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ONTOLOGY REPORT - ANNOTATIONS


Term:acetyl-CoA metabolic process
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Accession:GO:0006084 term browser browse the term
Definition:The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
Synonyms:exact_synonym: acetyl coenzyme A metabolic process;   acetyl coenzyme A metabolism;   acetyl-CoA metabolism


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acetyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 ISO RGD PMID:16476568 RGD:2317620 NCBI chrNW_004955402:34,857,317...34,885,169
Ensembl chrNW_004955402:34,857,317...34,885,169
JBrowse link
G Acaca acetyl-CoA carboxylase alpha ISO (MGI:MGI:4840155|PMID:20952656) UniProtKB PMID:20952656 MGI:MGI:4840155 NCBI chrNW_004955451:679,033...909,892
Ensembl chrNW_004955451:600,254...909,892
JBrowse link
G Acacb acetyl-CoA carboxylase beta ISO (PMID:20952656) UniProtKB PMID:20952656 NCBI chrNW_004955455:10,282,308...10,427,439
Ensembl chrNW_004955455:10,308,192...10,426,076
JBrowse link
G Acly ATP citrate lyase ISO RGD PMID:18062843 RGD:2317315 NCBI chrNW_004955451:16,058,916...16,091,831
Ensembl chrNW_004955451:16,058,727...16,092,589
JBrowse link
G Acot12 acyl-CoA thioesterase 12 ISO (MGI:MGI:2450440|PMID:12545200) MGI PMID:12545200 MGI:MGI:2450440 NCBI chrNW_004955418:28,829,316...28,872,629
Ensembl chrNW_004955418:28,829,144...28,875,486
JBrowse link
G Cs citrate synthase ISO RGD PMID:818082, PMID:938457, PMID:5820645 RGD:2306824, RGD:2306825, RGD:2306828 NCBI chrNW_004955458:3,881,798...3,913,044
Ensembl chrNW_004955458:3,881,798...3,893,401
JBrowse link
G Fasn fatty acid synthase ISO RGD PMID:18062843 RGD:2317315 NCBI chrNW_004955506:1,063,002...1,079,939
Ensembl chrNW_004955506:1,063,002...1,079,939
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 ISO (PMID:23751782) UniProt PMID:23751782 NCBI chrNW_004955435:22,804,484...22,820,807
Ensembl chrNW_004955435:22,804,484...22,821,482
JBrowse link
acetyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 ISO (PMID:17371050) BHF-UCL PMID:17371050 NCBI chrNW_004955412:10,350,088...10,369,806
Ensembl chrNW_004955412:10,349,593...10,369,806
JBrowse link
G Acly ATP citrate lyase ISO (PMID:1371749) BHF-UCL PMID:1371749 NCBI chrNW_004955451:16,058,916...16,091,831
Ensembl chrNW_004955451:16,058,727...16,092,589
JBrowse link
G Acss1 acyl-CoA synthetase short chain family member 1 ISO (MGI:MGI:2151932|PMID:11150295)
(PMID:16788062)
MGI
UniProtKB
PMID:11150295, PMID:16788062 MGI:MGI:2151932 NCBI chrNW_004955415:31,117,542...31,154,654
Ensembl chrNW_004955415:31,117,303...31,154,654
JBrowse link
G Acss2 acyl-CoA synthetase short chain family member 2 ISO (MGI:MGI:2151932|PMID:11150295) MGI PMID:11150295 MGI:MGI:2151932 NCBI chrNW_004955422:26,450,899...26,500,336
Ensembl chrNW_004955422:26,451,598...26,500,546
JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase ISO (PMID:29754768) UniProt PMID:29754768 NCBI chrNW_004955537:2,080,865...2,084,199
Ensembl chrNW_004955537:2,080,865...2,085,003
JBrowse link
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004955412:13,718,091...13,746,220
Ensembl chrNW_004955412:13,718,067...13,744,239
JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004955410:12,212,981...12,238,561
Ensembl chrNW_004955410:12,212,963...12,238,561
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 subunit ISO (PMID:19081061) RGD
UniProtKB
PMID:7487891, PMID:19081061 RGD:1599112 NCBI chrNW_004955586:98,492...114,927
Ensembl chrNW_004955586:97,172...114,928
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 alpha 2 subunit ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004955405:6,383,088...6,383,946 JBrowse link
G Pdhb pyruvate dehydrogenase E1 beta subunit ISO (PMID:19081061) UniProtKB
RGD
PMID:7487891, PMID:19081061 RGD:1599112 NCBI chrNW_004955430:1,707,615...1,713,541
Ensembl chrNW_004955430:1,707,615...1,713,541
JBrowse link
acetyl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 ISO (PMID:17371050) BHF-UCL PMID:17371050 NCBI chrNW_004955412:10,350,088...10,369,806
Ensembl chrNW_004955412:10,349,593...10,369,806
JBrowse link
G Nudt7 nudix hydrolase 7 ISO (MGI:MGI:2137102|PMID:11415433), (MGI:MGI:6450264|PMID:18799520) UniProt PMID:11415433, PMID:18799520 MGI:MGI:2137102, MGI:MGI:6450264 NCBI chrNW_004955522:945,186...960,094
Ensembl chrNW_004955522:944,565...960,244
JBrowse link
isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvd mevalonate diphosphate decarboxylase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004955541:2,578,584...2,581,823
