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ONTOLOGY REPORT - ANNOTATIONS

Term:acetyl-CoA metabolic process
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Accession:GO:0006084 term browser browse the term
Definition:The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
Synonyms:exact_synonym: acetyl coenzyme A metabolic process;   acetyl coenzyme A metabolism;   acetyl-CoA metabolism


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acetyl-CoA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA2 acetyl-CoA acyltransferase 2 ISO RGD PMID:16476568 RGD:2317620 NCBI chr18:49,782,164...49,813,533
Ensembl chr18:49,782,164...49,813,953 		JBrowse link
G ACACA acetyl-CoA carboxylase alpha involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G ACACB acetyl-CoA carboxylase beta involved_in IDA (PMID:20952656) UniProt PMID:20952656 NCBI chr12:109,111,189...109,268,226
Ensembl chr12:109,116,587...109,268,226 		JBrowse link
G ACLY ATP citrate lyase ISO RGD PMID:18062843 RGD:2317315 NCBI chr17:41,866,917...41,930,545
Ensembl chr17:41,866,917...41,930,542 		JBrowse link
G ACOT12 acyl-CoA thioesterase 12 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:12545200) Ensembl
MGI
GO_Central		 PMID:12545200 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:81,308,609...81,394,134
Ensembl chr 5:81,329,996...81,394,179 		JBrowse link
G CS citrate synthase ISO RGD PMID:818082 PMID:5820645 RGD:2306824 RGD:2306825 NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391 		JBrowse link
G FASN fatty acid synthase ISO RGD PMID:18062843 RGD:2317315 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 involved_in IEA
IBA		 InterPro
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:43,287,470...43,313,412
Ensembl chr 5:43,287,470...43,313,512 		JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in IMP
IEA
IBA		 (PMID:23751782) UniProt
TreeGrafter
GO_Central
InterPro		 PMID:23751782 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:119,747,996...119,768,932
Ensembl chr 1:119,748,002...119,768,905 		JBrowse link
acetyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAT1 acetyl-CoA acetyltransferase 1 involved_in IDA (PMID:17371050) BHF-UCL PMID:17371050 NCBI chr11:108,116,705...108,147,603
Ensembl chr11:108,116,695...108,147,603 		JBrowse link
G ACLY ATP citrate lyase involved_in IDA
IBA
IEA		 (PMID:1371749) BHF-UCL
GO_Central
TreeGrafter
InterPro		 PMID:1371749 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr17:41,866,917...41,930,545
Ensembl chr17:41,866,917...41,930,542 		JBrowse link
G ACSS1 acyl-CoA synthetase short chain family member 1 involved_in
acts_upstream_of_or_within		 IDA
ISO
IEA
IBA		 (PMID:16788062)
(PMID:11150295)		 UniProt
MGI
TreeGrafter
GO_Central
Ensembl		 PMID:11150295 PMID:16788062 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr20:25,006,237...25,058,139
Ensembl chr20:25,006,230...25,058,980 		JBrowse link
G ACSS2 acyl-CoA synthetase short chain family member 2 involved_in
acts_upstream_of_or_within		 IBA
ISO
IEA		 (PMID:11150295) GO_Central
MGI
TreeGrafter		 PMID:11150295 GO_REF:0000033 GO_REF:0000118 NCBI chr20:34,874,989...34,927,959
Ensembl chr20:34,872,146...34,927,962 		JBrowse link
G DIP2A disco interacting protein 2 homolog A involved_in ISS UniProt GO_REF:0000024 NCBI chr21:46,458,891...46,583,871
Ensembl chr21:46,458,891...46,570,015 		JBrowse link
G MLYCD malonyl-CoA decarboxylase involved_in ISO
IBA
IDA
IEA		 (PMID:10417274), (PMID:10455107), (PMID:9869665) RGD
GO_Central
UniProt
Ensembl		 PMID:9869665 PMID:10417274 PMID:10455107 PMID:17316539 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 RGD:1600790 NCBI chr16:83,899,115...83,927,031
Ensembl chr16:83,899,115...83,951,445 		JBrowse link
G PPCS phosphopantothenoylcysteine synthetase involved_in IMP (PMID:29754768) UniProt PMID:29754768 NCBI chr 1:42,456,341...42,473,417
Ensembl chr 1:42,456,117...42,473,385 		JBrowse link
acetyl-CoA biosynthetic process from acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACSS1 acyl-CoA synthetase short chain family member 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr20:25,006,237...25,058,139
