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ONTOLOGY REPORT - ANNOTATIONS


Term:acetyl-CoA biosynthetic process
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Accession:GO:0006085 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
Synonyms:exact_synonym: acetyl-CoA anabolism;   acetyl-CoA biosynthesis;   acetyl-CoA formation;   acetyl-CoA synthesis
 xref: MetaCyc:PWY-5173



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acetyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-Coenzyme A acetyltransferase 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 9:53,580,522...53,610,350
Ensembl chr 9:53,580,522...53,610,382
JBrowse link
G Acly ATP citrate lyase involved_in ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr11:100,476,352...100,528,000
Ensembl chr11:100,476,353...100,528,000
JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 acts_upstream_of_or_within
involved_in
IDA
ISO
(MGI:2151932|PMID:11150295) MGI PMID:11150295 GO_REF:0000096 MGI:2151932 MGI:4834177 NCBI chr 2:150,618,111...150,668,240
Ensembl chr 2:150,618,105...150,668,500
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 acts_upstream_of_or_within IDA (MGI:2151932|PMID:11150295) MGI PMID:11150295 MGI:2151932 NCBI chr 2:155,518,043...155,562,743
Ensembl chr 2:155,517,948...155,585,724
JBrowse link
G Dip2a disco interacting protein 2 homolog A involved_in IDA (MGI:6478983|PMID:30672040) UniProt PMID:30672040 MGI:6478983 NCBI chr10:76,263,034...76,345,360
Ensembl chr10:76,259,429...76,345,291
JBrowse link
G Mlycd malonyl-CoA decarboxylase involved_in ISO
IBA
(MGI:6201960|PMID:21873635) MGI
RGD
GO_Central
PMID:17316539 PMID:21873635 GO_REF:0000096 MGI:4417868 MGI:4834177 MGI:6201960 RGD:1600790 NCBI chr 8:119,394,852...119,421,838
Ensembl chr 8:119,394,878...119,411,102
JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 4:119,418,527...119,422,440
Ensembl chr 4:119,418,530...119,422,420
JBrowse link
acetyl-CoA biosynthetic process from acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acss1 acyl-CoA synthetase short-chain family member 1 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 2:150,618,111...150,668,240
Ensembl chr 2:150,618,105...150,668,500
JBrowse link
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
RGD
PMID:7487891 PMID:21873635 GO_REF:0000096 MGI:4417868 MGI:6201960 RGD:1599112 NCBI chr 9:50,634,633...50,659,780
Ensembl chr 9:50,634,633...50,659,780
JBrowse link
G Dld dihydrolipoamide dehydrogenase involved_in ISO RGD
MGI
PMID:7487891 GO_REF:0000096 MGI:4417868 RGD:1599112 NCBI chr12:31,331,562...31,351,471
Ensembl chr12:31,331,277...31,351,453
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 involved_in ISO
IBA
(MGI:6201960|PMID:21873635) MGI
RGD
GO_Central
PMID:7487891 PMID:21873635 GO_REF:0000096 MGI:4417868 MGI:4834177 MGI:6201960 RGD:1599112 NCBI chr  X:160,122,219...160,138,430
Ensembl chr  X:160,122,209...160,138,413
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 alpha 2 involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
RGD
PMID:7487891 PMID:21873635 GO_REF:0000096 MGI:4417868 MGI:6201960 RGD:1599112 NCBI chr 3:141,210,004...141,212,355
Ensembl chr 3:141,210,004...141,212,355
JBrowse link
G Pdhb pyruvate dehydrogenase (lipoamide) beta involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
RGD
PMID:7487891 PMID:21873635 GO_REF:0000096 MGI:4417868 MGI:4834177 MGI:6201960 RGD:1599112 NCBI chr14:8,165,991...8,173,303
Ensembl chr14:8,165,996...8,173,025
JBrowse link
mitochondrial acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) acts_upstream_of_or_within ISO
IC
(MGI:2388500|PMID:12108679) MGI PMID:12108679 GO_REF:0000008 MGI:2154458 MGI:2388500 NCBI chr 9:50,634,633...50,659,780
Ensembl chr 9:50,634,633...50,659,780
JBrowse link
G Dld dihydrolipoamide dehydrogenase acts_upstream_of_or_within ISO
IC
(MGI:1101694|PMID:9405644) MGI PMID:9405644 GO_REF:0000008 MGI:1101694 MGI:2154458 NCBI chr12:31,331,562...31,351,471
Ensembl chr12:31,331,277...31,351,453
JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 acts_upstream_of_or_within IC
IMP
(MGI:5428353|PMID:22628554)
(MGI:5428352|PMID:22628558)
MGI PMID:22628554 PMID:22628558 MGI:5428352 MGI:5428353 NCBI chr17:8,283,787...8,297,667
Ensembl chr17:8,282,904...8,297,661
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 acts_upstream_of_or_within IMP (MGI:5428352|PMID:22628558)
(MGI:5576400|PMID:24910426)
MGI PMID:22628558 PMID:24910426 MGI:5428352 MGI:5576400 NCBI chr 1:165,461,260...165,481,218
Ensembl chr 1:165,460,637...165,481,214
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 acts_upstream_of_or_within IMP (MGI:3817854|PMID:18586888) MGI PMID:18586888 MGI:3817854 NCBI chr  X:160,122,219...160,138,430
Ensembl chr  X:160,122,209...160,138,413
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 alpha 2 acts_upstream_of_or_within ISO MGI GO_REF:0000008 MGI:2154458 NCBI chr 3:141,210,004...141,212,355
Ensembl chr 3:141,210,004...141,212,355
JBrowse link
G Pdhb pyruvate dehydrogenase (lipoamide) beta acts_upstream_of_or_within ISO MGI GO_REF:0000008 MGI:2154458 NCBI chr14:8,165,991...8,173,303
Ensembl chr14:8,165,996...8,173,025
JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X acts_upstream_of_or_within ISO MGI GO_REF:0000008 MGI:2154458 NCBI chr 2:103,021,055...103,073,513
Ensembl chr 2:103,021,075...103,073,513
JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 involved_in IMP (MGI:5487511|PMID:22195962) UniProt PMID:22195962 MGI:5487511 NCBI chr 2:71,873,215...71,903,858
Ensembl chr 2:71,873,224...71,903,858
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 involved_in IMP (MGI:5428826|PMID:22360721) UniProt PMID:22360721 MGI:5428826 NCBI chr11:95,026,258...95,041,371
Ensembl chr11:95,026,258...95,041,354
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase, isoenzyme 3 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr  X:93,764,616...93,832,150
Ensembl chr  X:93,764,607...93,832,201
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 involved_in
acts_upstream_of_or_within
IMP
ISO
TAS
(MGI:3692363|PMID:16606348)
(MGI:1349328|PMID:10548532)
UniProt
MGI
PMID:10548532 PMID:16606348 GO_REF:0000096 MGI:1349328 MGI:3692363 MGI:4834177 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 29900
    metabolic process 11255
      organic substance metabolic process 10847
        thioester metabolic process 89
          acyl-CoA metabolic process 89
            acetyl-CoA metabolic process 35
              acetyl-CoA biosynthetic process 19
                acetyl-CoA biosynthetic process from acetate 1
                acetyl-CoA biosynthetic process from ethanol 0
                acetyl-CoA biosynthetic process from pantothenate 0
                acetyl-CoA biosynthetic process from pyruvate + 12
                carbon fixation by acetyl-CoA pathway 0
Path 2
Term Annotations click to browse term
  biological_process 29900
    metabolic process 11255
      cellular metabolic process 10089
        cellular aromatic compound metabolic process 5478
          nucleobase-containing compound metabolic process 5250
            nucleobase-containing small molecule metabolic process 528
              nucleoside phosphate metabolic process 468
                nucleotide metabolic process 460
                  ribonucleotide metabolic process 376
                    purine ribonucleotide metabolic process 358
                      purine ribonucleotide biosynthetic process 154
                        acyl-CoA biosynthetic process 26
                          acetyl-CoA biosynthetic process 19
                            acetyl-CoA biosynthetic process from acetate 1
                            acetyl-CoA biosynthetic process from ethanol 0
                            acetyl-CoA biosynthetic process from pantothenate 0
                            acetyl-CoA biosynthetic process from pyruvate + 12
                            carbon fixation by acetyl-CoA pathway 0
paths to the root