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ONTOLOGY REPORT - ANNOTATIONS

Term:acetyl-CoA metabolic process
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Accession:GO:0006084 term browser browse the term
Definition:The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
Synonyms:exact_synonym: acetyl coenzyme A metabolic process;   acetyl coenzyme A metabolism;   acetyl-CoA metabolism


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acetyl-CoA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 IDA RGD PMID:16476568 RGD:2317620 NCBI chr18:70,620,310...70,648,417
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha involved_in IEA
ISO		 GO_REF:0000107
(PMID:20952656)		 Ensembl
RGD		 PMID:20952656 GO_REF:0000107 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acacb acetyl-CoA carboxylase beta involved_in ISO
IEA		 (PMID:20952656)
GO_REF:0000107		 RGD
Ensembl		 PMID:20952656 GO_REF:0000107 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655 		JBrowse link
G Acly ATP citrate lyase IDA RGD PMID:18062843 RGD:2317315 NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Acot12 acyl-CoA thioesterase 12 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:12545200)		 GO_Central
Ensembl
RGD		 PMID:12545200 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536 		JBrowse link
G Cs citrate synthase IDA RGD PMID:5820645 PMID:818082 RGD:2306824, RGD:2306825 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Fasn fatty acid synthase IDA RGD PMID:18062843 RGD:2317315 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in ISO
IEA
IBA		 (PMID:23751782)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033		 RGD
Ensembl
InterPro
GO_Central		 PMID:23751782 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
acetyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 involved_in ISO
IEA		 (PMID:17371050)
GO_REF:0000107		 RGD
Ensembl		 PMID:17371050 GO_REF:0000107 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855 		JBrowse link
G Acly ATP citrate lyase involved_in NAS
ISO
IBA
IEA		 (PMID:1371749), (PMID:39881208)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002		 RGD
GO_Central
Ensembl
InterPro		 PMID:1371749 PMID:39881208 PMID:2295639 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:631761 NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 (PMID:16788062)
GO_REF:0000107
GO_REF:0000033
(PMID:11150295)		 RGD
Ensembl
GO_Central		 PMID:11150295 PMID:16788062 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:159,910,809...159,960,748
Ensembl chr 3:139,450,383...139,500,325 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:11150295)
GO_REF:0000033		 RGD
GO_Central		 PMID:11150295 GO_REF:0000033 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675 		JBrowse link
G Dip2a disco-interacting protein 2 homolog A involved_in ISO (PMID:30672040) RGD PMID:30672040 NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217 		JBrowse link
G Mlycd malonyl-CoA decarboxylase involved_in IDA
IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
GO_REF:0000041
(PMID:10417274), (PMID:10455107), (PMID:9869665)		 Ensembl
GO_Central
UniProt
RGD		 PMID:9869665 PMID:10417274 PMID:10455107 PMID:17316539 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107, RGD:1600790 NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793 		JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase involved_in ISO
IEA		 (PMID:29754768)
GO_REF:0000107		 RGD
Ensembl		 PMID:29754768 GO_REF:0000107 NCBI chr 5:133,023,077...133,026,899
Ensembl chr 5:133,023,121...133,026,933 		JBrowse link
acetyl-CoA biosynthetic process from acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acss1 acyl-CoA synthetase short-chain family member 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:159,910,809...159,960,748
Ensembl chr 3:139,450,383...139,500,325 		JBrowse link
acetyl-CoA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 involved_in ISO
IEA		 (PMID:17371050)
GO_REF:0000107		 RGD
Ensembl		 PMID:17371050 GO_REF:0000107 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855 		JBrowse link
G Nudt7 nudix hydrolase 7 acts_upstream_of_or_within
involved_in		 ISO (PMID:11415433)
(PMID:18799520), (PMID:29378847)		 RGD PMID:11415433 PMID:18799520 PMID:29378847 NCBI chr19:42,125,679...42,151,198
Ensembl chr19:42,125,711...42,151,081 		JBrowse link
G Nudt8 nudix hydrolase 8 involved_in ISO (PMID:31004344) RGD PMID:31004344 NCBI chr 1:201,293,660...201,295,233
Ensembl chr 1:201,292,619...201,295,224 		JBrowse link
isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvd mevalonate diphosphate decarboxylase involved_in IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000104
GO_REF:0000002		 GO_Central
UniProt
InterPro
RGD		 PMID:197206 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104, RGD:2316852 NCBI chr19:67,404,911...67,414,974
Ensembl chr19:50,496,367...50,507,971 		JBrowse link
G Mvk mevalonate kinase involved_in IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000041		 GO_Central
UniProt
RGD		 PMID:197206 GO_REF:0000033 GO_REF:0000041, RGD:2316852 NCBI chr12:47,802,002...47,819,503
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Pmvk phosphomevalonate kinase involved_in IDA
IEA
IBA		 GO_REF:0000104
GO_REF:0000033
GO_REF:0000041		 UniProt
GO_Central
RGD		 PMID:197206 GO_REF:0000033 GO_REF:0000041 GO_REF:0000104, RGD:2316852 NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364 		JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pipox pipecolic acid and sarcosine oxidase involved_in ISO
IEA
IBA		 (PMID:10642506)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:10642506 GO_REF:0000033 GO_REF:0000107 NCBI chr10:62,769,874...62,783,484
Ensembl chr10:62,769,900...62,782,370 		JBrowse link
L-lysine catabolic process to acetyl-CoA via saccharopine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332 		JBrowse link
G Aass aminoadipate-semialdehyde synthase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 4:51,606,461...51,663,136
Ensembl chr 4:51,606,462...51,663,136 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
L-tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kynu kynureninase IDA RGD PMID:7236232 RGD:2303721 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase involved_in IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:7236232 GO_REF:0000033, RGD:2303721 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