Ensembl chr20:25,006,230...25,058,980 		JBrowse link
G ACSS2 acyl-CoA synthetase short chain family member 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr20:34,874,989...34,927,959
Ensembl chr20:34,872,146...34,927,962 		JBrowse link
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLAT dihydrolipoamide S-acetyltransferase involved_in ISO
IEA
IBA
ISS
IDA		 (PMID:24534072) RGD
TreeGrafter
GO_Central
Ensembl
ComplexPortal
InterPro		 PMID:7487891 PMID:24534072 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000114 GO_REF:0000118 RGD:1599112 NCBI chr11:112,025,408...112,064,404
Ensembl chr11:112,025,033...112,064,404 		JBrowse link
G DLD dihydrolipoamide dehydrogenase involved_in
acts_upstream_of_or_within		 ISO
IEA
ISS
IC
IDA		 (PMID:9242632)
(PMID:24534072)		 RGD
Ensembl
ComplexPortal
MGI		 PMID:7487891 PMID:9242632 PMID:24534072 GO_REF:0000107 GO_REF:0000114 RGD:1599112 NCBI chr 7:107,891,107...107,921,198
Ensembl chr 7:107,891,162...107,931,730 		JBrowse link
G MPC1 mitochondrial pyruvate carrier 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:22628558) MGI PMID:22628558 NCBI chr 6:166,364,919...166,382,940
Ensembl chr 6:166,364,919...166,383,013 		JBrowse link
G MPC2 mitochondrial pyruvate carrier 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24910426)
(PMID:22628558)		 Ensembl
MGI		 PMID:22628558 PMID:24910426 GO_REF:0000107 NCBI chr 1:167,916,675...167,937,072
Ensembl chr 1:167,916,675...167,937,072 		JBrowse link
G PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA
IDA		 (PMID:18586888)
(PMID:19081061), (PMID:24534072)		 RGD
MGI
TreeGrafter
GO_Central
Ensembl
InterPro
UniProt		 PMID:7487891 PMID:18586888 PMID:19081061 PMID:24534072 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:1599112 NCBI chr  X:19,343,927...19,361,718
Ensembl chr  X:19,343,893...19,361,718 		JBrowse link
G PDHA2 pyruvate dehydrogenase E1 subunit alpha 2 involved_in ISO
IBA
ISS
IEA		 RGD
GO_Central
ComplexPortal
InterPro		 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000114 RGD:1599112 NCBI chr 4:95,840,093...95,841,464
Ensembl chr 4:95,840,093...95,841,464 		JBrowse link
G PDHB pyruvate dehydrogenase E1 subunit beta involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA
ISS
IC
IDA		 (PMID:18164639)
(PMID:19081061), (PMID:24534072)		 RGD
TreeGrafter
GO_Central
ComplexPortal
MGI
InterPro
UniProt		 PMID:7487891 PMID:18164639 PMID:19081061 PMID:24534072 GO_REF:0000002 GO_REF:0000033 GO_REF:0000114 GO_REF:0000118 RGD:1599112 NCBI chr 3:58,427,630...58,433,832
Ensembl chr 3:58,427,630...58,433,857 		JBrowse link
G PDHX pyruvate dehydrogenase complex component X involved_in
acts_upstream_of_or_within		 IDA
ISS
IC
IEA		 (PMID:24534072)
(PMID:9242632)		 ComplexPortal
MGI
InterPro		 PMID:9242632 PMID:24534072 GO_REF:0000002 GO_REF:0000114 NCBI chr11:34,915,920...34,996,128
Ensembl chr11:34,915,829...35,020,591 		JBrowse link
acetyl-CoA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAT1 acetyl-CoA acetyltransferase 1 involved_in IDA (PMID:17371050) BHF-UCL PMID:17371050 NCBI chr11:108,116,705...108,147,603
Ensembl chr11:108,116,695...108,147,603 		JBrowse link
G NUDT7 nudix hydrolase 7 involved_in
acts_upstream_of_or_within		 ISS
IEA
ISO		 (PMID:11415433) UniProt
Ensembl
MGI		 PMID:11415433 GO_REF:0000024 GO_REF:0000107 NCBI chr16:77,722,514...77,742,260
Ensembl chr16:77,722,492...77,742,260 		JBrowse link
G NUDT8 nudix hydrolase 8 involved_in ISS UniProt GO_REF:0000024 NCBI chr11:67,627,938...67,629,937
Ensembl chr11:67,627,938...67,629,937 		JBrowse link
isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MVD mevalonate diphosphate decarboxylase involved_in ISO
IBA
IEA		 RGD
GO_Central
InterPro		 PMID:197206 GO_REF:0000002 GO_REF:0000033 RGD:2316852 NCBI chr16:88,651,940...88,663,091
Ensembl chr16:88,651,935...88,663,161 		JBrowse link
G MVK mevalonate kinase involved_in ISO
IBA
IEA		 RGD
GO_Central
TreeGrafter
UniProt		 PMID:197206 GO_REF:0000033 GO_REF:0000041 GO_REF:0000118 RGD:2316852 NCBI chr12:109,573,272...109,598,125
Ensembl chr12:109,573,255...109,598,125 		JBrowse link
G PMVK phosphomevalonate kinase involved_in ISO
IBA
IEA		 RGD
GO_Central
