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ONTOLOGY REPORT - ANNOTATIONS

Term:acetyl-CoA biosynthetic process
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Accession:GO:0006085 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
Synonyms:exact_synonym: acetyl-CoA anabolism;   acetyl-CoA biosynthesis;   acetyl-CoA formation;   acetyl-CoA synthesis
 xref: MetaCyc:Acetyl-CoA-Biosynthesis


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acetyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 involved_in ISO
IEA 		(PMID:17371050)
GO_REF:0000107 		RGD
Ensembl		 PMID:17371050 GO_REF:0000107 NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:53,979,813...54,008,855 		JBrowse link
G Acly ATP citrate lyase involved_in NAS
IEA
IBA
ISO 		GO_REF:0000002
GO_REF:0000107
GO_REF:0000033
(PMID:1371749), (PMID:39881208) 		InterPro
Ensembl
GO_Central
RGD		 PMID:1371749 PMID:39881208 PMID:2295639 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:631761 NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:16788062)
GO_REF:0000107
GO_REF:0000033
(PMID:11150295) 		RGD
Ensembl
GO_Central		 PMID:11150295 PMID:16788062 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:139,450,383...139,500,325
Ensembl chr 3:139,450,383...139,500,325 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 acts_upstream_of_or_within
involved_in 		ISO
IBA 		(PMID:11150295)
GO_REF:0000033 		RGD
GO_Central		 PMID:11150295 GO_REF:0000033 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675 		JBrowse link
G Dip2a disco-interacting protein 2 homolog A involved_in ISO (PMID:30672040) RGD PMID:30672040 NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217 		JBrowse link
G Mlycd malonyl-CoA decarboxylase involved_in IDA
IEA
IBA
ISO 		GO_REF:0000107
GO_REF:0000033
GO_REF:0000041
(PMID:10417274), (PMID:10455107), (PMID:9869665) 		Ensembl
GO_Central
UniProt
RGD		 PMID:9869665 PMID:10417274 PMID:10455107 PMID:17316539 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107, RGD:1600790 NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793 		JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase involved_in ISO
IEA 		(PMID:29754768)
GO_REF:0000107 		RGD
Ensembl		 PMID:29754768 GO_REF:0000107 NCBI chr 5:133,023,077...133,026,899
Ensembl chr 5:133,023,121...133,026,933 		JBrowse link
acetyl-CoA biosynthetic process from acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acss1 acyl-CoA synthetase short-chain family member 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:139,450,383...139,500,325
Ensembl chr 3:139,450,383...139,500,325 		JBrowse link
negative regulation of pyruvate decarboxylation to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pgk1 phosphoglycerate kinase 1 involved_in ISO
IEA 		(PMID:26942675)
GO_REF:0000107 		RGD
Ensembl		 PMID:26942675 GO_REF:0000107 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Pgk1l1 phosphoglycerate kinase 1 like 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:42,754,605...42,755,929
Ensembl chr 2:42,754,639...42,755,856 		JBrowse link
pyruvate decarboxylation to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase involved_in IDA
IEA
ISO
IBA 		GO_REF:0000107
GO_REF:0000002
GO_REF:0000117
MGI:2386703 (PMID:17314311), (PMID:27621431)
GO_REF:0000033
(PMID:24534072) 		Ensembl
InterPro
UniProt
RGD
GO_Central		 PMID:17314311 PMID:24534072 PMID:27621431 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:1599112 NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:50,978,051...51,004,479
Ensembl chr 1:50,978,051...51,004,479 		JBrowse link
G Dld dihydrolipoamide dehydrogenase involved_in IDA
IEA
ISO 		GO_REF:0000107
MGI:2386703 (PMID:17314311), (PMID:27621431)
(PMID:24534072) 		Ensembl
RGD		 PMID:17314311 PMID:24534072 PMID:27621431 PMID:7487891 GO_REF:0000107, RGD:1599112 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 acts_upstream_of_or_within
involved_in 		ISO (PMID:22628558) RGD PMID:22628558 NCBI chr 1:52,437,745...52,449,399
Ensembl chr 1:52,437,741...52,449,400 		JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:22628558)
GO_REF:0000107
MGI:5635078 (PMID:22628558), (PMID:24910426) 		RGD
Ensembl		 PMID:22628558 PMID:24910426 GO_REF:0000107 NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 involved_in
acts_upstream_of_or_within 		IDA
IEA
ISO
IBA 		GO_REF:0000002
GO_REF:0000117
MGI:2182095|MGI:2386703 (PMID:18586888)
GO_REF:0000033
GO_REF:0000114
