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ONTOLOGY REPORT - ANNOTATIONS


Term:pentose-phosphate shunt
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Accession:GO:0006098 term browser browse the term
Definition:The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate).
Synonyms:exact_synonym: hexose monophosphate pathway;   pentose phosphate pathway
 xref: KEGG_PATHWAY:map00030;   MetaCyc:PENTOSE-P-PWY;   Reactome:R-HSA-71336 "Pentose phosphate pathway (hexose monophosphate shunt), Homo sapiens";   Wikipedia:Pentose_phosphate_pathway



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pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pd glucose-6-phosphate dehydrogenase involved_in IDA
ISO
(PMID:2297768) RGD PMID:2297768 PMID:2843500 RGD:1599574 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) acts_upstream_of_or_within ISO (MGI:2668276|PMID:12831846) RGD PMID:12831846 MGI:2668276 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
JBrowse link
G Kif1b kinesin family member 1B involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Pgd phosphogluconate dehydrogenase involved_in IDA
IEA
ISS
GO_REF:0000041
GO_REF:0000024
UniProt
RGD
PMID:2843500 GO_REF:0000024 GO_REF:0000041, RGD:1599574 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Pgls 6-phosphogluconolactonase involved_in ISO
IEA
(PMID:10518023)
GO_REF:0000041
RGD
UniProt
PMID:10518023 GO_REF:0000041 NCBI chr16:18,300,317...18,305,803
Ensembl chr16:18,300,317...18,305,803
JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 involved_in ISO (MGI:5602900|PMID:24855946) RGD PMID:24855946 MGI:5602900 NCBI chr  X:104,132,139...104,154,191
Ensembl chr  X:104,132,141...104,154,187
JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 involved_in ISO (MGI:5602900|PMID:24855946) RGD PMID:24855946 MGI:5602900 NCBI chr  X:26,975,915...27,013,184
Ensembl chr  X:26,976,061...27,013,181
JBrowse link
G Rbks ribokinase involved_in ISO (MGI:7261130|PMID:13405914) RGD PMID:13405914 MGI:7261130 NCBI chr 6:24,747,651...24,824,290
Ensembl chr 6:24,747,293...24,824,290
JBrowse link
G Rpe ribulose-5-phosphate-3-epimerase involved_in IDA
ISO
(MGI:7257768|PMID:5360673)
(PMID:20923965)
RGD PMID:5360673 PMID:20923965 PMID:2843500 MGI:7257768, RGD:1599574 NCBI chr 9:68,191,027...68,211,295
Ensembl chr 9:68,191,292...68,211,591
JBrowse link
G Rpia ribose 5-phosphate isomerase A involved_in IDA
ISO
(MGI:7257768|PMID:5360673) RGD PMID:5360673 PMID:2843500 MGI:7257768, RGD:1599574 NCBI chr 4:102,723,712...102,749,374
Ensembl chr 4:102,723,712...102,749,355
JBrowse link
G Taldo1 transaldolase 1 involved_in IDA
IEA
ISO
GO_REF:0000041
(MGI:3851036|PMID:19436114), (MGI:7257768|PMID:5360673), (MGI:7261130|PMID:13405914)
(MGI:7257768|PMID:5360673), (MGI:7261130|PMID:13405914)
UniProt
RGD
PMID:5360673 PMID:13405914 PMID:19436114 PMID:2843500 GO_REF:0000041 MGI:3851036 MGI:7257768 MGI:7261130, RGD:1599574 NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
JBrowse link
G Tkt transketolase involved_in IDA
IEA
ISO
GO_REF:0000107
(MGI:7257768|PMID:5360673), (MGI:7261130|PMID:13405914)
(PMID:20667822)
Ensembl
RGD
PMID:5360673 PMID:13405914 PMID:20667822 PMID:2843500 GO_REF:0000107 MGI:7257768 MGI:7261130, RGD:1599574 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
negative regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 involved_in ISO (PMID:21336310) RGD PMID:21336310 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
pentose-phosphate shunt, non-oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpe ribulose-5-phosphate-3-epimerase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:3079759 PMID:21873635 RGD:1641816, RGD:13792537 NCBI chr 9:68,191,027...68,211,295
Ensembl chr 9:68,191,292...68,211,591
JBrowse link
G Rpia ribose 5-phosphate isomerase A involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:3079759 PMID:21873635 RGD:1641816, RGD:13792537 NCBI chr 4:102,723,712...102,749,374