negative regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pgk1 phosphoglycerate kinase 1 involved_in ISO
IEA		 (PMID:26942675)
GO_REF:0000107		 RGD
Ensembl		 PMID:26942675 GO_REF:0000107 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Pgk1l1 phosphoglycerate kinase 1 like 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:42,754,605...42,755,929
Ensembl chr 2:42,754,639...42,755,856 		JBrowse link
pyruvate decarboxylation to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase involved_in IDA
IEA
ISO
IBA		 GO_REF:0000107
GO_REF:0000002
GO_REF:0000117
MGI:2386703 (PMID:17314311), (PMID:27621431)
GO_REF:0000033
(PMID:24534072)		 Ensembl
InterPro
UniProt
RGD
GO_Central		 PMID:17314311 PMID:24534072 PMID:27621431 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:1599112 NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
Ensembl chr 1:50,978,051...51,004,479 		JBrowse link
G Dld dihydrolipoamide dehydrogenase involved_in IDA
IEA
ISO		 GO_REF:0000107
MGI:2386703 (PMID:17314311), (PMID:27621431)
(PMID:24534072)		 Ensembl
RGD		 PMID:17314311 PMID:24534072 PMID:27621431 PMID:7487891 GO_REF:0000107, RGD:1599112 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 acts_upstream_of_or_within
involved_in		 ISO (PMID:22628558) RGD PMID:22628558 NCBI chr 1:52,437,745...52,449,399
Ensembl chr 1:52,437,741...52,449,400 		JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:22628558)
GO_REF:0000107
MGI:5635078 (PMID:22628558), (PMID:24910426)		 RGD
Ensembl		 PMID:22628558 PMID:24910426 GO_REF:0000107 NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 involved_in
acts_upstream_of_or_within		 IDA
IEA
ISO
IBA		 GO_REF:0000002
GO_REF:0000117
MGI:2182095|MGI:2386703 (PMID:18586888)
GO_REF:0000033
GO_REF:0000114
(PMID:19081061), (PMID:24534072)		 InterPro
UniProt
RGD
GO_Central
ComplexPortal		 PMID:18586888 PMID:19081061 PMID:24534072 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000114 GO_REF:0000117, RGD:1599112 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pdha1l1 pyruvate dehydrogenase (lipoamide) alpha 1-like 1 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000117
GO_REF:0000002		 GO_Central
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000117 NCBI chr16:82,511,483...82,514,378
Ensembl chr16:82,511,511...82,514,372 		JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 involved_in IDA
IEA
IBA		 GO_REF:0000117
GO_REF:0000002
GO_REF:0000033		 UniProt
InterPro
GO_Central
RGD		 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000117, RGD:1599112 NCBI chr 2:229,872,300...229,873,848 JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta involved_in IDA
IBA
ISO
IEA		 GO_REF:0000033
GO_REF:0000114
GO_REF:0000002
(PMID:19081061), (PMID:24534072)
GO_REF:0000107		 GO_Central
ComplexPortal
InterPro
RGD
Ensembl		 PMID:19081061 PMID:24534072 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000114, RGD:1599112 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500 		JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X involved_in ISO
IEA		 (PMID:24534072)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000117
MGI:2386703 (PMID:17314311), (PMID:27621431)		 RGD
Ensembl
InterPro
UniProt		 PMID:17314311 PMID:24534072 PMID:27621431 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 NCBI chr 3:89,372,248...89,431,779
Ensembl chr 3:89,371,497...89,431,773 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 TAS RGD PMID:12435272 RGD:729541 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bckdk branched chain ketoacid dehydrogenase kinase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:182,515,335...182,520,007
Ensembl chr 1:182,515,327...182,536,633 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 involved_in IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:22195962)		 Ensembl
GO_Central
RGD		 PMID:22195962 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:22360721)		 UniProt
GO_Central
RGD		 PMID:22360721 GO_REF:0000024 GO_REF:0000033 NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085 		JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 involved_in ISO (PMID:22865452) RGD PMID:22865452 NCBI chr  X:58,486,699...58,553,533
Ensembl chr  X:58,486,554...58,553,557 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 involved_in ISO
IBA
IEA
ISS		 (PMID:21852536)
GO_REF:0000033
(PMID:16606348)
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:16606348 PMID:21852536 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Tpk1 thiamin pyrophosphokinase 1 involved_in ISO
IEA		 (PMID:38547260)
GO_REF:0000107		 RGD
Ensembl		 PMID:38547260 GO_REF:0000107 NCBI chr 4:72,170,134...72,557,707
Ensembl chr 4:72,170,134...72,557,694 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        purine-containing compound metabolic process 610
          acyl-CoA metabolic process 98
            acetyl-CoA metabolic process 43
              L-lysine catabolic process to acetyl-CoA + 4
              L-threonine catabolic process to acetyl-CoA 0
              L-tryptophan catabolic process to acetyl-CoA 2
              acetyl-CoA biosynthetic process + 24
              acetyl-CoA catabolic process + 3
              butyryl-CoA biosynthetic process from acetyl-CoA + 0
              isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        primary metabolic process 10745
          nucleobase-containing compound metabolic process 5888
            nucleobase-containing small molecule metabolic process 723
              nucleoside phosphate metabolic process 689
                acyl-CoA metabolic process 98
                  acetyl-CoA metabolic process 43
                    L-lysine catabolic process to acetyl-CoA + 4
                    L-threonine catabolic process to acetyl-CoA 0
                    L-tryptophan catabolic process to acetyl-CoA 2
                    acetyl-CoA biosynthetic process + 24
                    acetyl-CoA catabolic process + 3
                    butyryl-CoA biosynthetic process from acetyl-CoA + 0
                    isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
paths to the root