
ISO
(PMID:20923965) RGD PMID:20923965, PMID:2843500 RGD:1599574 NCBI chr 9:73,687,684...73,713,643
Ensembl chr 9:73,687,743...73,711,571
JBrowse link
G Rpia ribose 5-phosphate isomerase A IDA RGD PMID:2843500 RGD:1599574 NCBI chr 4:98,568,028...98,593,664
Ensembl chr 4:98,568,028...98,593,664
JBrowse link
G Taldo1 transaldolase 1 IDA RGD PMID:2843500 RGD:1599574 NCBI chr 1:214,375,555...214,385,886
Ensembl chr 1:214,375,515...214,385,885
JBrowse link
G Tkt transketolase involved_in IDA
IEA
ISO
GO_REF:0000107
(PMID:20667822)
Ensembl
RGD
PMID:20667822, PMID:2843500 GO_REF:0000107, RGD:1599574 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
negative regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 involved_in ISO (PMID:21336310) RGD PMID:21336310 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
pentose-phosphate shunt, non-oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpe ribulose-5-phosphate-3-epimerase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:3079759, PMID:21873635 RGD:1641816, RGD:13792537 NCBI chr 9:73,687,684...73,713,643
Ensembl chr 9:73,687,743...73,711,571
JBrowse link
G Rpia ribose 5-phosphate isomerase A involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:3079759, PMID:21873635 RGD:1641816, RGD:13792537 NCBI chr 4:98,568,028...98,593,664
Ensembl chr 4:98,568,028...98,593,664
JBrowse link
G Shpk sedoheptulokinase involved_in ISO (MGI:5428058|PMID:22682222) RGD PMID:22682222 MGI:5428058 NCBI chr10:59,765,328...59,789,676
Ensembl chr10:59,765,258...59,789,678
JBrowse link
G Taldo1 transaldolase 1 involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:8477719, PMID:21873635, PMID:3079759 RGD:1641803, RGD:13792537, RGD:1641816 NCBI chr 1:214,375,555...214,385,886
Ensembl chr 1:214,375,515...214,385,885
JBrowse link
G Tkt transketolase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:16116031, PMID:21873635, PMID:3079759 RGD:1580394, RGD:13792537, RGD:1641816 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
pentose-phosphate shunt, oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pd glucose-6-phosphate dehydrogenase involved_in IMP
ISO
(PMID:2420826) RGD PMID:2420826, PMID:9794092 RGD:1641793 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) involved_in ISO (PMID:18628520), (PMID:23132696) RGD PMID:18628520 PMID:23132696 NCBI chr 5:166,994,683...167,030,441
Ensembl chr 5:166,998,881...167,030,441
JBrowse link
G Pgd phosphogluconate dehydrogenase involved_in IMP
ISO
IBA
(PMID:3858849)
PMID:21873635
RGD PMID:3858849, PMID:9794092, PMID:21873635 RGD:1641793, RGD:13792537 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Pgls 6-phosphogluconolactonase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:971315, PMID:21873635 RGD:2311501, RGD:13792537 NCBI chr16:20,020,444...20,025,930
Ensembl chr16:20,020,444...20,025,930
JBrowse link
regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 IDA RGD PMID:16234247 RGD:1625062 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Pgam1 phosphoglycerate mutase 1 involved_in ISO (PMID:12189148) RGD PMID:12189148 NCBI chr 1:261,158,204...261,165,814
Ensembl chr 1:261,158,261...261,165,808
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase involved_in IBA
ISO
PMID:21873635
(PMID:25928429)
RGD PMID:25928429, PMID:21873635 RGD:13792537 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      NADP metabolic process 38
        NADPH regeneration 15
          pentose-phosphate shunt 14
            negative regulation of pentose-phosphate shunt 1
            pentose-phosphate shunt, non-oxidative branch 5
            pentose-phosphate shunt, oxidative branch 4
            positive regulation of pentose-phosphate shunt 0
            regulation of pentose-phosphate shunt + 4
Path 2
Term Annotations click to browse term
  biological_process 19491
    cellular process 18343
      cellular metabolic process 10755
        phosphorus metabolic process 2829
          phosphate-containing compound metabolic process 2807
            glucose 6-phosphate metabolic process 25
              pentose-phosphate shunt 14
                negative regulation of pentose-phosphate shunt 1
                pentose-phosphate shunt, non-oxidative branch 5
                pentose-phosphate shunt, oxidative branch 4
                positive regulation of pentose-phosphate shunt 0
                regulation of pentose-phosphate shunt + 4
paths to the root