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ONTOLOGY REPORT - ANNOTATIONS


Term:acetyl-CoA biosynthetic process
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Accession:GO:0006085 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
Synonyms:exact_synonym: acetyl-CoA anabolism;   acetyl-CoA biosynthesis;   acetyl-CoA formation;   acetyl-CoA synthesis
 xref: MetaCyc:PWY-5173



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acetyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAT1 acetyl-CoA acetyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:24,361,301...24,379,807
Ensembl chr 5:24,361,301...24,379,812
JBrowse link
G ACLY ATP citrate lyase involved_in IEA InterPro GO_REF:0000002 NCBI chr 9:20,929,530...20,974,200
Ensembl chr 9:20,929,614...20,973,663
JBrowse link
G ACSS1 acyl-CoA synthetase short chain family member 1 involved_in
acts_upstream_of_or_within
ISO (PMID:16788062)
(MGI:2151932|PMID:11150295)
UniProt
MGI
PMID:11150295 PMID:16788062 MGI:2151932 NCBI chr23:1,192,771...1,251,724
Ensembl chr23:1,184,392...1,252,255
JBrowse link
G ACSS2 acyl-CoA synthetase short chain family member 2 acts_upstream_of_or_within ISO (MGI:2151932|PMID:11150295) MGI PMID:11150295 MGI:2151932 NCBI chr24:23,928,800...23,973,383
Ensembl chr24:23,928,838...23,972,651
JBrowse link
G DIP2A disco interacting protein 2 homolog A involved_in ISO (MGI:6478983|PMID:30672040) UniProt PMID:30672040 MGI:6478983 NCBI chr31:39,695,620...39,778,527
Ensembl chr31:39,686,465...39,777,484
JBrowse link
G MLYCD malonyl-CoA decarboxylase involved_in ISO (PMID:10417274), (PMID:10455107), (PMID:9869665) RGD
UniProt
PMID:9869665 PMID:10417274 PMID:10455107 PMID:17316539 RGD:1600790 NCBI chr 5:68,385,058...68,399,965
Ensembl chr 5:68,384,618...68,399,965
JBrowse link
G PPCS phosphopantothenoylcysteine synthetase involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:813,435...817,732
Ensembl chr15:813,870...816,825
JBrowse link
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLAT dihydrolipoamide S-acetyltransferase involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:7487891 PMID:21873635 RGD:1599112 NCBI chr 5:21,062,833...21,094,235
Ensembl chr 5:21,064,026...21,094,153
JBrowse link
G DLD dihydrolipoamide dehydrogenase ISO RGD PMID:7487891 RGD:1599112 NCBI chr18:12,703,340...12,734,408
Ensembl chr18:12,703,341...12,734,479
JBrowse link
G PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 involved_in ISS
ISO
UniProt
RGD
PMID:7487891 GO_REF:0000024 RGD:1599112 NCBI chr  X:15,338,364...15,354,011
Ensembl chr  X:15,338,202...15,387,458
JBrowse link
G PDHB pyruvate dehydrogenase E1 subunit beta involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:7487891 PMID:21873635 RGD:1599112 NCBI chr20:32,185,420...32,191,592 JBrowse link
mitochondrial acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MPC1 mitochondrial pyruvate carrier 1 acts_upstream_of_or_within ISO (MGI:5428352|PMID:22628558) MGI PMID:22628558 MGI:5428352 NCBI chr 1:54,379,195...54,395,697 JBrowse link
G MPC2 mitochondrial pyruvate carrier 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5428352|PMID:22628558)
(MGI:5576400|PMID:24910426)
Ensembl
MGI
PMID:22628558 PMID:24910426 GO_REF:0000107 MGI:5428352 MGI:5576400 NCBI chr 7:30,544,986...30,574,102
Ensembl chr 7:30,545,152...30,574,080
JBrowse link
G PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 acts_upstream_of_or_within ISO (MGI:3817854|PMID:18586888) MGI PMID:18586888 MGI:3817854 NCBI chr  X:15,338,364...15,354,011
Ensembl chr  X:15,338,202...15,387,458
JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDK1 pyruvate dehydrogenase kinase 1 involved_in ISO (MGI:5487511|PMID:22195962) UniProt PMID:22195962 MGI:5487511 NCBI chr36:16,918,329...16,944,532
Ensembl chr36:16,918,058...16,944,620
JBrowse link
G PDK2 pyruvate dehydrogenase kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:26,099,457...26,116,094
Ensembl chr 9:26,100,343...26,115,423
JBrowse link
G PDK3 pyruvate dehydrogenase kinase 3 involved_in ISO (PMID:22865452) UniProt PMID:22865452 NCBI chr  X:19,994,383...20,058,979
Ensembl chr  X:19,994,393...20,058,485
JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:20,825,861...20,839,290
Ensembl chr14:20,827,831...20,839,256
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13875
    metabolic process 8978
      organic substance metabolic process 8627
        thioester metabolic process 73
          acyl-CoA metabolic process 73
            acetyl-CoA metabolic process 33
              acetyl-CoA biosynthetic process 17
                acetyl-CoA biosynthetic process from acetate 0
                acetyl-CoA biosynthetic process from ethanol 0
                acetyl-CoA biosynthetic process from pantothenate 0
                acetyl-CoA biosynthetic process from pyruvate + 10
                carbon fixation by acetyl-CoA pathway 0
Path 2
Term Annotations click to browse term
  biological_process 13875
    metabolic process 8978
      cellular metabolic process 8168
        cellular aromatic compound metabolic process 4387
          nucleobase-containing compound metabolic process 4194
            nucleobase-containing small molecule metabolic process 440
              nucleoside phosphate metabolic process 387
                nucleotide metabolic process 380
                  ribonucleotide metabolic process 316
                    purine ribonucleotide metabolic process 301
                      purine ribonucleotide biosynthetic process 132
                        acyl-CoA biosynthetic process 28
                          acetyl-CoA biosynthetic process 17
                            acetyl-CoA biosynthetic process from acetate 0
                            acetyl-CoA biosynthetic process from ethanol 0
                            acetyl-CoA biosynthetic process from pantothenate 0
                            acetyl-CoA biosynthetic process from pyruvate + 10
                            carbon fixation by acetyl-CoA pathway 0
paths to the root