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ONTOLOGY REPORT - ANNOTATIONS


Term:acetyl-CoA metabolic process
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Accession:GO:0006084 term browser browse the term
Definition:The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
Synonyms:exact_synonym: acetyl coenzyme A metabolic process;   acetyl coenzyme A metabolism;   acetyl-CoA metabolism


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acetyl-CoA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 ISO RGD PMID:16476568 RGD:2317620 NCBI chrNW_004936497:13,242,644...13,269,007 JBrowse link
G Acaca acetyl-CoA carboxylase alpha involved_in ISO (MGI:4840155|PMID:20952656) UniProt PMID:20952656 MGI:4840155 NCBI chrNW_004936490:927,769...1,191,483 JBrowse link
G Acacb acetyl-CoA carboxylase beta involved_in ISO (PMID:20952656) UniProt PMID:20952656 NCBI chrNW_004936769:950,970...1,053,671 JBrowse link
G Acly ATP citrate lyase ISO RGD PMID:18062843 RGD:2317315 NCBI chrNW_004936490:16,758,001...16,798,152 JBrowse link
G Acot12 acyl-CoA thioesterase 12 acts_upstream_of_or_within ISO (MGI:2450440|PMID:12545200) MGI PMID:12545200 MGI:2450440 NCBI chrNW_004936469:635,663...681,373 JBrowse link
G Cs citrate synthase ISO RGD PMID:818082 PMID:938457 PMID:5820645 RGD:2306824 RGD:2306825 RGD:2306828 NCBI chrNW_004936646:676,926...704,988 JBrowse link
G Fasn fatty acid synthase ISO RGD PMID:18062843 RGD:2317315 NCBI chrNW_004936594:5,591,785...5,609,886 JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in ISO (PMID:23751782) UniProt PMID:23751782 NCBI chrNW_004936627:4,451,847...4,473,163 JBrowse link
acetyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 involved_in ISO (PMID:17371050) BHF-UCL PMID:17371050 NCBI chrNW_004936551:594,647...626,016 JBrowse link
G Acly ATP citrate lyase involved_in ISO (PMID:1371749) BHF-UCL PMID:1371749 NCBI chrNW_004936490:16,758,001...16,798,152 JBrowse link
G Acss1 acyl-CoA synthetase short chain family member 1 involved_in
acts_upstream_of_or_within
ISO (PMID:16788062)
(MGI:2151932|PMID:11150295)
UniProt
MGI
PMID:11150295 PMID:16788062 MGI:2151932 NCBI chrNW_004936620:739,633...800,472 JBrowse link
G Acss2 acyl-CoA synthetase short chain family member 2 acts_upstream_of_or_within ISO (MGI:2151932|PMID:11150295) MGI PMID:11150295 MGI:2151932 NCBI chrNW_004936561:5,794,685...5,842,619 JBrowse link
G Dip2a disco interacting protein 2 homolog A involved_in ISO (MGI:6478983|PMID:30672040) UniProt PMID:30672040 MGI:6478983 NCBI chrNW_004936778:49,130...123,345 JBrowse link
G Mlycd malonyl-CoA decarboxylase involved_in ISO (PMID:10417274), (PMID:10455107), (PMID:9869665) RGD
UniProt
PMID:9869665 PMID:10417274 PMID:10455107 PMID:17316539 RGD:1600790 NCBI chrNW_004936641:3,836,418...3,846,485 JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase involved_in ISO (PMID:29754768) UniProt PMID:29754768 NCBI chrNW_004936474:23,867,117...23,870,832 JBrowse link
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004936612:2,395,452...2,437,592 JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004936479:16,247,230...16,271,597 JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 involved_in ISO (PMID:19081061) RGD
UniProt
PMID:7487891 PMID:19081061 RGD:1599112 NCBI chrNW_004936844:889,720...906,631 JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004936717:2,377,982...2,379,137 JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta involved_in ISO (PMID:19081061) RGD
UniProt
PMID:7487891 PMID:19081061 RGD:1599112 NCBI chrNW_004936473:2,580,642...2,586,266 JBrowse link
acetyl-CoA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 involved_in ISO (PMID:17371050) BHF-UCL PMID:17371050 NCBI chrNW_004936551:594,647...626,016 JBrowse link
G Nudt7 nudix hydrolase 7 acts_upstream_of_or_within
involved_in
ISO (MGI:2137102|PMID:11415433)
(MGI:6157214|PMID:29378847), (MGI:6450264|PMID:18799520)
MGI
UniProt
PMID:11415433 PMID:18799520 PMID:29378847 MGI:2137102 MGI:6157214 MGI:6450264 NCBI chrNW_004936475:26,079,298...26,095,466 JBrowse link
isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvd mevalonate diphosphate decarboxylase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004936641:1,030,465...1,035,967 JBrowse link
G Mvk mevalonate kinase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004936769:1,274,595...1,295,186 JBrowse link
G Pmvk phosphomevalonate kinase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004936580:4,473,554...4,482,396 JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pipox pipecolic acid and sarcosine oxidase involved_in ISO (PMID:10642506) UniProt PMID:10642506 NCBI chrNW_004936538:5,218,097...5,252,579 JBrowse link
mitochondrial acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpc1 mitochondrial pyruvate carrier 1 acts_upstream_of_or_within ISO (MGI:5428352|PMID:22628558) MGI PMID:22628558 MGI:5428352 NCBI chrNW_004936489:16,179,321...16,181,991 JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 acts_upstream_of_or_within ISO (MGI:5428352|PMID:22628558)
(MGI:5576400|PMID:24910426)
MGI PMID:22628558 PMID:24910426 MGI:5428352 MGI:5576400 NCBI chrNW_004936481:18,253,929...18,259,738 JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 acts_upstream_of_or_within ISO (MGI:3817854|PMID:18586888) MGI PMID:18586888 MGI:3817854 NCBI chrNW_004936844:889,720...906,631 JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdk1 pyruvate dehydrogenase kinase 1 involved_in ISO (MGI:5487511|PMID:22195962) UniProt PMID:22195962 MGI:5487511 NCBI chrNW_004936509:2,597,593...2,633,780 JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 involved_in ISO (MGI:5428826|PMID:22360721) UniProt PMID:22360721 MGI:5428826 NCBI chrNW_004936490:11,534,412...11,549,128 JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 involved_in ISO (PMID:22865452) UniProt PMID:22865452 NCBI chrNW_004936624:141,745...213,495 JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 involved_in ISO (PMID:21852536)
(MGI:3692363|PMID:16606348)
UniProt PMID:16606348 PMID:21852536 MGI:3692363 NCBI chrNW_004936585:4,701,012...4,713,421 JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kynu kynureninase ISO RGD PMID:7236232 RGD:2303721 NCBI chrNW_004936469:33,632,885...33,805,158 JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase ISO RGD PMID:7236232 RGD:2303721 NCBI chrNW_004936576:2,537,702...2,555,790 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12173
    metabolic process 7652
      organic substance metabolic process 7378
        thioester metabolic process 64
          acyl-CoA metabolic process 64
            acetyl-CoA metabolic process 32
              L-lysine catabolic process to acetyl-CoA + 1
              L-threonine catabolic process to acetyl-CoA 0
              acetyl-CoA biosynthetic process + 18
              acetyl-CoA catabolic process + 2
              butyryl-CoA biosynthetic process from acetyl-CoA + 0
              isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
              tryptophan catabolic process to acetyl-CoA 2
Path 2
Term Annotations click to browse term
  biological_process 12173
    cellular process 11372
      cellular metabolic process 7017
        heterocycle metabolic process 3727
          nucleobase-containing compound metabolic process 3616
            nucleobase-containing small molecule metabolic process 371
              nucleoside phosphate metabolic process 333
                nucleotide metabolic process 327
                  ribonucleotide metabolic process 274
                    purine ribonucleotide metabolic process 259
                      acyl-CoA metabolic process 64
                        acetyl-CoA metabolic process 32
                          L-lysine catabolic process to acetyl-CoA + 1
                          L-threonine catabolic process to acetyl-CoA 0
                          acetyl-CoA biosynthetic process + 18
                          acetyl-CoA catabolic process + 2
                          butyryl-CoA biosynthetic process from acetyl-CoA + 0
                          isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
                          tryptophan catabolic process to acetyl-CoA 2
paths to the root