Ensembl chrNW_004955541:2,579,074...2,581,821
JBrowse link
G Mvk mevalonate kinase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004955455:8,933,250...8,953,883
Ensembl chrNW_004955455:8,930,125...8,953,894
JBrowse link
G Pmvk phosphomevalonate kinase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004955545:1,421,562...1,440,038
Ensembl chrNW_004955545:1,421,562...1,440,038
JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pipox pipecolic acid and sarcosine oxidase ISO (PMID:10642506) UniProtKB PMID:10642506 NCBI chrNW_004955481:4,128,503...4,225,027
Ensembl chrNW_004955481:4,128,509...4,143,334
JBrowse link
mitochondrial acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpc1 mitochondrial pyruvate carrier 1 ISO (MGI:MGI:5428352|PMID:22628558) MGI PMID:22628558 MGI:MGI:5428352 NCBI chrNW_004955439:15,515,966...15,531,618
Ensembl chrNW_004955439:15,516,090...15,531,116
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 ISO (MGI:MGI:5428352|PMID:22628558)
(MGI:MGI:5576400|PMID:24910426)
MGI PMID:22628558, PMID:24910426 MGI:MGI:5428352, MGI:MGI:5576400 NCBI chrNW_004955462:9,177,484...9,193,646 JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 subunit ISO (MGI:MGI:3817854|PMID:18586888) MGI PMID:18586888 MGI:MGI:3817854 NCBI chrNW_004955586:98,492...114,927
Ensembl chrNW_004955586:97,172...114,928
JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdk1 pyruvate dehydrogenase kinase 1 ISO (MGI:MGI:5487511|PMID:22195962) UniProtKB PMID:22195962 MGI:MGI:5487511 NCBI chrNW_004955449:2,546,790...2,582,402
Ensembl chrNW_004955449:2,549,139...2,582,243
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 ISO (MGI:MGI:5428826|PMID:22360721) UniProtKB PMID:22360721 MGI:MGI:5428826 NCBI chrNW_004955451:11,547,660...11,559,266
Ensembl chrNW_004955451:11,547,660...11,559,403
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 ISO (PMID:22865452) UniProtKB PMID:22865452 NCBI chrNW_004955509:4,809,422...4,888,802
Ensembl chrNW_004955509:4,809,399...4,878,976
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 ISO (MGI:MGI:3692363|PMID:16606348)
(PMID:21852536)
UniProtKB PMID:16606348, PMID:21852536 MGI:MGI:3692363 NCBI chrNW_004955432:12,169,548...12,182,064
Ensembl chrNW_004955432:12,169,435...12,182,409
JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kynu kynureninase ISO RGD PMID:7236232 RGD:2303721 NCBI chrNW_004955440:9,420,141...9,536,767
Ensembl chrNW_004955440:9,420,009...9,536,761
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase ISO RGD PMID:7236232 RGD:2303721 NCBI chrNW_004955471:11,229,795...11,245,255
Ensembl chrNW_004955471:11,229,273...11,245,375
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11892
    metabolic process 7610
      organic substance metabolic process 7321
        thioester metabolic process 61
          acyl-CoA metabolic process 61
            acetyl-CoA metabolic process 30
              L-lysine catabolic process to acetyl-CoA + 1
              L-threonine catabolic process to acetyl-CoA 0
              acetyl-CoA biosynthetic process + 16
              acetyl-CoA catabolic process + 2
              butyryl-CoA biosynthetic process from acetyl-CoA + 0
              isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
              tryptophan catabolic process to acetyl-CoA 2
Path 2
Term Annotations click to browse term
  biological_process 11892
    cellular process 11094
      cellular metabolic process 7025
        heterocycle metabolic process 3675
          nucleobase-containing compound metabolic process 3563
            nucleobase-containing small molecule metabolic process 356
              nucleoside phosphate metabolic process 311
                nucleotide metabolic process 301
                  ribonucleotide metabolic process 243
                    purine ribonucleotide metabolic process 236
                      acyl-CoA metabolic process 61
                        acetyl-CoA metabolic process 30
                          L-lysine catabolic process to acetyl-CoA + 1
                          L-threonine catabolic process to acetyl-CoA 0
                          acetyl-CoA biosynthetic process + 16
                          acetyl-CoA catabolic process + 2
                          butyryl-CoA biosynthetic process from acetyl-CoA + 0
                          isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
                          tryptophan catabolic process to acetyl-CoA 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.