Ensembl chr 4:102,723,712...102,749,355
JBrowse link
G Shpk sedoheptulokinase involved_in ISO (MGI:5428058|PMID:22682222) RGD PMID:22682222 MGI:5428058 NCBI chr10:57,817,551...57,841,981
Ensembl chr10:57,817,629...57,841,980
JBrowse link
G Taldo1 transaldolase 1 involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:8477719 PMID:21873635 PMID:3079759 RGD:1641803, RGD:13792537, RGD:1641816 NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
JBrowse link
G Tkt transketolase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:16116031 PMID:21873635 PMID:3079759 RGD:1580394, RGD:13792537, RGD:1641816 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
pentose-phosphate shunt, oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pd glucose-6-phosphate dehydrogenase involved_in IMP
IBA
ISO
PMID:21873635
MGI:2182739 (MGI:5446538|PMID:22829586), (MGI:7257767|PMID:12466018)
(PMID:2420826)
RGD PMID:2420826 PMID:12466018 PMID:22829586 PMID:9794092 PMID:21873635 MGI:5446538 MGI:7257767, RGD:1641793, RGD:13792537 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) involved_in ISO
IBA
(PMID:18628520), (PMID:23132696)
PMID:21873635
RGD PMID:18628520 PMID:23132696 PMID:21873635 RGD:13792537 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
JBrowse link
G Pgd phosphogluconate dehydrogenase involved_in IMP
IBA
ISO
PMID:21873635
(MGI:7257767|PMID:12466018), (MGI:7257768|PMID:5360673), (MGI:7257880|PMID:7496990)
(PMID:3858849)
RGD PMID:3858849 PMID:5360673 PMID:7496990 PMID:12466018 PMID:9794092 More... MGI:7257767 MGI:7257768 MGI:7257880, RGD:1641793, RGD:13792537 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Pgls 6-phosphogluconolactonase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:971315 PMID:21873635 RGD:2311501, RGD:13792537 NCBI chr16:18,300,317...18,305,803
Ensembl chr16:18,300,317...18,305,803
JBrowse link
regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 IDA RGD PMID:16234247 RGD:1625062 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Pgam1 phosphoglycerate mutase 1 involved_in ISO (PMID:12189148) RGD PMID:12189148 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase involved_in ISO
IBA
(PMID:25928429)
PMID:21873635
RGD PMID:25928429 PMID:21873635 RGD:13792537 NCBI chr 4:159,927,138...159,946,094
Ensembl chr 4:159,927,139...159,946,029
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19876
    metabolic process 12192
      cellular metabolic process 10295
        generation of precursor metabolites and energy 541
          NADPH regeneration 20
            pentose-phosphate shunt 17
              negative regulation of pentose-phosphate shunt 1
              pentose-phosphate shunt, non-oxidative branch 5
              pentose-phosphate shunt, oxidative branch 4
              positive regulation of pentose-phosphate shunt 0
              regulation of pentose-phosphate shunt + 4
Path 2
Term Annotations click to browse term
  biological_process 19876
    metabolic process 12192
      organic substance metabolic process 11723
        organic cyclic compound metabolic process 6236
          nucleobase-containing compound metabolic process 5756
            nucleobase-containing small molecule metabolic process 691
              nucleoside phosphate metabolic process 617
                nucleotide metabolic process 607
                  pyridine nucleotide metabolic process 80
                    nicotinamide nucleotide metabolic process 80
                      NADP metabolic process 47
                        NADPH regeneration 20
                          pentose-phosphate shunt 17
                            negative regulation of pentose-phosphate shunt 1
                            pentose-phosphate shunt, non-oxidative branch 5
                            pentose-phosphate shunt, oxidative branch 4
                            positive regulation of pentose-phosphate shunt 0
                            regulation of pentose-phosphate shunt + 4
paths to the root