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ONTOLOGY REPORT - ANNOTATIONS


Term:acetyl-CoA metabolic process
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Accession:GO:0006084 term browser browse the term
Definition:The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
Synonyms:exact_synonym: acetyl coenzyme A metabolic process;   acetyl coenzyme A metabolism;   acetyl-CoA metabolism



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acetyl-CoA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 involved_in ISO RGD
MGI
PMID:16476568 GO_REF:0000096 MGI:4417868 RGD:2317620 NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha involved_in IDA (MGI:4840155|PMID:20952656) UniProt PMID:20952656 MGI:4840155 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822
JBrowse link
G Acly ATP citrate lyase involved_in ISO RGD
MGI
PMID:18062843 GO_REF:0000096 MGI:4417868 RGD:2317315 NCBI chr11:100,367,178...100,418,826
Ensembl chr11:100,367,179...100,418,826
JBrowse link
G Acot12 acyl-CoA thioesterase 12 acts_upstream_of_or_within
involved_in
IDA
IBA
(PMID:12545200) MGI
GO_Central
PMID:12545200 GO_REF:0000033 NCBI chr13:91,889,635...91,934,271
Ensembl chr13:91,889,631...91,934,267
JBrowse link
G Cs citrate synthase involved_in ISO MGI
RGD
PMID:818082 PMID:5820645 GO_REF:0000096 MGI:4417868 RGD:2306824 RGD:2306825 NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348
JBrowse link
G Csl citrate synthase like involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr10:99,593,567...99,595,346
Ensembl chr10:99,593,568...99,595,520
JBrowse link
G Fasn fatty acid synthase involved_in ISO RGD
MGI
PMID:18062843 GO_REF:0000096 MGI:4417868 RGD:2317315 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 involved_in ISO
IBA
MGI
GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054
JBrowse link
acetyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-Coenzyme A acetyltransferase 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
JBrowse link
G Acly ATP citrate lyase involved_in ISO
IBA
MGI
GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr11:100,367,178...100,418,826
Ensembl chr11:100,367,179...100,418,826
JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 involved_in
acts_upstream_of_or_within
ISO
IBA
IDA
(PMID:11150295) MGI
GO_Central
PMID:11150295 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:150,460,031...150,510,160
Ensembl chr 2:150,460,025...150,510,420
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 acts_upstream_of_or_within
involved_in
IDA
IBA
(PMID:11150295) MGI
GO_Central
PMID:11150295 GO_REF:0000033 NCBI chr 2:155,359,963...155,404,663
Ensembl chr 2:155,359,868...155,427,644
JBrowse link
G Dip2a disco interacting protein 2 homolog A involved_in IDA (MGI:6478983|PMID:30672040) UniProt PMID:30672040 MGI:6478983 NCBI chr10:76,098,581...76,181,194
Ensembl chr10:76,095,263...76,181,125
JBrowse link
G Mlycd malonyl-CoA decarboxylase involved_in ISO
IBA
RGD
GO_Central
MGI
PMID:17316539 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1600790 NCBI chr 8:120,121,591...120,148,577
Ensembl chr 8:120,121,617...120,137,841
JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:119,275,724...119,279,673
Ensembl chr 4:119,275,727...119,279,617
JBrowse link
acetyl-CoA biosynthetic process from acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acss1 acyl-CoA synthetase short-chain family member 1 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 2:150,460,031...150,510,160
Ensembl chr 2:150,460,025...150,510,420
JBrowse link
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase involved_in
acts_upstream_of_or_within
ISO
IMP
IC
IBA
(PMID:27621431)
(PMID:17314311)
(PMID:12108679)
RGD
MGI
GO_Central
PMID:7487891 PMID:12108679 PMID:17314311 PMID:27621431 GO_REF:0000008 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1599112 NCBI chr 9:50,545,933...50,571,080
Ensembl chr 9:50,545,933...50,571,080
JBrowse link
G Dld dihydrolipoamide dehydrogenase involved_in
acts_upstream_of_or_within
ISO
IMP
IC
(PMID:17314311)
(PMID:27621431)
(PMID:9405644)
RGD
MGI
PMID:7487891 PMID:9405644 PMID:17314311 PMID:27621431 GO_REF:0000008 GO_REF:0000096 MGI:4417868 RGD:1599112 NCBI chr12:31,381,561...31,401,470
Ensembl chr12:31,381,276...31,401,452
JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 acts_upstream_of_or_within
involved_in
IMP
IC
(PMID:22628558)
(PMID:22628554)
MGI PMID:22628554 PMID:22628558 NCBI chr17:8,502,590...8,516,499
Ensembl chr17:8,501,736...8,516,493
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 acts_upstream_of_or_within
involved_in
IMP (PMID:24910426)
(PMID:22628558)
MGI PMID:22628558 PMID:24910426 NCBI chr 1:165,288,829...165,308,787
Ensembl chr 1:165,288,206...165,308,783
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 involved_in
acts_upstream_of_or_within
ISO
IBA
IMP
(PMID:18586888) RGD
GO_Central
MGI
PMID:7487891 PMID:18586888 GO_REF:0000033 GO_REF:0000119 MGI:4834177 RGD:1599112 NCBI chr  X:158,905,215...158,921,426
Ensembl chr  X:158,905,205...158,921,409
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 alpha 2 involved_in
acts_upstream_of_or_within
ISO
IBA
RGD
GO_Central
MGI
PMID:7487891 GO_REF:0000008 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:1599112 NCBI chr 3:140,915,765...140,918,116
