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ONTOLOGY REPORT - ANNOTATIONS


Term:lactate metabolic process
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Accession:GO:0006089 term browser browse the term
Definition:The chemical reactions and pathways involving lactate, the anion of lactic acid.
Synonyms:exact_synonym: 2-hydroxypropanoate metabolic process;   2-hydroxypropanoate metabolism;   alpha-hydroxypropionate metabolic process;   alpha-hydroxypropionate metabolism;   lactate metabolism



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lactate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386679 (MGI:3576386|PMID:15328538)
Ensembl
RGD
PMID:15328538 GO_REF:0000107 MGI:3576386 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Ldha lactate dehydrogenase A IDA RGD PMID:17447164 RGD:1624966 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Ldhb lactate dehydrogenase B IDA RGD PMID:17447164 RGD:1624966 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
JBrowse link
G Mrs2 magnesium transporter MRS2 IMP RGD PMID:21253565 RGD:12793070 NCBI chr17:40,063,924...40,087,073
Ensembl chr17:40,063,962...40,081,887
JBrowse link
G Mtch2 mitochondrial carrier 2 acts_upstream_of_or_within ISO MGI:2449949|MGI:5566664 (MGI:5662300|PMID:26219591) RGD PMID:26219591 MGI:5662300 NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189
JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 IDA RGD PMID:16980436 RGD:2304071 NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699
JBrowse link
G Slc37a4 solute carrier family 37 member 4 acts_upstream_of_or_within ISO MGI:3046091 (MGI:3695950|PMID:16891306) RGD PMID:16891306 MGI:3695950 NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
JBrowse link
glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldha lactate dehydrogenase A acts_upstream_of_or_within ISO MGI:2384559 (MGI:62497|PMID:8224816) RGD PMID:8224816 MGI:62497 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
lactate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins2 insulin 2 involved_in ISO (PMID:8069456) RGD PMID:8069456 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISO (PMID:22523093) RGD PMID:22523093 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Per2 period circadian regulator 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5546525|PMID:23977055)
UniProt
RGD
PMID:23977055 GO_REF:0000024 MGI:5546525 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
lactate biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htt huntingtin acts_upstream_of_or_within ISO (MGI:3757902|PMID:17708681) RGD PMID:17708681 MGI:3757902 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070
JBrowse link
G Ldhc lactate dehydrogenase C involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3775056|PMID:18367675)
Ensembl
RGD
PMID:18367675 GO_REF:0000107 MGI:3775056 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378
JBrowse link
lactate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldhd lactate dehydrogenase D involved_in IBA
ISO
PMID:21873635
(PMID:30931947)
RGD PMID:30931947 PMID:21873635 RGD:13792537 NCBI chr19:39,573,621...39,595,575
Ensembl chr19:39,573,621...39,595,575
JBrowse link
lactate oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldhc lactate dehydrogenase C involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3775056|PMID:18367675)
Ensembl
RGD
PMID:18367675 GO_REF:0000107 MGI:3775056 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378
JBrowse link
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hagh hydroxyacyl glutathione hydrolase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:13,874,883...13,889,527
Ensembl chr10:13,875,241...13,889,504
JBrowse link
G Haghl hydroxyacylglutathione hydrolase-like involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:14,804,957...14,809,495
Ensembl chr10:14,804,997...14,807,665
JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:75,868,620...75,937,126
Ensembl chr 9:75,867,468...75,937,124
JBrowse link
methylglyoxal catabolic process to lactate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:28993701)
Ensembl
UniProt
RGD
PMID:28993701 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
negative regulation of glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc25a12 solute carrier family 25 member 12 IMP RGD PMID:19764902 RGD:13628741 NCBI chr 3:56,098,080...56,192,188
Ensembl chr 3:56,097,269...56,192,100
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase acts_upstream_of_or_within ISO (MGI:4867601|PMID:20935145) RGD PMID:20935145 MGI:4867601 NCBI chr 4:159,927,138...159,946,094
Ensembl chr 4:159,927,139...159,946,029
JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO (MGI:4867601|PMID:20935145) RGD PMID:20935145 MGI:4867601 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
positive regulation of glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 involved_in ISO (MGI:3759354|PMID:17828264) RGD PMID:17828264 MGI:3759354 NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012
JBrowse link
protein deglycation, methylglyoxal removal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase NOT|involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:27903648)
(PMID:25416785), (PMID:30150385)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:25416785 PMID:27903648 PMID:30150385 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    metabolic process 11736
      organic substance metabolic process 11278
        organic hydroxy compound metabolic process 556
          lactate metabolic process 20
            L-threonine catabolic process to D-lactate 0
            glucose catabolic process to lactate + 5
            lactate biosynthetic process + 5
            lactate catabolic process + 1
            lactate oxidation 1
            lactate racemization 0
            methylglyoxal catabolic process to lactate + 4
Path 2
Term Annotations click to browse term
  biological_process 19390
    metabolic process 11736
      cellular metabolic process 10656
        organic acid metabolic process 1008
          oxoacid metabolic process 976
            carboxylic acid metabolic process 957
              monocarboxylic acid metabolic process 656
                lactate metabolic process 20
                  L-threonine catabolic process to D-lactate 0
                  glucose catabolic process to lactate + 5
                  lactate biosynthetic process + 5
                  lactate catabolic process + 1
                  lactate oxidation 1
                  lactate racemization 0
                  methylglyoxal catabolic process to lactate + 4
paths to the root