(PMID:19081061), (PMID:24534072) 		InterPro
UniProt
RGD
GO_Central
ComplexPortal		 PMID:18586888 PMID:19081061 PMID:24534072 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000114 GO_REF:0000117, RGD:1599112 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pdha1l1 pyruvate dehydrogenase (lipoamide) alpha 1-like 1 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000117
GO_REF:0000002 		GO_Central
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000117 NCBI chr16:82,511,483...82,514,378
Ensembl chr16:82,511,511...82,514,372 		JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 involved_in IDA
IEA
IBA 		GO_REF:0000117
GO_REF:0000002
GO_REF:0000033 		UniProt
InterPro
GO_Central
RGD		 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000117, RGD:1599112 NCBI chr 2:229,872,300...229,873,848 JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta involved_in IDA
IBA
ISO
IEA 		GO_REF:0000033
GO_REF:0000114
GO_REF:0000002
(PMID:19081061), (PMID:24534072)
GO_REF:0000107 		GO_Central
ComplexPortal
InterPro
RGD
Ensembl		 PMID:19081061 PMID:24534072 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000114, RGD:1599112 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500 		JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X involved_in ISO
IEA 		(PMID:24534072)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000117
MGI:2386703 (PMID:17314311), (PMID:27621431) 		RGD
Ensembl
InterPro
UniProt		 PMID:17314311 PMID:24534072 PMID:27621431 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 NCBI chr 3:109,826,579...109,886,869
Ensembl chr 3:89,371,497...89,431,773 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 TAS RGD PMID:12435272 RGD:729541 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
regulation of pyruvate decarboxylation to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bckdk branched chain ketoacid dehydrogenase kinase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:191,945,809...191,950,480
Ensembl chr 1:182,515,327...182,536,633 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 involved_in IEA
ISO
IBA 		GO_REF:0000107
(PMID:22195962)
GO_REF:0000033 		Ensembl
RGD
GO_Central		 PMID:22195962 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 involved_in ISS
ISO
IBA 		GO_REF:0000024
(PMID:22360721)
GO_REF:0000033 		UniProt
RGD
GO_Central		 PMID:22360721 GO_REF:0000024 GO_REF:0000033 NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085 		JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 involved_in ISO (PMID:22865452) RGD PMID:22865452 NCBI chr  X:58,486,699...58,553,533
Ensembl chr  X:58,486,554...58,553,557 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 involved_in ISO
ISS
IEA
IBA 		(PMID:21852536)
GO_REF:0000024
GO_REF:0000107
(PMID:16606348)
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:16606348 PMID:21852536 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Tpk1 thiamin pyrophosphokinase 1 involved_in ISO
IEA 		(PMID:38547260)
GO_REF:0000107 		RGD
Ensembl		 PMID:38547260 GO_REF:0000107 NCBI chr 4:72,170,134...72,557,707
Ensembl chr 4:72,170,134...72,557,694 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        amide metabolic process 495
          acyl-CoA metabolic process 99
            acyl-CoA biosynthetic process 40
              acetyl-CoA biosynthetic process 24
                acetyl-CoA biosynthetic process from acetate 1
                acetyl-CoA biosynthetic process from ethanol 0
                acetyl-CoA biosynthetic process from pantothenate 0
                carbon fixation by acetyl-CoA pathway 0
                pyruvate decarboxylation to acetyl-CoA + 17
Path 2
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        primary metabolic process 10727
          nucleobase-containing compound metabolic process 5900
            nucleobase-containing small molecule metabolic process 730
              nucleoside phosphate metabolic process 699
                nucleoside phosphate biosynthetic process 312
                  acyl-CoA biosynthetic process 40
                    acetyl-CoA biosynthetic process 24
                      acetyl-CoA biosynthetic process from acetate 1
                      acetyl-CoA biosynthetic process from ethanol 0
                      acetyl-CoA biosynthetic process from pantothenate 0
                      carbon fixation by acetyl-CoA pathway 0
                      pyruvate decarboxylation to acetyl-CoA + 17
paths to the root