Ensembl chr 3:140,915,765...140,918,116
JBrowse link
G Pdhb pyruvate dehydrogenase (lipoamide) beta involved_in
acts_upstream_of_or_within
ISO
IBA
RGD
GO_Central
MGI
PMID:7487891 GO_REF:0000008 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:1599112 NCBI chr14:14,296,470...14,303,782
Ensembl chr14:14,296,748...14,303,777
JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X involved_in
acts_upstream_of_or_within
ISO (PMID:24534072) ComplexPortal
MGI
PMID:24534072 GO_REF:0000008 NCBI chr 2:102,851,400...102,903,858
Ensembl chr 2:102,851,420...102,903,858
JBrowse link
G Vdac1 voltage-dependent anion channel 1 involved_in ISO (PMID:8726225) MGI PMID:8726225 NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224
JBrowse link
acetyl-CoA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-Coenzyme A acetyltransferase 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
JBrowse link
G Nudt7 nudix hydrolase 7 involved_in
acts_upstream_of_or_within
IDA (MGI:6157214|PMID:29378847), (MGI:6450264|PMID:18799520)
(PMID:11415433)
UniProt
MGI
PMID:11415433 PMID:18799520 PMID:29378847 MGI:6157214 MGI:6450264 NCBI chr 8:114,860,314...114,881,471
Ensembl chr 8:114,860,297...114,881,479
JBrowse link
isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvd mevalonate (diphospho) decarboxylase involved_in ISO
IBA
RGD
GO_Central
MGI
PMID:197206 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:2316852 NCBI chr 8:123,160,335...123,170,161
Ensembl chr 8:123,160,340...123,170,161
JBrowse link
G Mvk mevalonate kinase involved_in ISO
IBA
RGD
GO_Central
MGI
PMID:197206 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:2316852 NCBI chr 5:114,582,324...114,598,652
Ensembl chr 5:114,582,330...114,598,652
JBrowse link
G Pmvk phosphomevalonate kinase involved_in ISO
IBA
RGD
GO_Central
MGI
PMID:197206 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:2316852 NCBI chr 3:89,361,848...89,376,321
Ensembl chr 3:89,361,848...89,376,320
JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pipox pipecolic acid oxidase involved_in ISS
IBA
ISO
(MGI:1353685|PMID:10642506) UniProt
GO_Central
MGI
PMID:10642506 GO_REF:0000033 GO_REF:0000119 MGI:1353685 MGI:4834177 NCBI chr11:77,771,440...77,784,698
Ensembl chr11:77,771,441...77,784,922
JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 involved_in IMP (MGI:5487511|PMID:22195962) UniProt PMID:22195962 MGI:5487511 NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 involved_in IMP (MGI:5428826|PMID:22360721) UniProt PMID:22360721 MGI:5428826 NCBI chr11:94,917,084...94,932,197
Ensembl chr11:94,917,084...94,932,180
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase, isoenzyme 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:92,798,923...92,875,756
Ensembl chr  X:92,808,213...92,875,807
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 involved_in
acts_upstream_of_or_within
IMP
TAS
ISO
(MGI:3692363|PMID:16606348)
(PMID:10548532)
UniProt
MGI
PMID:10548532 PMID:16606348 GO_REF:0000119 MGI:3692363 MGI:4834177 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kynu kynureninase involved_in ISO RGD
MGI
PMID:7236232 GO_REF:0000096 MGI:4417868 RGD:2303721 NCBI chr 2:43,445,270...43,572,734
Ensembl chr 2:43,445,341...43,572,734
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase involved_in ISO
IBA
RGD
GO_Central
MGI
PMID:7236232 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:2303721 NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    metabolic process 11001
      amide metabolic process 454
        acyl-CoA metabolic process 89
          acetyl-CoA metabolic process 36
            L-lysine catabolic process to acetyl-CoA + 1
            L-threonine catabolic process to acetyl-CoA 0
            acetyl-CoA biosynthetic process + 20
            acetyl-CoA catabolic process + 2
            butyryl-CoA biosynthetic process from acetyl-CoA + 0
            isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
            tryptophan catabolic process to acetyl-CoA 2
Path 2
Term Annotations click to browse term
  biological_process 28573
    metabolic process 11001
      organic substance metabolic process 10573
        organic cyclic compound metabolic process 5906
          nucleobase-containing compound metabolic process 5390
            nucleobase-containing small molecule metabolic process 667
              nucleoside phosphate metabolic process 608
                nucleotide metabolic process 600
                  ribonucleotide metabolic process 479
                    purine ribonucleotide metabolic process 460
                      acyl-CoA metabolic process 89
                        acetyl-CoA metabolic process 36
                          L-lysine catabolic process to acetyl-CoA + 1
                          L-threonine catabolic process to acetyl-CoA 0
                          acetyl-CoA biosynthetic process + 20
                          acetyl-CoA catabolic process + 2
                          butyryl-CoA biosynthetic process from acetyl-CoA + 0
                          isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
                          tryptophan catabolic process to acetyl-CoA 2
paths to the root