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ONTOLOGY REPORT - ANNOTATIONS


Term:acetyl-CoA biosynthetic process from pyruvate
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Accession:GO:0006086 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
Synonyms:exact_synonym: acetyl-CoA anabolism from pyruvate;   acetyl-CoA formation from pyruvate;   acetyl-CoA synthesis from pyruvate;   pyruvate dehydrogenase pathway
 xref: MetaCyc:PYRUVDEHYD-PWY


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acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004955412:13,718,091...13,746,220
Ensembl chrNW_004955412:13,718,067...13,744,239
JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004955410:12,212,981...12,238,561
Ensembl chrNW_004955410:12,212,963...12,238,561
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 subunit ISO (PMID:19081061) RGD
UniProtKB
PMID:7487891, PMID:19081061 RGD:1599112 NCBI chrNW_004955586:98,492...114,927
Ensembl chrNW_004955586:97,172...114,928
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 alpha 2 subunit ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004955405:6,383,088...6,383,946 JBrowse link
G Pdhb pyruvate dehydrogenase E1 beta subunit ISO (PMID:19081061) UniProtKB
RGD
PMID:7487891, PMID:19081061 RGD:1599112 NCBI chrNW_004955430:1,707,615...1,713,541
Ensembl chrNW_004955430:1,707,615...1,713,541
JBrowse link
mitochondrial acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpc1 mitochondrial pyruvate carrier 1 ISO (MGI:MGI:5428352|PMID:22628558) MGI PMID:22628558 MGI:MGI:5428352 NCBI chrNW_004955439:15,515,966...15,531,618
Ensembl chrNW_004955439:15,516,090...15,531,116
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 ISO (MGI:MGI:5428352|PMID:22628558)
(MGI:MGI:5576400|PMID:24910426)
MGI PMID:22628558, PMID:24910426 MGI:MGI:5428352, MGI:MGI:5576400 NCBI chrNW_004955462:9,177,484...9,193,646 JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 subunit ISO (MGI:MGI:3817854|PMID:18586888) MGI PMID:18586888 MGI:MGI:3817854 NCBI chrNW_004955586:98,492...114,927
Ensembl chrNW_004955586:97,172...114,928
JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdk1 pyruvate dehydrogenase kinase 1 ISO (MGI:MGI:5487511|PMID:22195962) UniProtKB PMID:22195962 MGI:MGI:5487511 NCBI chrNW_004955449:2,546,790...2,582,402
Ensembl chrNW_004955449:2,549,139...2,582,243
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 ISO (MGI:MGI:5428826|PMID:22360721) UniProtKB PMID:22360721 MGI:MGI:5428826 NCBI chrNW_004955451:11,547,660...11,559,266
Ensembl chrNW_004955451:11,547,660...11,559,403
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 ISO (PMID:22865452) UniProtKB PMID:22865452 NCBI chrNW_004955509:4,809,422...4,888,802
Ensembl chrNW_004955509:4,809,399...4,878,976
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 ISO (MGI:MGI:3692363|PMID:16606348)
(PMID:21852536)
UniProtKB PMID:16606348, PMID:21852536 MGI:MGI:3692363 NCBI chrNW_004955432:12,169,548...12,182,064
Ensembl chrNW_004955432:12,169,435...12,182,409
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11889
    metabolic process 7609
      organic substance metabolic process 7318
        thioester metabolic process 61
          acyl-CoA metabolic process 61
            acetyl-CoA metabolic process 30
              acetyl-CoA biosynthetic process 16
                acetyl-CoA biosynthetic process from pyruvate 11
                  mitochondrial acetyl-CoA biosynthetic process from pyruvate 3
                  regulation of acetyl-CoA biosynthetic process from pyruvate 4
Path 2
Term Annotations click to browse term
  biological_process 11889
    metabolic process 7609
      cellular metabolic process 7027
        cellular aromatic compound metabolic process 3735
          nucleobase-containing compound metabolic process 3563
            nucleobase-containing small molecule metabolic process 356
              nucleoside phosphate metabolic process 311
                nucleotide metabolic process 301
                  ribonucleotide metabolic process 243
                    purine ribonucleotide metabolic process 236
                      purine ribonucleotide biosynthetic process 105
                        acyl-CoA biosynthetic process 23
                          acetyl-CoA biosynthetic process 16
                            acetyl-CoA biosynthetic process from pyruvate 11
                              mitochondrial acetyl-CoA biosynthetic process from pyruvate 3
                              regulation of acetyl-CoA biosynthetic process from pyruvate 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.