TreeGrafter
UniProt
Ensembl		 PMID:197206 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 RGD:2316852 NCBI chr 1:154,924,740...154,942,658
Ensembl chr 1:154,924,740...154,936,719 		JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIPOX pipecolic acid and sarcosine oxidase involved_in IDA
IEA
IBA		 (PMID:10642506) UniProt
TreeGrafter
GO_Central		 PMID:10642506 GO_REF:0000033 GO_REF:0000118 NCBI chr17:29,043,141...29,057,216
Ensembl chr17:28,950,513...29,057,216 		JBrowse link
L-lysine catabolic process to acetyl-CoA via saccharopine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AADAT aminoadipate aminotransferase involved_in IEA UniProt GO_REF:0000041 NCBI chr 4:170,060,222...170,094,292
Ensembl chr 4:170,060,222...170,091,699 		JBrowse link
G AASS aminoadipate-semialdehyde synthase involved_in IEA UniProt GO_REF:0000041 NCBI chr 7:122,073,549...122,144,249
Ensembl chr 7:122,064,583...122,144,308 		JBrowse link
G DLST dihydrolipoamide S-succinyltransferase involved_in IEA UniProt GO_REF:0000041 NCBI chr14:74,881,916...74,903,743
Ensembl chr14:74,881,891...74,903,743 		JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDK1 pyruvate dehydrogenase kinase 1 involved_in TAS
IEA		 Reactome
Ensembl		 GO_REF:0000107 Reactome:R-HSA-204174 NCBI chr 2:172,555,373...172,724,312
Ensembl chr 2:172,555,373...172,608,669 		JBrowse link
G PDK2 pyruvate dehydrogenase kinase 2 involved_in IEA
ISS
TAS		 Ensembl
UniProt
Reactome		 GO_REF:0000024 GO_REF:0000107 Reactome:R-HSA-204174 NCBI chr17:50,094,737...50,112,152
Ensembl chr17:50,094,737...50,112,152 		JBrowse link
G PDK3 pyruvate dehydrogenase kinase 3 involved_in TAS
IMP		 (PMID:22865452) Reactome
UniProt		 PMID:22865452 Reactome:R-HSA-204174 NCBI chr  X:24,465,286...24,550,466
Ensembl chr  X:24,465,244...24,550,466 		JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 involved_in TAS
IMP
IEA		 (PMID:21852536) Reactome
UniProt
Ensembl		 PMID:21852536 GO_REF:0000107 Reactome:R-HSA-204174 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516 		JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KYNU kynureninase ISO RGD PMID:7236232 RGD:2303721 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833 		JBrowse link
G TDO2 tryptophan 2,3-dioxygenase involved_in ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:7236232 GO_REF:0000033 GO_REF:0000107 RGD:2303721 NCBI chr 4:155,903,696...155,920,406
Ensembl chr 4:155,854,738...155,920,406 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      amide metabolic process 508
        acyl-CoA metabolic process 104
          acetyl-CoA metabolic process 38
            L-lysine catabolic process to acetyl-CoA + 4
            L-threonine catabolic process to acetyl-CoA 0
            acetyl-CoA biosynthetic process + 19
            acetyl-CoA catabolic process + 3
            butyryl-CoA biosynthetic process from acetyl-CoA + 0
            isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
            tryptophan catabolic process to acetyl-CoA 2
Path 2
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      organic substance metabolic process 11967
        organic cyclic compound metabolic process 7069
          nucleobase-containing compound metabolic process 6539
            nucleobase-containing small molecule metabolic process 743
              nucleoside phosphate metabolic process 665
                nucleotide metabolic process 659
                  ribonucleotide metabolic process 522
                    purine ribonucleotide metabolic process 501
                      acyl-CoA metabolic process 104
                        acetyl-CoA metabolic process 38
                          L-lysine catabolic process to acetyl-CoA + 4
                          L-threonine catabolic process to acetyl-CoA 0
                          acetyl-CoA biosynthetic process + 19
                          acetyl-CoA catabolic process + 3
                          butyryl-CoA biosynthetic process from acetyl-CoA + 0
                          isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
                          tryptophan catabolic process to acetyl-CoA 2
paths to the root