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ONTOLOGY REPORT - ANNOTATIONS


Term:lactate metabolic process
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Accession:GO:0006089 term browser browse the term
Definition:The chemical reactions and pathways involving lactate, the anion of lactic acid.
Synonyms:exact_synonym: 2-hydroxypropanoate metabolic process;   2-hydroxypropanoate metabolism;   alpha-hydroxypropionate metabolic process;   alpha-hydroxypropionate metabolism;   lactate metabolism


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lactate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha IEA
ISO
GO_REF:0000107
MGI:2386679 (MGI:3576386|PMID:15328538)
Ensembl
RGD
PMID:15328538 GO_REF:0000107, MGI:3576386 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Ldha lactate dehydrogenase A IDA RGD PMID:17447164 RGD:1624966 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ldhb lactate dehydrogenase B IDA RGD PMID:17447164 RGD:1624966 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Mrs2 magnesium transporter MRS2 IMP RGD PMID:21253565 RGD:12793070 NCBI chr17:42,064,271...42,083,602
Ensembl chr17:42,064,376...42,082,300
JBrowse link
G Mtch2 mitochondrial carrier 2 ISO MGI:2449949|MGI:5566664 (MGI:5662300|PMID:26219591) RGD PMID:26219591 MGI:5662300 NCBI chr 3:79,678,141...79,695,356
Ensembl chr 3:79,678,201...79,694,006
JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 IDA RGD PMID:16980436 RGD:2304071 NCBI chr13:47,413,453...47,440,682
Ensembl chr13:47,413,458...47,440,682
JBrowse link
G Slc37a4 solute carrier family 37 member 4 ISO MGI:3046091 (MGI:3695950|PMID:16891306) RGD PMID:16891306 MGI:3695950 NCBI chr 8:48,716,914...48,723,024
Ensembl chr 8:48,716,939...48,723,024
JBrowse link
glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldha lactate dehydrogenase A ISO MGI:2384559 (MGI:62497|PMID:8224816) RGD PMID:8224816 MGI:62497 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
lactate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins2 insulin 2 ISO (PMID:8069456) RGD PMID:8069456 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Park7 Parkinsonism associated deglycase ISO (PMID:22523093) RGD PMID:22523093 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Per2 period circadian regulator 2 ISS
ISO
GO_REF:0000024
(MGI:5546525|PMID:23977055)
UniProt
RGD
PMID:23977055 GO_REF:0000024, MGI:5546525 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
lactate biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htt huntingtin ISO (MGI:3757902|PMID:17708681) RGD PMID:17708681 MGI:3757902 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Ldhc lactate dehydrogenase C IEA
ISO
GO_REF:0000107
(MGI:3775056|PMID:18367675)
Ensembl
RGD
PMID:18367675 GO_REF:0000107, MGI:3775056 NCBI chr 1:102,914,875...102,931,843
Ensembl chr 1:102,915,191...102,931,839
JBrowse link
lactate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldhd lactate dehydrogenase D ISO
IBA
(PMID:30931947)
PMID:21873635
RGD PMID:30931947, PMID:21873635 RGD:13792537 NCBI chr19:43,826,989...43,848,937
Ensembl chr19:43,826,993...43,848,937
JBrowse link
lactate oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldhc lactate dehydrogenase C IEA
ISO
GO_REF:0000107
(MGI:3775056|PMID:18367675)
Ensembl
RGD
PMID:18367675 GO_REF:0000107, MGI:3775056 NCBI chr 1:102,914,875...102,931,843
Ensembl chr 1:102,915,191...102,931,839
JBrowse link
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hagh hydroxyacyl glutathione hydrolase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:14,215,913...14,230,506
Ensembl chr10:14,216,155...14,230,515
JBrowse link
G Haghl hydroxyacylglutathione hydrolase-like IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:15,152,736...15,157,221
Ensembl chr10:15,152,709...15,155,412
JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:81,566,074...81,634,531
Ensembl chr 9:81,566,074...81,634,534
JBrowse link
methylglyoxal catabolic process to lactate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase ISS
ISO
IEA
GO_REF:0000024
(PMID:28993701)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:28993701 GO_REF:0000024, GO_REF:0000107 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
negative regulation of glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc25a12 solute carrier family 25 member 12 IMP RGD PMID:19764902 RGD:13628741 NCBI chr 3:57,881,951...57,998,214
Ensembl chr 3:57,882,370...57,957,346
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase ISO (MGI:4867601|PMID:20935145) RGD PMID:20935145 MGI:4867601 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063
JBrowse link
G Tp53 tumor protein p53 ISO (MGI:4867601|PMID:20935145) RGD PMID:20935145 MGI:4867601 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
positive regulation of glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 ISO (MGI:3759354|PMID:17828264) RGD PMID:17828264 MGI:3759354 NCBI chr 1:220,120,532...220,136,460
Ensembl chr 1:220,120,533...220,136,470
JBrowse link
protein deglycation, methylglyoxal removal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase NOT ISO
ISS
IEA
(PMID:27903648)
GO_REF:0000024
(PMID:25416785), (PMID:30150385)
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:25416785, PMID:27903648, PMID:30150385 GO_REF:0000024, GO_REF:0000107 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20030
    metabolic process 12185
      organic substance metabolic process 11552
        organic hydroxy compound metabolic process 540
          lactate metabolic process 20
            L-threonine catabolic process to D-lactate 0
            glucose catabolic process to lactate + 5
            lactate biosynthetic process + 5
            lactate catabolic process + 1
            lactate oxidation 1
            lactate racemization 0
            methylglyoxal catabolic process to lactate + 4
Path 2
Term Annotations click to browse term
  biological_process 20030
    metabolic process 12185
      cellular metabolic process 10964
        organic acid metabolic process 1007
          oxoacid metabolic process 969
            carboxylic acid metabolic process 950
              monocarboxylic acid metabolic process 650
                lactate metabolic process 20
                  L-threonine catabolic process to D-lactate 0
                  glucose catabolic process to lactate + 5
                  lactate biosynthetic process + 5
                  lactate catabolic process + 1
                  lactate oxidation 1
                  lactate racemization 0
                  methylglyoxal catabolic process to lactate + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.